- Author:
- Michael Clerx <michael.clerx@nottingham.ac.uk>
- Date:
- 2022-01-27 23:10:33+00:00
- Desc:
- Fixed issues with number representation.
- Permanent Source URI:
- https://models.cellml.org/workspace/6ed/rawfile/2c123f3eba5bb8b39bf7c8b2b4e5be92488f3c76/kernik-2019.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model xmlns="http://www.cellml.org/cellml/1.0#"
xmlns:cellml="http://www.cellml.org/cellml/1.0#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
name="kernik_2019"
cmeta:id="kernik_2019"
>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/">
<rdf:Description rdf:about="#kernik_2019">
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>electrophysiology</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<units name="A_per_F">
<unit units="gram" multiplier="1000"/>
<unit units="metre" exponent="2.0"/>
<unit units="second" exponent="-4.0"/>
<unit units="ampere" exponent="-1.0"/>
</units>
<units name="C_per_mmol">
<unit units="second" multiplier="1000"/>
<unit units="ampere"/>
<unit units="mole" exponent="-1.0"/>
</units>
<units name="J_per_mol_per_K">
<unit units="gram" multiplier="1000"/>
<unit units="metre" exponent="2.0"/>
<unit units="second" exponent="-2.0"/>
<unit units="kelvin" exponent="-1.0"/>
<unit units="mole" exponent="-1.0"/>
</units>
<units name="L_per_F_per_ms_times_1e0">
<unit units="gram"/>
<unit units="metre" exponent="5.0"/>
<unit units="second" exponent="-5.0"/>
<unit units="ampere" exponent="-2.0"/>
</units>
<units name="mM">
<unit units="metre" exponent="-3.0"/>
<unit units="mole"/>
</units>
<units name="mM_per_ms">
<unit units="metre" exponent="-3.0" multiplier="1000"/>
<unit units="second" exponent="-1.0"/>
<unit units="mole"/>
</units>
<units name="mS_per_uF">
<unit units="second" exponent="-1.0" multiplier="1000"/>
</units>
<units name="mV">
<unit units="gram"/>
<unit units="metre" exponent="2.0"/>
<unit units="second" exponent="-3.0"/>
<unit units="ampere" exponent="-1.0"/>
</units>
<units name="ms">
<unit units="second" multiplier="0.001"/>
</units>
<units name="pF">
<unit units="gram" exponent="-1.0" multiplier="1e-15"/>
<unit units="metre" exponent="-2.0"/>
<unit units="second" exponent="4.0"/>
<unit units="ampere" exponent="2.0"/>
</units>
<units name="per_mM2_per_ms">
<unit units="metre" exponent="6.0" multiplier="1000"/>
<unit units="second" exponent="-1.0"/>
<unit units="mole" exponent="-2.0"/>
</units>
<units name="per_mM_per_ms">
<unit units="metre" exponent="3.0" multiplier="1000"/>
<unit units="second" exponent="-1.0"/>
<unit units="mole" exponent="-1.0"/>
</units>
<units name="per_mV">
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<unit units="second" exponent="3.0"/>
<unit units="ampere"/>
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<units name="s4_A2_per_g_per_m2_per_mol_times_1e3">
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<unit units="mole" exponent="-1.0"/>
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<variable name="Cai" units="mM" public_interface="out" initial_value="2.19191642424964390e-04"/>
<variable name="Cai_bufc" units="dimensionless"/>
<variable name="Cm" units="pF" public_interface="in"/>
<variable name="F" units="C_per_mmol" public_interface="in"/>
<variable name="Kbuf_C" units="mM" initial_value="0.0006"/>
<variable name="Vc" units="um3" public_interface="in"/>
<variable name="i_CaL_Ca" units="A_per_F" public_interface="in"/>
<variable name="i_CaT" units="A_per_F" public_interface="in"/>
<variable name="i_NaCa" units="A_per_F" public_interface="in"/>
<variable name="i_PCa" units="A_per_F" public_interface="in"/>
<variable name="i_b_Ca" units="A_per_F" public_interface="in"/>
<variable name="i_leak" units="mM_per_ms" public_interface="in"/>
<variable name="i_rel" units="mM_per_ms" public_interface="in"/>
<variable name="i_up" units="mM_per_ms" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<diff/>
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<ci>time</ci>
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<times/>
<ci>Cai_bufc</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<plus/>
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<minus/>
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<times/>
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<divide/>
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<apply>
<times/>
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<times/>
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<ci>Vc</ci>
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<minus/>
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<plus/>
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<plus/>
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<plus/>
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<plus/>
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<ci>i_CaT</ci>
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<times/>
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<ci>i_NaCa</ci>
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<eq/>
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<plus/>
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<divide/>
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<times/>
<ci>Buf_C</ci>
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<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
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</apply>
</apply>
</math>
</component>
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<variable name="Buf_SR" units="mM"/>
<variable name="Ca_SR" units="mM" public_interface="out" initial_value="3.35086796732326109e-01"/>
<variable name="Ca_SR_bufSR" units="dimensionless"/>
