- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2007-06-14 00:12:33+12:00
- Desc:
- committing version03 of iyer_mazhari_winslow_2004
- Permanent Source URI:
- https://models.cellml.org/workspace/6fb/rawfile/87810d2539473de89c68248309b43c29ccf4588d/iyer_mazhari_winslow_2004.cellml
<?xml version='1.0' encoding='utf-8'?>
<!--
This CellML file was generated on 02/10/2006 at 14:58:24 using:
COR (0.9.31.365)
Copyright 2002-2006 Oxford Cardiac Electrophysiology Group
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
--><!-- FILE : iyer_mazhari_winslow_2005_version02.cellml
CREATED : 14th September 2004
LAST MODIFIED : 13/04/07 by James Lawson
AUTHOR : Penny Noble
Cardiac Electrophysiology Group
Oxford University
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the CellML Metadata 1.0 Specification released on 16th
January, 2002.
DESCRIPTION : This file contains a CellML description of Iyer et al.'s 2004 mathematical model of the human left ventricular epicardial myocyte.
CHANGES:
27/04/2005 - PJV - Made MathML id's unique. Removed undefined
initial values. Removed extraneous character.
Date unknown: Version 02 was created by Penny Noble of Oxford University. Errors were fixed such that the model now runs in COR and PCEnv. Version 02 also now produces a train of action potentials.
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A Computational Model of the Human Left-Ventricular Epicardial Myocyte</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
Version 02 was created from Version 01 by Penny Noble of Oxford University. This model now runs in COR and PCEnv and produces a train of action potentials. A PCEnv session file is also associated with this model.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Computational models of the mammalian ventricular myocyte have played a significant role in improving our understanding of the molecular mechanisms underlying the ventricular action potential, both in the normal, healthy individual and also in diseased states. As experimental techniques have become more sophisticated, more detailed biophysical data have been generated, and in turn, the mathematical models which are based on this data have also become more complex and physiologically more accurate. Examples of such computational models include:
</para>
<itemizedlist>
<listitem>
<para>
<ulink url="${HTML_EXMPL_LR_I_MODEL}">The Luo-Rudy Ventricular Model I, 1991;</ulink>
</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_LR_II_MODEL}">The Luo-Rudy Ventricular Model II (dynamic), 1994;</ulink>
</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_N98_MODEL}">The Noble <emphasis>et al.</emphasis> Ventricular Cell Model, 1998;</ulink>
</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_PRIEBE_MODEL}">The Priebe and Beuckelmann, Electrophysiological Model of the Human Ventricular Myocyte, 1998;</ulink>
</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_W_MODEL}">The Winslow <emphasis>et al.</emphasis> Canine Ventricular Cell Model, 1999;</ulink>
</para>
</listitem>
<listitem>
<para>and most recently, <ulink url="${HTML_EXMPL_TEN_TUSSCHER_MODEL04}">The Ten Tusscher <emphasis>et al</emphasis>. Model For Human Ventricular Tissue, 2004.</ulink>
</para>
</listitem>
</itemizedlist>
<para>
Please note that this list is not exhaustive and there are more examples of ventricular myocyte models (some of which can be found in the Ventricular Myocyte section of the CellML model repository).
</para>
<para>
The Priebe-Beuckelmann model and the Ten Tusscher <emphasis>et al.</emphasis> models are able to adequately describe the qualitative features of the human ventricular action potential and also the calcium transient morphology, however, these models utilise little of the existing experimental data on channel properties, whole-cell currents, excitation-contraction coupling, or on the processes which regulate intracellular sodium concentration. By contrast, in the Iyer <emphasis>et al.</emphasis> 2004 publication described here, the authors use this more extensive experimental data to develop their computational model of the human left-ventricular epicardial myocyte (see <xref linkend="fig_cell_diagram"/> below). The resulting model displays long-term stability of intracellular ion concentrations over a range of pacing frequencies, and it is also able to reproduce and predict the diverse behaviours which have been measured experimentally in isolated human ventricular myocytes.
