- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-12-06 08:25:06+13:00
- Desc:
- Adding units submodule manually
- Permanent Source URI:
- https://models.cellml.org/workspace/705/rawfile/9f1753b7ba6c67dc1d2964813a1ed5f3322a73ce/FCU_adenylylCyclase_new.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="FCU_adenylylCyclase" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="mM" units_ref="mM"/>
<units name="fmol" units_ref="fmol"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="microm3" units_ref="microm3"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
<units name="per_second" units_ref="per_second"/>
<units name="millivolt" units_ref="millivolt"/>
<units name="per_sec" units_ref="per_sec"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="fmol_per_L" units_ref="fmol_per_L"/>
<units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
<units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
<units name="uM" units_ref="uM"/>
<units name="mM_per_sec" units_ref="mM_per_sec"/>
<units name="uM_per_sec" units_ref="uM_per_sec"/>
<units name="pL" units_ref="pL"/>
<units name="m_to_u" units_ref="m_to_u"/>
</import>
<import xlink:href="units_and_constants/constants_BG.cellml">
<component component_ref="constants" name="constants"/>
</import>
<import xlink:href="cAMP/BG_cAMP.cellml">
<component component_ref="cAMP" name="cAMP"/>
</import>
<import xlink:href="GPCR_B1AR/BG_GPCR_B1AR.cellml">
<component component_ref="GPCR_B1AR" name="GPCR_B1AR"/>
</import>
<import xlink:href="GPCR_M2/BG_GPCR_M2.cellml">
<component component_ref="GPCR_M2" name="GPCR_M2"/>
</import>
<component name="BG_parameters">
<variable initial_value="1.60115e+09" name="kappa_1a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.334304" name="kappa_1b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2009.73" name="kappa_2a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000542308" name="kappa_2b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3.21901e+08" name="kappa_3a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3.74304e-17" name="kappa_3b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="25558.6" name="kappa_4a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0983027" name="kappa_4b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="924.349" name="kappa_5" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="324.127" name="kappa_6" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="5.1916e+06" name="kappa_7" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.73268" name="kappa_GiAC" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000286763" name="kappa_C_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.00064e-05" name="kappa_R_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.43469e-15" name="kappa_L_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="8.6898e-06" name="kappa_Doff1_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.52074" name="kappa_Ton1_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="243319" name="kappa_Act1_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000967846" name="kappa_Doff2_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="169.376" name="kappa_Ton2_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.71002e+07" name="kappa_Act2_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3.73542e-06" name="kappa_Hyd_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="702424" name="kappa_Reassoc_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="4.29017e-06" name="kappa_PiPhos" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="4.20135" name="kappa_InternRB1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="467.935" name="kappa_InternL_RB1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000688519" name="kappa_C_M2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00193479" name="kappa_R_M2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.71493e-12" name="kappa_L_M2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.29506e-05" name="kappa_Doff1_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="4.01644" name="kappa_Ton1_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="100411" name="kappa_Act1_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00084427" name="kappa_Doff2_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="147.75" name="kappa_Ton2_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="73875.1" name="kappa_Act2_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.93978e-06" name="kappa_Hyd_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="316945" name="kappa_Reassoc_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3.84246" name="kappa_InternRM2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.827" name="kappa_InternL_RM2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000468835" name="K_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0269484" name="K_cAMP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00104692" name="K_AC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0173912" name="K_AC_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="89.6863" name="K_Gsa_GTP_AC" public_interface="out" units="per_fmol"/>
<variable initial_value="455.632" name="K_Gsa_GTP_AC_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00559939" name="K_FSK_AC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0776636" name="K_FSK_AC_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="1.22691" name="K_PDE" public_interface="out" units="per_fmol"/>
