- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-10-18 16:31:40+13:00
- Desc:
- Working Python export of FCU cellml file. MATLAB is now outdated
- Permanent Source URI:
- https://models.cellml.org/workspace/705/rawfile/730cecb35995ae8a0003acc216a60cab6601de62/MATLAB/FCU_adenylylCyclaseTEMP.txt
def model FCU_composite as
def import using "units_and_constants/units_BG.cellml" for
unit mM using unit mM;
unit fmol using unit fmol;
unit per_fmol using unit per_fmol;
unit J_per_mol using unit J_per_mol;
unit fmol_per_sec using unit fmol_per_sec;
unit C_per_mol using unit C_per_mol;
unit J_per_C using unit J_per_C;
unit microm3 using unit microm3;
unit fF using unit fF;
unit fC using unit fC;
unit fA using unit fA;
unit per_second using unit per_second;
unit millivolt using unit millivolt;
unit per_sec using unit per_sec;
unit J_per_K_per_mol using unit J_per_K_per_mol;
unit fmol_per_L using unit fmol_per_L;
unit fmol_per_L_per_sec using unit fmol_per_L_per_sec;
unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L;
unit uM using unit uM;
unit mM_per_sec using unit mM_per_sec;
unit uM_per_sec using unit uM_per_sec;
unit pL using unit pL;
unit m_to_u using unit m_to_u;
enddef;
def import using "units_and_constants/constants_BG.cellml" for
comp constants using comp constants;
enddef;
def import using "cAMP/BG_cAMP.cellml" for
comp cAMP using comp cAMP;
enddef;
def import using "LRGbinding_B1AR/BG_LRGbinding_B1AR.cellml" for
comp LRGbinding_B1AR using comp LRGbinding_B1AR;
enddef;
def import using "LRGbinding_M2/BG_LRGbinding_M2.cellml" for
comp LRGbinding_M2 using comp LRGbinding_M2;
enddef;
def import using "B1AR/BG_B1AR.cellml" for
comp B1AR using comp B1AR;
enddef;
def import using "GsProtein/BG_GsProtein.cellml" for
comp GsProtein using comp GsProtein;
enddef;
def import using "GiProtein/BG_GiProtein.cellml" for
comp GiProtein using comp GiProtein;
enddef;
def comp BG_parameters as
var kappa_1a: fmol_per_sec {init: 617247, pub: out};
var kappa_1b: fmol_per_sec {init: 0.000128875, pub: out};
var kappa_2a: fmol_per_sec {init: 325858, pub: out};
var kappa_2b: fmol_per_sec {init: 0.0879301, pub: out};
var kappa_3a: fmol_per_sec {init: 8.57316e+07, pub: out};
var kappa_3b: fmol_per_sec {init: 9.96879e-18, pub: out};
var kappa_4a: fmol_per_sec {init: 107140, pub: out};
var kappa_4b: fmol_per_sec {init: 0.412077, pub: out};
var kappa_5: fmol_per_sec {init: 391.191, pub: out};
var kappa_6: fmol_per_sec {init: 54621.9, pub: out};
var kappa_7: fmol_per_sec {init: 1.43707e+06, pub: out};
var kappa_GiAC: fmol_per_sec {init: 3357.07, pub: out};
var kappa_sig1_B1: fmol_per_sec {init: 143475, pub: out};
var kappa_sig2_B1: fmol_per_sec {init: 52.5633, pub: out};
