- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-11-12 10:18:28+13:00
- Desc:
- Updating files
- Permanent Source URI:
- https://models.cellml.org/workspace/702/rawfile/835e5bf16e8987195f14b4e11c5696cf8266de6a/CellML/Current_If.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="Current_eq" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="unit.cellml">
<units name="ms" units_ref="ms"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="mM3" units_ref="mM3"/>
<units name="J_per_mol_per_kelvin" units_ref="J_per_mol_per_kelvin"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="nS_per_pF" units_ref="nS_per_pF"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="mV_ms" units_ref="mV_ms"/>
<units name="mM_per_ms" units_ref="mM_per_ms"/>
<units name="per_mM_per_ms" units_ref="per_mM_per_ms"/>
<units name="per_mM2_per_ms" units_ref="per_mM2_per_ms"/>
</import>
<import xlink:href="parameter.cellml">
<component component_ref="parameter" name="parameter"/>
</import>
<import xlink:href="parameter_If.cellml">
<component component_ref="parameter_If" name="parameter_If"/>
</import>
<import xlink:href="gating_If.cellml">
<component component_ref="gating_If" name="gating_If"/>
</import>
<component name="Current_If">
<variable name="v" private_interface="in" public_interface="out" units="mV"/>
<variable initial_value="8.314472" name="R" public_interface="out" units="J_per_mol_per_kelvin"/>
<variable initial_value="310.0" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96.4853415" name="F" public_interface="out" units="C_per_mol"/>
<variable name="E_K" public_interface="out" units="mV"/>
<variable name="E_Na" public_interface="out" units="mV"/>
<variable name="Ko" private_interface="in" public_interface="out" units="mM"/>
<variable initial_value="150" name="Ki" public_interface="out" units="mM"/>
<variable initial_value="135" name="Na_i" public_interface="out" units="mM"/>
<variable name="Nao" private_interface="in" public_interface="out" units="mM"/>
<variable name="x_f_inf_act" public_interface="in" units="dimensionless"/>
<variable initial_value="0" name="X_f_act" public_interface="out" units="dimensionless"/>
<!-- var dX_f_act: dimensionless {init: 0, pub: out};-->
<variable name="i_f" public_interface="out" units="pA_per_pF"/>
<variable name="i_fNa" public_interface="out" units="pA_per_pF"/>
<variable name="i_fK" public_interface="out" units="pA_per_pF"/>
<variable name="xf_1" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="xf_2" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="xf_5" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="xf_6" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="xf_const" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="g_f" private_interface="in" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.491" name="NatoK_ratio" public_interface="out" units="dimensionless"/>
<variable name="Na_frac" public_interface="out" units="dimensionless"/>
<variable name="tau_f_act" public_interface="in" units="ms"/>
<variable initial_value="1" name="t" public_interface="out" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>X_f_act</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_f_inf_act</ci>
<ci>X_f_act</ci>
</apply>
<ci>tau_f_act</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>v</ci>
</apply>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<eq/>
<ci>Na_frac</ci>
<apply>
<divide/>
<ci>NatoK_ratio</ci>
<apply>
<plus/>
<ci>NatoK_ratio</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fNa</ci>
<apply>
<times/>
<ci>Na_frac</ci>
<ci>g_f</ci>
<ci>X_f_act</ci>
<apply>
<minus/>
<ci>v</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fK</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>Na_frac</ci>
</apply>
<ci>g_f</ci>
<ci>X_f_act</ci>
<apply>
<minus/>
<ci>v</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f</ci>
<apply>
<plus/>
<ci>i_fNa</ci>
<ci>i_fK</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="Current_If" component_2="gating_If"/>
<map_variables variable_1="x_f_inf_act" variable_2="x_f_inf_act"/>
<map_variables variable_1="tau_f_act" variable_2="tau_f_act"/>
</connection>
<connection>
<map_components component_1="Current_If" component_2="parameter_If"/>
<map_variables variable_1="g_f" variable_2="g_f"/>
<map_variables variable_1="xf_1" variable_2="xf_1"/>
<map_variables variable_1="xf_2" variable_2="xf_2"/>
<map_variables variable_1="xf_5" variable_2="xf_5"/>
<map_variables variable_1="xf_6" variable_2="xf_6"/>
<map_variables variable_1="xf_const" variable_2="xf_const"/>
</connection>
<connection>
<map_components component_1="Current_If" component_2="parameter"/>
<map_variables variable_1="v" variable_2="v"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="gating_If" component_2="parameter"/>
<map_variables variable_1="v" variable_2="v"/>
</connection>
<connection>
<map_components component_1="parameter_If" component_2="gating_If"/>
<map_variables variable_1="xf_1" variable_2="xf_1"/>
<map_variables variable_1="xf_2" variable_2="xf_2"/>
<map_variables variable_1="xf_5" variable_2="xf_5"/>
<map_variables variable_1="xf_6" variable_2="xf_6"/>
<map_variables variable_1="xf_const" variable_2="xf_const"/>
</connection>
</model>
