- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-10-06 14:43:45+13:00
- Desc:
- Change the legends in the figures.
- Permanent Source URI:
- https://models.cellml.org/workspace/6bb/rawfile/e7aa3b86ede67a786b2f703dbed9b010c0f40211/Doc/Vramp_experiment.rst
Voltage ramp experiment
--------------------------
In the `Voltage ramp experiment <Experiments/Vramp_experiment.cellml/view>`_, the `Excitation-contraction unit <../Components/Unit_uSMC.cellml>`_ is configured and parameterised with an applied `voltage ramp protocol <../cellLib/Protocols/Patch_clamp_protocol.cellml>`_.
You can change the parameters of stimulation in the component ``Vstim_para``, while the ramp voltage signal has 1 mV/s rising rate and the range of variation is from -100 mv to 60 mV in the following simulation.
You can also bypass the parameters in the component ``model_parameters`` and ``initial_conditions`` and define your own parameters. We defined ``control_para`` to alter some parameters such as :math:`K_{Ca,1/2}` for this specific experiment.
The simulation experiment can be obtained by loading the `corresponding SED-ML document <../Simulation/Vramp_experiment.sedml>`_ into OpenCOR and executing the simulation.
Sensitivity Analysis for :math:`K_{Ca,1/2}`
-------------------------------------------
Figure [#]_ A uses the configurations in `Single stimulation experiment <Experiments/Single_stim_experiment.cellml/view>`_ and the experiment settings are listed in the following.
.. figure:: ../Simulation/table2.png
:width: 75%
:align: center
:alt: table2
Experiment setting.
The `Voltage ramp experiment <Experiments/Vramp_experiment.cellml/view>`_ is used to provide a voltage ramp ranging from -100 mv to 60 mV to compute the activation function in plot B.
.. [#]
.. figure:: ../Simulation/simFig7.png
:width: 75%
:align: center
:alt: simFig7
Sensitivity analysis for :math:`K_{Ca,1/2}`.
