- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-09-30 13:14:32+13:00
- Desc:
- fix the typos and tables in doc
- Permanent Source URI:
- https://models.cellml.org/workspace/6bb/rawfile/5766fc294ca1fb80e47e776c78d754cad7f5fc7f/Doc/Nai_experiment.rst
Sodium concentration experiment
-------------------------------
In the `Sodium concentration experiment <Experiments/Nai_experiment.cellml/view>`_, the `Excitation-contraction unit <../Components/Unit_uSMC.cellml>`_ is configured and parameterised with an applied `Single pulse patch clamp protocol <../cellLib/Protocols/Patch_clamp_protocol.cellml>`_. In addition, the component ``Nai`` is defined to generate a linear :math:`Na_i^{+}` profile from 1 mM to 46 mM.
You can change the parameters of stimulation in the component ``Vstim_para``, while -50 mV holding voltage is used for Figure 8B.
You can also bypass the parameters in the component ``model_parameters`` and ``initial_conditions`` and define your own parameters. We defined ``control_para`` to alter some parameters such as :math:`Ca_i^{2+}` for this specific experiment.
The simulation experiment can be obtained by loading the `corresponding SED-ML document <../Simulation/Nai_experiment.sedml>`_ into OpenCOR and executing the simulation.
Sensitivity Analysis for :math:`Na_i^{+}`
------------------------------------------
Figure [#]_ A uses the settings in `Single stimulation experiment <Experiments/Single_stim_experiment.cellml/view>`_ and the values are list in the following.
.. figure:: ../Simulation/table2.png
:width: 75%
:align: center
:alt: table2
Experiment setting.
The `Sodium concentration experiment <Experiments/Nai_experiment.cellml/view>`_ is used to generate a linear :math:`Na_i^{+}` from 1 mM to 46 mM for the computation of :math:`J_{Na/Ca}` in plot B.
.. [#]
.. figure:: ../Simulation/simFig8.png
:width: 75%
:align: center
:alt: simFig8
Sensitivity analysis for :math:`Na_i^{+}`.
