Location: FCU_adenylylCyclase @ 730cecb35995 / FCU_adenylylCyclase.cellml

Author:
Shelley Fong <s.fong@auckland.ac.nz>
Date:
2021-10-18 16:31:40+13:00
Desc:
Working Python export of FCU cellml file. MATLAB is now outdated
Permanent Source URI:
https://models.cellml.org/workspace/705/rawfile/730cecb35995ae8a0003acc216a60cab6601de62/FCU_adenylylCyclase.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="FCU_composite" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="units_and_constants/units_BG.cellml">
        <units name="mM" units_ref="mM"/>
        <units name="fmol" units_ref="fmol"/>
        <units name="per_fmol" units_ref="per_fmol"/>
        <units name="J_per_mol" units_ref="J_per_mol"/>
        <units name="fmol_per_sec" units_ref="fmol_per_sec"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="J_per_C" units_ref="J_per_C"/>
        <units name="microm3" units_ref="microm3"/>
        <units name="fF" units_ref="fF"/>
        <units name="fC" units_ref="fC"/>
        <units name="fA" units_ref="fA"/>
        <units name="per_second" units_ref="per_second"/>
        <units name="millivolt" units_ref="millivolt"/>
        <units name="per_sec" units_ref="per_sec"/>
        <units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
        <units name="fmol_per_L" units_ref="fmol_per_L"/>
        <units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
        <units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
        <units name="uM" units_ref="uM"/>
        <units name="mM_per_sec" units_ref="mM_per_sec"/>
        <units name="uM_per_sec" units_ref="uM_per_sec"/>
        <units name="pL" units_ref="pL"/>
        <units name="m_to_u" units_ref="m_to_u"/>
    </import>
    <import xlink:href="units_and_constants/constants_BG.cellml">
        <component component_ref="constants" name="constants"/>
    </import>
    <import xlink:href="cAMP/BG_cAMP.cellml">
        <component component_ref="cAMP" name="cAMP"/>
    </import>
    <import xlink:href="LRGbinding_B1AR/BG_LRGbinding_B1AR.cellml">
        <component component_ref="LRGbinding_B1AR" name="LRGbinding_B1AR"/>
    </import>
    <import xlink:href="LRGbinding_M2/BG_LRGbinding_M2.cellml">
        <component component_ref="LRGbinding_M2" name="LRGbinding_M2"/>
    </import>
    <import xlink:href="GsProtein/BG_GsProtein.cellml">
        <component component_ref="GsProtein" name="GsProtein"/>
    </import>
    <import xlink:href="GiProtein/BG_GiProtein.cellml">
        <component component_ref="GiProtein" name="GiProtein"/>
    </import>
    <component name="BG_parameters">
        <variable initial_value="3.63265e+06" name="kappa_1a" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.000758462" name="kappa_1b" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="333398" name="kappa_2a" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0899646" name="kappa_2b" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.40489e+08" name="kappa_3a" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.79639e-17" name="kappa_3b" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="30916.4" name="kappa_4a" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.11891" name="kappa_4b" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="824.604" name="kappa_5" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="6142.12" name="kappa_6" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="443048" name="kappa_7" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1734.45" name="kappa_GiAC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1320.77" name="kappa_sig1_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="24.8319" name="kappa_sig2_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="5.26566" name="kappa_sig3_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="4.19518e+06" name="kappa_sig4_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2426.3" name="kappa_sig1_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="68.6013" name="kappa_sig2_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="14.5471" name="kappa_sig3_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.90239e+06" name="kappa_sig4_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="24.1902" name="kappa_phos_RGs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="7.80819" name="kappa_phos_LRGs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.42953" name="kappa_act1_Gs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0374674" name="kappa_act2_Gs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.287462" name="kappa_hyd_Gs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.7312e+06" name="kappa_reassoc_Gs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="44.4383" name="kappa_phos_RGi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="21.5711" name="kappa_phos_LRGi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.410326" name="kappa_act1_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.000323464" name="kappa_act2_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.02938" name="kappa_hyd_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.70408e+06" name="kappa_reassoc_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="5.35546e-05" name="K_ATP" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0158165" name="K_cAMP" public_interface="out" units="per_fmol"/>
        <variable initial_value="4.03967" name="K_AC" public_interface="out" units="per_fmol"/>
        <variable initial_value="7.66545" name="K_AC_ATP" public_interface="out" units="per_fmol"/>
        <variable initial_value="4.73286" name="K_aGs_GTP_AC" public_interface="out" units="per_fmol"/>
        <variable initial_value="2.74656" name="K_aGs_GTP_AC_ATP" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0656131" name="K_FSK_AC" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.103955" name="K_FSK_AC_ATP" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.72816" name="K_PDE" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.22235" name="K_PDE_cAMP" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0158165" name="K_five_AMP" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0197666" name="K_IBMX" public_interface="out" units="per_fmol"/>