var kappa_sig3_B1: fmol_per_sec {init: 77.1867, pub: out};
var kappa_sig4_B1: fmol_per_sec {init: 9827.69, pub: out};
var kappa_sig1_M2: fmol_per_sec {init: 2.93719e+09, pub: out};
var kappa_sig2_M2: fmol_per_sec {init: 262659, pub: out};
var kappa_sig3_M2: fmol_per_sec {init: 280724, pub: out};
var kappa_sig4_M2: fmol_per_sec {init: 2.08729e+06, pub: out};
var kappa_B11: fmol_per_sec {init: 6.45993e-05, pub: out};
var kappa_B12: fmol_per_sec {init: 29363.3, pub: out};
var kappa_B21: fmol_per_sec {init: 6.45993e-05, pub: out};
var kappa_B22: fmol_per_sec {init: 29363.3, pub: out};
var kappa_P1: fmol_per_sec {init: 0.0240723, pub: out};
var kappa_P2: fmol_per_sec {init: 0.00231579, pub: out};
var kappa_act1_Gs: fmol_per_sec {init: 0.0073331, pub: out};
var kappa_act2_Gs: fmol_per_sec {init: 9.10152e-05, pub: out};
var kappa_hyd_Gs: fmol_per_sec {init: 0.0344808, pub: out};
var kappa_reassoc_Gs: fmol_per_sec {init: 443.387, pub: out};
var kappa_act1_Gi: fmol_per_sec {init: 16.6519, pub: out};
var kappa_act2_Gi: fmol_per_sec {init: 0.00519263, pub: out};
var kappa_hyd_Gi: fmol_per_sec {init: 0.100013, pub: out};
var kappa_reassoc_Gi: fmol_per_sec {init: 2927.33, pub: out};
var K_ATP: per_fmol {init: 0.00048728, pub: out};
var K_cAMP: per_fmol {init: 0.00048728, pub: out};
var K_AC: per_fmol {init: 2.61293, pub: out};
var K_AC_ATP: per_fmol {init: 45.1131, pub: out};
var K_aGs_GTP_AC: per_fmol {init: 0.5322, pub: out};
var K_aGs_GTP_AC_ATP: per_fmol {init: 2.81011, pub: out};
var K_FSK_AC: per_fmol {init: 0.0202285, pub: out};
var K_FSK_AC_ATP: per_fmol {init: 0.291608, pub: out};
var K_PDE: per_fmol {init: 16.1866, pub: out};
var K_PDE_cAMP: per_fmol {init: 0.352723, pub: out};
var K_five_AMP: per_fmol {init: 0.00048728, pub: out};
var K_IBMX: per_fmol {init: 0.00444855, pub: out};
var K_PDEinh: per_fmol {init: 74.311, pub: out};
var K_aGs_GTP: per_fmol {init: 0.0148023, pub: out};
var K_FSK: per_fmol {init: 5.11474e-06, pub: out};
var K_aGi_GTP: per_fmol {init: 0.00963373, pub: out};
var K_ACinh: per_fmol {init: 8.65927, pub: out};
var K_L_B1: per_fmol {init: 0.356212, pub: out};
var K_R_B1: per_fmol {init: 0.407286, pub: out};
var K_Gs: per_fmol {init: 0.00361468, pub: out};
var K_LR_B1: per_fmol {init: 265.938, pub: out};
var K_R_B1Gs: per_fmol {init: 26.7494, pub: out};
var K_LR_B1Gs: per_fmol {init: 265.938, pub: out};
var K_L_M2: per_fmol {init: 2.00506, pub: out};
var K_R_M2: per_fmol {init: 0.000245905, pub: out};
var K_Gi: per_fmol {init: 0.000290027, pub: out};
var K_LR_M2: per_fmol {init: 1.73472, pub: out};
var K_R_M2Gi: per_fmol {init: 0.00131755, pub: out};
var K_LR_M2Gi: per_fmol {init: 0.0384141, pub: out};
var K_B1d: per_fmol {init: 3.19126e-10, pub: out};
