Location: Reproducibility of the computational model of induced pluripotent stem-cell derived cardiomyocytes @ 430939c5c1b8 / Components / Current_Irel.cellml

Author:
David Nickerson <david.nickerson@gmail.com>
Date:
2021-11-25 11:13:34+13:00
Desc:
making internal links in overview relative instead of absolute
Permanent Source URI:
https://models.cellml.org/workspace/702/rawfile/430939c5c1b887fcf0d899b0dd11370b77bf495f/Components/Current_Irel.cellml
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<?xml version='1.0' encoding='UTF-8'?>
<model name="Current_eq" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="unit.cellml">
        <units name="mV" units_ref="mV"/>
        <units name="mM" units_ref="mM"/>
        <units name="pA_per_pF" units_ref="pA_per_pF"/>
        <units name="nS_per_pF" units_ref="nS_per_pF"/>
    </import>
    <component name="Current_release">
        <!--        var v: mV {pub: in};-->
        <variable name="ca_i" public_interface="in" units="mM"/>
        <variable name="ca_SR" public_interface="in" units="mM"/>
        <variable initial_value="12.5" name="ks" public_interface="out" units="per_ms"/>
        <variable initial_value="643751.68" name="koCa" public_interface="out" units="per_mM2_per_ms"/>
        <variable initial_value="18.495" name="kiCa" public_interface="out" units="per_mM_per_ms"/>
        <variable initial_value="0.21435" name="kom" public_interface="out" units="per_ms"/>
        <variable initial_value="0.0005571" name="kim" public_interface="out" units="per_ms"/>
        <variable initial_value="0.45" name="ec50SR" public_interface="out" units="dimensionless"/>
        <variable initial_value="15" name="MaxSR" public_interface="out" units="dimensionless"/>
        <variable initial_value="1" name="MinSR" public_interface="out" units="dimensionless"/>
        <variable name="kCaSR" public_interface="out" units="dimensionless"/>
        <variable name="koSRCa" public_interface="out" units="dimensionless"/>
        <variable name="kiSRCa" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.0113120363" name="C" public_interface="out" units="dimensionless"/>
        <variable initial_value="1.650451053E-4" name="O" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.0142153622" name="I" public_interface="out" units="dimensionless"/>
        <variable name="CI" public_interface="out" units="dimensionless"/>
        <variable name="dC" public_interface="out" units="dimensionless"/>
        <variable name="dO" public_interface="out" units="dimensionless"/>
        <variable name="dI" public_interface="out" units="dimensionless"/>
        <variable name="Vc" public_interface="in" units="mM3"/>
        <variable name="V_SR" public_interface="in" units="mM3"/>
        <variable name="j_rel" public_interface="out" units="mM_per_ms"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>kCaSR</ci>
                <apply>
                    <minus/>
                    <ci>MaxSR</ci>
                    <apply>
                        <divide/>
                        <apply>
                            <minus/>
                            <ci>MaxSR</ci>
                            <ci>MinSR</ci>
                        </apply>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <power/>
                                <apply>
                                    <divide/>
                                    <ci>ec50SR</ci>
                                    <ci>ca_SR</ci>
                                </apply>
                                <cn cellml:units="dimensionless">2.5</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>koSRCa</ci>
                <apply>
                    <divide/>
                    <ci>koCa</ci>
                    <ci>kCaSR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>kiSRCa</ci>
                <apply>
                    <times/>
                    <ci>kiCa</ci>
                    <ci>kCaSR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CI</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>C</ci>
                        </apply>
                        <ci>O</ci>
                    </apply>
                    <ci>I</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dC</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kim</ci>
                            <ci>CI</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kiSRCa</ci>
                            <ci>ca_i</ci>
                            <ci>C</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>koSRCa</ci>
                            <apply>
                                <power/>
                                <ci>ca_i</ci>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                            <ci>C</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kom</ci>
                            <ci>O</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dO</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>koSRCa</ci>
                            <apply>
                                <power/>
                                <ci>ca_i</ci>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                            <ci>C</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kom</ci>
                            <ci>O</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kiSRCa</ci>
                            <ci>ca_i</ci>
                            <ci>O</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kim</ci>
                            <ci>I</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dI</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kiSRCa</ci>
                            <ci>ca_i</ci>
                            <ci>O</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kim</ci>
                            <ci>I</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kom</ci>
                            <ci>I</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>koSRCa</ci>
                            <apply>
                                <power/>
                                <ci>ca_i</ci>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                            <ci>CI</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>j_rel</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>ks</ci>
                        <ci>O</ci>
                        <apply>
                            <minus/>
                            <ci>ca_SR</ci>
                            <ci>ca_i</ci>
                        </apply>
                        <ci>V_SR</ci>
                    </apply>
                    <ci>Vc</ci>
                </apply>
            </apply>
        </math>
    </component>
</model>