        <variable initial_value="35.253" name="K_PDEinh" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.085145" name="K_aGs_GTP" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.07308e-05" name="K_FSK" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0120608" name="K_aGi_GTP" public_interface="out" units="per_fmol"/>
        <variable initial_value="16.7602" name="K_ACinh" public_interface="out" units="per_fmol"/>
        <variable initial_value="9.843e-05" name="K_PPi" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0480673" name="K_L_B1" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00573574" name="K_R_B1" public_interface="out" units="per_fmol"/>
        <variable initial_value="156.63" name="K_Gs" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.767984" name="K_LR_B1" public_interface="out" units="per_fmol"/>
        <variable initial_value="517.271" name="K_R_B1Gs" public_interface="out" units="per_fmol"/>
        <variable initial_value="456.649" name="K_LR_B1Gs" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0319627" name="K_L_M2" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0124678" name="K_R_M2" public_interface="out" units="per_fmol"/>
        <variable initial_value="39.2246" name="K_Gi" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.11006" name="K_LR_M2" public_interface="out" units="per_fmol"/>
        <variable initial_value="281.579" name="K_R_M2Gi" public_interface="out" units="per_fmol"/>
        <variable initial_value="165.295" name="K_LR_M2Gi" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.625296" name="K_R_B1GsP" public_interface="out" units="per_fmol"/>
        <variable initial_value="6.79829" name="K_LR_B1GsP" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.83091e-05" name="K_beta_gamma_Gs" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0215206" name="K_aGs_GDP" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00012979" name="K_Pi" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.340383" name="K_R_M2GiP" public_interface="out" units="per_fmol"/>
        <variable initial_value="2.4608" name="K_LR_M2GiP" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000207164" name="K_beta_gamma_Gi" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00304839" name="K_aGi_GDP" public_interface="out" units="per_fmol"/>
    </component>
    <component name="environment">
        <variable name="time" units="second"/>
        <variable initial_value="34.4" name="vol_myo" public_interface="out" units="pL"/>
        <variable initial_value="500" name="freq" units="dimensionless"/>
        <!-- stimulus
 ramp UP and ramp DOWN-->
        <variable initial_value="3.5e-4" name="stimSt" units="second"/>
        <variable initial_value="3e-4" name="stimSt2" units="second"/>
        <variable initial_value="0.25e-4" name="stimDur" units="second"/>
        <variable initial_value="1.8e-4" name="tR" units="second"/>
        <variable initial_value="1e1" name="stimMag" units="fmol"/>
        <variable initial_value="1e-5" name="stimHolding" units="fmol"/>
        <variable name="m" units="fmol_per_sec"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>m</ci>
                <apply>
                    <divide/>
                    <ci>stimMag</ci>
                    <ci>tR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_L_B1_init</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimHolding</ci>
                            <apply>
                                <times/>
                                <ci>m</ci>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <minus/>
                                        <ci>time</ci>
                                        <ci>stimSt</ci>
                                    </apply>
                                    <ci>tR</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <ci>stimSt</ci>
                            </apply>
                            <apply>
                                <gt/>
                                <ci>time</ci>
                                <apply>
                                    <minus/>
                                    <ci>stimSt</ci>
                                    <ci>tR</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimMag</ci>
                            <ci>stimHolding</ci>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <geq/>
                                <ci>time</ci>
                                <ci>stimSt</ci>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimHolding</ci>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>m</ci>
                                </apply>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <ci>time</ci>
                                            <ci>stimSt</ci>
                                        </apply>
                                        <ci>tR</ci>
                                    </apply>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt</ci>
                                    <ci>tR</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                            <apply>
                                <geq/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>stimHolding</ci>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>q_L_M2_init</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimHolding</ci>
                            <apply>
                                <times/>
                                <ci>m</ci>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <minus/>
                                        <ci>time</ci>
                                        <ci>stimSt2</ci>
                                    </apply>
                                    <ci>tR</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <ci>stimSt2</ci>
                            </apply>
                            <apply>
                                <gt/>
                                <ci>time</ci>