var K_BARK: per_fmol {init: 9.01813e-05, pub: out};
var K_LR_B1_BARK: per_fmol {init: 0.990003, pub: out};
var K_LR_B1Gs_BARK: per_fmol {init: 0.990003, pub: out};
var K_B1p: per_fmol {init: 0.0336751, pub: out};
var K_B1tot: per_fmol {init: 0.0336751, pub: out};
var K_PKACI: per_fmol {init: 0.0390101, pub: out};
var K_PKACI_B1p: per_fmol {init: 1.2076e-06, pub: out};
var K_beta_gamma_Gs: per_fmol {init: 0.0290698, pub: out};
var K_aGs_GDP: per_fmol {init: 0.0290698, pub: out};
var K_beta_gamma_Gi: per_fmol {init: 0.00206275, pub: out};
var K_aGi_GDP: per_fmol {init: 0.00701566, pub: out};
enddef;
def comp environment as
var time: second;
var vol_myo: pL {init: 34.4, pub: out};
// stimulus
q_L_init = sel
case time < 1e-1{second}:
1e-1{fmol};
otherwise:
1e-6{fmol};
endsel;
var q_ATP_init: fmol {init: 1e-13};
var q_cAMP_init: fmol {init: 1e-13};
var q_AC_init: fmol {init: 1e-13};
var q_AC_ATP_init: fmol {init: 1e-13};
var q_aGs_GTP_AC_init: fmol {init: 1e-13};
var q_aGs_GTP_AC_ATP_init: fmol {init: 1e-13};
var q_FSK_AC_init: fmol {init: 1e-13};
var q_FSK_AC_ATP_init: fmol {init: 1e-13};
var q_PDE_init: fmol {init: 1e-13};
var q_PDE_cAMP_init: fmol {init: 1e-13};
var q_five_AMP_init: fmol {init: 1e-13};
var q_IBMX_init: fmol {init: 1e-13};
var q_PDEinh_init: fmol {init: 1e-13};
var q_aGs_GTP_init: fmol {init: 1e-13};
var q_FSK_init: fmol {init: 1e-13};
var q_aGi_GTP_init: fmol {init: 1e-13};
var q_ACinh_init: fmol {init: 1e-13};
var q_L_B1_init: fmol {init: 1e-13};
var q_R_B1_init: fmol {init: 1e-13};
var q_Gs_init: fmol {init: 1e-13};
var q_LR_B1_init: fmol {init: 1e-13};
var q_R_B1Gs_init: fmol {init: 1e-13};
var q_LR_B1Gs_init: fmol {init: 1e-13};
var q_L_M2_init: fmol {init: 1e-13};
var q_R_M2_init: fmol {init: 1e-13};
var q_Gi_init: fmol {init: 1e-13};
var q_LR_M2_init: fmol {init: 1e-13};
var q_R_M2Gi_init: fmol {init: 1e-13};
var q_LR_M2Gi_init: fmol {init: 1e-13};
var q_B1d_init: fmol {init: 1e-13};
var q_BARK_init: fmol {init: 1e-13};
var q_LR_B1_BARK_init: fmol {init: 1e-13};
var q_LR_B1Gs_BARK_init: fmol {init: 1e-13};
var q_B1p_init: fmol {init: 1e-13};
var q_B1tot_init: fmol {init: 1e-13};
var q_PKACI_init: fmol {init: 1e-13};
var q_PKACI_B1p_init: fmol {init: 1e-13};
var q_beta_gamma_Gs_init: fmol {init: 1e-13};
var q_aGs_GDP_init: fmol {init: 1e-13};
var q_beta_gamma_Gi_init: fmol {init: 1e-13};
var q_aGi_GDP_init: fmol {init: 1e-13};
// Global value
var q_ATP: fmol {pub: out};
var q_cAMP: fmol {pub: out};
var q_AC: fmol {pub: out};
var q_AC_ATP: fmol {pub: out};
var q_aGs_GTP_AC: fmol {pub: out};
var q_aGs_GTP_AC_ATP: fmol {pub: out};
var q_FSK_AC: fmol {pub: out};
var q_FSK_AC_ATP: fmol {pub: out};