<variable initial_value="1.47858" name="K_PDE_cAMP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0269484" name="K_five_AMP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0248378" name="K_IBMX" public_interface="out" units="per_fmol"/>
<variable initial_value="31.4489" name="K_PDEinh" public_interface="out" units="per_fmol"/>
<variable initial_value="6225.76" name="K_Gsa_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00353358" name="K_FSK" public_interface="out" units="per_fmol"/>
<variable initial_value="11988.9" name="K_Gia_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="4317.71" name="K_ACinh" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00050574" name="K_PPi" public_interface="out" units="per_fmol"/>
<variable initial_value="0.487441" name="K_L_B1" public_interface="out" units="per_fmol"/>
<variable initial_value="7.12061e+15" name="K_RB1" public_interface="out" units="per_fmol"/>
<variable initial_value="4.13849e-12" name="K_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="3.34528e+07" name="K_RB1_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="3.40285e+16" name="K_L_RB1" public_interface="out" units="per_fmol"/>
<variable initial_value="300355" name="K_L_RB1_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="106886" name="K_Gsbetagamma" public_interface="out" units="per_fmol"/>
<variable initial_value="1.36191e-11" name="K_Gsa_GDP" public_interface="out" units="per_fmol"/>
<variable initial_value="1.6611e+09" name="K_Pi" public_interface="out" units="per_fmol"/>
<variable initial_value="8.20088" name="K_RB1_aby" public_interface="out" units="per_fmol"/>
<variable initial_value="1.91155e-06" name="K_RB1_abyT" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0736315" name="K_L_RB1_aby" public_interface="out" units="per_fmol"/>
<variable initial_value="1.71628e-08" name="K_L_RB1_abyT" public_interface="out" units="per_fmol"/>
<variable initial_value="0.677589" name="K_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0011858" name="K_GDP" public_interface="out" units="per_fmol"/>
<variable initial_value="1.51718e-23" name="K_RB1_tag" public_interface="out" units="per_fmol"/>
<variable initial_value="1.3622e-25" name="K_L_RB1_tag" public_interface="out" units="per_fmol"/>
<variable initial_value="6.91916e-07" name="K_RB1_GRKArr" public_interface="out" units="per_fmol"/>
<variable initial_value="6.21236e-09" name="K_L_RB1_GRKArr" public_interface="out" units="per_fmol"/>
<variable initial_value="1.32574e+23" name="K_GRKArr" public_interface="out" units="per_fmol"/>
<variable initial_value="0.000940441" name="K_L_M2" public_interface="out" units="per_fmol"/>
<variable initial_value="1.33817e+15" name="K_RM2" public_interface="out" units="per_fmol"/>
<variable initial_value="9.17186e-12" name="K_Gi" public_interface="out" units="per_fmol"/>
<variable initial_value="1.26662e+07" name="K_RM2_Gi" public_interface="out" units="per_fmol"/>
<variable initial_value="4.76203e+14" name="K_L_RM2" public_interface="out" units="per_fmol"/>
<variable initial_value="344318" name="K_L_RM2_Gi" public_interface="out" units="per_fmol"/>
<variable initial_value="123012" name="K_Gibetagamma" public_interface="out" units="per_fmol"/>
<variable initial_value="2.62263e-11" name="K_Gia_GDP" public_interface="out" units="per_fmol"/>
<variable initial_value="3.1051" name="K_RM2_aby" public_interface="out" units="per_fmol"/>
<variable initial_value="7.2377e-07" name="K_RM2_abyT" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0844089" name="K_L_RM2_aby" public_interface="out" units="per_fmol"/>
<variable initial_value="1.96749e-08" name="K_L_RM2_abyT" public_interface="out" units="per_fmol"/>
<variable initial_value="1.65888e-23" name="K_RM2_tag" public_interface="out" units="per_fmol"/>
<variable initial_value="2.25475e-23" name="K_L_RM2_tag" public_interface="out" units="per_fmol"/>
<variable initial_value="7.56541e-07" name="K_RM2_GRKArr" public_interface="out" units="per_fmol"/>
<variable initial_value="1.02829e-06" name="K_L_RM2_GRKArr" public_interface="out" units="per_fmol"/>
</component>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
<variable initial_value="34.4" name="vol_myo" public_interface="out" units="pL"/>
<variable initial_value="500" name="freq" units="dimensionless"/>
<!-- stimulus
ramp UP and ramp DOWN-->
<variable initial_value="3.5e-4" name="stimSt" units="second"/>
<variable initial_value="0.25e-4" name="stimDur" units="second"/>
<variable initial_value="1.8e-4" name="tRamp" units="second"/>
<variable initial_value="1e1" name="stimMag" units="fmol"/>
<variable initial_value="1e-5" name="stimHolding" units="fmol"/>
<variable name="m" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m</ci>
<apply>
<divide/>
<ci>stimMag</ci>
<ci>tRamp</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_B1_init</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<ci>m</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<ci>tRamp</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<apply>
<gt/>
<ci>time</ci>
<apply>
<minus/>
<ci>stimSt</ci>
<ci>tRamp</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimMag</ci>
<ci>stimHolding</ci>
</apply>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<ci>tRamp</ci>
</apply>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>tRamp</ci>
<ci>stimDur</ci>
</apply>
</apply>
<apply>
<geq/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>stimHolding</ci>
</otherwise>
</piecewise>
</apply>
</math>
<variable initial_value="190" name="q_ATP_init" units="fmol"/>
<variable initial_value="1.889e-3" name="q_cAMP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_AC_init" units="fmol"/>
