- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-10-29 08:41:03+13:00
- Desc:
- Updating wth parameters found using importlib of individual modules. plotting chemostat values and comparisons correctly
- Permanent Source URI:
- https://models.cellml.org/workspace/705/rawfile/816301de455dcfec7a4159eafdc3e4d84312972d/parameter_finder/TEMP.cellml.txt
def model FCU_composite as
def import using "units_and_constants/units_BG.cellml" for
unit mM using unit mM;
unit fmol using unit fmol;
unit per_fmol using unit per_fmol;
unit J_per_mol using unit J_per_mol;
unit fmol_per_sec using unit fmol_per_sec;
unit C_per_mol using unit C_per_mol;
unit J_per_C using unit J_per_C;
unit microm3 using unit microm3;
unit fF using unit fF;
unit fC using unit fC;
unit fA using unit fA;
unit per_second using unit per_second;
unit millivolt using unit millivolt;
unit per_sec using unit per_sec;
unit J_per_K_per_mol using unit J_per_K_per_mol;
unit fmol_per_L using unit fmol_per_L;
unit fmol_per_L_per_sec using unit fmol_per_L_per_sec;
unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L;
unit uM using unit uM;
unit mM_per_sec using unit mM_per_sec;
unit uM_per_sec using unit uM_per_sec;
unit pL using unit pL;
unit m_to_u using unit m_to_u;
enddef;
def import using "units_and_constants/constants_BG.cellml" for
comp constants using comp constants;
enddef;
def import using "cAMP/BG_cAMP.cellml" for
comp cAMP using comp cAMP;
enddef;
def import using "LRGbinding_B1AR/BG_LRGbinding_B1AR.cellml" for
comp LRGbinding_B1AR using comp LRGbinding_B1AR;
enddef;
def import using "LRGbinding_M2/BG_LRGbinding_M2.cellml" for
comp LRGbinding_M2 using comp LRGbinding_M2;
enddef;
def import using "GsProtein/BG_GsProtein.cellml" for
comp GsProtein using comp GsProtein;
enddef;
def import using "GiProtein/BG_GiProtein.cellml" for
comp GiProtein using comp GiProtein;
enddef;
def comp BG_parameters as
var kappa_1a: fmol_per_sec {init: 634930, pub: out};
var kappa_1b: fmol_per_sec {init: 0.00132567, pub: out};
var kappa_2a: fmol_per_sec {init: 84905.2, pub: out};
var kappa_2b: fmol_per_sec {init: 0.22911, pub: out};
var kappa_3a: fmol_per_sec {init: 5.63668e+07, pub: out};
var kappa_3b: fmol_per_sec {init: 6.55428e-17, pub: out};
var kappa_4a: fmol_per_sec {init: 6129.44, pub: out};
var kappa_4b: fmol_per_sec {init: 0.235757, pub: out};
var kappa_5: fmol_per_sec {init: 217.721, pub: out};
var kappa_6: fmol_per_sec {init: 1606.04, pub: out};
var kappa_7: fmol_per_sec {init: 106622, pub: out};
var kappa_GiAC: fmol_per_sec {init: 610.58, pub: out};
var kappa_sig1_B1: fmol_per_sec {init: 776.288, pub: out};
var kappa_sig2_B1: fmol_per_sec {init: 8.66678, pub: out};
var kappa_sig3_B1: fmol_per_sec {init: 1.877, pub: out};
var kappa_sig4_B1: fmol_per_sec {init: 32289.4, pub: out};
var kappa_sig1_M2: fmol_per_sec {init: 805.222, pub: out};
var kappa_sig2_M2: fmol_per_sec {init: 7.91177, pub: out};
var kappa_sig3_M2: fmol_per_sec {init: 21.6742, pub: out};
var kappa_sig4_M2: fmol_per_sec {init: 12494.2, pub: out};
