Location: Reproducibility of the computational model of induced pluripotent stem-cell derived cardiomyocytes @ 039d86eef7a8 / Components / Channels.cellml

Author:
nima <nafs080@aucklanduni.ac.nz>
Date:
2021-10-20 17:20:29+13:00
Desc:
Updated documentation
Permanent Source URI:
https://models.cellml.org/workspace/702/rawfile/039d86eef7a89663b867710b506bd7a266fcdbeb/Components/Channels.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="my_model" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="unit.cellml">
        <units name="ms" units_ref="ms"/>
        <units name="per_ms" units_ref="per_ms"/>
        <units name="mV" units_ref="mV"/>
        <units name="mM" units_ref="mM"/>
        <units name="J_per_mol_per_kelvin" units_ref="J_per_mol_per_kelvin"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="nS_per_pF" units_ref="nS_per_pF"/>
        <units name="pA_per_pF" units_ref="pA_per_pF"/>
        <units name="mV_ms" units_ref="mV_ms"/>
    </import>
    <import xlink:href="parameter.cellml">
        <component component_ref="parameter" name="parameter"/>
    </import>
    <import xlink:href="gating.cellml">
        <component component_ref="gating" name="gating"/>
    </import>
    <import xlink:href="Protocol.cellml">
        <component component_ref="Protocol" name="Protocol"/>
    </import>
    <import xlink:href="Nernst_potential.cellml">
        <component component_ref="Nernst" name="Nernst"/>
    </import>
    <import xlink:href="Current.cellml">
        <component component_ref="Current" name="Current"/>
    </import>
    <!--    def import using "act_inact.cellml" for
        comp main_act_inact using comp main_act_inact;
    enddef;-->
    <component name="main">
        <variable name="act_inact" private_interface="in" public_interface="out" units="dimensionless"/>
        <variable name="act_inact_new" private_interface="in" public_interface="out" units="dimensionless"/>
        <variable name="var_1" private_interface="in" public_interface="out" units="nS_per_pF"/>
        <variable name="var_2" private_interface="in" public_interface="out" units="per_ms"/>
        <variable name="var_3" private_interface="in" public_interface="out" units="mV"/>
        <variable name="var_4" private_interface="in" public_interface="out" units="mV"/>
        <variable name="var_5" private_interface="in" public_interface="out" units="mV_ms"/>
        <variable name="var_6" private_interface="in" public_interface="out" units="mV"/>
        <variable name="v" private_interface="in" public_interface="out" units="mV"/>
        <variable name="Ko" private_interface="in" public_interface="out" units="mM"/>
        <variable name="Ki" private_interface="in" public_interface="out" units="mM"/>
        <variable name="E_K" private_interface="in" public_interface="out" units="mV"/>
        <variable name="i_k1" private_interface="in" public_interface="out" units="pA_per_pF"/>
        <variable name="protocol" private_interface="in" public_interface="out" units="dimensionless"/>
        <variable initial_value="1" name="t" public_interface="out" units="ms"/>
        <variable initial_value="1" name="a" public_interface="out" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>t</ci>
                    </bvar>
                    <ci>a</ci>
                </apply>
                <cn cellml:units="dimensionless">1</cn>
            </apply>
        </math>
    </component>
    <group>
        <relationship_ref relationship="encapsulation"/>
        <component_ref component="main">
            <component_ref component="parameter"/>
            <component_ref component="gating"/>
            <component_ref component="Protocol"/>
            <component_ref component="Nernst"/>
            <component_ref component="Current"/>
            <!--            comp main_act_inact;-->
        </component_ref>
    </group>
    <connection>
        <map_components component_1="parameter" component_2="gating"/>
        <!--        vars var_1 and var_1;-->
        <map_variables variable_1="x1" variable_2="x1"/>
        <map_variables variable_1="x2" variable_2="x2"/>
        <map_variables variable_1="x5" variable_2="x5"/>
        <map_variables variable_1="x6" variable_2="x6"/>
        <map_variables variable_1="x7" variable_2="x7"/>
        <map_variables variable_1="var_2" variable_2="var_2"/>
        <map_variables variable_1="var_3" variable_2="var_3"/>
        <map_variables variable_1="var_4" variable_2="var_4"/>
        <map_variables variable_1="var_5" variable_2="var_5"/>
        <map_variables variable_1="var_6" variable_2="var_6"/>
    </connection>
    <connection>
        <map_components component_1="gating" component_2="main"/>
        <map_variables variable_1="act_inact" variable_2="act_inact"/>
        <map_variables variable_1="act_inact_new" variable_2="act_inact_new"/>
        <map_variables variable_1="v" variable_2="v"/>
    </connection>
    <connection>
        <map_components component_1="parameter" component_2="main"/>
        <map_variables variable_1="var_1" variable_2="var_1"/>
        <map_variables variable_1="var_2" variable_2="var_2"/>
        <map_variables variable_1="var_3" variable_2="var_3"/>
        <map_variables variable_1="var_4" variable_2="var_4"/>
        <map_variables variable_1="var_5" variable_2="var_5"/>
        <map_variables variable_1="var_6" variable_2="var_6"/>
    </connection>
    <connection>
        <map_components component_1="Protocol" component_2="main"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
        <map_variables variable_1="protocol" variable_2="protocol"/>
    </connection>
    <connection>
        <map_components component_1="Nernst" component_2="main"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
    </connection>
    <connection>
        <map_components component_1="Protocol" component_2="Nernst"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
    </connection>
    <connection>
        <map_components component_1="Nernst" component_2="parameter"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="Current" component_2="main"/>
        <map_variables variable_1="i_k1" variable_2="i_k1"/>
        <!--        vars g_k1 and g_k1;-->
    </connection>
    <connection>
        <map_components component_1="Current" component_2="gating"/>
        <map_variables variable_1="v" variable_2="v"/>
        <!--        vars act_inact and act_inact;-->
        <map_variables variable_1="act_inact_new" variable_2="act_inact_new"/>
    </connection>
    <connection>
        <map_components component_1="Current" component_2="parameter"/>
        <map_variables variable_1="var_1" variable_2="var_1"/>
    </connection>
    <connection>
        <map_components component_1="Current" component_2="Nernst"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
    </connection>
</model>