- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-10-22 11:11:27+13:00
- Desc:
- Adding updated files with GEF action and updated stoichs
- Permanent Source URI:
- https://models.cellml.org/workspace/705/rawfile/b269c5ae6fe9e8354ee5e156585106bf1f41c743/FCU_adenylylCyclase.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="FCU_composite" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="mM" units_ref="mM"/>
<units name="fmol" units_ref="fmol"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="microm3" units_ref="microm3"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
<units name="per_second" units_ref="per_second"/>
<units name="millivolt" units_ref="millivolt"/>
<units name="per_sec" units_ref="per_sec"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="fmol_per_L" units_ref="fmol_per_L"/>
<units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
<units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
<units name="uM" units_ref="uM"/>
<units name="mM_per_sec" units_ref="mM_per_sec"/>
<units name="uM_per_sec" units_ref="uM_per_sec"/>
<units name="pL" units_ref="pL"/>
<units name="m_to_u" units_ref="m_to_u"/>
</import>
<import xlink:href="units_and_constants/constants_BG.cellml">
<component component_ref="constants" name="constants"/>
</import>
<import xlink:href="cAMP/BG_cAMP.cellml">
<component component_ref="cAMP" name="cAMP"/>
</import>
<import xlink:href="LRGbinding_B1AR/BG_LRGbinding_B1AR.cellml">
<component component_ref="LRGbinding_B1AR" name="LRGbinding_B1AR"/>
</import>
<import xlink:href="LRGbinding_M2/BG_LRGbinding_M2.cellml">
<component component_ref="LRGbinding_M2" name="LRGbinding_M2"/>
</import>
<import xlink:href="GsProtein/BG_GsProtein.cellml">
<component component_ref="GsProtein" name="GsProtein"/>
</import>
<import xlink:href="GiProtein/BG_GiProtein.cellml">
<component component_ref="GiProtein" name="GiProtein"/>
</import>
<component name="BG_parameters">
<variable initial_value="1.19049e+06" name="kappa_1a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00248563" name="kappa_1b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="49840.4" name="kappa_2a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.13449" name="kappa_2b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="5.81948e+07" name="kappa_3a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.76684e-17" name="kappa_3b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6013.05" name="kappa_4a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.23128" name="kappa_4b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="220.24" name="kappa_5" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1173.07" name="kappa_6" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="136970" name="kappa_7" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="351.702" name="kappa_GiAC" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1949.85" name="kappa_sig1_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="14.6972" name="kappa_sig2_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="4.76612" name="kappa_sig3_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="48932.3" name="kappa_sig4_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3468.13" name="kappa_sig1_M2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="20.1802" name="kappa_sig2_M2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="82.6965" name="kappa_sig3_M2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="23570" name="kappa_sig4_M2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.363553" name="kappa_act1_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.472994" name="kappa_act2_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0560685" name="kappa_hyd_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1563.43" name="kappa_reassoc_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="428.713" name="kappa_PiPhos" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.10939" name="kappa_act1_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00358651" name="kappa_act2_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.413631" name="kappa_hyd_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3802.06" name="kappa_reassoc_Gi" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.842e-05" name="K_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0154937" name="K_cAMP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.964843" name="K_AC" public_interface="out" units="per_fmol"/>
<variable initial_value="2.33903" name="K_AC_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="2.4781" name="K_aGs_GTP_AC" public_interface="out" units="per_fmol"/>