                                <apply>
                                    <minus/>
                                    <ci>stimSt2</ci>
                                    <ci>tR</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimMag</ci>
                            <ci>stimHolding</ci>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <geq/>
                                <ci>time</ci>
                                <ci>stimSt2</ci>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt2</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimHolding</ci>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>m</ci>
                                </apply>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <ci>time</ci>
                                            <ci>stimSt2</ci>
                                        </apply>
                                        <ci>tR</ci>
                                    </apply>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt2</ci>
                                    <ci>tR</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                            <apply>
                                <geq/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt2</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>stimHolding</ci>
                    </otherwise>
                </piecewise>
            </apply>
        </math>
        <variable initial_value="190" name="q_ATP_init" units="fmol"/>
        <variable initial_value="1.889E-03" name="q_AC_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_cAMP_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_AC_ATP_init" units="fmol"/>
        <variable initial_value="3.800E-05" name="q_FSK_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_FSK_AC_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_FSK_AC_ATP_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_aGs_GTP_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_aGs_GTP_AC_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_aGs_GTP_AC_ATP_init" units="fmol"/>
        <variable initial_value="1.482E-03" name="q_PDE_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_PDEinh_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_PDE_cAMP_init" units="fmol"/>
        <variable initial_value="3.80E-02" name="q_IBMX_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_five_AMP_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_aGi_GTP_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_ACinh_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_PPi_init" units="fmol"/>
        <variable initial_value="0.0004579000" name="q_R_B1_init" units="fmol"/>
        <variable initial_value="0.1455400000" name="q_Gs_init" units="fmol"/>
        <variable name="q_L_B1_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_LR_B1_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_R_B1Gs_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_LR_B1Gs_init" units="fmol"/>
        <variable name="q_L_M2_init" units="fmol"/>
        <variable initial_value="0.00072" name="q_R_M2_init" units="fmol"/>
        <variable initial_value="0.00836" name="q_Gi_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_LR_M2_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_R_M2Gi_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_LR_M2Gi_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_beta_gamma_Gs_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_aGs_GDP_init" units="fmol"/>
        <variable initial_value="570" name="q_Pi_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_beta_gamma_Gi_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_aGi_GDP_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_R_B1GsP_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_LR_B1GsP_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_R_M2GiP_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_LR_M2GiP_init" units="fmol"/>
        <!-- mass conservation checks-->
        <variable name="L_B1_T" units="fmol"/>
        <variable name="L_M2_T" units="fmol"/>
        <variable name="R_B1_T" units="fmol"/>
        <variable name="R_M2_T" units="fmol"/>
        <variable name="Gs_T" units="fmol"/>
        <variable name="Gi_T" units="fmol"/>
        <variable name="adenosine_T" units="fmol"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>L_B1_T</ci>
                <apply>
                    <plus/>
                    <ci>q_L_B1</ci>
                    <ci>q_LR_B1Gs</ci>
                    <ci>q_LR_B1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>L_M2_T</ci>
                <apply>
                    <plus/>
                    <ci>q_L_M2</ci>
                    <ci>q_LR_M2Gi</ci>
                    <ci>q_LR_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>R_B1_T</ci>
                <apply>
                    <plus/>
                    <ci>q_R_B1</ci>
                    <ci>q_R_B1Gs</ci>
                    <ci>q_LR_B1</ci>
                    <ci>q_LR_B1Gs</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>R_M2_T</ci>
                <apply>
                    <plus/>
                    <ci>q_R_M2</ci>
                    <ci>q_R_M2Gi</ci>
                    <ci>q_LR_M2</ci>
                    <ci>q_LR_M2Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Gs_T</ci>
                <apply>
                    <plus/>
                    <ci>q_Gs</ci>
                    <ci>q_R_B1Gs</ci>
                    <ci>q_LR_B1Gs</ci>
                    <ci>q_R_B1GsP</ci>
                    <ci>q_LR_B1GsP</ci>
                    <ci>q_aGs_GTP</ci>
                    <ci>q_aGs_GDP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Gi_T</ci>
                <apply>
                    <plus/>
                    <ci>q_Gi</ci>
                    <ci>q_R_M2Gi</ci>
                    <ci>q_LR_M2Gi</ci>
                    <ci>q_R_M2GiP</ci>
                    <ci>q_LR_M2GiP</ci>
                    <ci>q_aGi_GTP</ci>
                    <ci>q_aGi_GDP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>adenosine_T</ci>