<variable initial_value="1e-18" name="q_AC_ATP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gsa_GTP_AC_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gsa_GTP_AC_ATP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_FSK_AC_init" units="fmol"/>
<variable initial_value="1e-18" name="q_FSK_AC_ATP_init" units="fmol"/>
<variable initial_value="1.482e-3" name="q_PDE_init" units="fmol"/>
<variable initial_value="1e-18" name="q_PDE_cAMP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_five_AMP_init" units="fmol"/>
<variable initial_value="3.8e-2" name="q_IBMX_init" units="fmol"/>
<variable initial_value="1e-18" name="q_PDEinh_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gsa_GTP_init" units="fmol"/>
<variable initial_value="3.8e-5" name="q_FSK_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gia_GTP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_ACinh_init" units="fmol"/>
<variable initial_value="1e-18" name="q_PPi_init" units="fmol"/>
<variable name="q_L_B1_init" units="fmol"/>
<variable initial_value="0.0004579000" name="q_RB1_init" units="fmol"/>
<variable initial_value="0.1455400000" name="q_Gs_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_Gs_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_Gs_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gsbetagamma_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gsa_GDP_init" units="fmol"/>
<variable initial_value="570" name="q_Pi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_aby_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_abyT_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_aby_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_abyT_init" units="fmol"/>
<variable initial_value="2.2" name="q_GTP_init" units="fmol"/>
<variable initial_value="1.1" name="q_GDP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_tag_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_tag_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_GRKArr_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_GRKArr_init" units="fmol"/>
<variable initial_value="1" name="q_GRKArr_init" units="fmol"/>
<variable name="q_L_M2_init" units="fmol"/>
<variable initial_value="0.00072" name="q_RM2_init" units="fmol"/>
<variable initial_value="0.00836" name="q_Gi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RM2_Gi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RM2_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RM2_Gi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gibetagamma_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gia_GDP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RM2_aby_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RM2_abyT_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RM2_aby_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RM2_abyT_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RM2_tag_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RM2_tag_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RM2_GRKArr_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RM2_GRKArr_init" units="fmol"/>
<!-- mass conservation checks-->
<variable name="L_B1_T" units="fmol"/>
<variable name="R_B1_T" units="fmol"/>
<variable name="Gs_T" units="fmol"/>
<variable name="adenosine_T" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>L_B1_T</ci>
<apply>
<plus/>
<ci>q_L_B1</ci>
<ci>q_LR_B1Gs</ci>
<ci>q_LR_B1</ci>
<ci>q_LR_B1_aby</ci>
<ci>q_LR_B1_aby_T</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>R_B1_T</ci>
<apply>
<plus/>
<ci>q_R_B1</ci>
<ci>q_R_B1Gs</ci>
<ci>q_LR_B1</ci>
<ci>q_LR_B1Gs</ci>
<ci>q_R_B1_aby</ci>
<ci>q_R_B1_aby_T</ci>
<ci>q_LR_B1_aby</ci>
<ci>q_LR_B1_aby_T</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Gs_T</ci>
<apply>
<plus/>
<ci>q_Gs</ci>
<ci>q_R_B1Gs</ci>
<ci>q_LR_B1Gs</ci>
<ci>q_a_Gs_GTP</ci>
<ci>q_a_Gs_GDP</ci>
<ci>q_R_B1_aby</ci>
<ci>q_R_B1_aby_T</ci>
<ci>q_LR_B1_aby</ci>
<ci>q_LR_B1_aby_T</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>adenosine_T</ci>
<apply>
<plus/>
<ci>q_cAMP</ci>
<ci>q_PDE_cAMP</ci>
<ci>q_five_AMP</ci>
<ci>q_ATP</ci>
<ci>q_AC_ATP</ci>
<ci>q_a_Gs_GTP_AC_ATP</ci>
<ci>q_FSK_AC_ATP</ci>
</apply>
</apply>
</math>
<!-- Global value-->
<variable name="q_ATP" public_interface="out" units="fmol"/>
<variable name="q_cAMP" public_interface="out" units="fmol"/>
<variable name="q_AC" public_interface="out" units="fmol"/>
<variable name="q_AC_ATP" public_interface="out" units="fmol"/>
<variable name="q_Gsa_GTP_AC" public_interface="out" units="fmol"/>
<variable name="q_Gsa_GTP_AC_ATP" public_interface="out" units="fmol"/>
<variable name="q_FSK_AC" public_interface="out" units="fmol"/>
<variable name="q_FSK_AC_ATP" public_interface="out" units="fmol"/>
<variable name="q_PDE" public_interface="out" units="fmol"/>
<variable name="q_PDE_cAMP" public_interface="out" units="fmol"/>
<variable name="q_five_AMP" public_interface="out" units="fmol"/>
<variable name="q_IBMX" public_interface="out" units="fmol"/>
<variable name="q_PDEinh" public_interface="out" units="fmol"/>
<variable name="q_Gsa_GTP" public_interface="out" units="fmol"/>
<variable name="q_FSK" public_interface="out" units="fmol"/>
<variable name="q_Gia_GTP" public_interface="out" units="fmol"/>
<variable name="q_ACinh" public_interface="out" units="fmol"/>
<variable name="q_PPi" public_interface="out" units="fmol"/>
<variable name="q_L_B1" public_interface="out" units="fmol"/>
<variable name="q_RB1" public_interface="out" units="fmol"/>