<variable initial_value="1.83726" name="K_aGs_GTP_AC_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0212235" name="K_FSK_AC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0429592" name="K_FSK_AC_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.907054" name="K_PDE" public_interface="out" units="per_fmol"/>
<variable initial_value="0.628454" name="K_PDE_cAMP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0154937" name="K_five_AMP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0141004" name="K_IBMX" public_interface="out" units="per_fmol"/>
<variable initial_value="13.1991" name="K_PDEinh" public_interface="out" units="per_fmol"/>
<variable initial_value="0.186657" name="K_aGs_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="1.45328e-05" name="K_FSK" public_interface="out" units="per_fmol"/>
<variable initial_value="0.024903" name="K_aGi_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="8.26545" name="K_ACinh" public_interface="out" units="per_fmol"/>
<variable initial_value="0.000128372" name="K_PPi" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0783988" name="K_L_B1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0220282" name="K_R_B1" public_interface="out" units="per_fmol"/>
<variable initial_value="1.31984" name="K_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="9.01184" name="K_LR_B1" public_interface="out" units="per_fmol"/>
<variable initial_value="73.3398" name="K_R_B1Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="56.3705" name="K_LR_B1Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="0.11083" name="K_L_M2" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0323495" name="K_R_M2" public_interface="out" units="per_fmol"/>
<variable initial_value="0.501288" name="K_Gi" public_interface="out" units="per_fmol"/>
<variable initial_value="1.35667" name="K_LR_M2" public_interface="out" units="per_fmol"/>
<variable initial_value="37.7835" name="K_R_M2Gi" public_interface="out" units="per_fmol"/>
<variable initial_value="23.0482" name="K_LR_M2Gi" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0048057" name="K_beta_gamma_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0612439" name="K_aGs_GDP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.546852" name="K_Pi" public_interface="out" units="per_fmol"/>
<variable initial_value="0.000340182" name="K_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0718472" name="K_GDP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0141226" name="K_beta_gamma_Gi" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00843467" name="K_aGi_GDP" public_interface="out" units="per_fmol"/>
</component>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
<variable initial_value="34.4" name="vol_myo" public_interface="out" units="pL"/>
<variable initial_value="500" name="freq" units="dimensionless"/>
<!-- stimulus
ramp UP and ramp DOWN-->
<variable initial_value="3.5e-4" name="stimSt" units="second"/>
<variable initial_value="3e-4" name="stimSt2" units="second"/>
<variable initial_value="0.25e-4" name="stimDur" units="second"/>
<variable initial_value="1.8e-4" name="tRamp" units="second"/>
<variable initial_value="1e1" name="stimMag" units="fmol"/>
<variable initial_value="1e-5" name="stimHolding" units="fmol"/>
<variable name="m" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m</ci>
<apply>
<divide/>
<ci>stimMag</ci>
<ci>tRamp</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_B1_init</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<ci>m</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<ci>tRamp</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<apply>
<gt/>
<ci>time</ci>
<apply>
<minus/>
<ci>stimSt</ci>
<ci>tRamp</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimMag</ci>
<ci>stimHolding</ci>
</apply>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<ci>tRamp</ci>
</apply>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>tRamp</ci>
<ci>stimDur</ci>
</apply>
</apply>
<apply>
<geq/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>stimHolding</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>q_L_M2_init</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<ci>m</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt2</ci>
</apply>
<ci>tRamp</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<ci>time</ci>
<ci>stimSt2</ci>
</apply>
<apply>
<gt/>
<ci>time</ci>
<apply>
<minus/>
<ci>stimSt2</ci>
<ci>tRamp</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimMag</ci>
<ci>stimHolding</ci>
</apply>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stimSt2</ci>
</apply>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt2</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt2</ci>
</apply>
<ci>tRamp</ci>
</apply>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt2</ci>
