- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-07-08 17:36:05+12:00
- Desc:
- Adding scheme for making LRG from L,R,G
- Permanent Source URI:
- https://models.cellml.org/workspace/6cb/rawfile/810eac117f2e040ef6f0932bcbc09346888139ac/saucerman_b1_AR_kinetic.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="saucerman_b1_AR_kinetic" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="uM">
<unit prefix="micro" units="mole"/>
<unit exponent="-1.0" units="liter"/>
</units>
<units name="per_sec">
<unit exponent="-1.0" units="second"/>
</units>
<units name="uM_per_sec">
<unit exponent="-1.0" units="second"/>
<unit units="uM"/>
</units>
<units name="per_uM_per_sec">
<unit exponent="-1.0" units="second"/>
<unit exponent="-1" units="uM"/>
</units>
<units name="mM">
<unit prefix="milli" units="mole"/>
<unit exponent="-1.0" units="liter"/>
</units>
<component name="b1_AR_module">
<variable name="time" units="second"/>
<variable initial_value="0.01" name="L_totmax" units="uM"/>
<variable initial_value="3.83" name="Gs_tot" units="uM"/>
<variable initial_value="0.285" name="Kl" units="uM"/>
<variable initial_value="0.062" name="Kr" units="uM"/>
<variable initial_value="33" name="Kc" units="uM"/>
<variable initial_value="1.1e-3" name="k_bar_kp" units="per_sec"/>
<variable initial_value="2.2e-3" name="k_bar_km" units="per_sec"/>
<variable initial_value="3.6e-3" name="k_p_kap" units="per_uM_per_sec"/>
<variable initial_value="2.2e-3" name="k_p_kam" units="per_sec"/>
<variable initial_value="16" name="k_g_act" units="per_sec"/>
<variable initial_value="0.8" name="k_hyd" units="per_sec"/>
<variable initial_value="1.21e3" name="k_reassoc" units="per_uM_per_sec"/>
<variable cmeta:id="LR" name="LR" public_interface="out" units="uM"/>
<variable cmeta:id="LRG" name="LRG" public_interface="out" units="uM"/>
<variable cmeta:id="RG" name="RG" public_interface="out" units="uM"/>
<variable cmeta:id="BARK_DESENS" name="BARK_DESENS" units="uM_per_sec"/>
<variable name="BARK_RESENS" units="uM_per_sec"/>
<variable cmeta:id="PKA_DESENS" name="PKA_DESENS" units="uM_per_sec"/>
<variable name="PKA_RESENS" units="uM_per_sec"/>
<variable cmeta:id="G_ACT" name="G_ACT" units="uM_per_sec"/>
<variable name="HYD" units="uM_per_sec"/>
<variable name="REASSOC" units="uM_per_sec"/>
<variable cmeta:id="L" name="L" public_interface="out" units="uM"/>
<variable cmeta:id="R" name="R" public_interface="out" units="uM"/>
<variable cmeta:id="Gs" name="Gs" public_interface="out" units="uM"/>
<variable initial_value="0.01205" name="b1_AR_tot" units="uM"/>
<variable initial_value="0" name="b1_AR_d" units="uM"/>
<variable initial_value="1.154e-3" name="b1_AR_p" units="uM"/>
<variable initial_value="0.02505" name="Gs_agtp_tot" units="uM"/>
<variable initial_value="6.446e-4" name="Gs_agdp" units="uM"/>
<variable initial_value="0.02569" name="Gs_bg" units="uM"/>
<variable initial_value="0.0587898478276673" name="PKAC_I" units="uM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>LR</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>L</ci>
<ci>R</ci>
</apply>
<ci>Kl</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>LRG</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>LR</ci>
<ci>Gs</ci>
</apply>
<ci>Kr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>RG</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>Gs</ci>
</apply>
<ci>Kc</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>BARK_DESENS</ci>
<apply>
<times/>
<ci>k_bar_kp</ci>
<apply>
<plus/>
<ci>LR</ci>
<ci>LRG</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>BARK_RESENS</ci>
<apply>
<times/>
<ci>k_bar_km</ci>
<ci>b1_AR_d</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>PKA_DESENS</ci>
<apply>
<times/>
<ci>k_p_kap</ci>
<ci>PKAC_I</ci>
<ci>b1_AR_tot</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>PKA_RESENS</ci>
<apply>
<times/>
<ci>k_p_kam</ci>
<ci>b1_AR_p</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>G_ACT</ci>
<apply>
<times/>
<ci>k_g_act</ci>
<apply>
<plus/>
<ci>RG</ci>
<ci>LRG</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>HYD</ci>
<apply>
<times/>
<ci>k_hyd</ci>
<ci>Gs_agtp_tot</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>REASSOC</ci>
<apply>
<times/>
<ci>k_reassoc</ci>
<ci>Gs_agdp</ci>
<ci>Gs_bg</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>L</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>L_totmax</ci>
<ci>LR</ci>
</apply>
<ci>LRG</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>R</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>b1_AR_tot</ci>
<ci>LR</ci>
</apply>
<ci>LRG</ci>
</apply>
<ci>RG</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Gs</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>Gs_tot</ci>
<ci>LRG</ci>
</apply>
<ci>RG</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>b1_AR_tot</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>BARK_RESENS</ci>
<ci>BARK_DESENS</ci>
</apply>
<ci>PKA_RESENS</ci>
</apply>
<ci>PKA_DESENS</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>b1_AR_d</ci>
</apply>
<apply>
<minus/>
<ci>BARK_DESENS</ci>
<ci>BARK_RESENS</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>b1_AR_p</ci>
</apply>
<apply>
<minus/>
<ci>PKA_DESENS</ci>
<ci>PKA_RESENS</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Gs_agtp_tot</ci>
</apply>
<apply>
<minus/>
<ci>G_ACT</ci>
<ci>HYD</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Gs_agdp</ci>
</apply>
<apply>
<minus/>
<ci>HYD</ci>
<ci>REASSOC</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Gs_bg</ci>
</apply>
<apply>
<minus/>
<ci>G_ACT</ci>
<ci>REASSOC</ci>
</apply>
</apply>
</math>
</component>
</model>