<variable name="Kbuf_SR" units="mM" initial_value="0.3"/>
<variable name="V_SR" units="um3" public_interface="in"/>
<variable name="Vc" units="um3" public_interface="in"/>
<variable name="i_leak" units="mM_per_ms" public_interface="in"/>
<variable name="i_rel" units="mM_per_ms" public_interface="in"/>
<variable name="i_up" units="mM_per_ms" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Buf_SR</ci>
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<times/>
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</apply>
<apply>
<eq/>
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<diff/>
<bvar>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_SR_bufSR</ci>
<ci>Vc</ci>
</apply>
<ci>V_SR</ci>
</apply>
<apply>
<minus/>
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<minus/>
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<ci>i_rel</ci>
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</apply>
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<eq/>
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<plus/>
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<apply>
<divide/>
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<times/>
<ci>Buf_SR</ci>
<ci>Kbuf_SR</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Ca_SR</ci>
<ci>Kbuf_SR</ci>
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</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="engine">
<variable name="pace" units="dimensionless" public_interface="out" initial_value="0.0"/>
<variable name="time" units="ms" public_interface="out"/>
</component>
<component name="erev">
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="Cao" units="mM" public_interface="in"/>
<variable name="E_Ca" units="mV" public_interface="out"/>
<variable name="E_K" units="mV" public_interface="out"/>
<variable name="E_Na" units="mV" public_interface="out"/>
<variable name="Ki" units="mM" public_interface="in"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="RTF" units="mV" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
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<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RTF</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="extra">
<variable name="Cao" units="mM" public_interface="out" initial_value="1.8"/>
<variable name="Ko" units="mM" public_interface="out" initial_value="5.4"/>
<variable name="Nao" units="mM" public_interface="out" initial_value="140.0"/>
</component>
<component name="geom">
<variable name="Cm" units="pF" public_interface="out" initial_value="60.0"/>
<variable name="VSR_tenT" units="um3" initial_value="1094.0"/>
<variable name="V_SR" units="um3" public_interface="out"/>
<variable name="V_tot" units="um3" initial_value="3960.0"/>
<variable name="V_tot_tenT" units="um3"/>
<variable name="Vc" units="um3" public_interface="out"/>
<variable name="Vc_tenT" units="um3" initial_value="16404.0"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_SR</ci>
<apply>
<times/>
<ci>V_tot</ci>
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<divide/>
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</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>V_tot_tenT</ci>
<apply>
<plus/>
<ci>Vc_tenT</ci>
<ci>VSR_tenT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vc</ci>
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<times/>
<ci>V_tot</ci>
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<divide/>
<ci>Vc_tenT</ci>
<ci>V_tot_tenT</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ibca">
<variable name="E_Ca" units="mV" public_interface="in"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="g_b_Ca" units="mS_per_uF"/>
<variable name="i_b_Ca" units="A_per_F" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_b_Ca</ci>
<apply>
<times/>
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<apply>
<eq/>
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<times/>
<ci>g_b_Ca</ci>
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<minus/>
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</apply>
</apply>
</apply>
</math>
</component>
<component name="ibna">
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<variable name="V" units="mV" public_interface="in"/>
<variable name="g_b_Na" units="mS_per_uF"/>
<variable name="i_b_Na" units="A_per_F" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_b_Na</ci>
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<times/>
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<apply>
<eq/>
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<times/>
<ci>g_b_Na</ci>
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<minus/>
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</apply>
</apply>
</apply>
</math>
</component>
<component name="ical">
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<variable name="Cao" units="mM" public_interface="in"/>
<variable name="FFRT" units="s4_A2_per_g_per_m2_per_mol_times_1e3" public_interface="in"/>
<variable name="FRT" units="per_mV" public_interface="in"/>
<variable name="Ki" units="mM" public_interface="in"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="alpha_fCa" units="dimensionless"/>
<variable name="beta_fCa" units="dimensionless"/>
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<variable name="d1" units="mS_per_uF" initial_value="1.29662941897219994e+01"/>
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<variable name="gamma_fCa" units="dimensionless"/>
<variable name="i_CaL" units="A_per_F" public_interface="out"/>
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<variable name="i_CaL_K" units="A_per_F" public_interface="out"/>
<variable name="i_CaL_Na" units="A_per_F" public_interface="out"/>