<ci>tRamp</ci>
<ci>stimDur</ci>
</apply>
</apply>
<apply>
<geq/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt2</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>stimHolding</ci>
</otherwise>
</piecewise>
</apply>
</math>
<variable initial_value="190" name="q_ATP_init" units="fmol"/>
<variable initial_value="1.889E-03" name="q_AC_init" units="fmol"/>
<variable initial_value="1e-18" name="q_cAMP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_AC_ATP_init" units="fmol"/>
<variable initial_value="3.800E-05" name="q_FSK_init" units="fmol"/>
<variable initial_value="1e-18" name="q_FSK_AC_init" units="fmol"/>
<variable initial_value="1e-18" name="q_FSK_AC_ATP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_aGs_GTP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_aGs_GTP_AC_init" units="fmol"/>
<variable initial_value="1e-18" name="q_aGs_GTP_AC_ATP_init" units="fmol"/>
<variable initial_value="1.482E-03" name="q_PDE_init" units="fmol"/>
<variable initial_value="1e-18" name="q_PDEinh_init" units="fmol"/>
<variable initial_value="1e-18" name="q_PDE_cAMP_init" units="fmol"/>
<variable initial_value="3.80E-02" name="q_IBMX_init" units="fmol"/>
<variable initial_value="1e-18" name="q_five_AMP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_aGi_GTP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_ACinh_init" units="fmol"/>
<variable initial_value="1e-18" name="q_PPi_init" units="fmol"/>
<variable initial_value="0.0004579000" name="q_R_B1_init" units="fmol"/>
<variable initial_value="0.1455400000" name="q_Gs_init" units="fmol"/>
<variable name="q_L_B1_init" units="fmol"/>
<variable initial_value="1e-18" name="q_LR_B1_init" units="fmol"/>
<variable initial_value="1e-18" name="q_R_B1Gs_init" units="fmol"/>
<variable initial_value="1e-18" name="q_LR_B1Gs_init" units="fmol"/>
<variable name="q_L_M2_init" units="fmol"/>
<variable initial_value="0.00072" name="q_R_M2_init" units="fmol"/>
<variable initial_value="0.00836" name="q_Gi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_LR_M2_init" units="fmol"/>
<variable initial_value="1e-18" name="q_R_M2Gi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_LR_M2Gi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_beta_gamma_Gs_init" units="fmol"/>
<variable initial_value="1e-18" name="q_aGs_GDP_init" units="fmol"/>
<variable initial_value="570" name="q_Pi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_beta_gamma_Gi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_aGi_GDP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_R_B1GsP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_LR_B1GsP_init" units="fmol"/>
<variable initial_value="2.2" name="q_GTP_init" public_interface="out" units="fmol"/>
<variable initial_value="1.1" name="q_GDP_init" public_interface="out" units="fmol"/>
<!-- mass conservation checks-->
<variable name="L_B1_T" units="fmol"/>
<variable name="L_M2_T" units="fmol"/>
<variable name="R_B1_T" units="fmol"/>
<variable name="R_M2_T" units="fmol"/>
<variable name="Gs_T" units="fmol"/>
<variable name="Gi_T" units="fmol"/>
<variable name="adenosine_T" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>L_B1_T</ci>
<apply>
<plus/>
<ci>q_L_B1</ci>
<ci>q_LR_B1Gs</ci>
<ci>q_LR_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>L_M2_T</ci>
<apply>
<plus/>
<ci>q_L_M2</ci>
<ci>q_LR_M2Gi</ci>
<ci>q_LR_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>R_B1_T</ci>
<apply>
<plus/>
<ci>q_R_B1</ci>
<ci>q_R_B1Gs</ci>
<ci>q_LR_B1</ci>
<ci>q_LR_B1Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>R_M2_T</ci>
<apply>
<plus/>
<ci>q_R_M2</ci>
<ci>q_R_M2Gi</ci>
<ci>q_LR_M2</ci>
<ci>q_LR_M2Gi</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Gs_T</ci>
<apply>
<plus/>
<ci>q_Gs</ci>
<ci>q_R_B1Gs</ci>
<ci>q_LR_B1Gs</ci>
<ci>q_aGs_GTP</ci>
<ci>q_aGs_GDP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Gi_T</ci>
<apply>
<plus/>
<ci>q_Gi</ci>
<ci>q_R_M2Gi</ci>
<ci>q_LR_M2Gi</ci>
<ci>q_aGi_GTP</ci>
<ci>q_aGi_GDP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>adenosine_T</ci>
<apply>
<plus/>
<ci>q_cAMP</ci>
<ci>q_PDE_cAMP</ci>
<ci>q_five_AMP</ci>
<ci>q_ATP</ci>
<ci>q_AC_ATP</ci>
<ci>q_aGs_GTP_AC_ATP</ci>
<ci>q_FSK_AC_ATP</ci>
</apply>
</apply>
</math>
<!-- Global value-->
<variable name="q_ATP" public_interface="out" units="fmol"/>
<variable name="q_cAMP" public_interface="out" units="fmol"/>
<variable name="q_AC" public_interface="out" units="fmol"/>
<variable name="q_AC_ATP" public_interface="out" units="fmol"/>
<variable name="q_aGs_GTP_AC" public_interface="out" units="fmol"/>
<variable name="q_aGs_GTP_AC_ATP" public_interface="out" units="fmol"/>
<variable name="q_FSK_AC" public_interface="out" units="fmol"/>
