- Author:
- nima <nafs080@aucklanduni.ac.nz>
- Date:
- 2021-11-22 17:40:52+13:00
- Desc:
- Updated documentation
- Permanent Source URI:
- https://models.cellml.org/workspace/702/rawfile/55a2ea283d9ae9252e062d31869c9d6819c9fcf0/Components/Current_Ica.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="Current_eq" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="unit.cellml">
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="nS_per_pF" units_ref="nS_per_pF"/>
</import>
<component name="Current_IcaL">
<variable name="v" public_interface="in" units="mV"/>
<variable name="x_ca_inf_act" public_interface="in" units="dimensionless"/>
<variable name="x_ca_inf_inact" public_interface="in" units="dimensionless"/>
<variable name="x_fca_inf_inact" public_interface="in" units="dimensionless"/>
<variable initial_value="0" name="X_ca_act" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="X_ca_inact" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="X_fca_inact" public_interface="out" units="dimensionless"/>
<variable name="dX_ca_act" public_interface="out" units="dimensionless"/>
<variable name="dX_ca_inact" public_interface="out" units="dimensionless"/>
<variable name="dX_fca_inact" public_interface="out" units="dimensionless"/>
<variable name="tau_fca" public_interface="in" units="dimensionless"/>
<!-- var Ki: dimensionless {pub: in};-->
<variable name="R" public_interface="in" units="J_per_mol_per_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="p_CaL" public_interface="out" units="nS_per_pF"/>
<!-- var i_to: dimensionless {pub: out};-->
<variable name="d_0" public_interface="in" units="nS_per_pF"/>
<variable initial_value="5.4e-4" name="p_CaL_shannonCa" public_interface="out" units="nS_per_pF"/>
<variable initial_value="1.5e-8" name="p_CaL_shannonNa" public_interface="out" units="nS_per_pF"/>
<variable initial_value="2.7e-7" name="p_CaL_shannonK" public_interface="out" units="nS_per_pF"/>
<variable name="p_CaL_shannonTot" public_interface="out" units="nS_per_pF"/>
<variable name="p_CaL_shannonCap" public_interface="out" units="nS_per_pF"/>
<variable name="p_CaL_shannonNap" public_interface="out" units="nS_per_pF"/>
<variable name="p_CaL_shannonKp" public_interface="out" units="nS_per_pF"/>
<variable name="p_CaL_Ca" public_interface="out" units="nS_per_pF"/>
<variable name="p_CaL_Na" public_interface="out" units="nS_per_pF"/>
<variable name="p_CaL_K" public_interface="out" units="nS_per_pF"/>
<variable name="ca_i" public_interface="in" units="mM"/>
<variable name="ibarca" public_interface="out" units="pA_per_pF"/>
<variable name="i_CaL_Ca" public_interface="out" units="pA_per_pF"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="ibarna" public_interface="out" units="pA_per_pF"/>
<variable name="i_CaL_Na" public_interface="out" units="pA_per_pF"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="ibark" public_interface="out" units="pA_per_pF"/>
<variable name="i_CaL_K" public_interface="out" units="pA_per_pF"/>
<variable name="i_CaL" public_interface="out" units="pA_per_pF"/>
<variable name="k_fca" public_interface="out" units="dimensionless"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_fca</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>x_fca_inf_inact</ci>
<ci>X_fca_inact</ci>
</apply>
<apply>
<gt/>
<ci>v</ci>
<apply>
<minus/>
<cn cellml:units="mv">60</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
</math>
<variable name="tau_ca_act" public_interface="in" units="ms"/>
<variable name="tau_ca_inact" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dX_ca_act</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_ca_inf_act</ci>
<ci>X_ca_act</ci>
</apply>
<ci>tau_ca_act</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dX_ca_inact</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_ca_inf_inact</ci>
<ci>X_ca_inact</ci>
</apply>
<ci>tau_ca_inact</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dX_fca_inact</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k_fca</ci>
<apply>
<minus/>
<ci>x_fca_inf_inact</ci>
<ci>X_fca_inact</ci>
</apply>
</apply>
<ci>tau_fca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_CaL</ci>
<ci>d_0</ci>
</apply>
<apply>
<eq/>
<ci>p_CaL_shannonTot</ci>
<apply>
<plus/>
<ci>p_CaL_shannonCa</ci>
<ci>p_CaL_shannonNa</ci>
<ci>p_CaL_shannonK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_CaL_shannonCap</ci>
<apply>
<divide/>
<ci>p_CaL_shannonCa</ci>
<ci>p_CaL_shannonTot</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_CaL_shannonNap</ci>
<apply>
<divide/>
<ci>p_CaL_shannonNa</ci>
<ci>p_CaL_shannonTot</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_CaL_shannonKp</ci>
<apply>
<divide/>
<ci>p_CaL_shannonK</ci>
<ci>p_CaL_shannonTot</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_CaL_Ca</ci>
<apply>
<times/>
<ci>p_CaL_shannonCap</ci>
<ci>p_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_CaL_Na</ci>
<apply>
<times/>
<ci>p_CaL_shannonNap</ci>
<ci>p_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_CaL_K</ci>
<apply>
<times/>
<ci>p_CaL_shannonKp</ci>
<ci>p_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ibarca</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>p_CaL_Ca</ci>
<cn cellml:units="dimensionless">4.0</cn>
<ci>v</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.341</cn>
<ci>ca_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>v</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.341</cn>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>v</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Ca</ci>
<apply>
<times/>
<ci>ibarca</ci>
<ci>X_ca_act</ci>
<ci>X_ca_inact</ci>
<ci>X_fca_inact</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ibarna</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>p_CaL_Na</ci>
<ci>v</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<ci>Na_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>v</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>v</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Na</ci>
<apply>
<times/>
<ci>ibarna</ci>
<ci>X_ca_act</ci>
<ci>X_ca_inact</ci>
<ci>X_fca_inact</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ibark</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>p_CaL_K</ci>
<ci>v</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>v</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<ci>Ko</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>v</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_K</ci>
<apply>
<times/>
<ci>ibark</ci>
<ci>X_ca_act</ci>
<ci>X_ca_inact</ci>
<ci>X_fca_inact</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL</ci>
<apply>
<plus/>
<ci>i_CaL_Ca</ci>
<ci>i_CaL_Na</ci>
<ci>i_CaL_K</ci>
</apply>
</apply>
</math>
</component>
</model>