<variable name="ibarca" units="A_per_F"/>
<variable name="ibark" units="A_per_F"/>
<variable name="ibarna" units="A_per_F"/>
<variable name="ical_d_a" units="mS_per_uF"/>
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<times/>
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<times/>
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<minus/>
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<variable name="Cao" units="mM" public_interface="in"/>
<variable name="FRT" units="per_mV" public_interface="in"/>
<variable name="KmCa" units="mM" initial_value="1.38"/>
<variable name="KmNai" units="mM" initial_value="87.5"/>
<variable name="Ksat" units="dimensionless" initial_value="0.1"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="alpha" units="dimensionless"/>
<variable name="gamma" units="dimensionless"/>
<variable name="i_NaCa" units="A_per_F" public_interface="out"/>
<variable name="kNaCa" units="A_per_F"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>alpha</ci>
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<times/>
<cn cellml:units="dimensionless">2.5</cn>
<cn cellml:units="dimensionless">1.1</cn>
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<eq/>
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<times/>
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<cn cellml:units="dimensionless">2.0</cn>
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<apply>
<eq/>
<ci>i_NaCa</ci>
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<divide/>
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<times/>
<ci>kNaCa</ci>
<apply>
<minus/>
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<times/>
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<times/>
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<exp/>
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<times/>
<apply>
<times/>
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<ci>V</ci>
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<power/>
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<ci>Cao</ci>
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<times/>
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<times/>
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<times/>
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<minus/>
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<power/>
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<times/>
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<times/>
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<plus/>
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<power/>
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<plus/>
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<times/>
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<exp/>
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<times/>
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<times/>
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<minus/>
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<ci>FRT</ci>
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<eq/>
<ci>kNaCa</ci>
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<times/>
<cn cellml:units="dimensionless">1000.0</cn>
<cn cellml:units="A_per_F">1.1</cn>
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<component name="inak">
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<variable name="Km_K" units="mM" initial_value="1.0"/>
<variable name="Km_Na" units="mM" initial_value="40.0"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="PNaK" units="A_per_F"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="i_NaK" units="A_per_F" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<times/>
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<cn cellml:units="A_per_F">1.818</cn>
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<eq/>
<ci>i_NaK</ci>
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<divide/>
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<times/>
<apply>
<times/>
<ci>PNaK</ci>
<ci>Ko</ci>
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<ci>Nai</ci>
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<times/>
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<times/>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_K</ci>
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<plus/>
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<ci>Km_Na</ci>
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<plus/>
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<plus/>
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<exp/>
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<times/>
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<times/>
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<minus/>
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<ci>V</ci>
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<ci>FRT</ci>
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<apply>
<times/>
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<exp/>
<apply>
<times/>
<apply>
<minus/>
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<ci>FRT</ci>
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</apply>
</apply>
</apply>
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<component name="ipca">
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<variable name="KPCa" units="mM" initial_value="0.0005"/>
<variable name="g_PCa" units="A_per_F"/>
<variable name="i_PCa" units="A_per_F" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_PCa</ci>
<apply>
<times/>
<cn cellml:units="A_per_F">0.025</cn>
<cn cellml:units="dimensionless">10.5</cn>