var kappa_Doff1_Gs: fmol_per_sec {init: 23.735, pub: out};
var kappa_Ton1_Gs: fmol_per_sec {init: 0.324713, pub: out};
var kappa_Act1_Gs: fmol_per_sec {init: 5.24204, pub: out};
var kappa_Doff2_Gs: fmol_per_sec {init: 30.5459, pub: out};
var kappa_Ton2_Gs: fmol_per_sec {init: 0.417892, pub: out};
var kappa_Act2_Gs: fmol_per_sec {init: 6.74628, pub: out};
var kappa_hyd_Gs: fmol_per_sec {init: 0.401534, pub: out};
var kappa_reassoc_Gs: fmol_per_sec {init: 277.933, pub: out};
var kappa_Doff1_Gi: fmol_per_sec {init: 26.3317, pub: out};
var kappa_Ton1_Gi: fmol_per_sec {init: 0.349072, pub: out};
var kappa_Act1_Gi: fmol_per_sec {init: 5.46061, pub: out};
var kappa_Doff2_Gi: fmol_per_sec {init: 49.7334, pub: out};
var kappa_Ton2_Gi: fmol_per_sec {init: 0.677502, pub: out};
var kappa_Act2_Gi: fmol_per_sec {init: 0.034034, pub: out};
var kappa_hyd_Gi: fmol_per_sec {init: 3.74875, pub: out};
var kappa_reassoc_Gi: fmol_per_sec {init: 561.624, pub: out};
var K_ATP: per_fmol {init: 5.49875e-05, pub: out};
var K_cAMP: per_fmol {init: 0.0146839, pub: out};
var K_AC: per_fmol {init: 2.251, pub: out};
var K_AC_ATP: per_fmol {init: 4.38567, pub: out};
var K_a_Gs_GTP_AC: per_fmol {init: 1.81003, pub: out};
var K_a_Gs_GTP_AC_ATP: per_fmol {init: 1.07849, pub: out};
var K_FSK_AC: per_fmol {init: 0.0272644, pub: out};
var K_FSK_AC_ATP: per_fmol {init: 0.0443523, pub: out};
var K_PDE: per_fmol {init: 0.938902, pub: out};
var K_PDE_cAMP: per_fmol {init: 0.61652, pub: out};
var K_five_AMP: per_fmol {init: 0.0146839, pub: out};
var K_IBMX: per_fmol {init: 0.0137798, pub: out};
var K_PDEinh: per_fmol {init: 13.3519, pub: out};
var K_a_Gs_GTP: per_fmol {init: 0.0584373, pub: out};
var K_FSK: per_fmol {init: 8.00217e-06, pub: out};
var K_a_Gi_GTP: per_fmol {init: 0.00614843, pub: out};
var K_ACinh: per_fmol {init: 4.76101, pub: out};
var K_PPi: per_fmol {init: 0.000108859, pub: out};
var K_L_B1: per_fmol {init: 0.0792561, pub: out};
var K_R_B1: per_fmol {init: 0.033021, pub: out};
var K_Gs: per_fmol {init: 3.31139, pub: out};
var K_LR_B1: per_fmol {init: 13.6568, pub: out};
var K_R_B1Gs: per_fmol {init: 123.025, pub: out};
var K_LR_B1Gs: per_fmol {init: 95.5936, pub: out};
var K_L_M2: per_fmol {init: 0.0981798, pub: out};
var K_R_M2: per_fmol {init: 0.0686555, pub: out};
var K_Gi: per_fmol {init: 1.51661, pub: out};
var K_LR_M2: per_fmol {init: 2.56806, pub: out};
var K_R_M2Gi: per_fmol {init: 109.161, pub: out};
var K_LR_M2Gi: per_fmol {init: 58.5882, pub: out};
var K_beta_gamma_Gs: per_fmol {init: 0.00117222, pub: out};
var K_a_Gs_GDP: per_fmol {init: 3.16665, pub: out};
var K_Pi: per_fmol {init: 0.00065869, pub: out};
var K_R_B1_aby: per_fmol {init: 0.16865, pub: out};
var K_R_B1_aby_T: per_fmol {init: 0.0891254, pub: out};
var K_LR_B1_aby: per_fmol {init: 0.131045, pub: out};
var K_LR_B1_aby_T: per_fmol {init: 0.0692529, pub: out};
var K_GTP: per_fmol {init: 1550.02, pub: out};
var K_GDP: per_fmol {init: 0.000210169, pub: out};
var K_beta_gamma_Gi: per_fmol {init: 0.00522573, pub: out};