                <apply>
                    <plus/>
                    <ci>q_cAMP</ci>
                    <ci>q_PDE_cAMP</ci>
                    <ci>q_five_AMP</ci>
                    <ci>q_ATP</ci>
                    <ci>q_AC_ATP</ci>
                    <ci>q_aGs_GTP_AC_ATP</ci>
                    <ci>q_FSK_AC_ATP</ci>
                </apply>
            </apply>
        </math>
        <!-- Global value-->
        <variable name="q_ATP" public_interface="out" units="fmol"/>
        <variable name="q_cAMP" public_interface="out" units="fmol"/>
        <variable name="q_AC" public_interface="out" units="fmol"/>
        <variable name="q_AC_ATP" public_interface="out" units="fmol"/>
        <variable name="q_aGs_GTP_AC" public_interface="out" units="fmol"/>
        <variable name="q_aGs_GTP_AC_ATP" public_interface="out" units="fmol"/>
        <variable name="q_FSK_AC" public_interface="out" units="fmol"/>
        <variable name="q_FSK_AC_ATP" public_interface="out" units="fmol"/>
        <variable name="q_PDE" public_interface="out" units="fmol"/>
        <variable name="q_PDE_cAMP" public_interface="out" units="fmol"/>
        <variable name="q_five_AMP" public_interface="out" units="fmol"/>
        <variable name="q_IBMX" public_interface="out" units="fmol"/>
        <variable name="q_PDEinh" public_interface="out" units="fmol"/>
        <variable name="q_aGs_GTP" public_interface="out" units="fmol"/>
        <variable name="q_FSK" public_interface="out" units="fmol"/>
        <variable name="q_aGi_GTP" public_interface="out" units="fmol"/>
        <variable name="q_ACinh" public_interface="out" units="fmol"/>
        <variable name="q_PPi" public_interface="out" units="fmol"/>
        <variable name="q_L_B1" public_interface="out" units="fmol"/>
        <variable name="q_R_B1" public_interface="out" units="fmol"/>
        <variable name="q_Gs" public_interface="out" units="fmol"/>
        <variable name="q_LR_B1" public_interface="out" units="fmol"/>
        <variable name="q_R_B1Gs" public_interface="out" units="fmol"/>
        <variable name="q_LR_B1Gs" public_interface="out" units="fmol"/>
        <variable name="q_L_M2" public_interface="out" units="fmol"/>
        <variable name="q_R_M2" public_interface="out" units="fmol"/>
        <variable name="q_Gi" public_interface="out" units="fmol"/>
        <variable name="q_LR_M2" public_interface="out" units="fmol"/>
        <variable name="q_R_M2Gi" public_interface="out" units="fmol"/>
        <variable name="q_LR_M2Gi" public_interface="out" units="fmol"/>
        <variable name="q_R_B1GsP" public_interface="out" units="fmol"/>
        <variable name="q_LR_B1GsP" public_interface="out" units="fmol"/>
        <variable name="q_beta_gamma_Gs" public_interface="out" units="fmol"/>
        <variable name="q_aGs_GDP" public_interface="out" units="fmol"/>
        <variable name="q_Pi" public_interface="out" units="fmol"/>
        <variable name="q_R_M2GiP" public_interface="out" units="fmol"/>
        <variable name="q_LR_M2GiP" public_interface="out" units="fmol"/>
        <variable name="q_beta_gamma_Gi" public_interface="out" units="fmol"/>
        <variable name="q_aGi_GDP" public_interface="out" units="fmol"/>
        <!-- cAMP imports-->
        <variable name="q_ATP_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_cAMP_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_AC_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_aGs_GTP_AC_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_aGs_GTP_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_FSK_AC_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_FSK_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_PDE_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_PDE_cAMP_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_five_AMP_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_IBMX_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_PDEinh_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_aGs_GTP_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_FSK_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_aGi_GTP_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_ACinh_mcAMP" public_interface="in" units="fmol"/>
        <variable name="q_PPi_mcAMP" public_interface="in" units="fmol"/>
        <!-- LRGbinding_B1AR imports-->
        <variable name="q_L_B1_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
        <variable name="q_R_B1_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
        <variable name="q_Gs_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
        <variable name="q_LR_B1_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
        <variable name="q_R_B1Gs_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
        <variable name="q_LR_B1Gs_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
        <!-- LRGbinding_M2 imports-->
        <variable name="q_L_M2_mLRGbinding_M2" public_interface="in" units="fmol"/>
        <variable name="q_R_M2_mLRGbinding_M2" public_interface="in" units="fmol"/>
        <variable name="q_Gi_mLRGbinding_M2" public_interface="in" units="fmol"/>
        <variable name="q_LR_M2_mLRGbinding_M2" public_interface="in" units="fmol"/>
        <variable name="q_R_M2Gi_mLRGbinding_M2" public_interface="in" units="fmol"/>
        <variable name="q_LR_M2Gi_mLRGbinding_M2" public_interface="in" units="fmol"/>
        <!-- GsProtein imports-->
        <variable name="q_R_B1_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_Gs_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_R_B1Gs_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_R_B1GsP_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_LR_B1_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_LR_B1Gs_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_LR_B1GsP_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_aGs_GTP_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_beta_gamma_Gs_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_aGs_GDP_mGsProtein" public_interface="in" units="fmol"/>