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<apply>
<eq/>
<ci>i_PCa</ci>
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<divide/>
<apply>
<times/>
<ci>g_PCa</ci>
<ci>Cai</ci>
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<apply>
<plus/>
<ci>Cai</ci>
<ci>KPCa</ci>
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</apply>
</apply>
</math>
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<component name="irel">
<variable name="Ca_SR" units="mM" public_interface="in"/>
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="I" units="dimensionless" initial_value="1.42153622323011597e-02"/>
<variable name="MaxSR" units="dimensionless" initial_value="15.0"/>
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<variable name="V_SR" units="um3" public_interface="in"/>
<variable name="Vc" units="um3" public_interface="in"/>
<variable name="ec50SR" units="mM" initial_value="0.45"/>
<variable name="i_rel" units="mM_per_ms" public_interface="out"/>
<variable name="kCaSR" units="dimensionless"/>
<variable name="kiCa" units="per_mM_per_ms"/>
<variable name="kiSRCa" units="per_mM_per_ms"/>
<variable name="kim" units="mS_per_uF"/>
<variable name="koCa" units="per_mM2_per_ms"/>
<variable name="koSRCa" units="per_mM2_per_ms"/>
<variable name="kom" units="mS_per_uF"/>
<variable name="ks" units="mS_per_uF" initial_value="12.5"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<diff/>
<bvar>
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<plus/>
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<minus/>
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<minus/>
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<times/>
<apply>
<times/>
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<times/>
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<times/>
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<times/>
<ci>koSRCa</ci>
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<power/>
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<diff/>
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<plus/>
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<minus/>
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<minus/>
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<times/>
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<times/>
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<power/>
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<times/>
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<times/>
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<minus/>
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<times/>
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<times/>
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<power/>
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<minus/>
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<minus/>
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<minus/>
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<times/>
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<times/>
<apply>
<times/>
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<minus/>
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<divide/>
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<apply>
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<minus/>
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<divide/>
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<minus/>
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<times/>
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<plus/>
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<component name="iup">
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<variable name="Kup" units="mM"/>
<variable name="VmaxUp" units="mM_per_ms"/>
<variable name="i_up" units="mM_per_ms" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Kup</ci>
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<times/>
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<cn cellml:units="mM">0.702</cn>
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<times/>
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<apply>
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<divide/>
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<divide/>
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<power/>
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<component name="ki">
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<variable name="F" units="C_per_mmol" public_interface="in"/>
<variable name="Ki" units="mM" public_interface="out" initial_value="1.04748824394112106e+02"/>
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<variable name="i_Ks" units="A_per_F" public_interface="in"/>
<variable name="i_NaK" units="A_per_F" public_interface="in"/>
<variable name="i_fK" units="A_per_F" public_interface="in"/>
<variable name="i_to" units="A_per_F" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>F</ci>
<ci>Vc</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>i_K1</ci>
</apply>
<ci>i_to</ci>
</apply>
<ci>i_Kr</ci>
</apply>
<ci>i_Ks</ci>
</apply>
<ci>i_fK</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>i_NaK</ci>
</apply>
</apply>
<ci>i_CaL_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="membrane">
<variable name="V" units="mV" public_interface="out" initial_value="-7.55966016388546791e+01"/>
<variable name="i_CaL" units="A_per_F" public_interface="in"/>
<variable name="i_CaT" units="A_per_F" public_interface="in"/>
<variable name="i_K1" units="A_per_F" public_interface="in"/>
<variable name="i_Kr" units="A_per_F" public_interface="in"/>