var K_a_Gi_GDP: per_fmol {init: 0.345299, pub: out};
var K_R_M2_aby: per_fmol {init: 0.15443, pub: out};
var K_R_M2_aby_T: per_fmol {init: 0.0842216, pub: out};
var K_LR_M2_aby: per_fmol {init: 0.0806585, pub: out};
var K_LR_M2_aby_T: per_fmol {init: 0.042807, pub: out};
enddef;
def comp environment as
var time: second {pub: out};
var vol_myo: pL {init: 34.4, pub: out};
var freq: dimensionless {init: 500};
// stimulus
// ramp UP and ramp DOWN
var stimSt: second {init: 3.5e-4};
var stimSt2: second {init: 3e-4};
var stimDur: second {init: 0.25e-4};
var tR: second {init: 1.8e-4};
var stimMag: fmol {init: 1e1};
var stimHolding: fmol {init: 1e-5};
var m: fmol_per_sec;
m = stimMag/tR;
q_L_B1_init = sel
case (time < stimSt) and (time > stimSt-tR):
stimHolding+m*(time-stimSt+tR);
case (time >= stimSt) and (time < stimSt+stimDur):
stimMag+stimHolding;
case (time < stimSt+tR+stimDur) and (time >= stimSt+stimDur):
stimHolding+-m*(time-stimSt-tR-stimDur);
otherwise:
stimHolding;
endsel;
q_L_M2_init = sel
case (time < stimSt2) and (time > stimSt2-tR):
stimHolding+m*(time-stimSt2+tR);
case (time >= stimSt2) and (time < stimSt2+stimDur):
stimMag+stimHolding;
case (time < stimSt2+tR+stimDur) and (time >= stimSt2+stimDur):
stimHolding+-m*(time-stimSt2-tR-stimDur);
otherwise:
stimHolding;
endsel;
var q_ATP_init: fmol {init: 1e-888};
var q_cAMP_init: fmol {init: 1e-888};
var q_AC_init: fmol {init: 1e-888};
var q_AC_ATP_init: fmol {init: 1e-888};
var q_a_Gs_GTP_AC_init: fmol {init: 1e-888};
var q_a_Gs_GTP_AC_ATP_init: fmol {init: 1e-888};
var q_FSK_AC_init: fmol {init: 1e-888};
var q_FSK_AC_ATP_init: fmol {init: 1e-888};
var q_PDE_init: fmol {init: 1e-888};
var q_PDE_cAMP_init: fmol {init: 1e-888};
var q_five_AMP_init: fmol {init: 1e-888};
var q_IBMX_init: fmol {init: 1e-888};
var q_PDEinh_init: fmol {init: 1e-888};
var q_a_Gs_GTP_init: fmol {init: 1e-888};
var q_FSK_init: fmol {init: 1e-888};
var q_a_Gi_GTP_init: fmol {init: 1e-888};
var q_ACinh_init: fmol {init: 1e-888};
var q_PPi_init: fmol {init: 1e-888};
var q_L_B1_init: fmol {init: 1e-888};
var q_R_B1_init: fmol {init: 1e-888};
var q_Gs_init: fmol {init: 1e-888};
var q_LR_B1_init: fmol {init: 1e-888};
var q_R_B1Gs_init: fmol {init: 1e-888};
var q_LR_B1Gs_init: fmol {init: 1e-888};
var q_L_M2_init: fmol {init: 1e-888};
var q_R_M2_init: fmol {init: 1e-888};
var q_Gi_init: fmol {init: 1e-888};
var q_LR_M2_init: fmol {init: 1e-888};
var q_R_M2Gi_init: fmol {init: 1e-888};
var q_LR_M2Gi_init: fmol {init: 1e-888};
var q_beta_gamma_Gs_init: fmol {init: 1e-888};
var q_a_Gs_GDP_init: fmol {init: 1e-888};
var q_Pi_init: fmol {init: 1e-888};
var q_R_B1_aby_init: fmol {init: 1e-888};
var q_R_B1_aby_T_init: fmol {init: 1e-888};
var q_LR_B1_aby_init: fmol {init: 1e-888};
var q_LR_B1_aby_T_init: fmol {init: 1e-888};
var q_GTP_init: fmol {init: 1e-888};
var q_GDP_init: fmol {init: 1e-888};
var q_beta_gamma_Gi_init: fmol {init: 1e-888};
var q_a_Gi_GDP_init: fmol {init: 1e-888};
var q_R_M2_aby_init: fmol {init: 1e-888};
var q_R_M2_aby_T_init: fmol {init: 1e-888};