        <variable name="q_Pi_mGsProtein" public_interface="in" units="fmol"/>
        <!-- GiProtein imports-->
        <variable name="q_R_M2_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_Gi_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_R_M2Gi_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_R_M2GiP_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_LR_M2_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_LR_M2Gi_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_LR_M2GiP_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_aGi_GTP_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_beta_gamma_Gi_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_aGi_GDP_mGiProtein" public_interface="in" units="fmol"/>
        <variable name="q_Pi_mGiProtein" public_interface="in" units="fmol"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>q_ATP</ci>
                <apply>
                    <plus/>
                    <ci>q_ATP_init</ci>
                    <ci>q_ATP_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_cAMP</ci>
                <apply>
                    <plus/>
                    <ci>q_cAMP_init</ci>
                    <ci>q_cAMP_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_AC</ci>
                <apply>
                    <plus/>
                    <ci>q_AC_init</ci>
                    <ci>q_AC_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_AC_ATP</ci>
                <apply>
                    <plus/>
                    <ci>q_AC_ATP_init</ci>
                    <ci>q_AC_ATP_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_aGs_GTP_AC</ci>
                <apply>
                    <plus/>
                    <ci>q_aGs_GTP_AC_init</ci>
                    <ci>q_aGs_GTP_AC_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_aGs_GTP_AC_ATP</ci>
                <apply>
                    <plus/>
                    <ci>q_aGs_GTP_AC_ATP_init</ci>
                    <ci>q_aGs_GTP_AC_ATP_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_FSK_AC</ci>
                <apply>
                    <plus/>
                    <ci>q_FSK_AC_init</ci>
                    <ci>q_FSK_AC_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_FSK_AC_ATP</ci>
                <apply>
                    <plus/>
                    <ci>q_FSK_AC_ATP_init</ci>
                    <ci>q_FSK_AC_ATP_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_PDE</ci>
                <apply>
                    <plus/>
                    <ci>q_PDE_init</ci>
                    <ci>q_PDE_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_PDE_cAMP</ci>
                <apply>
                    <plus/>
                    <ci>q_PDE_cAMP_init</ci>
                    <ci>q_PDE_cAMP_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_five_AMP</ci>
                <apply>
                    <plus/>
                    <ci>q_five_AMP_init</ci>
                    <ci>q_five_AMP_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_IBMX</ci>
                <apply>
                    <plus/>
                    <ci>q_IBMX_init</ci>
                    <ci>q_IBMX_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_PDEinh</ci>
                <apply>
                    <plus/>
                    <ci>q_PDEinh_init</ci>
                    <ci>q_PDEinh_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_aGs_GTP</ci>
                <apply>
                    <plus/>
                    <ci>q_aGs_GTP_init</ci>
                    <ci>q_aGs_GTP_mcAMP</ci>
                    <ci>q_aGs_GTP_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_FSK</ci>
                <apply>
                    <plus/>
                    <ci>q_FSK_init</ci>
                    <ci>q_FSK_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_aGi_GTP</ci>
                <apply>
                    <plus/>
                    <ci>q_aGi_GTP_init</ci>
                    <ci>q_aGi_GTP_mcAMP</ci>
                    <ci>q_aGi_GTP_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_ACinh</ci>
                <apply>
                    <plus/>
                    <ci>q_ACinh_init</ci>
                    <ci>q_ACinh_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_PPi</ci>
                <apply>
                    <plus/>
                    <ci>q_PPi_init</ci>
                    <ci>q_PPi_mcAMP</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_L_B1</ci>
                <apply>
                    <plus/>
                    <ci>q_L_B1_init</ci>
                    <ci>q_L_B1_mLRGbinding_B1AR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_R_B1</ci>
                <apply>
                    <plus/>
                    <ci>q_R_B1_init</ci>
                    <ci>q_R_B1_mLRGbinding_B1AR</ci>
                    <ci>q_R_B1_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Gs</ci>
                <apply>
                    <plus/>
                    <ci>q_Gs_init</ci>
                    <ci>q_Gs_mLRGbinding_B1AR</ci>
                    <ci>q_Gs_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LR_B1</ci>
                <apply>
                    <plus/>
                    <ci>q_LR_B1_init</ci>
                    <ci>q_LR_B1_mLRGbinding_B1AR</ci>
                    <ci>q_LR_B1_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_R_B1Gs</ci>
                <apply>
                    <plus/>
                    <ci>q_R_B1Gs_init</ci>
                    <ci>q_R_B1Gs_mLRGbinding_B1AR</ci>
                    <ci>q_R_B1Gs_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LR_B1Gs</ci>
                <apply>
                    <plus/>
                    <ci>q_LR_B1Gs_init</ci>
                    <ci>q_LR_B1Gs_mLRGbinding_B1AR</ci>
                    <ci>q_LR_B1Gs_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_L_M2</ci>
                <apply>
                    <plus/>
                    <ci>q_L_M2_init</ci>
                    <ci>q_L_M2_mLRGbinding_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_R_M2</ci>