<variable name="q_Gs" public_interface="out" units="fmol"/>
<variable name="q_RB1_Gs" public_interface="out" units="fmol"/>
<variable name="q_L_RB1" public_interface="out" units="fmol"/>
<variable name="q_L_RB1_Gs" public_interface="out" units="fmol"/>
<variable name="q_Gsbetagamma" public_interface="out" units="fmol"/>
<variable name="q_Gsa_GDP" public_interface="out" units="fmol"/>
<variable name="q_Pi" public_interface="out" units="fmol"/>
<variable name="q_RB1_aby" public_interface="out" units="fmol"/>
<variable name="q_RB1_abyT" public_interface="out" units="fmol"/>
<variable name="q_L_RB1_aby" public_interface="out" units="fmol"/>
<variable name="q_L_RB1_abyT" public_interface="out" units="fmol"/>
<variable name="q_GTP" public_interface="out" units="fmol"/>
<variable name="q_GDP" public_interface="out" units="fmol"/>
<variable name="q_RB1_tag" public_interface="out" units="fmol"/>
<variable name="q_L_RB1_tag" public_interface="out" units="fmol"/>
<variable name="q_RB1_GRKArr" public_interface="out" units="fmol"/>
<variable name="q_L_RB1_GRKArr" public_interface="out" units="fmol"/>
<variable name="q_GRKArr" public_interface="out" units="fmol"/>
<variable name="q_L_M2" public_interface="out" units="fmol"/>
<variable name="q_RM2" public_interface="out" units="fmol"/>
<variable name="q_Gi" public_interface="out" units="fmol"/>
<variable name="q_RM2_Gi" public_interface="out" units="fmol"/>
<variable name="q_L_RM2" public_interface="out" units="fmol"/>
<variable name="q_L_RM2_Gi" public_interface="out" units="fmol"/>
<variable name="q_Gibetagamma" public_interface="out" units="fmol"/>
<variable name="q_Gia_GDP" public_interface="out" units="fmol"/>
<variable name="q_RM2_aby" public_interface="out" units="fmol"/>
<variable name="q_RM2_abyT" public_interface="out" units="fmol"/>
<variable name="q_L_RM2_aby" public_interface="out" units="fmol"/>
<variable name="q_L_RM2_abyT" public_interface="out" units="fmol"/>
<variable name="q_RM2_tag" public_interface="out" units="fmol"/>
<variable name="q_L_RM2_tag" public_interface="out" units="fmol"/>
<variable name="q_RM2_GRKArr" public_interface="out" units="fmol"/>
<variable name="q_L_RM2_GRKArr" public_interface="out" units="fmol"/>
<!-- cAMP imports-->
<variable name="q_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_cAMP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_AC_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GTP_AC_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GTP_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_FSK_AC_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_FSK_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PDE_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PDE_cAMP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_five_AMP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_IBMX_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PDEinh_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GTP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_FSK_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_Gia_GTP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_ACinh_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PPi_mcAMP" public_interface="in" units="fmol"/>
<!-- GPCR_B1AR imports-->
<variable name="q_L_B1_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_RB1_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_Gs_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_RB1_Gs_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_Gs_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GTP_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_Gsbetagamma_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GDP_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_Pi_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_RB1_aby_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_RB1_abyT_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_aby_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_abyT_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_GTP_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_GDP_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_RB1_tag_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_tag_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_RB1_GRKArr_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_GRKArr_mGPCR_B1AR" public_interface="in" units="fmol"/>
<variable name="q_GRKArr_mGPCR_B1AR" public_interface="in" units="fmol"/>
<!-- GPCR_M2 imports-->
<variable name="q_L_M2_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_RM2_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_Gi_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_RM2_Gi_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_L_RM2_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_L_RM2_Gi_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_Gia_GTP_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_Gibetagamma_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_Gia_GDP_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_Pi_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_RM2_aby_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_RM2_abyT_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_L_RM2_aby_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_L_RM2_abyT_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_GTP_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_GDP_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_RM2_tag_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_L_RM2_tag_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_RM2_GRKArr_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_L_RM2_GRKArr_mGPCR_M2" public_interface="in" units="fmol"/>
