- Author:
- Soroush <ssaf006@aucklanduni.ac.nz>
- Date:
- 2021-09-23 17:53:12+12:00
- Desc:
- Upgraded the FTU model to the full version.
- Permanent Source URI:
- https://models.cellml.org/workspace/70b/rawfile/f5207925511951ca0e7c716e2586a85f2ebc5294/cycle.py
# Version using units in metres, Joules and seconds
import opencor as opencor
import math
import scipy
import numpy as np
import pdb
import matplotlib.pyplot as plt
from scipy.integrate import odeint
# Ensure the FTU model is the current simulation
s1 = opencor.open_simulation('Cardiac FTU v8.sedml')
s2 = opencor.open_simulation('main_cv7_diodeValves.sedml')
data1 = s1.data()
data2 = s2.data()
s1.reset(True) # initialise OpenCOR module 1
s2.reset(True) # initialise OpenCOR module 2
s1.clear_results() # clear graphs in OpenCOR module 1
s2.clear_results() # clear graphs in OpenCOR module 2
# iterate over the cardiac cycle
##################################### Initialise arrays #####################################
t = np.zeros(101)
p_AA = np.zeros(101)
p_LA = np.zeros(101)
p_LV = np.zeros(101)
q_LV = np.zeros(101)
r_LV = np.zeros(101)
l_LV = np.zeros(101)
To = np.zeros(101)
event = np.zeros(101)
t[0] = 0 # set initial time (s) in cardiac cycle to zero
dt = 0.01 # set time increment (s) for steps during cardiac cycle
To[0] = 0 # set initial active tension to zero
p_LV[0] = 6.7 # set initial LV pressure to zero
l_LV[0] = 1 # set initial LV extension ratio
r_LV[0] = 0.4 # set initial radius (dm) of LV endocardium to end-diastolic radius
p_LA[0] = 3.36 # set initial LA pressure to small value >0 to open mitral valve
q_LV[0] = l_LV[0]*math.pi*r_LV[0]**2 # calculate initial LV volume
data1.constants()["main/T_0"] = 0 # set active tension to zero
data1.constants()["main/r_endo"] = r_LV[0] # set initial r_endo in OpenCOR
data1.constants()["main/lambda_a"] = l_LV[0] # set initial lambda_a in OpenCOR
for i in range(0, 101, 1):
p_AA[i] = 7 # set aortic artery pressure
p_LA[i] = 3.36
i=0
def fxn(n):
print("\n Pause - c to continue, q to quit, n for next pause, s to step through code")
pdb.set_trace()
#fxn(1)
while 1>0:
print("t[%3d]=%8.4f To=%8.4f p_LV=%8.4f p_LA=%8.4f p_AA=%8.4f r_LV=%8.4f q_LV=%9.6f"
% (i, t[i], To[i], p_LV[i], p_LA[i], p_AA[i], r_LV[i], q_LV[i]))
##################################### Phase I Isovolumic contraction #####################################
print("\n Phase I - LV isovolumic contraction")
while p_LV[i] < p_AA[i]: # isovolumic contraction until aortic valve closes
i += 1
t[i] = t[i-1]+dt # increment time in cardiac cycle
To[i] = data2.algebraic()["Heart/To"] # no active contraction
q_LV[i] = q_LV[i-1] # keep LV volume at previous value
r_LV[i] = r_LV[i-1] # keep LV radius at previous value
s1.reset(True) # reset OpenCOR
data1.constants()["main/T_0"] = To[i] # set T_0 in OpenCOR
data1.constants()["main/r_endo"] = r_LV[i] # update r_endo in OpenCOR from previous (now constant) LV radius
s1.run() # run OpenCOR
p_LV[i] =-data1.algebraic()["main/p_LV"] # update LV pressure from OpenCOR
l_LV[i] = data1.constants()["main/lambda_a"] # update extension ratio from OpenCOR
data2.constants()["Heart/u_LV"] = p_LV[i] # update u_LV in CV model with LV pressure from wall calculation
# data2.states()["Heart/q_LV"] = q_LV[i] # update q_LV in CV model
data2.set_starting_point(t[i-1]) # set start time in s for OpenCOR CV model (module 2)
data2.set_ending_point(t[i]) # set end time
s2.run() # run CV model
p_AA[i] = data2.states()["Systemic/u_AA"] # update p_LA from CV model
p_LA[i] = data2.algebraic()["Heart/u_LA"] # update p_LA from CV model
print("Phase I: t[%3d]=%8.4f To=%7.2f p_LV=%7.2f p_LA=%7.2f p_AA=%7.2f r_LV=%7.3f q_LV=%9.6f"
% (i, t[i], To[i], p_LV[i], p_LA[i], p_AA[i], r_LV[i], q_LV[i]))
# fxn(1)
##################################### Phase II Systolic ejection #####################################
print("\n Phase II - LV ejection")
while p_LV[i] > p_AA[i]: # LV ejection phase
i += 1
t[i] = t[i-1]+dt # increment time
To[i] = data2.algebraic()["Heart/To"] # no active contraction # define To(t)
q_LV[i] = q_LV[i-1] # keep at previous value
l_LV[i] = l_LV[i-1] # keep at previous value
r_LV[i] = (q_LV[i]/(l_LV[i]*math.pi))**0.5 # calculate LV radius from LV volume & length
s1.reset(True) # reset OpenCOR
data1.constants()["main/T_0"] = To[i] # set T_0 in OpenCOR
data1.constants()["main/r_endo"] = r_LV[i] # update r_endo in OpenCOR from previous LV radius
s1.run() # run OpenCOR with current r_endo