                <apply>
                    <plus/>
                    <ci>q_R_M2_init</ci>
                    <ci>q_R_M2_mLRGbinding_M2</ci>
                    <ci>q_R_M2_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Gi</ci>
                <apply>
                    <plus/>
                    <ci>q_Gi_init</ci>
                    <ci>q_Gi_mLRGbinding_M2</ci>
                    <ci>q_Gi_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LR_M2</ci>
                <apply>
                    <plus/>
                    <ci>q_LR_M2_init</ci>
                    <ci>q_LR_M2_mLRGbinding_M2</ci>
                    <ci>q_LR_M2_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_R_M2Gi</ci>
                <apply>
                    <plus/>
                    <ci>q_R_M2Gi_init</ci>
                    <ci>q_R_M2Gi_mLRGbinding_M2</ci>
                    <ci>q_R_M2Gi_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LR_M2Gi</ci>
                <apply>
                    <plus/>
                    <ci>q_LR_M2Gi_init</ci>
                    <ci>q_LR_M2Gi_mLRGbinding_M2</ci>
                    <ci>q_LR_M2Gi_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_R_B1GsP</ci>
                <apply>
                    <plus/>
                    <ci>q_R_B1GsP_init</ci>
                    <ci>q_R_B1GsP_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LR_B1GsP</ci>
                <apply>
                    <plus/>
                    <ci>q_LR_B1GsP_init</ci>
                    <ci>q_LR_B1GsP_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_beta_gamma_Gs</ci>
                <apply>
                    <plus/>
                    <ci>q_beta_gamma_Gs_init</ci>
                    <ci>q_beta_gamma_Gs_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_aGs_GDP</ci>
                <apply>
                    <plus/>
                    <ci>q_aGs_GDP_init</ci>
                    <ci>q_aGs_GDP_mGsProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Pi</ci>
                <apply>
                    <plus/>
                    <ci>q_Pi_init</ci>
                    <ci>q_Pi_mGsProtein</ci>
                    <ci>q_Pi_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_R_M2GiP</ci>
                <apply>
                    <plus/>
                    <ci>q_R_M2GiP_init</ci>
                    <ci>q_R_M2GiP_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LR_M2GiP</ci>
                <apply>
                    <plus/>
                    <ci>q_LR_M2GiP_init</ci>
                    <ci>q_LR_M2GiP_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_beta_gamma_Gi</ci>
                <apply>
                    <plus/>
                    <ci>q_beta_gamma_Gi_init</ci>
                    <ci>q_beta_gamma_Gi_mGiProtein</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_aGi_GDP</ci>
                <apply>
                    <plus/>
                    <ci>q_aGi_GDP_init</ci>
                    <ci>q_aGi_GDP_mGiProtein</ci>
                </apply>
            </apply>
        </math>
    </component>
    <connection>
        <map_components component_1="environment" component_2="cAMP"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_ATP_mcAMP" variable_2="q_ATP"/>
        <map_variables variable_1="q_ATP" variable_2="q_ATP_global"/>
        <map_variables variable_1="q_cAMP_mcAMP" variable_2="q_cAMP"/>
        <map_variables variable_1="q_cAMP" variable_2="q_cAMP_global"/>
        <map_variables variable_1="q_AC_mcAMP" variable_2="q_AC"/>
        <map_variables variable_1="q_AC" variable_2="q_AC_global"/>
        <map_variables variable_1="q_AC_ATP_mcAMP" variable_2="q_AC_ATP"/>
        <map_variables variable_1="q_AC_ATP" variable_2="q_AC_ATP_global"/>
        <map_variables variable_1="q_aGs_GTP_AC_mcAMP" variable_2="q_aGs_GTP_AC"/>
        <map_variables variable_1="q_aGs_GTP_AC" variable_2="q_aGs_GTP_AC_global"/>
        <map_variables variable_1="q_aGs_GTP_AC_ATP_mcAMP" variable_2="q_aGs_GTP_AC_ATP"/>
        <map_variables variable_1="q_aGs_GTP_AC_ATP" variable_2="q_aGs_GTP_AC_ATP_global"/>
        <map_variables variable_1="q_FSK_AC_mcAMP" variable_2="q_FSK_AC"/>
        <map_variables variable_1="q_FSK_AC" variable_2="q_FSK_AC_global"/>
        <map_variables variable_1="q_FSK_AC_ATP_mcAMP" variable_2="q_FSK_AC_ATP"/>
        <map_variables variable_1="q_FSK_AC_ATP" variable_2="q_FSK_AC_ATP_global"/>
        <map_variables variable_1="q_PDE_mcAMP" variable_2="q_PDE"/>
        <map_variables variable_1="q_PDE" variable_2="q_PDE_global"/>
        <map_variables variable_1="q_PDE_cAMP_mcAMP" variable_2="q_PDE_cAMP"/>
        <map_variables variable_1="q_PDE_cAMP" variable_2="q_PDE_cAMP_global"/>
        <map_variables variable_1="q_five_AMP_mcAMP" variable_2="q_five_AMP"/>
        <map_variables variable_1="q_five_AMP" variable_2="q_five_AMP_global"/>
        <map_variables variable_1="q_IBMX_mcAMP" variable_2="q_IBMX"/>
        <map_variables variable_1="q_IBMX" variable_2="q_IBMX_global"/>
        <map_variables variable_1="q_PDEinh_mcAMP" variable_2="q_PDEinh"/>
        <map_variables variable_1="q_PDEinh" variable_2="q_PDEinh_global"/>
        <map_variables variable_1="q_aGs_GTP_mcAMP" variable_2="q_aGs_GTP"/>
        <map_variables variable_1="q_aGs_GTP" variable_2="q_aGs_GTP_global"/>
        <map_variables variable_1="q_FSK_mcAMP" variable_2="q_FSK"/>
        <map_variables variable_1="q_FSK" variable_2="q_FSK_global"/>
        <map_variables variable_1="q_aGi_GTP_mcAMP" variable_2="q_aGi_GTP"/>
        <map_variables variable_1="q_aGi_GTP" variable_2="q_aGi_GTP_global"/>
        <map_variables variable_1="q_ACinh_mcAMP" variable_2="q_ACinh"/>
        <map_variables variable_1="q_ACinh" variable_2="q_ACinh_global"/>
        <map_variables variable_1="q_PPi_mcAMP" variable_2="q_PPi"/>
        <map_variables variable_1="q_PPi" variable_2="q_PPi_global"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="LRGbinding_B1AR"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_L_B1_mLRGbinding_B1AR" variable_2="q_L_B1"/>