<variable name="q_GRKArr_mGPCR_M2" public_interface="in" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_ATP</ci>
<apply>
<plus/>
<ci>q_ATP_init</ci>
<ci>q_ATP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_cAMP</ci>
<apply>
<plus/>
<ci>q_cAMP_init</ci>
<ci>q_cAMP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_AC</ci>
<apply>
<plus/>
<ci>q_AC_init</ci>
<ci>q_AC_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_AC_ATP</ci>
<apply>
<plus/>
<ci>q_AC_ATP_init</ci>
<ci>q_AC_ATP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gsa_GTP_AC</ci>
<apply>
<plus/>
<ci>q_Gsa_GTP_AC_init</ci>
<ci>q_Gsa_GTP_AC_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gsa_GTP_AC_ATP</ci>
<apply>
<plus/>
<ci>q_Gsa_GTP_AC_ATP_init</ci>
<ci>q_Gsa_GTP_AC_ATP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_FSK_AC</ci>
<apply>
<plus/>
<ci>q_FSK_AC_init</ci>
<ci>q_FSK_AC_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_FSK_AC_ATP</ci>
<apply>
<plus/>
<ci>q_FSK_AC_ATP_init</ci>
<ci>q_FSK_AC_ATP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PDE</ci>
<apply>
<plus/>
<ci>q_PDE_init</ci>
<ci>q_PDE_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PDE_cAMP</ci>
<apply>
<plus/>
<ci>q_PDE_cAMP_init</ci>
<ci>q_PDE_cAMP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_five_AMP</ci>
<apply>
<plus/>
<ci>q_five_AMP_init</ci>
<ci>q_five_AMP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_IBMX</ci>
<apply>
<plus/>
<ci>q_IBMX_init</ci>
<ci>q_IBMX_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PDEinh</ci>
<apply>
<plus/>
<ci>q_PDEinh_init</ci>
<ci>q_PDEinh_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gsa_GTP</ci>
<apply>
<plus/>
<ci>q_Gsa_GTP_init</ci>
<ci>q_Gsa_GTP_mcAMP</ci>
<ci>q_Gsa_GTP_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_FSK</ci>
<apply>
<plus/>
<ci>q_FSK_init</ci>
<ci>q_FSK_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gia_GTP</ci>
<apply>
<plus/>
<ci>q_Gia_GTP_init</ci>
<ci>q_Gia_GTP_mcAMP</ci>
<ci>q_Gia_GTP_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_ACinh</ci>
<apply>
<plus/>
<ci>q_ACinh_init</ci>
<ci>q_ACinh_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PPi</ci>
<apply>
<plus/>
<ci>q_PPi_init</ci>
<ci>q_PPi_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_B1</ci>
<apply>
<plus/>
<ci>q_L_B1_init</ci>
<ci>q_L_B1_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1</ci>
<apply>
<plus/>
<ci>q_RB1_init</ci>
<ci>q_RB1_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gs</ci>
<apply>
<plus/>
<ci>q_Gs_init</ci>
<ci>q_Gs_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1_Gs</ci>
<apply>
<plus/>
<ci>q_RB1_Gs_init</ci>
<ci>q_RB1_Gs_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1</ci>
<apply>
<plus/>
<ci>q_L_RB1_init</ci>
<ci>q_L_RB1_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1_Gs</ci>
<apply>
<plus/>
<ci>q_L_RB1_Gs_init</ci>
<ci>q_L_RB1_Gs_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gsbetagamma</ci>
<apply>
<plus/>
<ci>q_Gsbetagamma_init</ci>
<ci>q_Gsbetagamma_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gsa_GDP</ci>
<apply>
<plus/>
<ci>q_Gsa_GDP_init</ci>
<ci>q_Gsa_GDP_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Pi</ci>
<apply>
<plus/>
<ci>q_Pi_init</ci>
<ci>q_Pi_mGPCR_B1AR</ci>
<ci>q_Pi_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1_aby</ci>
<apply>
<plus/>
<ci>q_RB1_aby_init</ci>
<ci>q_RB1_aby_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1_abyT</ci>
<apply>
<plus/>
<ci>q_RB1_abyT_init</ci>
<ci>q_RB1_abyT_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1_aby</ci>
<apply>
<plus/>
<ci>q_L_RB1_aby_init</ci>
<ci>q_L_RB1_aby_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1_abyT</ci>
<apply>
<plus/>
<ci>q_L_RB1_abyT_init</ci>
<ci>q_L_RB1_abyT_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_GTP</ci>
<apply>
<plus/>
<ci>q_GTP_init</ci>
<ci>q_GTP_mGPCR_B1AR</ci>
<ci>q_GTP_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_GDP</ci>
<apply>
<plus/>
<ci>q_GDP_init</ci>
<ci>q_GDP_mGPCR_B1AR</ci>
<ci>q_GDP_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1_tag</ci>
<apply>
<plus/>
<ci>q_RB1_tag_init</ci>
<ci>q_RB1_tag_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1_tag</ci>
<apply>
<plus/>
<ci>q_L_RB1_tag_init</ci>
<ci>q_L_RB1_tag_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1_GRKArr</ci>
<apply>
<plus/>
<ci>q_RB1_GRKArr_init</ci>
<ci>q_RB1_GRKArr_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1_GRKArr</ci>
<apply>
<plus/>
<ci>q_L_RB1_GRKArr_init</ci>
<ci>q_L_RB1_GRKArr_mGPCR_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_GRKArr</ci>
<apply>
<plus/>
<ci>q_GRKArr_init</ci>
<ci>q_GRKArr_mGPCR_B1AR</ci>
<ci>q_GRKArr_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_M2</ci>
<apply>
<plus/>
<ci>q_L_M2_init</ci>
<ci>q_L_M2_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RM2</ci>
<apply>
<plus/>
<ci>q_RM2_init</ci>
<ci>q_RM2_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gi</ci>
<apply>
<plus/>
<ci>q_Gi_init</ci>
<ci>q_Gi_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RM2_Gi</ci>
<apply>
<plus/>
<ci>q_RM2_Gi_init</ci>
<ci>q_RM2_Gi_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RM2</ci>
<apply>
<plus/>
<ci>q_L_RM2_init</ci>
<ci>q_L_RM2_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RM2_Gi</ci>
<apply>
<plus/>
<ci>q_L_RM2_Gi_init</ci>
<ci>q_L_RM2_Gi_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gibetagamma</ci>