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Iyer <emphasis>et al.</emphasis> 2004 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.biophysj.org/cgi/content/abstract/87/3/1507">A Computational Model of the Human Left-Ventricular Epicardial Myocyte</ulink>, Vivek Iyer, Reza Mazhari and Raimond L. Winslow, 2004, <ulink url="http://www.biophysj.org/">
<emphasis>Biophysical Journal</emphasis>
</ulink>, 87, 1507-1525. (<ulink url="http://www.biophysj.org/cgi/content/full/87/3/1507">Full text (HTML)</ulink> and <ulink url="http://www.biophysj.org/cgi/reprint/87/3/1507.pdf">PDF</ulink> versions of the article are available to subscribers on the <emphasis>Biophysical Journal</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15345532&dopt=Abstract">PubMed ID: 15345532</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
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<title>cell diagram</title>
</objectinfo>
<imagedata fileref="cell_diagram.gif"/>
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<caption>A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Iyer <emphasis>et al.</emphasis> 2004 mathematical model of the human left-ventricular epicardial myocyte.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>omega</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>K</ci>
<ci>T</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">121955</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_kelvin_mole">225.175</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>eta</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>K</ci>
<ci>T</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">147814</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_kelvin_mole">338.915</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.136</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>nu</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>K</ci>
<ci>T</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">121322</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_kelvin_mole">193.265</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.7429</cn>
</apply>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cn</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>K</ci>
<ci>T</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">287913</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_kelvin_mole">786.217</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cf</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>K</ci>
<ci>T</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">59565</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_kelvin_mole">0.00711</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta</ci>
<ci>C1Na</ci>
</apply>
<apply>
<times/>
<ci>Cf</ci>
<ci>CI0Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
</apply>
<ci>Cn</ci>
</apply>
<ci>C0Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>C0Na</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
<ci>C2Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Cf</ci>
<ci>a</ci>
</apply>
<ci>CI1Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>beta</ci>
<apply>
<times/>
<ci>Cn</ci>
<ci>a</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
</apply>
</apply>
<ci>C1Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>C1Na</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
<ci>C3Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>CI2Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
</apply>
</apply>
<ci>C2Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>C2Na</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>C4Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>CI3Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>alpha</ci>
</apply>
<ci>C3Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>C3Na</ci>
</apply>
<apply>
<times/>
<ci>delta</ci>
<ci>O1Na</ci>
</apply>
<apply>
<times/>
<ci>nu</ci>
<ci>O2Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<ci>CI4Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<ci>gamma</ci>
<ci>eta</ci>
</apply>
<ci>C4Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>gamma</ci>
<ci>C4Na</ci>
</apply>
<apply>
<times/>
<ci>omega</ci>
<ci>O2Na</ci>
</apply>
<apply>
<times/>
<ci>Of</ci>
<ci>INa</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>delta</ci>
<ci>epsilon</ci>
<ci>On</ci>
</apply>
<ci>O1Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon</ci>
<ci>O1Na</ci>
</apply>
<apply>
<times/>
<ci>eta</ci>
<ci>C4Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>omega</ci>
<ci>nu</ci>
</apply>
<ci>O2Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI0Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<ci>beta</ci>
<ci>a</ci>
</apply>
<ci>CI1Na</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<ci>C0Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Cf</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>a</ci>
</apply>
</apply>
<ci>CI0Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI1Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>a</ci>
<ci>CI0Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<ci>CI2Na</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<ci>a</ci>
<ci>C1Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<ci>beta</ci>
<ci>a</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>a</ci>
</apply>
<apply>
<divide/>
<ci>Cf</ci>
<ci>a</ci>
</apply>
</apply>
<ci>CI1Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI2Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>a</ci>
<ci>CI1Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<ci>CI3Na</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>C2Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>a</ci>
</apply>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>CI2Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI3Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>a</ci>
<ci>CI2Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<ci>CI4Na</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>C3Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<apply>
<times/>
<ci>alpha</ci>
<ci>a</ci>
</apply>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<ci>CI3Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI4Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>a</ci>
<ci>CI3Na</ci>
</apply>
<apply>
<times/>
<ci>delta_delta</ci>
<ci>INa</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<ci>C4Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<ci>gamma_gamma</ci>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
<ci>CI4Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>INa</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>gamma_gamma</ci>
<ci>CI4Na</ci>
</apply>
<apply>
<times/>
<ci>On</ci>
<ci>O1Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>delta_delta</ci>
<ci>Of</ci>
</apply>
<ci>INa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapidly_activating_delayed_rectifier_potassium_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Kr" cmeta:id="rapidly_activating_delayed_rectifier_potassium_current_i_Kr"/>
<variable units="millivolt" public_interface="out" name="E_K"/>
<variable units="milliS_per_microF" name="g_Kr" initial_value="0.0186"/>
<variable units="dimensionless" name="f_Ko"/>
<variable units="dimensionless" name="IKr" initial_value="1.533e-6"/>
<variable units="dimensionless" name="C1Kr" initial_value="9.967e-1"/>
<variable units="dimensionless" name="C2Kr" initial_value="4.341e-4"/>
<variable units="dimensionless" name="C3Kr" initial_value="7.634e-5"/>
<variable units="dimensionless" name="OKr" initial_value="9.512e-6"/>
<variable units="first_order_rate_constant" name="alpha0"/>
<variable units="first_order_rate_constant" name="beta0"/>
<variable units="first_order_rate_constant" name="alpha1"/>
<variable units="first_order_rate_constant" name="beta1"/>
<variable units="first_order_rate_constant" name="alphai"/>
<variable units="first_order_rate_constant" name="betai"/>
