- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-11-10 13:31:05+13:00
- Desc:
- t
- Permanent Source URI:
- https://models.cellml.org/workspace/705/rawfile/ef7f7e6e493de26dd70ed5844cc53e1c80b2c883/exposure/exposure_frontpage.rst
About this model
====================
This is a Functional Cell Unit for adenylyl cyclase metabolism in the cardiac cell.
Model status
=============
The current CellML implementation runs in OpenCOR.
Model overview
===================
All components are presented in `bond-graph` form.
Components are made by converting an existing kinetic model and translating into bond-graph form.
.. figure:: exposure/FCU_picture.png
:width: 25%
:align: center
:alt: Components of the model
Components of the model.
Modular description
===================
Components
----------
CellML divides the mathematical model into distinct components, which are able to be re-used.
The main CellML components are:
- :math:`{\beta}`-1 adrenergic receptor ( :math:`{\beta}` 1AR)
- Gs Protein
- muscarinic receptor (M2)
- Gi Protein
- cyclic AMP (cAMP)
.. csv-table:: Origin of kinetic model components
:header: "Source", "Components"
:widths: 15, 30
"`Saucerman et al. <https://models.physiomeproject.org/exposure/9766d9bd0325c31e47a31b291e26ccad>`_", ":math:`{\beta}` 1AR, Gs Protein, cAMP"
"`Iancu et al. <https://models.physiomeproject.org/exposure/f67b68f901fc3986fcea0dcfceb503f9>`_", "M2, Gs Protein"
Each of these blocks is itself a CellML model, which enables us to reuse the various components in future studies.