var q_PDE: fmol {pub: out};
var q_PDE_cAMP: fmol {pub: out};
var q_five_AMP: fmol {pub: out};
var q_IBMX: fmol {pub: out};
var q_PDEinh: fmol {pub: out};
var q_aGs_GTP: fmol {pub: out};
var q_FSK: fmol {pub: out};
var q_aGi_GTP: fmol {pub: out};
var q_ACinh: fmol {pub: out};
var q_L_B1: fmol {pub: out};
var q_R_B1: fmol {pub: out};
var q_Gs: fmol {pub: out};
var q_LR_B1: fmol {pub: out};
var q_R_B1Gs: fmol {pub: out};
var q_LR_B1Gs: fmol {pub: out};
var q_L_M2: fmol {pub: out};
var q_R_M2: fmol {pub: out};
var q_Gi: fmol {pub: out};
var q_LR_M2: fmol {pub: out};
var q_R_M2Gi: fmol {pub: out};
var q_LR_M2Gi: fmol {pub: out};
var q_B1d: fmol {pub: out};
var q_BARK: fmol {pub: out};
var q_LR_B1_BARK: fmol {pub: out};
var q_LR_B1Gs_BARK: fmol {pub: out};
var q_B1p: fmol {pub: out};
var q_B1tot: fmol {pub: out};
var q_PKACI: fmol {pub: out};
var q_PKACI_B1p: fmol {pub: out};
var q_beta_gamma_Gs: fmol {pub: out};
var q_aGs_GDP: fmol {pub: out};
var q_beta_gamma_Gi: fmol {pub: out};
var q_aGi_GDP: fmol {pub: out};
// cAMP imports
var q_ATP_mcAMP: fmol {pub: in};
var q_cAMP_mcAMP: fmol {pub: in};
var q_AC_mcAMP: fmol {pub: in};
var q_AC_ATP_mcAMP: fmol {pub: in};
var q_aGs_GTP_AC_mcAMP: fmol {pub: in};
var q_aGs_GTP_AC_ATP_mcAMP: fmol {pub: in};
var q_FSK_AC_mcAMP: fmol {pub: in};
var q_FSK_AC_ATP_mcAMP: fmol {pub: in};
var q_PDE_mcAMP: fmol {pub: in};
var q_PDE_cAMP_mcAMP: fmol {pub: in};
var q_five_AMP_mcAMP: fmol {pub: in};
var q_IBMX_mcAMP: fmol {pub: in};
var q_PDEinh_mcAMP: fmol {pub: in};
var q_aGs_GTP_mcAMP: fmol {pub: in};
var q_FSK_mcAMP: fmol {pub: in};
var q_aGi_GTP_mcAMP: fmol {pub: in};
var q_ACinh_mcAMP: fmol {pub: in};
// LRGbinding_B1AR imports
var q_L_B1_mLRGbinding_B1AR: fmol {pub: in};
var q_R_B1_mLRGbinding_B1AR: fmol {pub: in};
var q_Gs_mLRGbinding_B1AR: fmol {pub: in};
var q_LR_B1_mLRGbinding_B1AR: fmol {pub: in};
var q_R_B1Gs_mLRGbinding_B1AR: fmol {pub: in};
var q_LR_B1Gs_mLRGbinding_B1AR: fmol {pub: in};
// LRGbinding_M2 imports
var q_L_M2_mLRGbinding_M2: fmol {pub: in};
var q_R_M2_mLRGbinding_M2: fmol {pub: in};
var q_Gi_mLRGbinding_M2: fmol {pub: in};
var q_LR_M2_mLRGbinding_M2: fmol {pub: in};
var q_R_M2Gi_mLRGbinding_M2: fmol {pub: in};
var q_LR_M2Gi_mLRGbinding_M2: fmol {pub: in};
// B1AR imports
var q_LR_B1_mB1AR: fmol {pub: in};
var q_LR_B1Gs_mB1AR: fmol {pub: in};
var q_B1d_mB1AR: fmol {pub: in};
var q_BARK_mB1AR: fmol {pub: in};
var q_LR_B1_BARK_mB1AR: fmol {pub: in};
var q_LR_B1Gs_BARK_mB1AR: fmol {pub: in};
var q_B1p_mB1AR: fmol {pub: in};
var q_B1tot_mB1AR: fmol {pub: in};
var q_PKACI_mB1AR: fmol {pub: in};
var q_PKACI_B1p_mB1AR: fmol {pub: in};
// GsProtein imports
var q_R_B1_mGsProtein: fmol {pub: in};
var q_Gs_mGsProtein: fmol {pub: in};