<variable name="q_FSK_AC_ATP" public_interface="out" units="fmol"/>
<variable name="q_PDE" public_interface="out" units="fmol"/>
<variable name="q_PDE_cAMP" public_interface="out" units="fmol"/>
<variable name="q_five_AMP" public_interface="out" units="fmol"/>
<variable name="q_IBMX" public_interface="out" units="fmol"/>
<variable name="q_PDEinh" public_interface="out" units="fmol"/>
<variable name="q_aGs_GTP" public_interface="out" units="fmol"/>
<variable name="q_FSK" public_interface="out" units="fmol"/>
<variable name="q_aGi_GTP" public_interface="out" units="fmol"/>
<variable name="q_ACinh" public_interface="out" units="fmol"/>
<variable name="q_PPi" public_interface="out" units="fmol"/>
<variable name="q_L_B1" public_interface="out" units="fmol"/>
<variable name="q_R_B1" public_interface="out" units="fmol"/>
<variable name="q_Gs" public_interface="out" units="fmol"/>
<variable name="q_LR_B1" public_interface="out" units="fmol"/>
<variable name="q_R_B1Gs" public_interface="out" units="fmol"/>
<variable name="q_LR_B1Gs" public_interface="out" units="fmol"/>
<variable name="q_L_M2" public_interface="out" units="fmol"/>
<variable name="q_R_M2" public_interface="out" units="fmol"/>
<variable name="q_Gi" public_interface="out" units="fmol"/>
<variable name="q_LR_M2" public_interface="out" units="fmol"/>
<variable name="q_R_M2Gi" public_interface="out" units="fmol"/>
<variable name="q_LR_M2Gi" public_interface="out" units="fmol"/>
<variable name="q_beta_gamma_Gs" public_interface="out" units="fmol"/>
<variable name="q_aGs_GDP" public_interface="out" units="fmol"/>
<variable name="q_Pi" public_interface="out" units="fmol"/>
<variable name="q_GTP" public_interface="out" units="fmol"/>
<variable name="q_GDP" public_interface="out" units="fmol"/>
<variable name="q_beta_gamma_Gi" public_interface="out" units="fmol"/>
<variable name="q_aGi_GDP" public_interface="out" units="fmol"/>
<!-- cAMP imports-->
<variable name="q_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_cAMP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_AC_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_aGs_GTP_AC_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_aGs_GTP_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_FSK_AC_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_FSK_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PDE_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PDE_cAMP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_five_AMP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_IBMX_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PDEinh_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_aGs_GTP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_FSK_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_aGi_GTP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_ACinh_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PPi_mcAMP" public_interface="in" units="fmol"/>
<!-- LRGbinding_B1AR imports-->
<variable name="q_L_B1_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
<variable name="q_R_B1_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
<variable name="q_Gs_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
<variable name="q_LR_B1_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
<variable name="q_R_B1Gs_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
<variable name="q_LR_B1Gs_mLRGbinding_B1AR" public_interface="in" units="fmol"/>
<!-- LRGbinding_M2 imports-->
<variable name="q_L_M2_mLRGbinding_M2" public_interface="in" units="fmol"/>
<variable name="q_R_M2_mLRGbinding_M2" public_interface="in" units="fmol"/>
<variable name="q_Gi_mLRGbinding_M2" public_interface="in" units="fmol"/>
<variable name="q_LR_M2_mLRGbinding_M2" public_interface="in" units="fmol"/>
<variable name="q_R_M2Gi_mLRGbinding_M2" public_interface="in" units="fmol"/>
<variable name="q_LR_M2Gi_mLRGbinding_M2" public_interface="in" units="fmol"/>
<!-- GsProtein imports-->
<variable name="q_R_B1_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_Gs_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_R_B1Gs_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_LR_B1_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_LR_B1Gs_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_aGs_GTP_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_beta_gamma_Gs_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_aGs_GDP_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_Pi_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_GTP_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_GDP_mGsProtein" public_interface="in" units="fmol"/>
<!-- GiProtein imports-->