<apply>
<plus/>
<ci>q_Gibetagamma_init</ci>
<ci>q_Gibetagamma_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gia_GDP</ci>
<apply>
<plus/>
<ci>q_Gia_GDP_init</ci>
<ci>q_Gia_GDP_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RM2_aby</ci>
<apply>
<plus/>
<ci>q_RM2_aby_init</ci>
<ci>q_RM2_aby_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RM2_abyT</ci>
<apply>
<plus/>
<ci>q_RM2_abyT_init</ci>
<ci>q_RM2_abyT_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RM2_aby</ci>
<apply>
<plus/>
<ci>q_L_RM2_aby_init</ci>
<ci>q_L_RM2_aby_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RM2_abyT</ci>
<apply>
<plus/>
<ci>q_L_RM2_abyT_init</ci>
<ci>q_L_RM2_abyT_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RM2_tag</ci>
<apply>
<plus/>
<ci>q_RM2_tag_init</ci>
<ci>q_RM2_tag_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RM2_tag</ci>
<apply>
<plus/>
<ci>q_L_RM2_tag_init</ci>
<ci>q_L_RM2_tag_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RM2_GRKArr</ci>
<apply>
<plus/>
<ci>q_RM2_GRKArr_init</ci>
<ci>q_RM2_GRKArr_mGPCR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RM2_GRKArr</ci>
<apply>
<plus/>
<ci>q_L_RM2_GRKArr_init</ci>
<ci>q_L_RM2_GRKArr_mGPCR_M2</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="cAMP"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_ATP_mcAMP" variable_2="q_ATP"/>
<map_variables variable_1="q_ATP" variable_2="q_ATP_global"/>
<map_variables variable_1="q_cAMP_mcAMP" variable_2="q_cAMP"/>
<map_variables variable_1="q_cAMP" variable_2="q_cAMP_global"/>
<map_variables variable_1="q_AC_mcAMP" variable_2="q_AC"/>
<map_variables variable_1="q_AC" variable_2="q_AC_global"/>
<map_variables variable_1="q_AC_ATP_mcAMP" variable_2="q_AC_ATP"/>
<map_variables variable_1="q_AC_ATP" variable_2="q_AC_ATP_global"/>
<map_variables variable_1="q_Gsa_GTP_AC_mcAMP" variable_2="q_Gsa_GTP_AC"/>
<map_variables variable_1="q_Gsa_GTP_AC" variable_2="q_Gsa_GTP_AC_global"/>
<map_variables variable_1="q_Gsa_GTP_AC_ATP_mcAMP" variable_2="q_Gsa_GTP_AC_ATP"/>
<map_variables variable_1="q_Gsa_GTP_AC_ATP" variable_2="q_Gsa_GTP_AC_ATP_global"/>
<map_variables variable_1="q_FSK_AC_mcAMP" variable_2="q_FSK_AC"/>
<map_variables variable_1="q_FSK_AC" variable_2="q_FSK_AC_global"/>
<map_variables variable_1="q_FSK_AC_ATP_mcAMP" variable_2="q_FSK_AC_ATP"/>
<map_variables variable_1="q_FSK_AC_ATP" variable_2="q_FSK_AC_ATP_global"/>
<map_variables variable_1="q_PDE_mcAMP" variable_2="q_PDE"/>
<map_variables variable_1="q_PDE" variable_2="q_PDE_global"/>
<map_variables variable_1="q_PDE_cAMP_mcAMP" variable_2="q_PDE_cAMP"/>
<map_variables variable_1="q_PDE_cAMP" variable_2="q_PDE_cAMP_global"/>
<map_variables variable_1="q_five_AMP_mcAMP" variable_2="q_five_AMP"/>
<map_variables variable_1="q_five_AMP" variable_2="q_five_AMP_global"/>
<map_variables variable_1="q_IBMX_mcAMP" variable_2="q_IBMX"/>
<map_variables variable_1="q_IBMX" variable_2="q_IBMX_global"/>
<map_variables variable_1="q_PDEinh_mcAMP" variable_2="q_PDEinh"/>
<map_variables variable_1="q_PDEinh" variable_2="q_PDEinh_global"/>
<map_variables variable_1="q_Gsa_GTP_mcAMP" variable_2="q_Gsa_GTP"/>
<map_variables variable_1="q_Gsa_GTP" variable_2="q_Gsa_GTP_global"/>
<map_variables variable_1="q_FSK_mcAMP" variable_2="q_FSK"/>
<map_variables variable_1="q_FSK" variable_2="q_FSK_global"/>
<map_variables variable_1="q_Gia_GTP_mcAMP" variable_2="q_Gia_GTP"/>
<map_variables variable_1="q_Gia_GTP" variable_2="q_Gia_GTP_global"/>
<map_variables variable_1="q_ACinh_mcAMP" variable_2="q_ACinh"/>
<map_variables variable_1="q_ACinh" variable_2="q_ACinh_global"/>
<map_variables variable_1="q_PPi_mcAMP" variable_2="q_PPi"/>
<map_variables variable_1="q_PPi" variable_2="q_PPi_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="GPCR_B1AR"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_L_B1_mGPCR_B1AR" variable_2="q_L_B1"/>
<map_variables variable_1="q_L_B1" variable_2="q_L_B1_global"/>
<map_variables variable_1="q_RB1_mGPCR_B1AR" variable_2="q_RB1"/>
<map_variables variable_1="q_RB1" variable_2="q_RB1_global"/>
<map_variables variable_1="q_Gs_mGPCR_B1AR" variable_2="q_Gs"/>
<map_variables variable_1="q_Gs" variable_2="q_Gs_global"/>
<map_variables variable_1="q_RB1_Gs_mGPCR_B1AR" variable_2="q_RB1_Gs"/>
<map_variables variable_1="q_RB1_Gs" variable_2="q_RB1_Gs_global"/>
<map_variables variable_1="q_L_RB1_mGPCR_B1AR" variable_2="q_L_RB1"/>
<map_variables variable_1="q_L_RB1" variable_2="q_L_RB1_global"/>
<map_variables variable_1="q_L_RB1_Gs_mGPCR_B1AR" variable_2="q_L_RB1_Gs"/>
<map_variables variable_1="q_L_RB1_Gs" variable_2="q_L_RB1_Gs_global"/>
<map_variables variable_1="q_Gsa_GTP_mGPCR_B1AR" variable_2="q_Gsa_GTP"/>
<map_variables variable_1="q_Gsa_GTP" variable_2="q_Gsa_GTP_global"/>
<map_variables variable_1="q_Gsbetagamma_mGPCR_B1AR" variable_2="q_Gsbetagamma"/>
<map_variables variable_1="q_Gsbetagamma" variable_2="q_Gsbetagamma_global"/>
<map_variables variable_1="q_Gsa_GDP_mGPCR_B1AR" variable_2="q_Gsa_GDP"/>
<map_variables variable_1="q_Gsa_GDP" variable_2="q_Gsa_GDP_global"/>
<map_variables variable_1="q_Pi_mGPCR_B1AR" variable_2="q_Pi"/>
<map_variables variable_1="q_Pi" variable_2="q_Pi_global"/>
<map_variables variable_1="q_RB1_aby_mGPCR_B1AR" variable_2="q_RB1_aby"/>
<map_variables variable_1="q_RB1_aby" variable_2="q_RB1_aby_global"/>
<map_variables variable_1="q_RB1_abyT_mGPCR_B1AR" variable_2="q_RB1_abyT"/>
<map_variables variable_1="q_RB1_abyT" variable_2="q_RB1_abyT_global"/>
<map_variables variable_1="q_L_RB1_aby_mGPCR_B1AR" variable_2="q_L_RB1_aby"/>