var q_R_B1Gs_mGsProtein: fmol {pub: in};
var q_LR_B1_mGsProtein: fmol {pub: in};
var q_LR_B1Gs_mGsProtein: fmol {pub: in};
var q_aGs_GTP_mGsProtein: fmol {pub: in};
var q_beta_gamma_Gs_mGsProtein: fmol {pub: in};
var q_aGs_GDP_mGsProtein: fmol {pub: in};
// GiProtein imports
var q_R_M2_mGiProtein: fmol {pub: in};
var q_Gi_mGiProtein: fmol {pub: in};
var q_R_M2Gi_mGiProtein: fmol {pub: in};
var q_LR_M2_mGiProtein: fmol {pub: in};
var q_LR_M2Gi_mGiProtein: fmol {pub: in};
var q_aGi_GTP_mGiProtein: fmol {pub: in};
var q_beta_gamma_Gi_mGiProtein: fmol {pub: in};
var q_aGi_GDP_mGiProtein: fmol {pub: in};
q_ATP = q_ATP_init + q_ATP_mcAMP ;
q_cAMP = q_cAMP_init + q_cAMP_mcAMP ;
q_AC = q_AC_init + q_AC_mcAMP ;
q_AC_ATP = q_AC_ATP_init + q_AC_ATP_mcAMP ;
q_aGs_GTP_AC = q_aGs_GTP_AC_init + q_aGs_GTP_AC_mcAMP ;
q_aGs_GTP_AC_ATP = q_aGs_GTP_AC_ATP_init + q_aGs_GTP_AC_ATP_mcAMP ;
q_FSK_AC = q_FSK_AC_init + q_FSK_AC_mcAMP ;
q_FSK_AC_ATP = q_FSK_AC_ATP_init + q_FSK_AC_ATP_mcAMP ;
q_PDE = q_PDE_init + q_PDE_mcAMP ;
q_PDE_cAMP = q_PDE_cAMP_init + q_PDE_cAMP_mcAMP ;
q_five_AMP = q_five_AMP_init + q_five_AMP_mcAMP ;
q_IBMX = q_IBMX_init + q_IBMX_mcAMP ;
q_PDEinh = q_PDEinh_init + q_PDEinh_mcAMP ;
q_aGs_GTP = q_aGs_GTP_init + q_aGs_GTP_mcAMP + q_aGs_GTP_mGsProtein ;
q_FSK = q_FSK_init + q_FSK_mcAMP ;
q_aGi_GTP = q_aGi_GTP_init + q_aGi_GTP_mcAMP + q_aGi_GTP_mGiProtein ;
q_ACinh = q_ACinh_init + q_ACinh_mcAMP ;
q_L_B1 = q_L_B1_init + q_L_B1_mLRGbinding_B1AR ;
q_R_B1 = q_R_B1_init + q_R_B1_mLRGbinding_B1AR + q_R_B1_mGsProtein ;
q_Gs = q_Gs_init + q_Gs_mLRGbinding_B1AR + q_Gs_mGsProtein ;
q_LR_B1 = q_LR_B1_init + q_LR_B1_mLRGbinding_B1AR + q_LR_B1_mB1AR + q_LR_B1_mGsProtein ;
q_R_B1Gs = q_R_B1Gs_init + q_R_B1Gs_mLRGbinding_B1AR + q_R_B1Gs_mGsProtein ;
q_LR_B1Gs = q_LR_B1Gs_init + q_LR_B1Gs_mLRGbinding_B1AR + q_LR_B1Gs_mB1AR + q_LR_B1Gs_mGsProtein ;
q_L_M2 = q_L_M2_init + q_L_M2_mLRGbinding_M2 ;
q_R_M2 = q_R_M2_init + q_R_M2_mLRGbinding_M2 + q_R_M2_mGiProtein ;
q_Gi = q_Gi_init + q_Gi_mLRGbinding_M2 + q_Gi_mGiProtein ;
q_LR_M2 = q_LR_M2_init + q_LR_M2_mLRGbinding_M2 + q_LR_M2_mGiProtein ;
q_R_M2Gi = q_R_M2Gi_init + q_R_M2Gi_mLRGbinding_M2 + q_R_M2Gi_mGiProtein ;
q_LR_M2Gi = q_LR_M2Gi_init + q_LR_M2Gi_mLRGbinding_M2 + q_LR_M2Gi_mGiProtein ;
q_B1d = q_B1d_init + q_B1d_mB1AR ;
q_BARK = q_BARK_init + q_BARK_mB1AR ;
q_LR_B1_BARK = q_LR_B1_BARK_init + q_LR_B1_BARK_mB1AR ;
q_LR_B1Gs_BARK = q_LR_B1Gs_BARK_init + q_LR_B1Gs_BARK_mB1AR ;
q_B1p = q_B1p_init + q_B1p_mB1AR ;
q_B1tot = q_B1tot_init + q_B1tot_mB1AR ;
q_PKACI = q_PKACI_init + q_PKACI_mB1AR ;
q_PKACI_B1p = q_PKACI_B1p_init + q_PKACI_B1p_mB1AR ;
q_beta_gamma_Gs = q_beta_gamma_Gs_init + q_beta_gamma_Gs_mGsProtein ;