<variable name="q_R_M2_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_Gi_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_R_M2Gi_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_LR_M2_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_LR_M2Gi_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_aGi_GTP_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_beta_gamma_Gi_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_aGi_GDP_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_Pi_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_GTP_mGiProtein" public_interface="in" units="fmol"/>
<variable name="q_GDP_mGiProtein" public_interface="in" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_ATP</ci>
<apply>
<plus/>
<ci>q_ATP_init</ci>
<ci>q_ATP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_cAMP</ci>
<apply>
<plus/>
<ci>q_cAMP_init</ci>
<ci>q_cAMP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_AC</ci>
<apply>
<plus/>
<ci>q_AC_init</ci>
<ci>q_AC_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_AC_ATP</ci>
<apply>
<plus/>
<ci>q_AC_ATP_init</ci>
<ci>q_AC_ATP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_aGs_GTP_AC</ci>
<apply>
<plus/>
<ci>q_aGs_GTP_AC_init</ci>
<ci>q_aGs_GTP_AC_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_aGs_GTP_AC_ATP</ci>
<apply>
<plus/>
<ci>q_aGs_GTP_AC_ATP_init</ci>
<ci>q_aGs_GTP_AC_ATP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_FSK_AC</ci>
<apply>
<plus/>
<ci>q_FSK_AC_init</ci>
<ci>q_FSK_AC_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_FSK_AC_ATP</ci>
<apply>
<plus/>
<ci>q_FSK_AC_ATP_init</ci>
<ci>q_FSK_AC_ATP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PDE</ci>
<apply>
<plus/>
<ci>q_PDE_init</ci>
<ci>q_PDE_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PDE_cAMP</ci>
<apply>
<plus/>
<ci>q_PDE_cAMP_init</ci>
<ci>q_PDE_cAMP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_five_AMP</ci>
<apply>
<plus/>
<ci>q_five_AMP_init</ci>
<ci>q_five_AMP_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_IBMX</ci>
<apply>
<plus/>
<ci>q_IBMX_init</ci>
<ci>q_IBMX_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PDEinh</ci>
<apply>
<plus/>
<ci>q_PDEinh_init</ci>
<ci>q_PDEinh_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_aGs_GTP</ci>
<apply>
<plus/>
<ci>q_aGs_GTP_init</ci>
<ci>q_aGs_GTP_mcAMP</ci>
<ci>q_aGs_GTP_mGsProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_FSK</ci>
<apply>
<plus/>
<ci>q_FSK_init</ci>
<ci>q_FSK_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_aGi_GTP</ci>
<apply>
<plus/>
<ci>q_aGi_GTP_init</ci>
<ci>q_aGi_GTP_mcAMP</ci>
<ci>q_aGi_GTP_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_ACinh</ci>
<apply>
<plus/>
<ci>q_ACinh_init</ci>
<ci>q_ACinh_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PPi</ci>
<apply>
<plus/>
<ci>q_PPi_init</ci>
<ci>q_PPi_mcAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_B1</ci>
<apply>
<plus/>
<ci>q_L_B1_init</ci>
<ci>q_L_B1_mLRGbinding_B1AR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_R_B1</ci>
<apply>
<plus/>
<ci>q_R_B1_init</ci>
<ci>q_R_B1_mLRGbinding_B1AR</ci>
<ci>q_R_B1_mGsProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gs</ci>
<apply>
<plus/>
<ci>q_Gs_init</ci>
<ci>q_Gs_mLRGbinding_B1AR</ci>
<ci>q_Gs_mGsProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LR_B1</ci>
<apply>
<plus/>
<ci>q_LR_B1_init</ci>
<ci>q_LR_B1_mLRGbinding_B1AR</ci>
<ci>q_LR_B1_mGsProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_R_B1Gs</ci>
<apply>
<plus/>
<ci>q_R_B1Gs_init</ci>
<ci>q_R_B1Gs_mLRGbinding_B1AR</ci>
<ci>q_R_B1Gs_mGsProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LR_B1Gs</ci>
<apply>
<plus/>
<ci>q_LR_B1Gs_init</ci>
<ci>q_LR_B1Gs_mLRGbinding_B1AR</ci>
<ci>q_LR_B1Gs_mGsProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_M2</ci>
<apply>
<plus/>
<ci>q_L_M2_init</ci>
<ci>q_L_M2_mLRGbinding_M2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_R_M2</ci>
<apply>
<plus/>
<ci>q_R_M2_init</ci>
<ci>q_R_M2_mLRGbinding_M2</ci>
<ci>q_R_M2_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gi</ci>
<apply>
<plus/>
<ci>q_Gi_init</ci>
<ci>q_Gi_mLRGbinding_M2</ci>
<ci>q_Gi_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LR_M2</ci>
<apply>
<plus/>
<ci>q_LR_M2_init</ci>
<ci>q_LR_M2_mLRGbinding_M2</ci>
<ci>q_LR_M2_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_R_M2Gi</ci>
<apply>
<plus/>
<ci>q_R_M2Gi_init</ci>
<ci>q_R_M2Gi_mLRGbinding_M2</ci>
<ci>q_R_M2Gi_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LR_M2Gi</ci>
<apply>
<plus/>
<ci>q_LR_M2Gi_init</ci>
<ci>q_LR_M2Gi_mLRGbinding_M2</ci>
<ci>q_LR_M2Gi_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_beta_gamma_Gs</ci>
<apply>
<plus/>
<ci>q_beta_gamma_Gs_init</ci>