var q_LR_M2_aby_init: fmol {init: 1e-888};
var q_LR_M2_aby_T_init: fmol {init: 1e-888};
// Global value
var q_ATP: fmol {pub: out};
var q_cAMP: fmol {pub: out};
var q_AC: fmol {pub: out};
var q_AC_ATP: fmol {pub: out};
var q_a_Gs_GTP_AC: fmol {pub: out};
var q_a_Gs_GTP_AC_ATP: fmol {pub: out};
var q_FSK_AC: fmol {pub: out};
var q_FSK_AC_ATP: fmol {pub: out};
var q_PDE: fmol {pub: out};
var q_PDE_cAMP: fmol {pub: out};
var q_five_AMP: fmol {pub: out};
var q_IBMX: fmol {pub: out};
var q_PDEinh: fmol {pub: out};
var q_a_Gs_GTP: fmol {pub: out};
var q_FSK: fmol {pub: out};
var q_a_Gi_GTP: fmol {pub: out};
var q_ACinh: fmol {pub: out};
var q_PPi: fmol {pub: out};
var q_L_B1: fmol {pub: out};
var q_R_B1: fmol {pub: out};
var q_Gs: fmol {pub: out};
var q_LR_B1: fmol {pub: out};
var q_R_B1Gs: fmol {pub: out};
var q_LR_B1Gs: fmol {pub: out};
var q_L_M2: fmol {pub: out};
var q_R_M2: fmol {pub: out};
var q_Gi: fmol {pub: out};
var q_LR_M2: fmol {pub: out};
var q_R_M2Gi: fmol {pub: out};
var q_LR_M2Gi: fmol {pub: out};
var q_beta_gamma_Gs: fmol {pub: out};
var q_a_Gs_GDP: fmol {pub: out};
var q_Pi: fmol {pub: out};
var q_R_B1_aby: fmol {pub: out};
var q_R_B1_aby_T: fmol {pub: out};
var q_LR_B1_aby: fmol {pub: out};
var q_LR_B1_aby_T: fmol {pub: out};
var q_GTP: fmol {pub: out};
var q_GDP: fmol {pub: out};
var q_beta_gamma_Gi: fmol {pub: out};
var q_a_Gi_GDP: fmol {pub: out};
var q_R_M2_aby: fmol {pub: out};
var q_R_M2_aby_T: fmol {pub: out};
var q_LR_M2_aby: fmol {pub: out};
var q_LR_M2_aby_T: fmol {pub: out};
// cAMP imports
var q_ATP_mcAMP: fmol {pub: in};
var q_cAMP_mcAMP: fmol {pub: in};
var q_AC_mcAMP: fmol {pub: in};
var q_AC_ATP_mcAMP: fmol {pub: in};
var q_a_Gs_GTP_AC_mcAMP: fmol {pub: in};
var q_a_Gs_GTP_AC_ATP_mcAMP: fmol {pub: in};
var q_FSK_AC_mcAMP: fmol {pub: in};
var q_FSK_AC_ATP_mcAMP: fmol {pub: in};
var q_PDE_mcAMP: fmol {pub: in};
var q_PDE_cAMP_mcAMP: fmol {pub: in};
var q_five_AMP_mcAMP: fmol {pub: in};
var q_IBMX_mcAMP: fmol {pub: in};
var q_PDEinh_mcAMP: fmol {pub: in};
var q_a_Gs_GTP_mcAMP: fmol {pub: in};
var q_FSK_mcAMP: fmol {pub: in};
var q_a_Gi_GTP_mcAMP: fmol {pub: in};
var q_ACinh_mcAMP: fmol {pub: in};
var q_PPi_mcAMP: fmol {pub: in};
// LRGbinding_B1AR imports
var q_L_B1_mLRGbinding_B1AR: fmol {pub: in};
var q_R_B1_mLRGbinding_B1AR: fmol {pub: in};
var q_Gs_mLRGbinding_B1AR: fmol {pub: in};
var q_LR_B1_mLRGbinding_B1AR: fmol {pub: in};
var q_R_B1Gs_mLRGbinding_B1AR: fmol {pub: in};
var q_LR_B1Gs_mLRGbinding_B1AR: fmol {pub: in};
// LRGbinding_M2 imports
var q_L_M2_mLRGbinding_M2: fmol {pub: in};
var q_R_M2_mLRGbinding_M2: fmol {pub: in};
var q_Gi_mLRGbinding_M2: fmol {pub: in};
var q_LR_M2_mLRGbinding_M2: fmol {pub: in};
var q_R_M2Gi_mLRGbinding_M2: fmol {pub: in};
var q_LR_M2Gi_mLRGbinding_M2: fmol {pub: in};
// GsProtein imports
var q_R_B1_mGsProtein: fmol {pub: in};
var q_Gs_mGsProtein: fmol {pub: in};
var q_R_B1Gs_mGsProtein: fmol {pub: in};
var q_LR_B1_mGsProtein: fmol {pub: in};
var q_LR_B1Gs_mGsProtein: fmol {pub: in};