<variable units="first_order_rate_constant" name="alphai3"/>
<variable units="first_order_rate_constant" name="kf"/>
<variable units="first_order_rate_constant" name="kb"/>
<variable units="dimensionless" name="psi"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Ki"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>g_Kr</ci>
<ci>f_Ko</ci>
<ci>OKr</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_Ko</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="millimolar">4</cn>
</apply>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>kf</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0261</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>kb</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.1483</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0171</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.033</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0397</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.0431</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0206</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0262</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0013</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.0269</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alphai</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.1067</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0057</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betai</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0065</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.0454</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alphai3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">8.04e-5</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">6.98e-7</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>psi</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>beta1</ci>
<ci>betai</ci>
<ci>alphai3</ci>
</apply>
<apply>
<times/>
<ci>alpha1</ci>
<ci>alphai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Kr</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>beta0</ci>
<ci>C2Kr</ci>
</apply>
<apply>
<times/>
<ci>alpha0</ci>
<ci>C1Kr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Kr</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha0</ci>
<ci>C1Kr</ci>
</apply>
<apply>
<times/>
<ci>kb</ci>
<ci>C3Kr</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>beta0</ci>
<ci>kf</ci>
</apply>
<ci>C2Kr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Kr</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>psi</ci>
<ci>IKr</ci>
</apply>
<apply>
<times/>
<ci>beta1</ci>
<ci>OKr</ci>
</apply>
<apply>
<times/>
<ci>kf</ci>
<ci>C2Kr</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kb</ci>
<ci>alpha1</ci>
<ci>alphai3</ci>
</apply>
<ci>C3Kr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OKr</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha1</ci>
<ci>C3Kr</ci>
</apply>
<apply>
<times/>
<ci>betai</ci>
<ci>IKr</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>beta1</ci>
<ci>alphai</ci>
</apply>
<ci>OKr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IKr</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alphai3</ci>
<ci>C3Kr</ci>
</apply>
<apply>
<times/>
<ci>alphai</ci>
<ci>OKr</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>psi</ci>
<ci>betai</ci>
</apply>
<ci>IKr</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slowly_activating_delayed_rectifier_potassium_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Ks" cmeta:id="slowly_activating_delayed_rectifier_potassium_current_i_Ks"/>
<variable units="milliS_per_microF" name="g_Ks" initial_value="0.0035"/>
<variable units="dimensionless" name="C0Ks" initial_value="9.646e-1"/>
<variable units="dimensionless" name="C1Ks" initial_value="3.543e-2"/>
<variable units="dimensionless" name="O1Ks" initial_value="2.492e-7"/>
<variable units="dimensionless" name="O2Ks" initial_value="1.299e-5"/>
<variable units="first_order_rate_constant" name="alpha" initial_value="7.956e-3"/>
<variable units="first_order_rate_constant" name="beta"/>
<variable units="first_order_rate_constant" name="gamma" initial_value="3.97e-2"/>
<variable units="first_order_rate_constant" name="delta"/>
<variable units="first_order_rate_constant" name="epsilon"/>
<variable units="first_order_rate_constant" name="omega"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<plus/>
<ci>O1Ks</ci>
<ci>O2Ks</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">2.16e-1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00002</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">7e-3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.15</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">7.67e-3</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.087</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>omega</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">3.8e-3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.014</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0Ks</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>beta</ci>
<ci>C1Ks</ci>
</apply>
<apply>
<times/>
<ci>alpha</ci>
<ci>C0Ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Ks</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>C0Ks</ci>
</apply>
<apply>
<times/>
<ci>delta</ci>
<ci>O1Ks</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>beta</ci>
<ci>gamma</ci>
</apply>
<ci>C1Ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1Ks</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>gamma</ci>
<ci>C1Ks</ci>
</apply>
<apply>
<times/>
<ci>omega</ci>
<ci>O2Ks</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>delta</ci>
<ci>epsilon</ci>
</apply>
<ci>O1Ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2Ks</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>epsilon</ci>
<ci>O1Ks</ci>
</apply>
<apply>
<times/>
<ci>omega</ci>
<ci>O2Ks</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_potassium_current_fast_recovering_component">
<variable units="picoA_per_picoF" public_interface="out" name="i_Kv4_3"/>
<variable units="milliS_per_microF" name="g_Kv4_3" initial_value="0.0775208"/>
<variable units="dimensionless" name="C1Kvf" initial_value="9.514e-1"/>
<variable units="dimensionless" name="C2Kvf" initial_value="2.668e-2"/>
<variable units="dimensionless" name="C3Kvf" initial_value="2.806e-4"/>
<variable units="dimensionless" name="C4Kvf" initial_value="1.312e-6"/>
<variable units="dimensionless" name="OKvf" initial_value="2.3e-9"/>
<variable units="dimensionless" name="CI1Kvf" initial_value="1.513e-2"/>
<variable units="dimensionless" name="CI2Kvf" initial_value="5.443e-3"/>
<variable units="dimensionless" name="CI3Kvf" initial_value="9.918e-4"/>
<variable units="dimensionless" name="CI4Kvf" initial_value="9.5144e-5"/>
<variable units="dimensionless" name="OIKvf" initial_value="2.743e-6"/>
<variable units="first_order_rate_constant" name="alphaa"/>
<variable units="first_order_rate_constant" name="betaa"/>
<variable units="first_order_rate_constant" name="alphai"/>
<variable units="first_order_rate_constant" name="betai"/>
<variable units="first_order_rate_constant" name="f1" initial_value="1.8936"/>
<variable units="first_order_rate_constant" name="f2" initial_value="14.2246"/>
<variable units="first_order_rate_constant" name="f3" initial_value="158.5743"/>
<variable units="first_order_rate_constant" name="f4" initial_value="142.9366"/>
<variable units="first_order_rate_constant" name="b1" initial_value="6.77348"/>
<variable units="first_order_rate_constant" name="b2" initial_value="15.6212"/>
<variable units="first_order_rate_constant" name="b3" initial_value="28.7532"/>
<variable units="first_order_rate_constant" name="b4" initial_value="524.5762"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kv4_3</ci>
<apply>
<times/>
<ci>g_Kv4_3</ci>