q_aGs_GDP = q_aGs_GDP_init + q_aGs_GDP_mGsProtein ;
q_beta_gamma_Gi = q_beta_gamma_Gi_init + q_beta_gamma_Gi_mGiProtein ;
q_aGi_GDP = q_aGi_GDP_init + q_aGi_GDP_mGiProtein ;
enddef;
def map between environment and cAMP for
vars time and time;
vars q_ATP_mcAMP and q_ATP;
vars q_ATP and q_ATP_global;
vars q_cAMP_mcAMP and q_cAMP;
vars q_cAMP and q_cAMP_global;
vars q_AC_mcAMP and q_AC;
vars q_AC and q_AC_global;
vars q_AC_ATP_mcAMP and q_AC_ATP;
vars q_AC_ATP and q_AC_ATP_global;
vars q_aGs_GTP_AC_mcAMP and q_aGs_GTP_AC;
vars q_aGs_GTP_AC and q_aGs_GTP_AC_global;
vars q_aGs_GTP_AC_ATP_mcAMP and q_aGs_GTP_AC_ATP;
vars q_aGs_GTP_AC_ATP and q_aGs_GTP_AC_ATP_global;
vars q_FSK_AC_mcAMP and q_FSK_AC;
vars q_FSK_AC and q_FSK_AC_global;
vars q_FSK_AC_ATP_mcAMP and q_FSK_AC_ATP;
vars q_FSK_AC_ATP and q_FSK_AC_ATP_global;
vars q_PDE_mcAMP and q_PDE;
vars q_PDE and q_PDE_global;
vars q_PDE_cAMP_mcAMP and q_PDE_cAMP;
vars q_PDE_cAMP and q_PDE_cAMP_global;
vars q_five_AMP_mcAMP and q_five_AMP;
vars q_five_AMP and q_five_AMP_global;
vars q_IBMX_mcAMP and q_IBMX;
vars q_IBMX and q_IBMX_global;
vars q_PDEinh_mcAMP and q_PDEinh;
vars q_PDEinh and q_PDEinh_global;
vars q_aGs_GTP_mcAMP and q_aGs_GTP;
vars q_aGs_GTP and q_aGs_GTP_global;
vars q_FSK_mcAMP and q_FSK;
vars q_FSK and q_FSK_global;
vars q_aGi_GTP_mcAMP and q_aGi_GTP;
vars q_aGi_GTP and q_aGi_GTP_global;
vars q_ACinh_mcAMP and q_ACinh;
vars q_ACinh and q_ACinh_global;
enddef;
def map between environment and LRGbinding_B1AR for
vars time and time;
vars q_L_B1_mLRGbinding_B1AR and q_L_B1;
vars q_L_B1 and q_L_B1_global;
vars q_R_B1_mLRGbinding_B1AR and q_R_B1;
vars q_R_B1 and q_R_B1_global;
vars q_Gs_mLRGbinding_B1AR and q_Gs;
vars q_Gs and q_Gs_global;
vars q_LR_B1_mLRGbinding_B1AR and q_LR_B1;
vars q_LR_B1 and q_LR_B1_global;
vars q_R_B1Gs_mLRGbinding_B1AR and q_R_B1Gs;
vars q_R_B1Gs and q_R_B1Gs_global;
vars q_LR_B1Gs_mLRGbinding_B1AR and q_LR_B1Gs;
vars q_LR_B1Gs and q_LR_B1Gs_global;
enddef;
def map between environment and LRGbinding_M2 for
vars time and time;
vars q_L_M2_mLRGbinding_M2 and q_L_M2;
vars q_L_M2 and q_L_M2_global;
vars q_R_M2_mLRGbinding_M2 and q_R_M2;
vars q_R_M2 and q_R_M2_global;
vars q_Gi_mLRGbinding_M2 and q_Gi;
vars q_Gi and q_Gi_global;
vars q_LR_M2_mLRGbinding_M2 and q_LR_M2;
vars q_LR_M2 and q_LR_M2_global;
vars q_R_M2Gi_mLRGbinding_M2 and q_R_M2Gi;
vars q_R_M2Gi and q_R_M2Gi_global;
vars q_LR_M2Gi_mLRGbinding_M2 and q_LR_M2Gi;
vars q_LR_M2Gi and q_LR_M2Gi_global;
enddef;
def map between environment and B1AR for
vars time and time;
vars q_LR_B1_mB1AR and q_LR_B1;
vars q_LR_B1 and q_LR_B1_global;
vars q_LR_B1Gs_mB1AR and q_LR_B1Gs;
vars q_LR_B1Gs and q_LR_B1Gs_global;
vars q_B1d_mB1AR and q_B1d;