var q_a_Gs_GTP_mGsProtein: fmol {pub: in};
var q_beta_gamma_Gs_mGsProtein: fmol {pub: in};
var q_a_Gs_GDP_mGsProtein: fmol {pub: in};
var q_Pi_mGsProtein: fmol {pub: in};
var q_R_B1_aby_mGsProtein: fmol {pub: in};
var q_R_B1_aby_T_mGsProtein: fmol {pub: in};
var q_LR_B1_aby_mGsProtein: fmol {pub: in};
var q_LR_B1_aby_T_mGsProtein: fmol {pub: in};
var q_GTP_mGsProtein: fmol {pub: in};
var q_GDP_mGsProtein: fmol {pub: in};
// GiProtein imports
var q_R_M2_mGiProtein: fmol {pub: in};
var q_Gi_mGiProtein: fmol {pub: in};
var q_R_M2Gi_mGiProtein: fmol {pub: in};
var q_LR_M2_mGiProtein: fmol {pub: in};
var q_LR_M2Gi_mGiProtein: fmol {pub: in};
var q_a_Gi_GTP_mGiProtein: fmol {pub: in};
var q_beta_gamma_Gi_mGiProtein: fmol {pub: in};
var q_a_Gi_GDP_mGiProtein: fmol {pub: in};
var q_Pi_mGiProtein: fmol {pub: in};
var q_R_M2_aby_mGiProtein: fmol {pub: in};
var q_R_M2_aby_T_mGiProtein: fmol {pub: in};
var q_LR_M2_aby_mGiProtein: fmol {pub: in};
var q_LR_M2_aby_T_mGiProtein: fmol {pub: in};
var q_GTP_mGiProtein: fmol {pub: in};
var q_GDP_mGiProtein: fmol {pub: in};
q_ATP = q_ATP_init + q_ATP_mcAMP ;
q_cAMP = q_cAMP_init + q_cAMP_mcAMP ;
q_AC = q_AC_init + q_AC_mcAMP ;
q_AC_ATP = q_AC_ATP_init + q_AC_ATP_mcAMP ;
q_a_Gs_GTP_AC = q_a_Gs_GTP_AC_init + q_a_Gs_GTP_AC_mcAMP ;
q_a_Gs_GTP_AC_ATP = q_a_Gs_GTP_AC_ATP_init + q_a_Gs_GTP_AC_ATP_mcAMP ;
q_FSK_AC = q_FSK_AC_init + q_FSK_AC_mcAMP ;
q_FSK_AC_ATP = q_FSK_AC_ATP_init + q_FSK_AC_ATP_mcAMP ;
q_PDE = q_PDE_init + q_PDE_mcAMP ;
q_PDE_cAMP = q_PDE_cAMP_init + q_PDE_cAMP_mcAMP ;
q_five_AMP = q_five_AMP_init + q_five_AMP_mcAMP ;
q_IBMX = q_IBMX_init + q_IBMX_mcAMP ;
q_PDEinh = q_PDEinh_init + q_PDEinh_mcAMP ;
q_a_Gs_GTP = q_a_Gs_GTP_init + q_a_Gs_GTP_mcAMP + q_a_Gs_GTP_mGsProtein ;
q_FSK = q_FSK_init + q_FSK_mcAMP ;
q_a_Gi_GTP = q_a_Gi_GTP_init + q_a_Gi_GTP_mcAMP + q_a_Gi_GTP_mGiProtein ;
q_ACinh = q_ACinh_init + q_ACinh_mcAMP ;
q_PPi = q_PPi_init + q_PPi_mcAMP ;
q_L_B1 = q_L_B1_init + q_L_B1_mLRGbinding_B1AR ;
q_R_B1 = q_R_B1_init + q_R_B1_mLRGbinding_B1AR + q_R_B1_mGsProtein ;
q_Gs = q_Gs_init + q_Gs_mLRGbinding_B1AR + q_Gs_mGsProtein ;
q_LR_B1 = q_LR_B1_init + q_LR_B1_mLRGbinding_B1AR + q_LR_B1_mGsProtein ;
q_R_B1Gs = q_R_B1Gs_init + q_R_B1Gs_mLRGbinding_B1AR + q_R_B1Gs_mGsProtein ;
q_LR_B1Gs = q_LR_B1Gs_init + q_LR_B1Gs_mLRGbinding_B1AR + q_LR_B1Gs_mGsProtein ;
q_L_M2 = q_L_M2_init + q_L_M2_mLRGbinding_M2 ;
q_R_M2 = q_R_M2_init + q_R_M2_mLRGbinding_M2 + q_R_M2_mGiProtein ;
q_Gi = q_Gi_init + q_Gi_mLRGbinding_M2 + q_Gi_mGiProtein ;
q_LR_M2 = q_LR_M2_init + q_LR_M2_mLRGbinding_M2 + q_LR_M2_mGiProtein ;
q_R_M2Gi = q_R_M2Gi_init + q_R_M2Gi_mLRGbinding_M2 + q_R_M2Gi_mGiProtein ;
q_LR_M2Gi = q_LR_M2Gi_init + q_LR_M2Gi_mLRGbinding_M2 + q_LR_M2Gi_mGiProtein ;
q_beta_gamma_Gs = q_beta_gamma_Gs_init + q_beta_gamma_Gs_mGsProtein ;
q_a_Gs_GDP = q_a_Gs_GDP_init + q_a_Gs_GDP_mGsProtein ;
q_Pi = q_Pi_init + q_Pi_mGsProtein + q_Pi_mGiProtein ;
q_R_B1_aby = q_R_B1_aby_init + q_R_B1_aby_mGsProtein ;
q_R_B1_aby_T = q_R_B1_aby_T_init + q_R_B1_aby_T_mGsProtein ;