<ci>OKvf</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alphaa</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.543708</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02898</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betaa</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.080185</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.04684</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alphai</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.0498424</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.000373016</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betai</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.000819482</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.00000005374</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Kvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>betaa</ci>
<ci>C2Kvf</ci>
</apply>
<apply>
<times/>
<ci>alphai</ci>
<ci>CI1Kvf</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
</apply>
<ci>betai</ci>
</apply>
<ci>C1Kvf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Kvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
<ci>C1Kvf</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
<ci>C3Kvf</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b1</ci>
</apply>
<ci>CI2Kvf</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>betaa</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
</apply>
<apply>
<times/>
<ci>f1</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>C2Kvf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Kvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
<ci>C2Kvf</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
<ci>C4Kvf</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b2</ci>
</apply>
<ci>CI3Kvf</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
</apply>
<apply>
<times/>
<ci>f2</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>C3Kvf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4Kvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
<ci>C3Kvf</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
<ci>OKvf</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b3</ci>
</apply>
<ci>CI4Kvf</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
</apply>
<ci>alphaa</ci>
<apply>
<times/>
<ci>f3</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>C4Kvf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OKvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alphaa</ci>
<ci>C4Kvf</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b4</ci>
</apply>
<ci>OIKvf</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
</apply>
<apply>
<times/>
<ci>f4</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>OKvf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI1Kvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<ci>betaa</ci>
<ci>f1</ci>
</apply>
<ci>CI2Kvf</ci>
</apply>
<apply>
<times/>
<ci>betai</ci>
<ci>C1Kvf</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>b1</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
</apply>
<ci>alphai</ci>
</apply>
<ci>CI1Kvf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI2Kvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>b1</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
<ci>CI1Kvf</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f1</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
</apply>
<ci>f2</ci>
</apply>
<ci>CI3Kvf</ci>
</apply>
<apply>
<times/>
<ci>f1</ci>
<ci>betai</ci>
<ci>C2Kvf</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<ci>betaa</ci>
<ci>f1</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>b2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
</apply>
<ci>b1</ci>
</apply>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b1</ci>
</apply>
</apply>
<ci>CI2Kvf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI3Kvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>b2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
</apply>
<ci>b1</ci>
</apply>
<ci>CI2Kvf</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
</apply>
<ci>f3</ci>
</apply>
<ci>CI4Kvf</ci>
</apply>
<apply>
<times/>
<ci>f2</ci>
<ci>betai</ci>
<ci>C3Kvf</ci>
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<divide/>
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<times/>
<ci>f1</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
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<times/>
<ci>b3</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
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<ci>b2</ci>
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<ci>b2</ci>
</apply>
</apply>
<ci>CI3Kvf</ci>
</apply>
</apply>
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<eq/>
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<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI4Kvf</ci>
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<minus/>
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<plus/>
<apply>
<times/>
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<divide/>
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<times/>
<ci>b3</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
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<ci>b2</ci>
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<ci>CI3Kvf</ci>
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<times/>
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<divide/>
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<times/>
<ci>f3</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
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<ci>f4</ci>
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<ci>OIKvf</ci>
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<times/>
<ci>f3</ci>
<ci>betai</ci>
<ci>C4Kvf</ci>
</apply>
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<times/>
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<plus/>
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<divide/>
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<times/>
<ci>f2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
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<ci>f3</ci>
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<apply>
<times/>
<ci>b4</ci>
<ci>alphaa</ci>
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<ci>b3</ci>
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<apply>
<divide/>
<ci>alphai</ci>
<ci>b3</ci>
</apply>
</apply>
<ci>CI4Kvf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OIKvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
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<divide/>
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<times/>
<ci>b4</ci>
<ci>alphaa</ci>
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<ci>b3</ci>
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<ci>CI4Kvf</ci>
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<times/>
<ci>f4</ci>
<ci>betai</ci>
<ci>OKvf</ci>
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<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>f3</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
</apply>
<ci>f4</ci>
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<apply>
<divide/>
<ci>alphai</ci>
<ci>b4</ci>
</apply>
</apply>
<ci>OIKvf</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_potassium_current_slowly_recovering_component">
<variable units="picoA_per_picoF" public_interface="out" name="i_Kv1_4"/>
<variable units="picoA_per_picoF" public_interface="out" name="i_Kv1_4Na"/>
<variable units="picoA_per_picoF" public_interface="out" name="i_Kv1_4K"/>
<variable units="cm_per_second" name="P_Kv1_4" initial_value="4.161e-8"/>
<variable units="dimensionless" name="C1Kvs" initial_value="5.977e-1"/>
<variable units="dimensionless" name="C2Kvs" initial_value="1.731e-1"/>
<variable units="dimensionless" name="C3Kvs" initial_value="1.881e-2"/>
<variable units="dimensionless" name="C4Kvs" initial_value="9.161e-4"/>
<variable units="dimensionless" name="OKvs" initial_value="1.976e-5"/>