<ci>q_beta_gamma_Gs_mGsProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_aGs_GDP</ci>
<apply>
<plus/>
<ci>q_aGs_GDP_init</ci>
<ci>q_aGs_GDP_mGsProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Pi</ci>
<apply>
<plus/>
<ci>q_Pi_init</ci>
<ci>q_Pi_mGsProtein</ci>
<ci>q_Pi_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_GTP</ci>
<apply>
<plus/>
<ci>q_GTP_init</ci>
<ci>q_GTP_mGsProtein</ci>
<ci>q_GTP_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_GDP</ci>
<apply>
<plus/>
<ci>q_GDP_init</ci>
<ci>q_GDP_mGsProtein</ci>
<ci>q_GDP_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_beta_gamma_Gi</ci>
<apply>
<plus/>
<ci>q_beta_gamma_Gi_init</ci>
<ci>q_beta_gamma_Gi_mGiProtein</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_aGi_GDP</ci>
<apply>
<plus/>
<ci>q_aGi_GDP_init</ci>
<ci>q_aGi_GDP_mGiProtein</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="cAMP"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_ATP_mcAMP" variable_2="q_ATP"/>
<map_variables variable_1="q_ATP" variable_2="q_ATP_global"/>
<map_variables variable_1="q_cAMP_mcAMP" variable_2="q_cAMP"/>
<map_variables variable_1="q_cAMP" variable_2="q_cAMP_global"/>
<map_variables variable_1="q_AC_mcAMP" variable_2="q_AC"/>
<map_variables variable_1="q_AC" variable_2="q_AC_global"/>
<map_variables variable_1="q_AC_ATP_mcAMP" variable_2="q_AC_ATP"/>
<map_variables variable_1="q_AC_ATP" variable_2="q_AC_ATP_global"/>
<map_variables variable_1="q_aGs_GTP_AC_mcAMP" variable_2="q_aGs_GTP_AC"/>
<map_variables variable_1="q_aGs_GTP_AC" variable_2="q_aGs_GTP_AC_global"/>
<map_variables variable_1="q_aGs_GTP_AC_ATP_mcAMP" variable_2="q_aGs_GTP_AC_ATP"/>
<map_variables variable_1="q_aGs_GTP_AC_ATP" variable_2="q_aGs_GTP_AC_ATP_global"/>
<map_variables variable_1="q_FSK_AC_mcAMP" variable_2="q_FSK_AC"/>
<map_variables variable_1="q_FSK_AC" variable_2="q_FSK_AC_global"/>
<map_variables variable_1="q_FSK_AC_ATP_mcAMP" variable_2="q_FSK_AC_ATP"/>
<map_variables variable_1="q_FSK_AC_ATP" variable_2="q_FSK_AC_ATP_global"/>
<map_variables variable_1="q_PDE_mcAMP" variable_2="q_PDE"/>
<map_variables variable_1="q_PDE" variable_2="q_PDE_global"/>
<map_variables variable_1="q_PDE_cAMP_mcAMP" variable_2="q_PDE_cAMP"/>
<map_variables variable_1="q_PDE_cAMP" variable_2="q_PDE_cAMP_global"/>
<map_variables variable_1="q_five_AMP_mcAMP" variable_2="q_five_AMP"/>
<map_variables variable_1="q_five_AMP" variable_2="q_five_AMP_global"/>
<map_variables variable_1="q_IBMX_mcAMP" variable_2="q_IBMX"/>
<map_variables variable_1="q_IBMX" variable_2="q_IBMX_global"/>
<map_variables variable_1="q_PDEinh_mcAMP" variable_2="q_PDEinh"/>
<map_variables variable_1="q_PDEinh" variable_2="q_PDEinh_global"/>
<map_variables variable_1="q_aGs_GTP_mcAMP" variable_2="q_aGs_GTP"/>
<map_variables variable_1="q_aGs_GTP" variable_2="q_aGs_GTP_global"/>
<map_variables variable_1="q_FSK_mcAMP" variable_2="q_FSK"/>
<map_variables variable_1="q_FSK" variable_2="q_FSK_global"/>
<map_variables variable_1="q_aGi_GTP_mcAMP" variable_2="q_aGi_GTP"/>
<map_variables variable_1="q_aGi_GTP" variable_2="q_aGi_GTP_global"/>
<map_variables variable_1="q_ACinh_mcAMP" variable_2="q_ACinh"/>
<map_variables variable_1="q_ACinh" variable_2="q_ACinh_global"/>
<map_variables variable_1="q_PPi_mcAMP" variable_2="q_PPi"/>
<map_variables variable_1="q_PPi" variable_2="q_PPi_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="LRGbinding_B1AR"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_L_B1_mLRGbinding_B1AR" variable_2="q_L_B1"/>
<map_variables variable_1="q_L_B1" variable_2="q_L_B1_global"/>
<map_variables variable_1="q_R_B1_mLRGbinding_B1AR" variable_2="q_R_B1"/>
<map_variables variable_1="q_R_B1" variable_2="q_R_B1_global"/>
<map_variables variable_1="q_Gs_mLRGbinding_B1AR" variable_2="q_Gs"/>
<map_variables variable_1="q_Gs" variable_2="q_Gs_global"/>
<map_variables variable_1="q_LR_B1_mLRGbinding_B1AR" variable_2="q_LR_B1"/>
<map_variables variable_1="q_LR_B1" variable_2="q_LR_B1_global"/>
<map_variables variable_1="q_R_B1Gs_mLRGbinding_B1AR" variable_2="q_R_B1Gs"/>
<map_variables variable_1="q_R_B1Gs" variable_2="q_R_B1Gs_global"/>
<map_variables variable_1="q_LR_B1Gs_mLRGbinding_B1AR" variable_2="q_LR_B1Gs"/>
<map_variables variable_1="q_LR_B1Gs" variable_2="q_LR_B1Gs_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="LRGbinding_M2"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_L_M2_mLRGbinding_M2" variable_2="q_L_M2"/>
<map_variables variable_1="q_L_M2" variable_2="q_L_M2_global"/>
<map_variables variable_1="q_R_M2_mLRGbinding_M2" variable_2="q_R_M2"/>
<map_variables variable_1="q_R_M2" variable_2="q_R_M2_global"/>
<map_variables variable_1="q_Gi_mLRGbinding_M2" variable_2="q_Gi"/>
<map_variables variable_1="q_Gi" variable_2="q_Gi_global"/>