q_LR_B1_aby = q_LR_B1_aby_init + q_LR_B1_aby_mGsProtein ;
q_LR_B1_aby_T = q_LR_B1_aby_T_init + q_LR_B1_aby_T_mGsProtein ;
q_GTP = q_GTP_init + q_GTP_mGsProtein + q_GTP_mGiProtein ;
q_GDP = q_GDP_init + q_GDP_mGsProtein + q_GDP_mGiProtein ;
q_beta_gamma_Gi = q_beta_gamma_Gi_init + q_beta_gamma_Gi_mGiProtein ;
q_a_Gi_GDP = q_a_Gi_GDP_init + q_a_Gi_GDP_mGiProtein ;
q_R_M2_aby = q_R_M2_aby_init + q_R_M2_aby_mGiProtein ;
q_R_M2_aby_T = q_R_M2_aby_T_init + q_R_M2_aby_T_mGiProtein ;
q_LR_M2_aby = q_LR_M2_aby_init + q_LR_M2_aby_mGiProtein ;
q_LR_M2_aby_T = q_LR_M2_aby_T_init + q_LR_M2_aby_T_mGiProtein ;
enddef;
def map between environment and cAMP for
vars time and time;
vars q_ATP_mcAMP and q_ATP;
vars q_ATP and q_ATP_global;
vars q_cAMP_mcAMP and q_cAMP;
vars q_cAMP and q_cAMP_global;
vars q_AC_mcAMP and q_AC;
vars q_AC and q_AC_global;
vars q_AC_ATP_mcAMP and q_AC_ATP;
vars q_AC_ATP and q_AC_ATP_global;
vars q_a_Gs_GTP_AC_mcAMP and q_a_Gs_GTP_AC;
vars q_a_Gs_GTP_AC and q_a_Gs_GTP_AC_global;
vars q_a_Gs_GTP_AC_ATP_mcAMP and q_a_Gs_GTP_AC_ATP;
vars q_a_Gs_GTP_AC_ATP and q_a_Gs_GTP_AC_ATP_global;
vars q_FSK_AC_mcAMP and q_FSK_AC;
vars q_FSK_AC and q_FSK_AC_global;
vars q_FSK_AC_ATP_mcAMP and q_FSK_AC_ATP;
vars q_FSK_AC_ATP and q_FSK_AC_ATP_global;
vars q_PDE_mcAMP and q_PDE;
vars q_PDE and q_PDE_global;
vars q_PDE_cAMP_mcAMP and q_PDE_cAMP;
vars q_PDE_cAMP and q_PDE_cAMP_global;
vars q_five_AMP_mcAMP and q_five_AMP;
vars q_five_AMP and q_five_AMP_global;
vars q_IBMX_mcAMP and q_IBMX;
vars q_IBMX and q_IBMX_global;
vars q_PDEinh_mcAMP and q_PDEinh;
vars q_PDEinh and q_PDEinh_global;
vars q_a_Gs_GTP_mcAMP and q_a_Gs_GTP;
vars q_a_Gs_GTP and q_a_Gs_GTP_global;
vars q_FSK_mcAMP and q_FSK;
vars q_FSK and q_FSK_global;
vars q_a_Gi_GTP_mcAMP and q_a_Gi_GTP;
vars q_a_Gi_GTP and q_a_Gi_GTP_global;
vars q_ACinh_mcAMP and q_ACinh;
vars q_ACinh and q_ACinh_global;
vars q_PPi_mcAMP and q_PPi;
vars q_PPi and q_PPi_global;
enddef;
def map between environment and LRGbinding_B1AR for
vars time and time;
vars q_L_B1_mLRGbinding_B1AR and q_L_B1;
vars q_L_B1 and q_L_B1_global;
vars q_R_B1_mLRGbinding_B1AR and q_R_B1;
vars q_R_B1 and q_R_B1_global;
vars q_Gs_mLRGbinding_B1AR and q_Gs;
vars q_Gs and q_Gs_global;
vars q_LR_B1_mLRGbinding_B1AR and q_LR_B1;
vars q_LR_B1 and q_LR_B1_global;
vars q_R_B1Gs_mLRGbinding_B1AR and q_R_B1Gs;
vars q_R_B1Gs and q_R_B1Gs_global;
vars q_LR_B1Gs_mLRGbinding_B1AR and q_LR_B1Gs;
vars q_LR_B1Gs and q_LR_B1Gs_global;
enddef;
def map between environment and LRGbinding_M2 for
vars time and time;
vars q_L_M2_mLRGbinding_M2 and q_L_M2;
vars q_L_M2 and q_L_M2_global;
vars q_R_M2_mLRGbinding_M2 and q_R_M2;
vars q_R_M2 and q_R_M2_global;
vars q_Gi_mLRGbinding_M2 and q_Gi;
vars q_Gi and q_Gi_global;
vars q_LR_M2_mLRGbinding_M2 and q_LR_M2;
vars q_LR_M2 and q_LR_M2_global;
vars q_R_M2Gi_mLRGbinding_M2 and q_R_M2Gi;
vars q_R_M2Gi and q_R_M2Gi_global;
vars q_LR_M2Gi_mLRGbinding_M2 and q_LR_M2Gi;
vars q_LR_M2Gi and q_LR_M2Gi_global;
enddef;
def map between environment and GsProtein for
