- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-09-30 13:14:32+13:00
- Desc:
- fix the typos and tables in doc
- Permanent Source URI:
- https://models.cellml.org/workspace/6bb/rawfile/5766fc294ca1fb80e47e776c78d754cad7f5fc7f/Doc/Multi_stim_experiment.rst
Multiple stimulation experiment
-------------------------------
In the `Multiple stimulation experiment <Experiments/Multi_stim_experiment.cellml/view>`_, the `Excitation-contraction component <../Components/EC_uSMC.cellml>`_ is configured and parameterised with an applied `multiple pulses patch clamp protocol <../cellLib/Protocols/Patch_clamp_protocol.cellml>`_.
You can change the parameters of stimulation in the component ``Vstim_para``.
You can also bypass the parameters in the component ``model_parameters`` and ``initial_conditions`` and define your own parameters. We defined ``control_para`` to alter some parameters such as intracellular :math:`Na^{+}` concentration, inhibition of :math:`Ca^{2+}` pumps control :math:`inhPump`, for specific experiments.
The simulation experiment can be obtained by loading the `corresponding SED-ML document <../Simulation/Multi_stim_experiment.sedml>`_ into OpenCOR and executing the simulation.
The model reaction to a train of pulse potentials
--------------------------------------------------
We parameterise the multiple pulses patch clamp protocol to generate a train of 10 voltage pulses of 100 ms duration from a holding potential of −80 mV to a pulse potential of 0 mV, with an interval of 330 ms between the pulses.
Figure [#]_ shows the model :math:`Ca_i^{2+}` to the train of pulse potentials.
.. [#]
.. figure:: ../Simulation/simFig6.png
:width: 75%
:align: center
:alt: simFig6
Simulated model reaction to a train of pulse potentials.
The experiment setting to reproduce Figure 2 is summarized in the following:
.. figure:: ../Simulation/table3.png
:width: 75%
:align: center
:alt: table3
Experiment setting.
Figure [#]_ shows simulations of changes in :math:`Ca_i^{2+}` and stress in response to pacing pulses.
.. [#]
.. figure:: ../Simulation/simFig11.png
:width: 75%
:align: center
:alt: simFig11