<map_variables variable_1="q_LR_M2_mLRGbinding_M2" variable_2="q_LR_M2"/>
<map_variables variable_1="q_LR_M2" variable_2="q_LR_M2_global"/>
<map_variables variable_1="q_R_M2Gi_mLRGbinding_M2" variable_2="q_R_M2Gi"/>
<map_variables variable_1="q_R_M2Gi" variable_2="q_R_M2Gi_global"/>
<map_variables variable_1="q_LR_M2Gi_mLRGbinding_M2" variable_2="q_LR_M2Gi"/>
<map_variables variable_1="q_LR_M2Gi" variable_2="q_LR_M2Gi_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="GsProtein"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_R_B1_mGsProtein" variable_2="q_R_B1"/>
<map_variables variable_1="q_R_B1" variable_2="q_R_B1_global"/>
<map_variables variable_1="q_Gs_mGsProtein" variable_2="q_Gs"/>
<map_variables variable_1="q_Gs" variable_2="q_Gs_global"/>
<map_variables variable_1="q_R_B1Gs_mGsProtein" variable_2="q_R_B1Gs"/>
<map_variables variable_1="q_R_B1Gs" variable_2="q_R_B1Gs_global"/>
<map_variables variable_1="q_LR_B1_mGsProtein" variable_2="q_LR_B1"/>
<map_variables variable_1="q_LR_B1" variable_2="q_LR_B1_global"/>
<map_variables variable_1="q_LR_B1Gs_mGsProtein" variable_2="q_LR_B1Gs"/>
<map_variables variable_1="q_LR_B1Gs" variable_2="q_LR_B1Gs_global"/>
<map_variables variable_1="q_aGs_GTP_mGsProtein" variable_2="q_aGs_GTP"/>
<map_variables variable_1="q_aGs_GTP" variable_2="q_aGs_GTP_global"/>
<map_variables variable_1="q_beta_gamma_Gs_mGsProtein" variable_2="q_beta_gamma_Gs"/>
<map_variables variable_1="q_beta_gamma_Gs" variable_2="q_beta_gamma_Gs_global"/>
<map_variables variable_1="q_aGs_GDP_mGsProtein" variable_2="q_aGs_GDP"/>
<map_variables variable_1="q_aGs_GDP" variable_2="q_aGs_GDP_global"/>
<map_variables variable_1="q_Pi_mGsProtein" variable_2="q_Pi"/>
<map_variables variable_1="q_Pi" variable_2="q_Pi_global"/>
<map_variables variable_1="q_GTP_mGsProtein" variable_2="q_GTP"/>
<map_variables variable_1="q_GTP" variable_2="q_GTP_global"/>
<map_variables variable_1="q_GDP_mGsProtein" variable_2="q_GDP"/>
<map_variables variable_1="q_GDP" variable_2="q_GDP_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="GiProtein"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_R_M2_mGiProtein" variable_2="q_R_M2"/>
<map_variables variable_1="q_R_M2" variable_2="q_R_M2_global"/>
<map_variables variable_1="q_Gi_mGiProtein" variable_2="q_Gi"/>
<map_variables variable_1="q_Gi" variable_2="q_Gi_global"/>
<map_variables variable_1="q_R_M2Gi_mGiProtein" variable_2="q_R_M2Gi"/>
<map_variables variable_1="q_R_M2Gi" variable_2="q_R_M2Gi_global"/>
<map_variables variable_1="q_LR_M2_mGiProtein" variable_2="q_LR_M2"/>
<map_variables variable_1="q_LR_M2" variable_2="q_LR_M2_global"/>
<map_variables variable_1="q_LR_M2Gi_mGiProtein" variable_2="q_LR_M2Gi"/>
<map_variables variable_1="q_LR_M2Gi" variable_2="q_LR_M2Gi_global"/>
<map_variables variable_1="q_aGi_GTP_mGiProtein" variable_2="q_aGi_GTP"/>
<map_variables variable_1="q_aGi_GTP" variable_2="q_aGi_GTP_global"/>
<map_variables variable_1="q_beta_gamma_Gi_mGiProtein" variable_2="q_beta_gamma_Gi"/>
<map_variables variable_1="q_beta_gamma_Gi" variable_2="q_beta_gamma_Gi_global"/>
<map_variables variable_1="q_aGi_GDP_mGiProtein" variable_2="q_aGi_GDP"/>
<map_variables variable_1="q_aGi_GDP" variable_2="q_aGi_GDP_global"/>
<map_variables variable_1="q_Pi_mGiProtein" variable_2="q_Pi"/>
<map_variables variable_1="q_Pi" variable_2="q_Pi_global"/>
<map_variables variable_1="q_GTP_mGiProtein" variable_2="q_GTP"/>
<map_variables variable_1="q_GTP" variable_2="q_GTP_global"/>
<map_variables variable_1="q_GDP_mGiProtein" variable_2="q_GDP"/>
<map_variables variable_1="q_GDP" variable_2="q_GDP_global"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="cAMP"/>
<map_variables variable_1="kappa_1a" variable_2="kappa_1a"/>
<map_variables variable_1="kappa_1b" variable_2="kappa_1b"/>
<map_variables variable_1="kappa_2a" variable_2="kappa_2a"/>
<map_variables variable_1="kappa_2b" variable_2="kappa_2b"/>
<map_variables variable_1="kappa_3a" variable_2="kappa_3a"/>
<map_variables variable_1="kappa_3b" variable_2="kappa_3b"/>
<map_variables variable_1="kappa_4a" variable_2="kappa_4a"/>
<map_variables variable_1="kappa_4b" variable_2="kappa_4b"/>
<map_variables variable_1="kappa_5" variable_2="kappa_5"/>
<map_variables variable_1="kappa_6" variable_2="kappa_6"/>
<map_variables variable_1="kappa_7" variable_2="kappa_7"/>
<map_variables variable_1="kappa_GiAC" variable_2="kappa_GiAC"/>
<map_variables variable_1="K_ATP" variable_2="K_ATP"/>
<map_variables variable_1="K_cAMP" variable_2="K_cAMP"/>
<map_variables variable_1="K_AC" variable_2="K_AC"/>
<map_variables variable_1="K_AC_ATP" variable_2="K_AC_ATP"/>
<map_variables variable_1="K_aGs_GTP_AC" variable_2="K_aGs_GTP_AC"/>