<variable units="dimensionless" name="CI1Kvs" initial_value="3.539e-2"/>
<variable units="dimensionless" name="CI2Kvs" initial_value="5.429e-3"/>
<variable units="dimensionless" name="CI3Kvs" initial_value="2.288e-2"/>
<variable units="dimensionless" name="CI4Kvs" initial_value="3.234e-2"/>
<variable units="dimensionless" name="OIKvs" initial_value="1.134e-1"/>
<variable units="first_order_rate_constant" name="alphaa"/>
<variable units="first_order_rate_constant" name="betaa"/>
<variable units="first_order_rate_constant" name="alphai" initial_value="0.003058"/>
<variable units="first_order_rate_constant" name="betai" initial_value="2.44936e-6"/>
<variable units="first_order_rate_constant" name="f1" initial_value="0.52465"/>
<variable units="first_order_rate_constant" name="f2" initial_value="17.5188"/>
<variable units="first_order_rate_constant" name="f3" initial_value="938.587"/>
<variable units="first_order_rate_constant" name="f4" initial_value="54749.2"/>
<variable units="first_order_rate_constant" name="b1" initial_value="1.00948"/>
<variable units="first_order_rate_constant" name="b2" initial_value="1.171"/>
<variable units="first_order_rate_constant" name="b3" initial_value="0.63903"/>
<variable units="first_order_rate_constant" name="b4" initial_value="2.12035"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="picoA_per_picoF" public_interface="in" name="C_sc"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<variable units="millimolar" public_interface="in" name="Ki"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kv1_4</ci>
<apply>
<plus/>
<ci>i_Kv1_4K</ci>
<ci>i_Kv1_4Na</ci>
</apply>
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<eq/>
<ci>i_Kv1_4K</ci>
<apply>
<divide/>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_Kv1_4</ci>
<ci>OKvs</ci>
<ci>C_sc</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
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<times/>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
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<times/>
<ci>V</ci>
<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<minus/>
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<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
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<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
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<ci>i_Kv1_4Na</ci>
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<divide/>
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<times/>
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<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02</cn>
<ci>P_Kv1_4</ci>
<ci>OKvs</ci>
<ci>C_sc</ci>
<ci>V</ci>
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<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Nai</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
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<ci>Nao</ci>
</apply>
</apply>
<apply>
<minus/>
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<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
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<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
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<apply>
<eq/>
<ci>alphaa</ci>
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<times/>
<cn cellml:units="first_order_rate_constant">1.840024</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0077</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betaa</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.010817</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.0779</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Kvs</ci>
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<minus/>
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<plus/>
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<times/>
<ci>betaa</ci>
<ci>C2Kvs</ci>
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<ci>alphai</ci>
<ci>CI1Kvs</ci>
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<times/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
</apply>
<ci>betai</ci>
</apply>
<ci>C1Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Kvs</ci>
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<minus/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
<ci>C1Kvs</ci>
</apply>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
<ci>C3Kvs</ci>
</apply>
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<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b1</ci>
</apply>
<ci>CI2Kvs</ci>
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<times/>
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<plus/>
<ci>betaa</ci>
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<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
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<times/>
<ci>f1</ci>
<ci>betai</ci>
</apply>
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<ci>C2Kvs</ci>
</apply>
</apply>
</apply>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Kvs</ci>
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<minus/>
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<plus/>
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<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
<ci>C2Kvs</ci>
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<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
<ci>C4Kvs</ci>
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<times/>
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<divide/>
<ci>alphai</ci>
<ci>b2</ci>
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<ci>CI3Kvs</ci>
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<times/>
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<plus/>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
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<times/>
<ci>f2</ci>
<ci>betai</ci>
</apply>
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<ci>C3Kvs</ci>
</apply>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4Kvs</ci>
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<minus/>
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<plus/>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
<ci>C3Kvs</ci>
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<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
<ci>OKvs</ci>
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<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b3</ci>
</apply>
<ci>CI4Kvs</ci>
</apply>
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<times/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
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<ci>alphaa</ci>
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<times/>
<ci>f3</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>C4Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OKvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alphaa</ci>
<ci>C4Kvs</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b4</ci>
</apply>
<ci>OIKvs</ci>
</apply>
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<times/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
</apply>
<apply>
<times/>
<ci>f4</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>OKvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI1Kvs</ci>
</apply>
<apply>
<minus/>
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<plus/>
<apply>
<times/>
<apply>
<divide/>
<ci>betaa</ci>
<ci>f1</ci>
</apply>
<ci>CI2Kvs</ci>
</apply>
<apply>
<times/>
<ci>betai</ci>
<ci>C1Kvs</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>b1</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
</apply>
<ci>alphai</ci>
</apply>
<ci>CI1Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI2Kvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>b1</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
<ci>CI1Kvs</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f1</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
