- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-11-09 17:07:27+13:00
- Desc:
- with picture
- Permanent Source URI:
- https://models.cellml.org/workspace/705/rawfile/5db0ba8e1f3e1e2202dbe72645ebaf293934e217/exposure/exposure_frontpage.rst
About this model
====================
This is a Functional Cell Unit for adenylyl cyclase metabolism in the cardiac cell.
Model status
=============
The current CellML implementation runs in OpenCOR.
Model overview
===================
All components are presented in `bond-graph` form.
Components are made by converting an existing kinetic model and translating into bond-graph form.
Modular description
===================
Components
----------
CellML divides the mathematical model into distinct components, which are able to be re-used.
The main CellML components are:
- :math:`{\beta}`-1 adrenergic receptor ( :math:`{\beta}`1AR)
- Derived from: `Saucerman et al.`_
- Gs Protein
- Derived from: `Saucerman et al.`_
- muscarinic receptor (M2)
- Derived from: `Iancu et al.`_
- Gi Protein
- Derived from: `Iancu et al.`_
- cAMP
- Derived from: `Saucerman et al.`_
.. _`Saucerman et al`:
https://models.physiomeproject.org/exposure/9766d9bd0325c31e47a31b291e26ccad
.. _`Iancu et al.`:
https://models.physiomeproject.org/exposure/f67b68f901fc3986fcea0dcfceb503f9
Each of these blocks is itself a CellML model, which enables us to reuse the various components in future studies and models.
