Location: Reproducibility of the computational model of induced pluripotent stem-cell derived cardiomyocytes @ c63c733e2057 / Current_Ik1.cellml

Author:
Shelley Fong <sfon036@UoA.auckland.ac.nz>
Date:
2024-09-24 13:57:30+12:00
Desc:
Adding new py files and moving pics into folder
Permanent Source URI:
https://models.cellml.org/workspace/702/rawfile/c63c733e2057d3e417439cf01363b411899eb53d/Current_Ik1.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="Current_eq" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="unit.cellml">
        <units name="ms" units_ref="ms"/>
        <units name="per_ms" units_ref="per_ms"/>
        <units name="mV" units_ref="mV"/>
        <units name="mM" units_ref="mM"/>
        <units name="mM3" units_ref="mM3"/>
        <units name="J_per_mol_per_kelvin" units_ref="J_per_mol_per_kelvin"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="nS_per_pF" units_ref="nS_per_pF"/>
        <units name="pA_per_pF" units_ref="pA_per_pF"/>
        <units name="mV_ms" units_ref="mV_ms"/>
        <units name="mM_per_ms" units_ref="mM_per_ms"/>
        <units name="per_mM_per_ms" units_ref="per_mM_per_ms"/>
        <units name="per_mM2_per_ms" units_ref="per_mM2_per_ms"/>
    </import>
    <import xlink:href="parameter.cellml">
        <component component_ref="parameter" name="parameter"/>
    </import>
    <import xlink:href="parameter_Ik1.cellml">
        <component component_ref="parameter_Ik1" name="parameter_Ik1"/>
    </import>
    <import xlink:href="gating_Ik1.cellml">
        <component component_ref="gating_Ik1" name="gating_Ik1"/>
    </import>
    <component name="Current_Ik1">
        <variable name="v" public_interface="in" units="mV"/>
        <variable name="R" public_interface="in" units="J_per_mol_per_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="C_per_mol"/>
        <variable name="E_K" public_interface="out" units="mV"/>
        <variable name="x_inf_act_Ik1" public_interface="in" units="dimensionless"/>
        <variable name="Ko" public_interface="in" units="mM"/>
        <variable name="i_k1" public_interface="out" units="pA_per_pF"/>
        <variable name="g_k1" public_interface="out" units="nS_per_pF"/>
        <variable name="var_1" private_interface="in" public_interface="out" units="nS_per_pF"/>
        <variable name="var_2" private_interface="in" public_interface="out" units="per_ms"/>
        <variable name="var_3" private_interface="in" public_interface="out" units="mV"/>
        <variable name="var_4" private_interface="in" public_interface="out" units="mV"/>
        <variable name="var_5" private_interface="in" public_interface="out" units="mV_ms"/>
        <variable name="var_6" private_interface="in" public_interface="out" units="mV"/>
        <variable initial_value="150" name="Ki" public_interface="out" units="mM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>E_K</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Ko</ci>
                            <ci>Ki</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>g_k1</ci>
                <ci>var_1</ci>
            </apply>
            <apply>
                <eq/>
                <ci>i_k1</ci>
                <apply>
                    <times/>
                    <ci>g_k1</ci>
                    <apply>
                        <root/>
                        <apply>
                            <divide/>
                            <ci>Ko</ci>
                            <cn cellml:units="mM">5.4</cn>
                        </apply>
                    </apply>
                    <ci>x_inf_act_Ik1</ci>
                    <apply>
                        <minus/>
                        <ci>v</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
        <variable initial_value="1" name="t" public_interface="out" units="ms"/>
        <variable initial_value="1" name="a" public_interface="out" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>t</ci>
                    </bvar>
                    <ci>a</ci>
                </apply>
                <cn cellml:units="dimensionless">1</cn>
            </apply>
        </math>
    </component>
    <connection>
        <map_components component_1="Current_Ik1" component_2="parameter"/>
        <map_variables variable_1="v" variable_2="v"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
    </connection>
    <connection>
        <map_components component_1="gating_Ik1" component_2="parameter"/>
        <map_variables variable_1="v" variable_2="v"/>
    </connection>
    <connection>
        <map_components component_1="Current_Ik1" component_2="parameter_Ik1"/>
        <map_variables variable_1="var_1" variable_2="var_1"/>
        <map_variables variable_1="var_2" variable_2="var_2"/>
        <map_variables variable_1="var_3" variable_2="var_3"/>
        <map_variables variable_1="var_4" variable_2="var_4"/>
        <map_variables variable_1="var_5" variable_2="var_5"/>
        <map_variables variable_1="var_6" variable_2="var_6"/>
    </connection>
    <connection>
        <map_components component_1="gating_Ik1" component_2="parameter_Ik1"/>
        <map_variables variable_1="var_2" variable_2="var_2"/>
        <map_variables variable_1="var_3" variable_2="var_3"/>
        <map_variables variable_1="var_4" variable_2="var_4"/>
        <map_variables variable_1="var_5" variable_2="var_5"/>
        <map_variables variable_1="var_6" variable_2="var_6"/>
    </connection>
    <connection>
        <map_components component_1="Current_Ik1" component_2="gating_Ik1"/>
        <map_variables variable_1="x_inf_act_Ik1" variable_2="x_inf_act_Ik1"/>
    </connection>
</model>