- Author:
- nima <nafs080@aucklanduni.ac.nz>
- Date:
- 2021-10-11 16:09:41+13:00
- Desc:
- Updated documentation
- Permanent Source URI:
- https://models.cellml.org/workspace/702/rawfile/853940fc7b794f99d2f1b8c97263b0e91bf9487c/Overview.rst
About this model
====================
:Original publication: `Colleen E. Clancy, Eleonora Grandi, et al (2019)`_:
"A computational model of induced pluripotent stem-cell derived cardiomyocytes \
incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.
:DOI: https://dx.doi.org/10.1113%2FJP277724
.. _`Colleen E. Clancy, Eleonora Grandi, et al (2019)`: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767694/
Model status
=============
The current CellML model implementation runs OpenCOR_.
The simulation setting saved in SEDML file. \
SEDML file then loaded into Python script in order for the code to go through \
the loop and capture the results for different initial conditions and inputs.
Each CellML file in the navigation panel along with SEDML file and python script can reproduce \
one of the figure in the primary published paper (`Colleen E. Clancy, Eleonora Grandi, et al (2019)`_).
Model overview
===================
This workspace holds a CellML_ and Python encoding of the `Colleen E. Clancy, Eleonora Grandi, et al (2019)`_ model.
The original model was built in MATLAB which can be downloaded from GitHub_.
`Colleen E. Clancy, Eleonora Grandi, et al (2019)`_ developed a whole cell model of \
induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) /
composed of simple model components comprising ion channel models with single exponential \
voltage‐dependent gating variable rate constants, parameterized to fit experimental \
iPSC-CM data for all major ionic currents. They optimized ionic current model parameters\
to multiple experimental datasets. The resulting population of cellular models predicts \
robust inter‐subject variability in iPSC-CMs. This approach links molecular mechanisms to \
known cellular-level iPSC-CM phenotypes, as shown by comparing immature and mature subpopulations \
of models to analyse the contributing factors underlying each phenotype.
.. figure:: schematic-diagram.jpg
:width: 85%
:align: center
:alt: Schematics of the model
A diagrammatic representation of the Colleen E. Clancy, Eleonora Grandi, et al (2019) model.
.. _CellML: https://www.cellml.org/
.. _OpenCOR: https://opencor.ws/
.. _GitHub: https://github.com/ClancyLabUCD/IPSC-model/
