- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-11-10 14:21:38+13:00
- Desc:
- h
- Permanent Source URI:
- https://models.cellml.org/workspace/705/rawfile/b9271799f470c9b416216708e310ff63b44017a2/exposure/exposure_frontpage.rst
About this model
====================
This is a Functional Cell Unit for adenylyl cyclase metabolism in the cardiac cell.
Model status
=============
The current CellML implementation runs in OpenCOR.
Model overview
===================
All components are presented in `bond-graph` form.
Components are made by converting an existing kinetic model and translating into bond-graph form.
.. figure:: exposure/FCU_picture.png
:width: 25%
:align: center
:alt: Components of the model
Components of the model.
A description of the process to find bond-graph parameter is shown in the folder `parameter_finder <parameter_finder>`_, which relies on:
1. stoichiometry of system
2. kinetic constants for forward/reverse reactions
- If not already, all reactions are made reversible by assigning a small value to the reverse direction.
3. linear algebra script. Here, this solver is performed in Python.
Modular description
===================
Components
----------
CellML divides the mathematical model into distinct components, which are able to be re-used in other composite models.
These CellML components are:
- `:math:{\beta}-1 adrenergic receptor ( :math:{\beta} 1AR) <https://models.physiomeproject.org/workspace/6f7>`_
- `Gs Protein <https://models.physiomeproject.org/workspace/6f8>`_
- `muscarinic receptor (M2) <https://models.physiomeproject.org/workspace/707>`_
- `Gi Protein <https://models.physiomeproject.org/workspace/6f9>`_
- `cyclic AMP (cAMP) <https://models.physiomeproject.org/workspace/674>`_
.. csv-table:: Origin of kinetic model components
:header: "Source", "Components"
:widths: 15, 30
"`Saucerman et al. <https://models.physiomeproject.org/exposure/9766d9bd0325c31e47a31b291e26ccad>`_", ":math:`{\beta}` 1AR, Gs Protein, cAMP"
"`Iancu et al. <https://models.physiomeproject.org/exposure/f67b68f901fc3986fcea0dcfceb503f9>`_", "M2, Gs Protein"
Each of these blocks is itself a CellML model, complete with bond-graph parameters appropriate for the isolated system.