        <map_variables variable_1="q_L_B1" variable_2="q_L_B1_global"/>
        <map_variables variable_1="q_R_B1_mLRGbinding_B1AR" variable_2="q_R_B1"/>
        <map_variables variable_1="q_R_B1" variable_2="q_R_B1_global"/>
        <map_variables variable_1="q_Gs_mLRGbinding_B1AR" variable_2="q_Gs"/>
        <map_variables variable_1="q_Gs" variable_2="q_Gs_global"/>
        <map_variables variable_1="q_LR_B1_mLRGbinding_B1AR" variable_2="q_LR_B1"/>
        <map_variables variable_1="q_LR_B1" variable_2="q_LR_B1_global"/>
        <map_variables variable_1="q_R_B1Gs_mLRGbinding_B1AR" variable_2="q_R_B1Gs"/>
        <map_variables variable_1="q_R_B1Gs" variable_2="q_R_B1Gs_global"/>
        <map_variables variable_1="q_LR_B1Gs_mLRGbinding_B1AR" variable_2="q_LR_B1Gs"/>
        <map_variables variable_1="q_LR_B1Gs" variable_2="q_LR_B1Gs_global"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="LRGbinding_M2"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_L_M2_mLRGbinding_M2" variable_2="q_L_M2"/>
        <map_variables variable_1="q_L_M2" variable_2="q_L_M2_global"/>
        <map_variables variable_1="q_R_M2_mLRGbinding_M2" variable_2="q_R_M2"/>
        <map_variables variable_1="q_R_M2" variable_2="q_R_M2_global"/>
        <map_variables variable_1="q_Gi_mLRGbinding_M2" variable_2="q_Gi"/>
        <map_variables variable_1="q_Gi" variable_2="q_Gi_global"/>
        <map_variables variable_1="q_LR_M2_mLRGbinding_M2" variable_2="q_LR_M2"/>
        <map_variables variable_1="q_LR_M2" variable_2="q_LR_M2_global"/>
        <map_variables variable_1="q_R_M2Gi_mLRGbinding_M2" variable_2="q_R_M2Gi"/>
        <map_variables variable_1="q_R_M2Gi" variable_2="q_R_M2Gi_global"/>
        <map_variables variable_1="q_LR_M2Gi_mLRGbinding_M2" variable_2="q_LR_M2Gi"/>
        <map_variables variable_1="q_LR_M2Gi" variable_2="q_LR_M2Gi_global"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="GsProtein"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_R_B1_mGsProtein" variable_2="q_R_B1"/>
        <map_variables variable_1="q_R_B1" variable_2="q_R_B1_global"/>
        <map_variables variable_1="q_Gs_mGsProtein" variable_2="q_Gs"/>
        <map_variables variable_1="q_Gs" variable_2="q_Gs_global"/>
        <map_variables variable_1="q_R_B1Gs_mGsProtein" variable_2="q_R_B1Gs"/>
        <map_variables variable_1="q_R_B1Gs" variable_2="q_R_B1Gs_global"/>
        <map_variables variable_1="q_R_B1GsP_mGsProtein" variable_2="q_R_B1GsP"/>
        <map_variables variable_1="q_R_B1GsP" variable_2="q_R_B1GsP_global"/>
        <map_variables variable_1="q_LR_B1_mGsProtein" variable_2="q_LR_B1"/>
        <map_variables variable_1="q_LR_B1" variable_2="q_LR_B1_global"/>
        <map_variables variable_1="q_LR_B1Gs_mGsProtein" variable_2="q_LR_B1Gs"/>
        <map_variables variable_1="q_LR_B1Gs" variable_2="q_LR_B1Gs_global"/>
        <map_variables variable_1="q_LR_B1GsP_mGsProtein" variable_2="q_LR_B1GsP"/>
        <map_variables variable_1="q_LR_B1GsP" variable_2="q_LR_B1GsP_global"/>
        <map_variables variable_1="q_aGs_GTP_mGsProtein" variable_2="q_aGs_GTP"/>
        <map_variables variable_1="q_aGs_GTP" variable_2="q_aGs_GTP_global"/>
        <map_variables variable_1="q_beta_gamma_Gs_mGsProtein" variable_2="q_beta_gamma_Gs"/>
        <map_variables variable_1="q_beta_gamma_Gs" variable_2="q_beta_gamma_Gs_global"/>
        <map_variables variable_1="q_aGs_GDP_mGsProtein" variable_2="q_aGs_GDP"/>
        <map_variables variable_1="q_aGs_GDP" variable_2="q_aGs_GDP_global"/>
        <map_variables variable_1="q_Pi_mGsProtein" variable_2="q_Pi"/>
        <map_variables variable_1="q_Pi" variable_2="q_Pi_global"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="GiProtein"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_R_M2_mGiProtein" variable_2="q_R_M2"/>
        <map_variables variable_1="q_R_M2" variable_2="q_R_M2_global"/>
        <map_variables variable_1="q_Gi_mGiProtein" variable_2="q_Gi"/>
        <map_variables variable_1="q_Gi" variable_2="q_Gi_global"/>
        <map_variables variable_1="q_R_M2Gi_mGiProtein" variable_2="q_R_M2Gi"/>
        <map_variables variable_1="q_R_M2Gi" variable_2="q_R_M2Gi_global"/>
        <map_variables variable_1="q_R_M2GiP_mGiProtein" variable_2="q_R_M2GiP"/>
        <map_variables variable_1="q_R_M2GiP" variable_2="q_R_M2GiP_global"/>
        <map_variables variable_1="q_LR_M2_mGiProtein" variable_2="q_LR_M2"/>
        <map_variables variable_1="q_LR_M2" variable_2="q_LR_M2_global"/>
        <map_variables variable_1="q_LR_M2Gi_mGiProtein" variable_2="q_LR_M2Gi"/>
        <map_variables variable_1="q_LR_M2Gi" variable_2="q_LR_M2Gi_global"/>
        <map_variables variable_1="q_LR_M2GiP_mGiProtein" variable_2="q_LR_M2GiP"/>
        <map_variables variable_1="q_LR_M2GiP" variable_2="q_LR_M2GiP_global"/>
        <map_variables variable_1="q_aGi_GTP_mGiProtein" variable_2="q_aGi_GTP"/>
        <map_variables variable_1="q_aGi_GTP" variable_2="q_aGi_GTP_global"/>
        <map_variables variable_1="q_beta_gamma_Gi_mGiProtein" variable_2="q_beta_gamma_Gi"/>
        <map_variables variable_1="q_beta_gamma_Gi" variable_2="q_beta_gamma_Gi_global"/>
        <map_variables variable_1="q_aGi_GDP_mGiProtein" variable_2="q_aGi_GDP"/>
        <map_variables variable_1="q_aGi_GDP" variable_2="q_aGi_GDP_global"/>
        <map_variables variable_1="q_Pi_mGiProtein" variable_2="q_Pi"/>
        <map_variables variable_1="q_Pi" variable_2="q_Pi_global"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="cAMP"/>
        <map_variables variable_1="kappa_1a" variable_2="kappa_1a"/>
        <map_variables variable_1="kappa_1b" variable_2="kappa_1b"/>
        <map_variables variable_1="kappa_2a" variable_2="kappa_2a"/>
        <map_variables variable_1="kappa_2b" variable_2="kappa_2b"/>
        <map_variables variable_1="kappa_3a" variable_2="kappa_3a"/>
        <map_variables variable_1="kappa_3b" variable_2="kappa_3b"/>
        <map_variables variable_1="kappa_4a" variable_2="kappa_4a"/>
        <map_variables variable_1="kappa_4b" variable_2="kappa_4b"/>