</apply>
<ci>f2</ci>
</apply>
<ci>CI3Kvs</ci>
</apply>
<apply>
<times/>
<ci>f1</ci>
<ci>betai</ci>
<ci>C2Kvs</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<ci>betaa</ci>
<ci>f1</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>b2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
</apply>
<ci>b1</ci>
</apply>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b1</ci>
</apply>
</apply>
<ci>CI2Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI3Kvs</ci>
</apply>
<apply>
<minus/>
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<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>b2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
</apply>
<ci>b1</ci>
</apply>
<ci>CI2Kvs</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
</apply>
<ci>f3</ci>
</apply>
<ci>CI4Kvs</ci>
</apply>
<apply>
<times/>
<ci>f2</ci>
<ci>betai</ci>
<ci>C3Kvs</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>f1</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
</apply>
<ci>f2</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>b3</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
</apply>
<ci>b2</ci>
</apply>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b2</ci>
</apply>
</apply>
<ci>CI3Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI4Kvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>b3</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
</apply>
<ci>b2</ci>
</apply>
<ci>CI3Kvs</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f3</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
</apply>
<ci>f4</ci>
</apply>
<ci>OIKvs</ci>
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<apply>
<times/>
<ci>f3</ci>
<ci>betai</ci>
<ci>C4Kvs</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>f2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
</apply>
<ci>f3</ci>
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<apply>
<divide/>
<apply>
<times/>
<ci>b4</ci>
<ci>alphaa</ci>
</apply>
<ci>b3</ci>
</apply>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b3</ci>
</apply>
</apply>
<ci>CI4Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OIKvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>b4</ci>
<ci>alphaa</ci>
</apply>
<ci>b3</ci>
</apply>
<ci>CI4Kvs</ci>
</apply>
<apply>
<times/>
<ci>f4</ci>
<ci>betai</ci>
<ci>OKvs</ci>
</apply>
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<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>f3</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
</apply>
<ci>f4</ci>
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<apply>
<divide/>
<ci>alphai</ci>
<ci>b4</ci>
</apply>
</apply>
<ci>OIKvs</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_K1"/>
<variable units="milliS_per_microF_millimolar_half" name="g_K1" initial_value="0.125305"/>
<variable units="dimensionless" name="K1_infinity"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>g_K1</ci>
<ci>K1_infinity</ci>
<apply>
<power/>
<ci>Ko</ci>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K1_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.94</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.26</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchange_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_NaCa"/>
<variable units="microA_per_microF" name="k_NaCa" initial_value="0.44"/>
<variable units="millimolar" name="Km_Na" initial_value="87.5"/>
<variable units="millimolar" name="Km_Ca" initial_value="1.38"/>
<variable units="dimensionless" name="k_sat" initial_value="0.2"/>
<variable units="dimensionless" name="eta" initial_value="0.35"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Cao"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_NaCa</ci>
<cn cellml:units="dimensionless">5000</cn>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>Km_Na</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>k_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>Km_Ca</ci>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_background_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Nab"/>
<variable units="milliS_per_microF" name="g_Nab" initial_value="0.001"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millivolt" public_interface="in" name="E_Na"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Nab</ci>
<apply>
<times/>
<ci>g_Nab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_NaK"/>
<variable units="microA_per_microF" name="k_NaK" initial_value="2.387"/>
<variable units="millimolar" name="f_NaK"/>
<variable units="dimensionless" name="sigma"/>
<variable units="millimolar" name="Km_Nai" initial_value="20"/>
<variable units="millimolar" name="Km_Ko" initial_value="1.5"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_NaK</ci>
<ci>f_NaK</ci>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<divide/>
<cn cellml:units="millimolar">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.33</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">7</cn>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sarcolemmal_calcium_pump_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_pCa"/>
<variable units="nanoS_per_picoF" name="I_pCa" initial_value="0.05"/>
<variable units="millimolar" name="Km_pCa" initial_value="0.0005"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_pCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_pCa</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>Km_pCa</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_background_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Cab"/>
<variable units="milliS_per_microF" name="g_Cab" initial_value="7.684e-5"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millivolt" public_interface="in" name="E_Ca"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cab</ci>
<apply>
<times/>
<ci>g_Cab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_calcium_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Ca" cmeta:id="L_type_calcium_current_i_Ca"/>
<variable units="picoA_per_picoF" public_interface="out" name="i_CaK"/>
<variable units="millivolt" public_interface="out" name="E_Ca"/>
<variable units="cm_per_second" name="P_Ca" initial_value="2.469e-4"/>
<variable units="dimensionless" name="Pscale" initial_value="7"/>
<variable units="cm_per_second" name="PK" initial_value="4.574e-7"/>
<variable units="cm_per_second" name="P_K"/>
<variable units="picoA_per_picoF" name="i_Ca_half" initial_value="-0.265"/>
<variable units="dimensionless" name="I_Ca"/>
<variable units="dimensionless" name="C0L" initial_value="8.622e-1"/>
<variable units="dimensionless" name="C1L" initial_value="1.141e-2"/>
<variable units="dimensionless" name="C2L" initial_value="5.666e-5"/>
<variable units="dimensionless" name="C3L" initial_value="1.25e-7"/>
<variable units="dimensionless" name="C4L" initial_value="1.034e-10"/>
<variable units="dimensionless" name="OL" initial_value="7.758e-12"/>
<variable units="dimensionless" name="CCa0L" initial_value="1.199e-1"/>
<variable units="dimensionless" name="CCa1L" initial_value="6.347e-3"/>
<variable units="dimensionless" name="CCa2L" initial_value="1.26e-4"/>
<variable units="dimensionless" name="CCa3L" initial_value="1.112e-6"/>
<variable units="dimensionless" name="CCa4L" initial_value="3.681e-9"/>
<variable units="first_order_rate_constant" name="alpha"/>
<variable units="first_order_rate_constant" name="beta"/>
<variable units="first_order_rate_constant" name="gamma"/>
<variable units="first_order_rate_constant" name="alpha_"/>
<variable units="first_order_rate_constant" name="beta_"/>
<variable units="dimensionless" name="y" initial_value="9.997e-1"/>
<variable units="first_order_rate_constant" name="f" initial_value="0.3"/>
<variable units="first_order_rate_constant" name="g" initial_value="4"/>
<variable units="dimensionless" name="a" initial_value="2"/>
<variable units="dimensionless" name="b" initial_value="2"/>
<variable units="per_millisecond_millimetre" name="omega" initial_value="2.5e-3"/>