<variable name="i_Ks" units="A_per_F" public_interface="in"/>
<variable name="i_Na" units="A_per_F" public_interface="in"/>
<variable name="i_NaCa" units="A_per_F" public_interface="in"/>
<variable name="i_NaK" units="A_per_F" public_interface="in"/>
<variable name="i_PCa" units="A_per_F" public_interface="in"/>
<variable name="i_b_Ca" units="A_per_F" public_interface="in"/>
<variable name="i_b_Na" units="A_per_F" public_interface="in"/>
<variable name="i_f" units="A_per_F" public_interface="in"/>
<variable name="i_stim" units="A_per_F" public_interface="in"/>
<variable name="i_to" units="A_per_F" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>i_K1</ci>
</apply>
<ci>i_to</ci>
</apply>
<ci>i_Kr</ci>
</apply>
<ci>i_Ks</ci>
</apply>
<ci>i_CaL</ci>
</apply>
<ci>i_CaT</ci>
</apply>
<ci>i_NaK</ci>
</apply>
<ci>i_Na</ci>
</apply>
<ci>i_NaCa</ci>
</apply>
<ci>i_PCa</ci>
</apply>
<ci>i_f</ci>
</apply>
<ci>i_b_Na</ci>
</apply>
<ci>i_b_Ca</ci>
</apply>
<ci>i_stim</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="nai">
<variable name="Cm" units="pF" public_interface="in"/>
<variable name="F" units="C_per_mmol" public_interface="in"/>
<variable name="Nai" units="mM" public_interface="out" initial_value="7.16928091250999167"/>
<variable name="Vc" units="um3" public_interface="in"/>
<variable name="i_CaL_Na" units="A_per_F" public_interface="in"/>
<variable name="i_Na" units="A_per_F" public_interface="in"/>
<variable name="i_NaCa" units="A_per_F" public_interface="in"/>
<variable name="i_NaK" units="A_per_F" public_interface="in"/>
<variable name="i_b_Na" units="A_per_F" public_interface="in"/>
<variable name="i_fNa" units="A_per_F" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>F</ci>
<ci>Vc</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>i_Na</ci>
</apply>
<ci>i_b_Na</ci>
</apply>
<ci>i_fNa</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>i_NaK</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<ci>i_CaL_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="phys">
<variable name="F" units="C_per_mmol" public_interface="out" initial_value="9.64853415000000041e+01"/>
<variable name="FFRT" units="s4_A2_per_g_per_m2_per_mol_times_1e3" public_interface="out"/>
<variable name="FRT" units="per_mV" public_interface="out"/>
<variable name="R" units="J_per_mol_per_K" initial_value="8.314472"/>
<variable name="RTF" units="mV" public_interface="out"/>
<variable name="T" units="kelvin" initial_value="310.0"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>FFRT</ci>
<apply>
<times/>
<ci>F</ci>
<ci>FRT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>FRT</ci>
<apply>
<divide/>
<ci>F</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>RTF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component name="stimulus">
<variable name="amplitude" units="A_per_F"/>
<variable name="i_stim" units="A_per_F" public_interface="out"/>
<variable name="pace" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>amplitude</ci>
<apply>
<minus/>
<cn cellml:units="A_per_F">3.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>i_stim</ci>
<apply>
<times/>
<ci>pace</ci>
<ci>amplitude</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="cai" component_2="engine"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="cai" component_2="erev"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="cai" component_2="geom"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Vc" variable_2="Vc"/>
</connection>
<connection>
<map_components component_1="cai" component_2="ibca"/>
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca"/>
</connection>
<connection>
<map_components component_1="cai" component_2="ical"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_CaL_Ca" variable_2="i_CaL_Ca"/>
</connection>
<connection>
<map_components component_1="cai" component_2="icat"/>
<map_variables variable_1="i_CaT" variable_2="i_CaT"/>
</connection>
<connection>
<map_components component_1="cai" component_2="ileak"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_leak" variable_2="i_leak"/>
</connection>
<connection>
<map_components component_1="cai" component_2="inaca"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="cai" component_2="ipca"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_PCa" variable_2="i_PCa"/>
</connection>
<connection>
<map_components component_1="cai" component_2="irel"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_rel" variable_2="i_rel"/>
</connection>
<connection>
<map_components component_1="cai" component_2="iup"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_up" variable_2="i_up"/>
</connection>
<connection>
<map_components component_1="cai" component_2="phys"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="casr" component_2="engine"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="casr" component_2="geom"/>
<map_variables variable_1="V_SR" variable_2="V_SR"/>
<map_variables variable_1="Vc" variable_2="Vc"/>
</connection>
<connection>
<map_components component_1="casr" component_2="ileak"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="i_leak" variable_2="i_leak"/>
</connection>
<connection>
<map_components component_1="casr" component_2="irel"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="i_rel" variable_2="i_rel"/>
</connection>
<connection>
<map_components component_1="casr" component_2="iup"/>