vars time and time;
vars q_R_B1_mGsProtein and q_R_B1;
vars q_R_B1 and q_R_B1_global;
vars q_Gs_mGsProtein and q_Gs;
vars q_Gs and q_Gs_global;
vars q_R_B1Gs_mGsProtein and q_R_B1Gs;
vars q_R_B1Gs and q_R_B1Gs_global;
vars q_LR_B1_mGsProtein and q_LR_B1;
vars q_LR_B1 and q_LR_B1_global;
vars q_LR_B1Gs_mGsProtein and q_LR_B1Gs;
vars q_LR_B1Gs and q_LR_B1Gs_global;
vars q_a_Gs_GTP_mGsProtein and q_a_Gs_GTP;
vars q_a_Gs_GTP and q_a_Gs_GTP_global;
vars q_beta_gamma_Gs_mGsProtein and q_beta_gamma_Gs;
vars q_beta_gamma_Gs and q_beta_gamma_Gs_global;
vars q_a_Gs_GDP_mGsProtein and q_a_Gs_GDP;
vars q_a_Gs_GDP and q_a_Gs_GDP_global;
vars q_Pi_mGsProtein and q_Pi;
vars q_Pi and q_Pi_global;
vars q_R_B1_aby_mGsProtein and q_R_B1_aby;
vars q_R_B1_aby and q_R_B1_aby_global;
vars q_R_B1_aby_T_mGsProtein and q_R_B1_aby_T;
vars q_R_B1_aby_T and q_R_B1_aby_T_global;
vars q_LR_B1_aby_mGsProtein and q_LR_B1_aby;
vars q_LR_B1_aby and q_LR_B1_aby_global;
vars q_LR_B1_aby_T_mGsProtein and q_LR_B1_aby_T;
vars q_LR_B1_aby_T and q_LR_B1_aby_T_global;
vars q_GTP_mGsProtein and q_GTP;
vars q_GTP and q_GTP_global;
vars q_GDP_mGsProtein and q_GDP;
vars q_GDP and q_GDP_global;
enddef;
def map between environment and GiProtein for
vars time and time;
vars q_R_M2_mGiProtein and q_R_M2;
vars q_R_M2 and q_R_M2_global;
vars q_Gi_mGiProtein and q_Gi;
vars q_Gi and q_Gi_global;
vars q_R_M2Gi_mGiProtein and q_R_M2Gi;
vars q_R_M2Gi and q_R_M2Gi_global;
vars q_LR_M2_mGiProtein and q_LR_M2;
vars q_LR_M2 and q_LR_M2_global;
vars q_LR_M2Gi_mGiProtein and q_LR_M2Gi;
vars q_LR_M2Gi and q_LR_M2Gi_global;
vars q_a_Gi_GTP_mGiProtein and q_a_Gi_GTP;
vars q_a_Gi_GTP and q_a_Gi_GTP_global;
vars q_beta_gamma_Gi_mGiProtein and q_beta_gamma_Gi;
vars q_beta_gamma_Gi and q_beta_gamma_Gi_global;
vars q_a_Gi_GDP_mGiProtein and q_a_Gi_GDP;
vars q_a_Gi_GDP and q_a_Gi_GDP_global;
vars q_Pi_mGiProtein and q_Pi;
vars q_Pi and q_Pi_global;
vars q_R_M2_aby_mGiProtein and q_R_M2_aby;
vars q_R_M2_aby and q_R_M2_aby_global;
vars q_R_M2_aby_T_mGiProtein and q_R_M2_aby_T;
vars q_R_M2_aby_T and q_R_M2_aby_T_global;
vars q_LR_M2_aby_mGiProtein and q_LR_M2_aby;
vars q_LR_M2_aby and q_LR_M2_aby_global;
vars q_LR_M2_aby_T_mGiProtein and q_LR_M2_aby_T;
vars q_LR_M2_aby_T and q_LR_M2_aby_T_global;
vars q_GTP_mGiProtein and q_GTP;
vars q_GTP and q_GTP_global;
vars q_GDP_mGiProtein and q_GDP;
vars q_GDP and q_GDP_global;
enddef;
def map between BG_parameters and cAMP for
vars kappa_1a and kappa_1a;
vars kappa_1b and kappa_1b;
vars kappa_2a and kappa_2a;
vars kappa_2b and kappa_2b;
vars kappa_3a and kappa_3a;
vars kappa_3b and kappa_3b;
vars kappa_4a and kappa_4a;
vars kappa_4b and kappa_4b;
vars kappa_5 and kappa_5;
vars kappa_6 and kappa_6;
vars kappa_7 and kappa_7;
vars kappa_GiAC and kappa_GiAC;
vars K_ATP and K_ATP;
vars K_cAMP and K_cAMP;
vars K_AC and K_AC;
vars K_AC_ATP and K_AC_ATP;
vars K_a_Gs_GTP_AC and K_a_Gs_GTP_AC;
vars K_a_Gs_GTP_AC_ATP and K_a_Gs_GTP_AC_ATP;
vars K_FSK_AC and K_FSK_AC;
vars K_FSK_AC_ATP and K_FSK_AC_ATP;
vars K_PDE and K_PDE;