<map_variables variable_1="q_L_RB1_aby" variable_2="q_L_RB1_aby_global"/>
<map_variables variable_1="q_L_RB1_abyT_mGPCR_B1AR" variable_2="q_L_RB1_abyT"/>
<map_variables variable_1="q_L_RB1_abyT" variable_2="q_L_RB1_abyT_global"/>
<map_variables variable_1="q_GTP_mGPCR_B1AR" variable_2="q_GTP"/>
<map_variables variable_1="q_GTP" variable_2="q_GTP_global"/>
<map_variables variable_1="q_GDP_mGPCR_B1AR" variable_2="q_GDP"/>
<map_variables variable_1="q_GDP" variable_2="q_GDP_global"/>
<map_variables variable_1="q_RB1_tag_mGPCR_B1AR" variable_2="q_RB1_tag"/>
<map_variables variable_1="q_RB1_tag" variable_2="q_RB1_tag_global"/>
<map_variables variable_1="q_L_RB1_tag_mGPCR_B1AR" variable_2="q_L_RB1_tag"/>
<map_variables variable_1="q_L_RB1_tag" variable_2="q_L_RB1_tag_global"/>
<map_variables variable_1="q_RB1_GRKArr_mGPCR_B1AR" variable_2="q_RB1_GRKArr"/>
<map_variables variable_1="q_RB1_GRKArr" variable_2="q_RB1_GRKArr_global"/>
<map_variables variable_1="q_L_RB1_GRKArr_mGPCR_B1AR" variable_2="q_L_RB1_GRKArr"/>
<map_variables variable_1="q_L_RB1_GRKArr" variable_2="q_L_RB1_GRKArr_global"/>
<map_variables variable_1="q_GRKArr_mGPCR_B1AR" variable_2="q_GRKArr"/>
<map_variables variable_1="q_GRKArr" variable_2="q_GRKArr_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="GPCR_M2"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_L_M2_mGPCR_M2" variable_2="q_L_M2"/>
<map_variables variable_1="q_L_M2" variable_2="q_L_M2_global"/>
<map_variables variable_1="q_RM2_mGPCR_M2" variable_2="q_RM2"/>
<map_variables variable_1="q_RM2" variable_2="q_RM2_global"/>
<map_variables variable_1="q_Gi_mGPCR_M2" variable_2="q_Gi"/>
<map_variables variable_1="q_Gi" variable_2="q_Gi_global"/>
<map_variables variable_1="q_RM2_Gi_mGPCR_M2" variable_2="q_RM2_Gi"/>
<map_variables variable_1="q_RM2_Gi" variable_2="q_RM2_Gi_global"/>
<map_variables variable_1="q_L_RM2_mGPCR_M2" variable_2="q_L_RM2"/>
<map_variables variable_1="q_L_RM2" variable_2="q_L_RM2_global"/>
<map_variables variable_1="q_L_RM2_Gi_mGPCR_M2" variable_2="q_L_RM2_Gi"/>
<map_variables variable_1="q_L_RM2_Gi" variable_2="q_L_RM2_Gi_global"/>
<map_variables variable_1="q_Gia_GTP_mGPCR_M2" variable_2="q_Gia_GTP"/>
<map_variables variable_1="q_Gia_GTP" variable_2="q_Gia_GTP_global"/>
<map_variables variable_1="q_Gibetagamma_mGPCR_M2" variable_2="q_Gibetagamma"/>
<map_variables variable_1="q_Gibetagamma" variable_2="q_Gibetagamma_global"/>
<map_variables variable_1="q_Gia_GDP_mGPCR_M2" variable_2="q_Gia_GDP"/>
<map_variables variable_1="q_Gia_GDP" variable_2="q_Gia_GDP_global"/>
<map_variables variable_1="q_Pi_mGPCR_M2" variable_2="q_Pi"/>
<map_variables variable_1="q_Pi" variable_2="q_Pi_global"/>
<map_variables variable_1="q_RM2_aby_mGPCR_M2" variable_2="q_RM2_aby"/>
<map_variables variable_1="q_RM2_aby" variable_2="q_RM2_aby_global"/>
<map_variables variable_1="q_RM2_abyT_mGPCR_M2" variable_2="q_RM2_abyT"/>
<map_variables variable_1="q_RM2_abyT" variable_2="q_RM2_abyT_global"/>
<map_variables variable_1="q_L_RM2_aby_mGPCR_M2" variable_2="q_L_RM2_aby"/>
<map_variables variable_1="q_L_RM2_aby" variable_2="q_L_RM2_aby_global"/>
<map_variables variable_1="q_L_RM2_abyT_mGPCR_M2" variable_2="q_L_RM2_abyT"/>
<map_variables variable_1="q_L_RM2_abyT" variable_2="q_L_RM2_abyT_global"/>
<map_variables variable_1="q_GTP_mGPCR_M2" variable_2="q_GTP"/>
<map_variables variable_1="q_GTP" variable_2="q_GTP_global"/>
<map_variables variable_1="q_GDP_mGPCR_M2" variable_2="q_GDP"/>
<map_variables variable_1="q_GDP" variable_2="q_GDP_global"/>
<map_variables variable_1="q_RM2_tag_mGPCR_M2" variable_2="q_RM2_tag"/>
<map_variables variable_1="q_RM2_tag" variable_2="q_RM2_tag_global"/>
<map_variables variable_1="q_L_RM2_tag_mGPCR_M2" variable_2="q_L_RM2_tag"/>
<map_variables variable_1="q_L_RM2_tag" variable_2="q_L_RM2_tag_global"/>
<map_variables variable_1="q_RM2_GRKArr_mGPCR_M2" variable_2="q_RM2_GRKArr"/>
<map_variables variable_1="q_RM2_GRKArr" variable_2="q_RM2_GRKArr_global"/>
<map_variables variable_1="q_L_RM2_GRKArr_mGPCR_M2" variable_2="q_L_RM2_GRKArr"/>
<map_variables variable_1="q_L_RM2_GRKArr" variable_2="q_L_RM2_GRKArr_global"/>
<map_variables variable_1="q_GRKArr_mGPCR_M2" variable_2="q_GRKArr"/>
<map_variables variable_1="q_GRKArr" variable_2="q_GRKArr_global"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="cAMP"/>
<map_variables variable_1="kappa_1a" variable_2="kappa_1a"/>
<map_variables variable_1="kappa_1b" variable_2="kappa_1b"/>
<map_variables variable_1="kappa_2a" variable_2="kappa_2a"/>
<map_variables variable_1="kappa_2b" variable_2="kappa_2b"/>
<map_variables variable_1="kappa_3a" variable_2="kappa_3a"/>
<map_variables variable_1="kappa_3b" variable_2="kappa_3b"/>
<map_variables variable_1="kappa_4a" variable_2="kappa_4a"/>
<map_variables variable_1="kappa_4b" variable_2="kappa_4b"/>
<map_variables variable_1="kappa_5" variable_2="kappa_5"/>
<map_variables variable_1="kappa_6" variable_2="kappa_6"/>
<map_variables variable_1="kappa_7" variable_2="kappa_7"/>
<map_variables variable_1="kappa_GiAC" variable_2="kappa_GiAC"/>
<map_variables variable_1="K_ATP" variable_2="K_ATP"/>
<map_variables variable_1="K_cAMP" variable_2="K_cAMP"/>
<map_variables variable_1="K_AC" variable_2="K_AC"/>
<map_variables variable_1="K_AC_ATP" variable_2="K_AC_ATP"/>
<map_variables variable_1="K_Gsa_GTP_AC" variable_2="K_Gsa_GTP_AC"/>
<map_variables variable_1="K_Gsa_GTP_AC_ATP" variable_2="K_Gsa_GTP_AC_ATP"/>
<map_variables variable_1="K_FSK_AC" variable_2="K_FSK_AC"/>
<map_variables variable_1="K_FSK_AC_ATP" variable_2="K_FSK_AC_ATP"/>
