- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-11-12 10:18:28+13:00
- Desc:
- Updating files
- Permanent Source URI:
- https://models.cellml.org/workspace/702/rawfile/835e5bf16e8987195f14b4e11c5696cf8266de6a/CellML/gating_Ikr.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="gating_eq" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="unit.cellml">
<units name="per_ms" units_ref="per_ms"/>
<units name="mV" units_ref="mV"/>
<!-- unit mM using unit mM;-->
<units name="mV_ms" units_ref="mV_ms"/>
<units name="ms" units_ref="ms"/>
<!-- unit pA_per_pF using unit pA_per_pF;
unit nS_per_pF using unit nS_per_pF;-->
</import>
<component name="gating_Ikr">
<variable name="v" public_interface="in" units="mV"/>
<variable name="alpha_act" public_interface="out" units="per_ms"/>
<variable name="beta_act" public_interface="out" units="per_ms"/>
<variable name="alpha_inact" public_interface="out" units="per_ms"/>
<variable name="beta_inact" public_interface="out" units="per_ms"/>
<!-- var act_inact: dimensionless {pub: out};
var g_Kr: dimensionless {pub: out};
var i_Kr: dimensionless {pub: out};
var Xr1_0: dimensionless {pub: in};-->
<variable name="Xr1_1" public_interface="in" units="dimensionless"/>
<variable name="Xr1_2" public_interface="in" units="dimensionless"/>
<variable name="Xr1_3" public_interface="out" units="dimensionless"/>
<variable name="Xr1_4" public_interface="out" units="dimensionless"/>
<variable name="Xr1_5" public_interface="in" units="dimensionless"/>
<variable name="Xr1_6" public_interface="in" units="dimensionless"/>
<variable name="Xr2_1" public_interface="in" units="dimensionless"/>
<variable name="Xr2_2" public_interface="in" units="dimensionless"/>
<variable name="Xr2_3" public_interface="out" units="dimensionless"/>
<variable name="Xr2_4" public_interface="out" units="dimensionless"/>
<variable name="Xr2_5" public_interface="in" units="dimensionless"/>
<variable name="Xr2_6" public_interface="in" units="dimensionless"/>
<variable name="Xr1_7" public_interface="in" units="dimensionless"/>
<variable name="Xr2_7" public_interface="in" units="dimensionless"/>
<variable name="x_inf_act" public_interface="out" units="dimensionless"/>
<variable name="x_inf_inact" public_interface="out" units="dimensionless"/>
<variable name="tau_kr_act" public_interface="out" units="ms"/>
<variable name="tau_kr_inact" public_interface="out" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Xr1_3</ci>
<apply>
<times/>
<ci>Xr1_5</ci>
<ci>Xr1_1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Xr2_3</ci>
<apply>
<times/>
<ci>Xr2_5</ci>
<ci>Xr2_1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Xr1_4</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>Xr1_2</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>Xr1_6</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Xr2_4</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>Xr2_2</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>Xr2_6</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_act</ci>
<apply>
<times/>
<ci>Xr1_1</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>v</ci>
<ci>Xr1_2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_act</ci>
<apply>
<times/>
<ci>Xr1_3</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>v</ci>
<ci>Xr1_4</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x_inf_act</ci>
<apply>
<divide/>
<ci>alpha_act</ci>
<apply>
<plus/>
<ci>alpha_act</ci>
<ci>beta_act</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_kr_act</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_act</ci>
<ci>beta_act</ci>
</apply>
</apply>
<ci>Xr1_7</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_inact</ci>
<apply>
<times/>
<ci>Xr2_1</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>v</ci>
<ci>Xr2_2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_inact</ci>
<apply>
<times/>
<ci>Xr2_3</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>v</ci>
<ci>Xr2_4</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x_inf_inact</ci>
<apply>
<divide/>
<ci>alpha_inact</ci>
<apply>
<plus/>
<ci>alpha_inact</ci>
<ci>beta_inact</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_kr_inact</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_inact</ci>
<ci>beta_inact</ci>
</apply>
</apply>
<ci>Xr2_7</ci>
</apply>
</apply>
</math>
</component>
</model>