vars K_PDE_cAMP and K_PDE_cAMP;
vars K_five_AMP and K_five_AMP;
vars K_IBMX and K_IBMX;
vars K_PDEinh and K_PDEinh;
vars K_a_Gs_GTP and K_a_Gs_GTP;
vars K_FSK and K_FSK;
vars K_a_Gi_GTP and K_a_Gi_GTP;
vars K_ACinh and K_ACinh;
vars K_PPi and K_PPi;
enddef;
def map between BG_parameters and LRGbinding_B1AR for
vars kappa_sig1_B1 and kappa_sig1_B1;
vars kappa_sig2_B1 and kappa_sig2_B1;
vars kappa_sig3_B1 and kappa_sig3_B1;
vars kappa_sig4_B1 and kappa_sig4_B1;
vars K_L_B1 and K_L_B1;
vars K_R_B1 and K_R_B1;
vars K_Gs and K_Gs;
vars K_LR_B1 and K_LR_B1;
vars K_R_B1Gs and K_R_B1Gs;
vars K_LR_B1Gs and K_LR_B1Gs;
enddef;
def map between BG_parameters and LRGbinding_M2 for
vars kappa_sig1_M2 and kappa_sig1_M2;
vars kappa_sig2_M2 and kappa_sig2_M2;
vars kappa_sig3_M2 and kappa_sig3_M2;
vars kappa_sig4_M2 and kappa_sig4_M2;
vars K_L_M2 and K_L_M2;
vars K_R_M2 and K_R_M2;
vars K_Gi and K_Gi;
vars K_LR_M2 and K_LR_M2;
vars K_R_M2Gi and K_R_M2Gi;
vars K_LR_M2Gi and K_LR_M2Gi;
enddef;
def map between BG_parameters and GsProtein for
vars kappa_Doff1_Gs and kappa_Doff1_Gs;
vars kappa_Ton1_Gs and kappa_Ton1_Gs;
vars kappa_Act1_Gs and kappa_Act1_Gs;
vars kappa_Doff2_Gs and kappa_Doff2_Gs;
vars kappa_Ton2_Gs and kappa_Ton2_Gs;
vars kappa_Act2_Gs and kappa_Act2_Gs;
vars kappa_hyd_Gs and kappa_hyd_Gs;
vars kappa_reassoc_Gs and kappa_reassoc_Gs;
vars K_R_B1 and K_R_B1;
vars K_Gs and K_Gs;
vars K_R_B1Gs and K_R_B1Gs;
vars K_LR_B1 and K_LR_B1;
vars K_LR_B1Gs and K_LR_B1Gs;
vars K_a_Gs_GTP and K_a_Gs_GTP;
vars K_beta_gamma_Gs and K_beta_gamma_Gs;
vars K_a_Gs_GDP and K_a_Gs_GDP;
vars K_Pi and K_Pi;
vars K_R_B1_aby and K_R_B1_aby;
vars K_R_B1_aby_T and K_R_B1_aby_T;
vars K_LR_B1_aby and K_LR_B1_aby;
vars K_LR_B1_aby_T and K_LR_B1_aby_T;
vars K_GTP and K_GTP;
vars K_GDP and K_GDP;
enddef;
def map between BG_parameters and GiProtein for
vars kappa_Doff1_Gi and kappa_Doff1_Gi;
vars kappa_Ton1_Gi and kappa_Ton1_Gi;
vars kappa_Act1_Gi and kappa_Act1_Gi;
vars kappa_Doff2_Gi and kappa_Doff2_Gi;
vars kappa_Ton2_Gi and kappa_Ton2_Gi;
vars kappa_Act2_Gi and kappa_Act2_Gi;
vars kappa_hyd_Gi and kappa_hyd_Gi;
vars kappa_reassoc_Gi and kappa_reassoc_Gi;
vars K_R_M2 and K_R_M2;
vars K_Gi and K_Gi;
vars K_R_M2Gi and K_R_M2Gi;
vars K_LR_M2 and K_LR_M2;
vars K_LR_M2Gi and K_LR_M2Gi;
vars K_a_Gi_GTP and K_a_Gi_GTP;
vars K_beta_gamma_Gi and K_beta_gamma_Gi;
vars K_a_Gi_GDP and K_a_Gi_GDP;
vars K_Pi and K_Pi;
vars K_R_M2_aby and K_R_M2_aby;
vars K_R_M2_aby_T and K_R_M2_aby_T;
vars K_LR_M2_aby and K_LR_M2_aby;
vars K_LR_M2_aby_T and K_LR_M2_aby_T;
vars K_GTP and K_GTP;
vars K_GDP and K_GDP;
enddef;
def map between constants and cAMP for
vars R and R;
vars T and T;
enddef;
def map between constants and LRGbinding_B1AR for
vars R and R;
vars T and T;
enddef;
def map between constants and LRGbinding_M2 for
vars R and R;
vars T and T;
enddef;
def map between constants and GsProtein for
vars R and R;
vars T and T;
enddef;
def map between constants and GiProtein for
vars R and R;
vars T and T;
enddef;
enddef;