<map_variables variable_1="i_up" variable_2="i_up"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ical"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="icat"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ifunny"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ikr"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="iks"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ina"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="irel"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ito"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ki"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="membrane"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="nai"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="stimulus"/>
<map_variables variable_1="pace" variable_2="pace"/>
</connection>
<connection>
<map_components component_1="erev" component_2="extra"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="erev" component_2="ibca"/>
<map_variables variable_1="E_Ca" variable_2="E_Ca"/>
</connection>
<connection>
<map_components component_1="erev" component_2="ibna"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="erev" component_2="icat"/>
<map_variables variable_1="E_Ca" variable_2="E_Ca"/>
</connection>
<connection>
<map_components component_1="erev" component_2="ifunny"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="erev" component_2="ik1"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="erev" component_2="ikr"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="erev" component_2="iks"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="erev" component_2="ina"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="erev" component_2="ito"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="erev" component_2="ki"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="erev" component_2="nai"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="erev" component_2="phys"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="extra" component_2="ical"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="extra" component_2="ik1"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="extra" component_2="ikr"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="extra" component_2="inaca"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="extra" component_2="inak"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="geom" component_2="irel"/>
<map_variables variable_1="V_SR" variable_2="V_SR"/>
<map_variables variable_1="Vc" variable_2="Vc"/>
</connection>
<connection>
<map_components component_1="geom" component_2="ki"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Vc" variable_2="Vc"/>
</connection>
<connection>
<map_components component_1="geom" component_2="nai"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Vc" variable_2="Vc"/>
</connection>
<connection>
<map_components component_1="ibca" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca"/>
</connection>
<connection>
<map_components component_1="ibna" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_b_Na" variable_2="i_b_Na"/>
</connection>
<connection>
<map_components component_1="ibna" component_2="nai"/>
<map_variables variable_1="i_b_Na" variable_2="i_b_Na"/>
</connection>
<connection>
<map_components component_1="ical" component_2="ki"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_CaL_K" variable_2="i_CaL_K"/>
</connection>
<connection>
<map_components component_1="ical" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
</connection>
<connection>
<map_components component_1="ical" component_2="nai"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_CaL_Na" variable_2="i_CaL_Na"/>
</connection>
<connection>
<map_components component_1="ical" component_2="phys"/>
<map_variables variable_1="FFRT" variable_2="FFRT"/>
<map_variables variable_1="FRT" variable_2="FRT"/>
</connection>
<connection>
<map_components component_1="icat" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_CaT" variable_2="i_CaT"/>
</connection>
<connection>
<map_components component_1="ifunny" component_2="ki"/>
<map_variables variable_1="i_fK" variable_2="i_fK"/>
</connection>
<connection>
<map_components component_1="ifunny" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_f" variable_2="i_f"/>
</connection>
<connection>
<map_components component_1="ifunny" component_2="nai"/>
<map_variables variable_1="i_fNa" variable_2="i_fNa"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="ki"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="ki"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="iks" component_2="ki"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="iks" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="ina" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="ina" component_2="nai"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="nai"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="phys"/>
<map_variables variable_1="FRT" variable_2="FRT"/>
</connection>
<connection>
<map_components component_1="inak" component_2="ki"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="inak" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="inak" component_2="nai"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="inak" component_2="phys"/>
<map_variables variable_1="FRT" variable_2="FRT"/>
</connection>
<connection>
<map_components component_1="ipca" component_2="membrane"/>
<map_variables variable_1="i_PCa" variable_2="i_PCa"/>
</connection>
<connection>
<map_components component_1="ito" component_2="ki"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection>
<map_components component_1="ito" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection>
<map_components component_1="ki" component_2="phys"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="stimulus"/>
<map_variables variable_1="i_stim" variable_2="i_stim"/>
</connection>
<connection>
<map_components component_1="nai" component_2="phys"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
</model>