<map_variables variable_1="K_aGs_GTP_AC_ATP" variable_2="K_aGs_GTP_AC_ATP"/>
<map_variables variable_1="K_FSK_AC" variable_2="K_FSK_AC"/>
<map_variables variable_1="K_FSK_AC_ATP" variable_2="K_FSK_AC_ATP"/>
<map_variables variable_1="K_PDE" variable_2="K_PDE"/>
<map_variables variable_1="K_PDE_cAMP" variable_2="K_PDE_cAMP"/>
<map_variables variable_1="K_five_AMP" variable_2="K_five_AMP"/>
<map_variables variable_1="K_IBMX" variable_2="K_IBMX"/>
<map_variables variable_1="K_PDEinh" variable_2="K_PDEinh"/>
<map_variables variable_1="K_aGs_GTP" variable_2="K_aGs_GTP"/>
<map_variables variable_1="K_FSK" variable_2="K_FSK"/>
<map_variables variable_1="K_aGi_GTP" variable_2="K_aGi_GTP"/>
<map_variables variable_1="K_ACinh" variable_2="K_ACinh"/>
<map_variables variable_1="K_PPi" variable_2="K_PPi"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="LRGbinding_B1AR"/>
<map_variables variable_1="kappa_sig1_B1" variable_2="kappa_sig1_B1"/>
<map_variables variable_1="kappa_sig2_B1" variable_2="kappa_sig2_B1"/>
<map_variables variable_1="kappa_sig3_B1" variable_2="kappa_sig3_B1"/>
<map_variables variable_1="kappa_sig4_B1" variable_2="kappa_sig4_B1"/>
<map_variables variable_1="K_L_B1" variable_2="K_L_B1"/>
<map_variables variable_1="K_R_B1" variable_2="K_R_B1"/>
<map_variables variable_1="K_Gs" variable_2="K_Gs"/>
<map_variables variable_1="K_LR_B1" variable_2="K_LR_B1"/>
<map_variables variable_1="K_R_B1Gs" variable_2="K_R_B1Gs"/>
<map_variables variable_1="K_LR_B1Gs" variable_2="K_LR_B1Gs"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="LRGbinding_M2"/>
<map_variables variable_1="kappa_sig1_M2" variable_2="kappa_sig1_M2"/>
<map_variables variable_1="kappa_sig2_M2" variable_2="kappa_sig2_M2"/>
<map_variables variable_1="kappa_sig3_M2" variable_2="kappa_sig3_M2"/>
<map_variables variable_1="kappa_sig4_M2" variable_2="kappa_sig4_M2"/>
<map_variables variable_1="K_L_M2" variable_2="K_L_M2"/>
<map_variables variable_1="K_R_M2" variable_2="K_R_M2"/>
<map_variables variable_1="K_Gi" variable_2="K_Gi"/>
<map_variables variable_1="K_LR_M2" variable_2="K_LR_M2"/>
<map_variables variable_1="K_R_M2Gi" variable_2="K_R_M2Gi"/>
<map_variables variable_1="K_LR_M2Gi" variable_2="K_LR_M2Gi"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="GsProtein"/>
<map_variables variable_1="kappa_act1_Gs" variable_2="kappa_act1_Gs"/>
<map_variables variable_1="kappa_act2_Gs" variable_2="kappa_act2_Gs"/>
<map_variables variable_1="kappa_hyd_Gs" variable_2="kappa_hyd_Gs"/>
<map_variables variable_1="kappa_reassoc_Gs" variable_2="kappa_reassoc_Gs"/>
<map_variables variable_1="kappa_PiPhos" variable_2="kappa_PiPhos"/>
<map_variables variable_1="K_R_B1" variable_2="K_R_B1"/>
<map_variables variable_1="K_Gs" variable_2="K_Gs"/>
<map_variables variable_1="K_R_B1Gs" variable_2="K_R_B1Gs"/>
<map_variables variable_1="K_LR_B1" variable_2="K_LR_B1"/>
<map_variables variable_1="K_LR_B1Gs" variable_2="K_LR_B1Gs"/>
<map_variables variable_1="K_aGs_GTP" variable_2="K_aGs_GTP"/>
<map_variables variable_1="K_beta_gamma_Gs" variable_2="K_beta_gamma_Gs"/>
<map_variables variable_1="K_aGs_GDP" variable_2="K_aGs_GDP"/>
<map_variables variable_1="K_Pi" variable_2="K_Pi"/>
<map_variables variable_1="K_GTP" variable_2="K_GTP"/>
<map_variables variable_1="K_GDP" variable_2="K_GDP"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="GiProtein"/>
<map_variables variable_1="kappa_act1_Gi" variable_2="kappa_act1_Gi"/>
<map_variables variable_1="kappa_act2_Gi" variable_2="kappa_act2_Gi"/>
<map_variables variable_1="kappa_hyd_Gi" variable_2="kappa_hyd_Gi"/>
<map_variables variable_1="kappa_reassoc_Gi" variable_2="kappa_reassoc_Gi"/>
<map_variables variable_1="K_R_M2" variable_2="K_R_M2"/>
<map_variables variable_1="K_Gi" variable_2="K_Gi"/>
<map_variables variable_1="K_R_M2Gi" variable_2="K_R_M2Gi"/>
<map_variables variable_1="K_LR_M2" variable_2="K_LR_M2"/>
<map_variables variable_1="K_LR_M2Gi" variable_2="K_LR_M2Gi"/>
<map_variables variable_1="K_aGi_GTP" variable_2="K_aGi_GTP"/>
<map_variables variable_1="K_beta_gamma_Gi" variable_2="K_beta_gamma_Gi"/>
<map_variables variable_1="K_aGi_GDP" variable_2="K_aGi_GDP"/>
<map_variables variable_1="K_Pi" variable_2="K_Pi"/>
<map_variables variable_1="K_GTP" variable_2="K_GTP"/>
<map_variables variable_1="K_GDP" variable_2="K_GDP"/>
</connection>
<connection>
<map_components component_1="constants" component_2="cAMP"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="LRGbinding_B1AR"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="LRGbinding_M2"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="GsProtein"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="GiProtein"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
</model>