<map_variables variable_1="K_PDE" variable_2="K_PDE"/>
<map_variables variable_1="K_PDE_cAMP" variable_2="K_PDE_cAMP"/>
<map_variables variable_1="K_five_AMP" variable_2="K_five_AMP"/>
<map_variables variable_1="K_IBMX" variable_2="K_IBMX"/>
<map_variables variable_1="K_PDEinh" variable_2="K_PDEinh"/>
<map_variables variable_1="K_Gsa_GTP" variable_2="K_Gsa_GTP"/>
<map_variables variable_1="K_FSK" variable_2="K_FSK"/>
<map_variables variable_1="K_Gia_GTP" variable_2="K_Gia_GTP"/>
<map_variables variable_1="K_ACinh" variable_2="K_ACinh"/>
<map_variables variable_1="K_PPi" variable_2="K_PPi"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="GPCR_B1AR"/>
<map_variables variable_1="kappa_C_B1" variable_2="kappa_C_B1"/>
<map_variables variable_1="kappa_R_B1" variable_2="kappa_R_B1"/>
<map_variables variable_1="kappa_L_B1" variable_2="kappa_L_B1"/>
<map_variables variable_1="kappa_Doff1_Gs" variable_2="kappa_Doff1_Gs"/>
<map_variables variable_1="kappa_Ton1_Gs" variable_2="kappa_Ton1_Gs"/>
<map_variables variable_1="kappa_Act1_Gs" variable_2="kappa_Act1_Gs"/>
<map_variables variable_1="kappa_Doff2_Gs" variable_2="kappa_Doff2_Gs"/>
<map_variables variable_1="kappa_Ton2_Gs" variable_2="kappa_Ton2_Gs"/>
<map_variables variable_1="kappa_Act2_Gs" variable_2="kappa_Act2_Gs"/>
<map_variables variable_1="kappa_Hyd_Gs" variable_2="kappa_Hyd_Gs"/>
<map_variables variable_1="kappa_Reassoc_Gs" variable_2="kappa_Reassoc_Gs"/>
<map_variables variable_1="kappa_PiPhos" variable_2="kappa_PiPhos"/>
<map_variables variable_1="kappa_InternRB1" variable_2="kappa_InternRB1"/>
<map_variables variable_1="kappa_InternL_RB1" variable_2="kappa_InternL_RB1"/>
<map_variables variable_1="K_L_B1" variable_2="K_L_B1"/>
<map_variables variable_1="K_RB1" variable_2="K_RB1"/>
<map_variables variable_1="K_Gs" variable_2="K_Gs"/>
<map_variables variable_1="K_RB1_Gs" variable_2="K_RB1_Gs"/>
<map_variables variable_1="K_L_RB1" variable_2="K_L_RB1"/>
<map_variables variable_1="K_L_RB1_Gs" variable_2="K_L_RB1_Gs"/>
<map_variables variable_1="K_Gsa_GTP" variable_2="K_Gsa_GTP"/>
<map_variables variable_1="K_Gsbetagamma" variable_2="K_Gsbetagamma"/>
<map_variables variable_1="K_Gsa_GDP" variable_2="K_Gsa_GDP"/>
<map_variables variable_1="K_Pi" variable_2="K_Pi"/>
<map_variables variable_1="K_RB1_aby" variable_2="K_RB1_aby"/>
<map_variables variable_1="K_RB1_abyT" variable_2="K_RB1_abyT"/>
<map_variables variable_1="K_L_RB1_aby" variable_2="K_L_RB1_aby"/>
<map_variables variable_1="K_L_RB1_abyT" variable_2="K_L_RB1_abyT"/>
<map_variables variable_1="K_GTP" variable_2="K_GTP"/>
<map_variables variable_1="K_GDP" variable_2="K_GDP"/>
<map_variables variable_1="K_RB1_tag" variable_2="K_RB1_tag"/>
<map_variables variable_1="K_L_RB1_tag" variable_2="K_L_RB1_tag"/>
<map_variables variable_1="K_RB1_GRKArr" variable_2="K_RB1_GRKArr"/>
<map_variables variable_1="K_L_RB1_GRKArr" variable_2="K_L_RB1_GRKArr"/>
<map_variables variable_1="K_GRKArr" variable_2="K_GRKArr"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="GPCR_M2"/>
<map_variables variable_1="kappa_C_M2" variable_2="kappa_C_M2"/>
<map_variables variable_1="kappa_R_M2" variable_2="kappa_R_M2"/>
<map_variables variable_1="kappa_L_M2" variable_2="kappa_L_M2"/>
<map_variables variable_1="kappa_Doff1_Gi" variable_2="kappa_Doff1_Gi"/>
<map_variables variable_1="kappa_Ton1_Gi" variable_2="kappa_Ton1_Gi"/>
<map_variables variable_1="kappa_Act1_Gi" variable_2="kappa_Act1_Gi"/>
<map_variables variable_1="kappa_Doff2_Gi" variable_2="kappa_Doff2_Gi"/>
<map_variables variable_1="kappa_Ton2_Gi" variable_2="kappa_Ton2_Gi"/>
<map_variables variable_1="kappa_Act2_Gi" variable_2="kappa_Act2_Gi"/>
<map_variables variable_1="kappa_Hyd_Gi" variable_2="kappa_Hyd_Gi"/>
<map_variables variable_1="kappa_Reassoc_Gi" variable_2="kappa_Reassoc_Gi"/>
<map_variables variable_1="kappa_InternRM2" variable_2="kappa_InternRM2"/>
<map_variables variable_1="kappa_InternL_RM2" variable_2="kappa_InternL_RM2"/>
<map_variables variable_1="K_L_M2" variable_2="K_L_M2"/>
<map_variables variable_1="K_RM2" variable_2="K_RM2"/>
<map_variables variable_1="K_Gi" variable_2="K_Gi"/>
<map_variables variable_1="K_RM2_Gi" variable_2="K_RM2_Gi"/>
<map_variables variable_1="K_L_RM2" variable_2="K_L_RM2"/>
<map_variables variable_1="K_L_RM2_Gi" variable_2="K_L_RM2_Gi"/>
<map_variables variable_1="K_Gia_GTP" variable_2="K_Gia_GTP"/>
<map_variables variable_1="K_Gibetagamma" variable_2="K_Gibetagamma"/>
<map_variables variable_1="K_Gia_GDP" variable_2="K_Gia_GDP"/>
<map_variables variable_1="K_Pi" variable_2="K_Pi"/>
<map_variables variable_1="K_RM2_aby" variable_2="K_RM2_aby"/>
<map_variables variable_1="K_RM2_abyT" variable_2="K_RM2_abyT"/>
<map_variables variable_1="K_L_RM2_aby" variable_2="K_L_RM2_aby"/>
<map_variables variable_1="K_L_RM2_abyT" variable_2="K_L_RM2_abyT"/>
<map_variables variable_1="K_GTP" variable_2="K_GTP"/>
<map_variables variable_1="K_GDP" variable_2="K_GDP"/>
<map_variables variable_1="K_RM2_tag" variable_2="K_RM2_tag"/>
<map_variables variable_1="K_L_RM2_tag" variable_2="K_L_RM2_tag"/>
<map_variables variable_1="K_RM2_GRKArr" variable_2="K_RM2_GRKArr"/>
<map_variables variable_1="K_L_RM2_GRKArr" variable_2="K_L_RM2_GRKArr"/>
<map_variables variable_1="K_GRKArr" variable_2="K_GRKArr"/>
</connection>
<connection>
<map_components component_1="constants" component_2="cAMP"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="GPCR_B1AR"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="GPCR_M2"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
</model>