<variable units="dimensionless" name="y_infinity"/>
<variable units="millisecond" name="tau_y"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="picoA_per_picoF" public_interface="in" name="C_sc"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Cao"/>
<variable units="millimolar" public_interface="in" name="Ki"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="millimolar" public_interface="in" name="Ca_ss"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">1.9968</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.012</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">35</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.0882</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.065</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">22</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_</ci>
<apply>
<times/>
<ci>alpha</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_</ci>
<apply>
<divide/>
<ci>beta</ci>
<ci>b</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">0.055398</cn>
<ci>Ca_ss</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta</ci>
<ci>C1L</ci>
</apply>
<apply>
<times/>
<ci>omega</ci>
<ci>CCa0L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
</apply>
<ci>gamma</ci>
</apply>
<ci>C0L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>C0L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
<ci>C2L</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<ci>b</ci>
</apply>
<ci>CCa1L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
</apply>
<ci>beta</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>a</ci>
</apply>
</apply>
<ci>C1L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>C1L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
<ci>C3L</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>CCa2L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>C2L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>C2L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>C4L</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>CCa3L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<ci>C3L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>C3L</ci>
</apply>
<apply>
<times/>
<ci>g</ci>
<ci>OL</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<ci>CCa4L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>f</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
<ci>C4L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OL</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>f</ci>
<ci>C4L</ci>
</apply>
<apply>
<times/>
<ci>g</ci>
<ci>OL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa0L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_</ci>
<ci>CCa1L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>C0L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha_</ci>
</apply>
<ci>omega</ci>
</apply>
<ci>CCa0L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa1L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha_</ci>
<ci>CCa0L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta_</ci>
<ci>CCa2L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>a</ci>
<ci>C1L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha_</ci>
</apply>
<ci>beta_</ci>
<apply>
<divide/>
<ci>omega</ci>
<ci>b</ci>
</apply>
</apply>
<ci>CCa1L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa2L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha_</ci>
<ci>CCa1L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta_</ci>
<ci>CCa3L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>C2L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha_</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta_</ci>
</apply>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>CCa2L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa3L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha_</ci>
<ci>CCa2L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta_</ci>
<ci>CCa4L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>C3L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta_</ci>
</apply>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<ci>CCa3L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa4L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_</ci>
<ci>CCa3L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<ci>C4L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta_</ci>
</apply>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
<ci>CCa4L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>y_infinity</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.82</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28.5</cn>
</apply>
<cn cellml:units="millivolt">7.8</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.18</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.0033634</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">5.539</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.00779</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">49.51</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Ca</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Pscale</ci>
<ci>P_Ca</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>C_sc</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.341</cn>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca</ci>
<apply>
<times/>
<ci>I_Ca</ci>
<ci>y</ci>
<ci>OL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_K</ci>
<ci>C_sc</ci>
<ci>y</ci>
<ci>OL</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_K</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>Pscale</ci>
<ci>PK</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>I_Ca</ci>
<ci>i_Ca_half</ci>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>I_Ca</ci>
<cn cellml:units="picoA_per_picoF">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>Pscale</ci>
<ci>PK</ci>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="RyR_channel">
<variable units="flux" public_interface="out" name="J_rel"/>
<variable units="dimensionless" name="PC1" initial_value="4.448e-1"/>
<variable units="dimensionless" name="PO1" initial_value="6.602e-4"/>
<variable units="dimensionless" name="PO2" initial_value="5.545e-1"/>
<variable units="dimensionless" name="PC2" initial_value="3.974e-9"/>
<variable units="fifth_order_rate_constant" name="ka_plus" initial_value="0.01215"/>
<variable units="first_order_rate_constant" name="ka_minus" initial_value="0.576"/>
<variable units="forth_order_rate_constant" name="kb_plus" initial_value="0.00405"/>
<variable units="first_order_rate_constant" name="kb_minus" initial_value="1.93"/>
<variable units="first_order_rate_constant" name="kc_plus" initial_value="0.1"/>
<variable units="first_order_rate_constant" name="kc_minus" initial_value="0.0008"/>
<variable units="first_order_rate_constant" name="v1" initial_value="1.8"/>
<variable units="dimensionless" name="m" initial_value="3"/>
<variable units="dimensionless" name="n" initial_value="4"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millimolar" public_interface="in" name="Ca_JSR"/>
<variable units="millimolar" public_interface="in" name="Ca_ss"/>
<variable units="picoA_per_picoF" public_interface="in" name="C_sc"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_rel</ci>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>PO1</ci>
<ci>PO2</ci>
</apply>
<apply>
<minus/>
<ci>Ca_JSR</ci>
<ci>Ca_ss</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PC1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ka_minus</ci>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>ka_plus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca_ss</ci>
<ci>C_sc</ci>
</apply>
<ci>n</ci>
</apply>
<ci>PC1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PO1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>ka_plus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca_ss</ci>
<ci>C_sc</ci>
</apply>
<ci>n</ci>
</apply>
<ci>PC1</ci>
</apply>
<apply>
<times/>
<ci>kb_minus</ci>
<ci>PO2</ci>
</apply>
<apply>
<times/>
<ci>kc_minus</ci>