        <map_variables variable_1="kappa_5" variable_2="kappa_5"/>
        <map_variables variable_1="kappa_6" variable_2="kappa_6"/>
        <map_variables variable_1="kappa_7" variable_2="kappa_7"/>
        <map_variables variable_1="kappa_GiAC" variable_2="kappa_GiAC"/>
        <map_variables variable_1="K_ATP" variable_2="K_ATP"/>
        <map_variables variable_1="K_cAMP" variable_2="K_cAMP"/>
        <map_variables variable_1="K_AC" variable_2="K_AC"/>
        <map_variables variable_1="K_AC_ATP" variable_2="K_AC_ATP"/>
        <map_variables variable_1="K_aGs_GTP_AC" variable_2="K_aGs_GTP_AC"/>
        <map_variables variable_1="K_aGs_GTP_AC_ATP" variable_2="K_aGs_GTP_AC_ATP"/>
        <map_variables variable_1="K_FSK_AC" variable_2="K_FSK_AC"/>
        <map_variables variable_1="K_FSK_AC_ATP" variable_2="K_FSK_AC_ATP"/>
        <map_variables variable_1="K_PDE" variable_2="K_PDE"/>
        <map_variables variable_1="K_PDE_cAMP" variable_2="K_PDE_cAMP"/>
        <map_variables variable_1="K_five_AMP" variable_2="K_five_AMP"/>
        <map_variables variable_1="K_IBMX" variable_2="K_IBMX"/>
        <map_variables variable_1="K_PDEinh" variable_2="K_PDEinh"/>
        <map_variables variable_1="K_aGs_GTP" variable_2="K_aGs_GTP"/>
        <map_variables variable_1="K_FSK" variable_2="K_FSK"/>
        <map_variables variable_1="K_aGi_GTP" variable_2="K_aGi_GTP"/>
        <map_variables variable_1="K_ACinh" variable_2="K_ACinh"/>
        <map_variables variable_1="K_PPi" variable_2="K_PPi"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="LRGbinding_B1AR"/>
        <map_variables variable_1="kappa_sig1_B1" variable_2="kappa_sig1_B1"/>
        <map_variables variable_1="kappa_sig2_B1" variable_2="kappa_sig2_B1"/>
        <map_variables variable_1="kappa_sig3_B1" variable_2="kappa_sig3_B1"/>
        <map_variables variable_1="kappa_sig4_B1" variable_2="kappa_sig4_B1"/>
        <map_variables variable_1="K_L_B1" variable_2="K_L_B1"/>
        <map_variables variable_1="K_R_B1" variable_2="K_R_B1"/>
        <map_variables variable_1="K_Gs" variable_2="K_Gs"/>
        <map_variables variable_1="K_LR_B1" variable_2="K_LR_B1"/>
        <map_variables variable_1="K_R_B1Gs" variable_2="K_R_B1Gs"/>
        <map_variables variable_1="K_LR_B1Gs" variable_2="K_LR_B1Gs"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="LRGbinding_M2"/>
        <map_variables variable_1="kappa_sig1_M2" variable_2="kappa_sig1_M2"/>
        <map_variables variable_1="kappa_sig2_M2" variable_2="kappa_sig2_M2"/>
        <map_variables variable_1="kappa_sig3_M2" variable_2="kappa_sig3_M2"/>
        <map_variables variable_1="kappa_sig4_M2" variable_2="kappa_sig4_M2"/>
        <map_variables variable_1="K_L_M2" variable_2="K_L_M2"/>
        <map_variables variable_1="K_R_M2" variable_2="K_R_M2"/>
        <map_variables variable_1="K_Gi" variable_2="K_Gi"/>
        <map_variables variable_1="K_LR_M2" variable_2="K_LR_M2"/>
        <map_variables variable_1="K_R_M2Gi" variable_2="K_R_M2Gi"/>
        <map_variables variable_1="K_LR_M2Gi" variable_2="K_LR_M2Gi"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="GsProtein"/>
        <map_variables variable_1="kappa_phos_RGs" variable_2="kappa_phos_RGs"/>
        <map_variables variable_1="kappa_phos_LRGs" variable_2="kappa_phos_LRGs"/>
        <map_variables variable_1="kappa_act1_Gs" variable_2="kappa_act1_Gs"/>
        <map_variables variable_1="kappa_act2_Gs" variable_2="kappa_act2_Gs"/>
        <map_variables variable_1="kappa_hyd_Gs" variable_2="kappa_hyd_Gs"/>
        <map_variables variable_1="kappa_reassoc_Gs" variable_2="kappa_reassoc_Gs"/>
        <map_variables variable_1="K_R_B1" variable_2="K_R_B1"/>
        <map_variables variable_1="K_Gs" variable_2="K_Gs"/>
        <map_variables variable_1="K_R_B1Gs" variable_2="K_R_B1Gs"/>
        <map_variables variable_1="K_R_B1GsP" variable_2="K_R_B1GsP"/>
        <map_variables variable_1="K_LR_B1" variable_2="K_LR_B1"/>
        <map_variables variable_1="K_LR_B1Gs" variable_2="K_LR_B1Gs"/>
        <map_variables variable_1="K_LR_B1GsP" variable_2="K_LR_B1GsP"/>
        <map_variables variable_1="K_aGs_GTP" variable_2="K_aGs_GTP"/>
        <map_variables variable_1="K_beta_gamma_Gs" variable_2="K_beta_gamma_Gs"/>
        <map_variables variable_1="K_aGs_GDP" variable_2="K_aGs_GDP"/>
        <map_variables variable_1="K_Pi" variable_2="K_Pi"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="GiProtein"/>
        <map_variables variable_1="kappa_phos_RGi" variable_2="kappa_phos_RGi"/>
        <map_variables variable_1="kappa_phos_LRGi" variable_2="kappa_phos_LRGi"/>
        <map_variables variable_1="kappa_act1_Gi" variable_2="kappa_act1_Gi"/>
        <map_variables variable_1="kappa_act2_Gi" variable_2="kappa_act2_Gi"/>
        <map_variables variable_1="kappa_hyd_Gi" variable_2="kappa_hyd_Gi"/>
        <map_variables variable_1="kappa_reassoc_Gi" variable_2="kappa_reassoc_Gi"/>
        <map_variables variable_1="K_R_M2" variable_2="K_R_M2"/>
        <map_variables variable_1="K_Gi" variable_2="K_Gi"/>
        <map_variables variable_1="K_R_M2Gi" variable_2="K_R_M2Gi"/>
        <map_variables variable_1="K_R_M2GiP" variable_2="K_R_M2GiP"/>
        <map_variables variable_1="K_LR_M2" variable_2="K_LR_M2"/>
        <map_variables variable_1="K_LR_M2Gi" variable_2="K_LR_M2Gi"/>
        <map_variables variable_1="K_LR_M2GiP" variable_2="K_LR_M2GiP"/>
        <map_variables variable_1="K_aGi_GTP" variable_2="K_aGi_GTP"/>
        <map_variables variable_1="K_beta_gamma_Gi" variable_2="K_beta_gamma_Gi"/>
        <map_variables variable_1="K_aGi_GDP" variable_2="K_aGi_GDP"/>
        <map_variables variable_1="K_Pi" variable_2="K_Pi"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="cAMP"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="LRGbinding_B1AR"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="LRGbinding_M2"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="GsProtein"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="GiProtein"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
</model>