vars q_B1d and q_B1d_global;
vars q_BARK_mB1AR and q_BARK;
vars q_BARK and q_BARK_global;
vars q_LR_B1_BARK_mB1AR and q_LR_B1_BARK;
vars q_LR_B1_BARK and q_LR_B1_BARK_global;
vars q_LR_B1Gs_BARK_mB1AR and q_LR_B1Gs_BARK;
vars q_LR_B1Gs_BARK and q_LR_B1Gs_BARK_global;
vars q_B1p_mB1AR and q_B1p;
vars q_B1p and q_B1p_global;
vars q_B1tot_mB1AR and q_B1tot;
vars q_B1tot and q_B1tot_global;
vars q_PKACI_mB1AR and q_PKACI;
vars q_PKACI and q_PKACI_global;
vars q_PKACI_B1p_mB1AR and q_PKACI_B1p;
vars q_PKACI_B1p and q_PKACI_B1p_global;
enddef;
def map between environment and GsProtein for
vars time and time;
vars q_R_B1_mGsProtein and q_R_B1;
vars q_R_B1 and q_R_B1_global;
vars q_Gs_mGsProtein and q_Gs;
vars q_Gs and q_Gs_global;
vars q_R_B1Gs_mGsProtein and q_R_B1Gs;
vars q_R_B1Gs and q_R_B1Gs_global;
vars q_LR_B1_mGsProtein and q_LR_B1;
vars q_LR_B1 and q_LR_B1_global;
vars q_LR_B1Gs_mGsProtein and q_LR_B1Gs;
vars q_LR_B1Gs and q_LR_B1Gs_global;
vars q_aGs_GTP_mGsProtein and q_aGs_GTP;
vars q_aGs_GTP and q_aGs_GTP_global;
vars q_beta_gamma_Gs_mGsProtein and q_beta_gamma_Gs;
vars q_beta_gamma_Gs and q_beta_gamma_Gs_global;
vars q_aGs_GDP_mGsProtein and q_aGs_GDP;
vars q_aGs_GDP and q_aGs_GDP_global;
enddef;
def map between environment and GiProtein for
vars time and time;
vars q_R_M2_mGiProtein and q_R_M2;
vars q_R_M2 and q_R_M2_global;
vars q_Gi_mGiProtein and q_Gi;
vars q_Gi and q_Gi_global;
vars q_R_M2Gi_mGiProtein and q_R_M2Gi;
vars q_R_M2Gi and q_R_M2Gi_global;
vars q_LR_M2_mGiProtein and q_LR_M2;
vars q_LR_M2 and q_LR_M2_global;
vars q_LR_M2Gi_mGiProtein and q_LR_M2Gi;
vars q_LR_M2Gi and q_LR_M2Gi_global;
vars q_aGi_GTP_mGiProtein and q_aGi_GTP;
vars q_aGi_GTP and q_aGi_GTP_global;
vars q_beta_gamma_Gi_mGiProtein and q_beta_gamma_Gi;
vars q_beta_gamma_Gi and q_beta_gamma_Gi_global;
vars q_aGi_GDP_mGiProtein and q_aGi_GDP;
vars q_aGi_GDP and q_aGi_GDP_global;
enddef;
def map between BG_parameters and cAMP for
vars kappa_1a and kappa_1a;
vars kappa_1b and kappa_1b;
vars kappa_2a and kappa_2a;
vars kappa_2b and kappa_2b;
vars kappa_3a and kappa_3a;
vars kappa_3b and kappa_3b;
vars kappa_4a and kappa_4a;
vars kappa_4b and kappa_4b;
vars kappa_5 and kappa_5;
vars kappa_6 and kappa_6;
vars kappa_7 and kappa_7;
vars kappa_GiAC and kappa_GiAC;
vars K_ATP and K_ATP;
vars K_cAMP and K_cAMP;
vars K_AC and K_AC;
vars K_AC_ATP and K_AC_ATP;
vars K_aGs_GTP_AC and K_aGs_GTP_AC;
vars K_aGs_GTP_AC_ATP and K_aGs_GTP_AC_ATP;
vars K_FSK_AC and K_FSK_AC;
vars K_FSK_AC_ATP and K_FSK_AC_ATP;
vars K_PDE and K_PDE;
vars K_PDE_cAMP and K_PDE_cAMP;
vars K_five_AMP and K_five_AMP;
vars K_IBMX and K_IBMX;
vars K_PDEinh and K_PDEinh;
vars K_aGs_GTP and K_aGs_GTP;