<ci>PC2</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>ka_minus</ci>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>kb_plus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca_ss</ci>
<ci>C_sc</ci>
</apply>
<ci>m</ci>
</apply>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>kc_plus</ci>
<ci>PO1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PO2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kb_plus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca_ss</ci>
<ci>C_sc</ci>
</apply>
<ci>m</ci>
</apply>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>kb_minus</ci>
<ci>PO2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PC2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kc_plus</ci>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>kc_minus</ci>
<ci>PC2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SERCA2a_pump">
<variable units="flux" public_interface="out" name="J_up"/>
<variable units="millimolar" name="Kfb" initial_value="0.000168"/>
<variable units="dimensionless" name="fb"/>
<variable units="dimensionless" name="rb"/>
<variable units="dimensionless" name="KSR" initial_value="1.2"/>
<variable units="flux" name="vmax_f" initial_value="0.0748e-3"/>
<variable units="flux" name="vmax_r" initial_value="0.318e-3"/>
<variable units="dimensionless" name="Nrb" initial_value="1"/>
<variable units="dimensionless" name="Nfb" initial_value="1.2"/>
<variable units="millimolar" name="Krb" initial_value="3.29"/>
<variable units="millimolar" public_interface="in" name="Ca_NSR"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KSR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>vmax_f</ci>
<ci>fb</ci>
</apply>
<apply>
<times/>
<ci>vmax_r</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fb</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kfb</ci>
</apply>
<ci>Nfb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>rb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_NSR</ci>
<ci>Krb</ci>
</apply>
<ci>Nrb</ci>
</apply>
</apply>
</math>
</component>
<component name="intracellular_calcium_fluxes">
<variable units="flux" public_interface="out" name="J_tr"/>
<variable units="flux" public_interface="out" name="J_xfer"/>
<variable units="flux" public_interface="out" name="J_trpn"/>
<variable units="millisecond" name="tau_tr" initial_value="0.5747"/>
<variable units="millisecond" name="tau_xfer" initial_value="26.7"/>
<variable units="millimolar" name="HTRPNCa" initial_value="9.772e-1"/>
<variable units="millimolar" name="LTRPNCa" initial_value="8.047e-2"/>
<variable units="millimolar" name="HTRPN_tot" initial_value="0.14"/>
<variable units="millimolar" name="LTRPN_tot" initial_value="0.07"/>
<variable units="flux" name="dHTRPNCa_dt"/>
<variable units="flux" name="dLTRPNCa_dt"/>
<variable units="second_order_rate_constant" name="K_plus_HTRPN" initial_value="20"/>
<variable units="first_order_rate_constant" name="K_minus_HTRPN" initial_value="0.066e-3"/>
<variable units="second_order_rate_constant" name="K_plus_LTRPN" initial_value="40"/>
<variable units="first_order_rate_constant" name="K_minus_LTRPN" initial_value="40e-3"/>
<variable units="millimolar" public_interface="in" name="Km_CMDN"/>
<variable units="millimolar" public_interface="in" name="Km_CSQN"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millimolar" public_interface="in" name="Ca_NSR"/>
<variable units="millimolar" public_interface="in" name="Ca_JSR"/>
<variable units="millimolar" public_interface="in" name="Ca_ss"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_NSR</ci>
<ci>Ca_JSR</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_xfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_ss</ci>
<ci>Cai</ci>
</apply>
<ci>tau_xfer</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_trpn</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>HTRPN_tot</ci>
<ci>dHTRPNCa_dt</ci>
</apply>
<apply>
<times/>
<ci>LTRPN_tot</ci>
<ci>dLTRPNCa_dt</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<ci>dHTRPNCa_dt</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<ci>dLTRPNCa_dt</ci>
</apply>
<apply>
<eq/>
<ci>dHTRPNCa_dt</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>K_plus_HTRPN</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>K_minus_HTRPN</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dLTRPNCa_dt</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>K_plus_LTRPN</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>K_minus_LTRPN</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_ion_concentrations_and_membrane_potential">
<variable units="millimolar" public_interface="out" name="Nai" initial_value="9.7983"/>
<variable units="millimolar" public_interface="out" name="Ki" initial_value="1.2556e2"/>
<variable units="millimolar" public_interface="out" name="Cai" initial_value="8.6012e-5"/>
<variable units="millimolar" public_interface="out" name="Ca_NSR" initial_value="2.855e-1"/>
<variable units="millimolar" public_interface="out" name="Ca_JSR" initial_value="2.852e-1"/>
<variable units="millimolar" public_interface="out" name="Ca_ss" initial_value="1.42e-4"/>
<variable units="millivolt" public_interface="out" cmeta:id="intracellular_ion_concentrations_and_membrane_potential_V" name="V" initial_value="-9.0658e1"/>
<variable units="picoA_per_picoF" name="i_stim"/>
<variable units="dimensionless" name="betai"/>
<variable units="dimensionless" name="betass"/>
<variable units="dimensionless" name="betaJSR"/>
<variable units="microlitre" name="V_myo" initial_value="25.84e-6"/>
<variable units="microlitre" name="V_ss" initial_value="1.2e-9"/>
<variable units="microlitre" name="V_JSR" initial_value="0.16e-6"/>
<variable units="microlitre" name="V_NSR" initial_value="2.1e-6"/>
<variable units="picoF" name="Acap" initial_value="1.534e-4"/>
<variable units="millimolar" name="Km_EGTA" initial_value="1.5e-4"/>
<variable units="millimolar" name="EGTA_tot" initial_value="0"/>
<variable units="millimolar" name="CMDN_tot" initial_value="0.05"/>
<variable units="millimolar" name="CSQN_tot" initial_value="15"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Na"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Ca"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_CaK"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kr"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Ks"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_K1"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaCa"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaK"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kv1_4"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kv1_4Na"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kv1_4K"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kv4_3"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_pCa"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Cab"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Nab"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Km_CMDN"/>
<variable units="millimolar" public_interface="in" name="Km_CSQN"/>
<variable units="picoA_per_picoF" public_interface="in" name="C_sc"/>
<variable units="flux" public_interface="in" name="J_tr"/>
<variable units="flux" public_interface="in" name="J_up"/>
<variable units="flux" public_interface="in" name="J_xfer"/>
<variable units="flux" public_interface="in" name="J_rel"/>
<variable units="flux" public_interface="in" name="J_trpn"/>
<variable units="millisecond" name="stim_start" initial_value="10"/>
<variable units="millisecond" name="stim_end" initial_value="50000"/>
<variable units="millisecond" name="stim_period" initial_value="1000"/>
<variable units="millisecond" name="stim_duration" initial_value="3"/>
<variable units="picoA_per_picoF" name="stim_amplitude" initial_value="-40"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>stim_end</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
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