vars K_FSK and K_FSK;
vars K_aGi_GTP and K_aGi_GTP;
vars K_ACinh and K_ACinh;
enddef;
def map between BG_parameters and LRGbinding_B1AR for
vars kappa_sig1_B1 and kappa_sig1_B1;
vars kappa_sig2_B1 and kappa_sig2_B1;
vars kappa_sig3_B1 and kappa_sig3_B1;
vars kappa_sig4_B1 and kappa_sig4_B1;
vars K_L_B1 and K_L_B1;
vars K_R_B1 and K_R_B1;
vars K_Gs and K_Gs;
vars K_LR_B1 and K_LR_B1;
vars K_R_B1Gs and K_R_B1Gs;
vars K_LR_B1Gs and K_LR_B1Gs;
enddef;
def map between BG_parameters and LRGbinding_M2 for
vars kappa_sig1_M2 and kappa_sig1_M2;
vars kappa_sig2_M2 and kappa_sig2_M2;
vars kappa_sig3_M2 and kappa_sig3_M2;
vars kappa_sig4_M2 and kappa_sig4_M2;
vars K_L_M2 and K_L_M2;
vars K_R_M2 and K_R_M2;
vars K_Gi and K_Gi;
vars K_LR_M2 and K_LR_M2;
vars K_R_M2Gi and K_R_M2Gi;
vars K_LR_M2Gi and K_LR_M2Gi;
enddef;
def map between BG_parameters and B1AR for
vars kappa_B11 and kappa_B11;
vars kappa_B12 and kappa_B12;
vars kappa_B21 and kappa_B21;
vars kappa_B22 and kappa_B22;
vars kappa_P1 and kappa_P1;
vars kappa_P2 and kappa_P2;
vars K_LR_B1 and K_LR_B1;
vars K_LR_B1Gs and K_LR_B1Gs;
vars K_B1d and K_B1d;
vars K_BARK and K_BARK;
vars K_LR_B1_BARK and K_LR_B1_BARK;
vars K_LR_B1Gs_BARK and K_LR_B1Gs_BARK;
vars K_B1p and K_B1p;
vars K_B1tot and K_B1tot;
vars K_PKACI and K_PKACI;
vars K_PKACI_B1p and K_PKACI_B1p;
enddef;
def map between BG_parameters and GsProtein for
vars kappa_act1_Gs and kappa_act1_Gs;
vars kappa_act2_Gs and kappa_act2_Gs;
vars kappa_hyd_Gs and kappa_hyd_Gs;
vars kappa_reassoc_Gs and kappa_reassoc_Gs;
vars K_R_B1 and K_R_B1;
vars K_Gs and K_Gs;
vars K_R_B1Gs and K_R_B1Gs;
vars K_LR_B1 and K_LR_B1;
vars K_LR_B1Gs and K_LR_B1Gs;
vars K_aGs_GTP and K_aGs_GTP;
vars K_beta_gamma_Gs and K_beta_gamma_Gs;
vars K_aGs_GDP and K_aGs_GDP;
enddef;
def map between BG_parameters and GiProtein for
vars kappa_act1_Gi and kappa_act1_Gi;
vars kappa_act2_Gi and kappa_act2_Gi;
vars kappa_hyd_Gi and kappa_hyd_Gi;
vars kappa_reassoc_Gi and kappa_reassoc_Gi;
vars K_R_M2 and K_R_M2;
vars K_Gi and K_Gi;
vars K_R_M2Gi and K_R_M2Gi;
vars K_LR_M2 and K_LR_M2;
vars K_LR_M2Gi and K_LR_M2Gi;
vars K_aGi_GTP and K_aGi_GTP;
vars K_beta_gamma_Gi and K_beta_gamma_Gi;
vars K_aGi_GDP and K_aGi_GDP;
enddef;
def map between constants and cAMP for
vars R and R;
vars T and T;
enddef;
def map between constants and LRGbinding_B1AR for
vars R and R;
vars T and T;
enddef;
def map between constants and LRGbinding_M2 for
vars R and R;
vars T and T;
enddef;
def map between constants and B1AR for
vars R and R;
vars T and T;
enddef;
def map between constants and GsProtein for
vars R and R;
vars T and T;
enddef;
def map between constants and GiProtein for
vars R and R;
vars T and T;
enddef;
enddef;