p_LV[i] =-data1.algebraic()["main/p_LV"] # obtain LV pressure from OpenCOR
l_LV[i] = data1.constants()["main/lambda_a"] # update extension ratio from OpenCOR
data2.constants()["Heart/u_LV"] = p_LV[i] # update u_LV in CV model with LV pressure from wall calculation
#data2.states()["Heart/q_LV"] = q_LV[i] # update q_LV in CV model
data2.set_starting_point(t[i-1]) # set start time in s for OpenCOR CV model (module 2)
data2.set_ending_point(t[i]) # set end time
s2.run() # run CV model
q_LV[i] = data2.states()["Heart/q_LV"] # update q_LV from CV model
p_LA[i] = data2.algebraic()["Heart/u_LA"] # update p_LA from CV model
p_AA[i] = data2.states()["Systemic/u_AA"] # update p_AA from CV model
print("Phase II: t[%3d]=%8.4f To=%7.2f p_LV=%7.2f p_LA=%7.2f p_AA=%7.2f r_LV=%7.3f q_LV=%9.6f"
% (i, t[i], To[i], p_LV[i], p_LA[i], p_AA[i], r_LV[i], q_LV[i]))
##################################### Phase III Isovolumic relaxation #####################################
print("\n Phase III - LV isovolumic relaxation - start time =%8.4f" % (t[i]))
while p_LV[i] > p_LA[i]: # isovolumic relaxation
i += 1
t[i] = t[i-1]+dt # increment time
To[i] = data2.algebraic()["Heart/To"] # no active contraction # define To(t)
q_LV[i] = q_LV[i-1] # keep at previous value
l_LV[i] = l_LV[i-1] # keep at previous value
r_LV[i] = r_LV[i-1] # calculate LV radius from LV volume & length
s1.reset(True) # reset OpenCOR
data1.constants()["main/T_0"] = To[i] # set T_0 in OpenCOR
data1.constants()["main/r_endo"] = r_LV[i] # update r_endo in OpenCOR from previous LV radius
s1.run() # run OpenCOR with current r_endo
p_LV[i] =-data1.algebraic()["main/p_LV"] # obtain LV pressure from OpenCOR
l_LV[i] = data1.constants()["main/lambda_a"] # update extension ratio from OpenCOR
data2.constants()["Heart/u_LV"] = p_LV[i] # update u_LV in CV model with LV pressure from wall calculation
data2.set_starting_point(t[i-1]) # set start time in s for OpenCOR CV model (module 2)
data2.set_ending_point(t[i]) # set end time
s2.run() # run CV model
q_LV[i] = data2.states()["Heart/q_LV"] # update q_LV from CV model
p_LA[i] = data2.algebraic()["Heart/u_LA"] # update p_LA from CV model
p_AA[i] = data2.states()["Systemic/u_AA"] # update p_AA from CV model
print("Phase III: t[%3d]=%8.4f To=%7.2f p_LV=%7.2f p_LA=%7.2f p_AA=%7.2f r_LV=%7.3f q_LV=%9.6f"
% (i, t[i], To[i], p_LV[i], p_LA[i], p_AA[i], r_LV[i], q_LV[i]))
##################################### Phase IV Rapid filling #####################################
print("\n Phase IV - LV rapid filling")
while p_LV[i] < p_LA[i]: # LV filling driven by stored energy of contracted tissue
i += 1
t[i] = t[i-1]+dt # increment time in cardiac cycle
To[i] = data2.algebraic()["Heart/To"] # no active contraction # define To(t)
l_LV[i] = l_LV[i-1] # keep at previous value
q_LV[i] = q_LV[i-1] # keep at previous value
r_LV[i] = (q_LV[i]/(l_LV[i]*math.pi))**0.5 # calculate LV radius from LV volume
s1.reset(True) # reset OpenCOR
data1.constants()["main/T_0"] = To[i] # set T_0 in OpenCOR
data1.constants()["main/r_endo"] = r_LV[i] # update r_endo in OpenCOR from previous LV radius
s1.run() # run OpenCOR with current r_endo
p_LV[i] =-data1.algebraic()["main/p_LV"] # obtain LV pressure from OpenCOR
l_LV[i] = data1.constants()["main/lambda_a"] # update extension ratio from OpenCOR
data2.constants()["Heart/u_LV"] = p_LV[i] # update u_LV in CV model with LV pressure from wall calculation
data2.states()["Heart/q_LV"] = q_LV[i-1] # update q_LV in CV model
data2.set_starting_point(t[i-1]) # set start time in ms for OpenCOR CV model (module 2)
data2.set_ending_point(t[i]) # set end time
s2.run() # run CV model
q_LV[i] = data2.states()["Heart/q_LV"] # update q_LV from CV model
p_LA[i] = data2.algebraic()["Heart/u_LA"] # update p_LA from CV model
p_AA[i] = data2.states()["Systemic/u_AA"] # update p_AA from CV model
print("Phase IV: t[%3d]=%8.4f To=%7.2f p_LV=%7.2f p_LA=%7.2f p_AA=%7.2f r_LV=%7.3f q_LV=%9.6f"
% (i, t[i], To[i], p_LV[i], p_LA[i], p_AA[i], r_LV[i], q_LV[i]))
##################################### Phase V Atrial Systole #####################################
print("\n Phase V - LA contraction")
while p_LA[i] > p_LV[i]: # LV filling driven by p_LA
i += 1
t[i] = t[i-1]+dt # increment time in cardiac cycle
s1.reset(True) # reset OpenCOR
data1.constants()["main/T_0"] = To[i] # set T_0 in OpenCOR
data1.constants()["main/r_endo"] = r_LV[i-1] # update r_endo in OpenCOR from previous LV radius
s1.run() # run OpenCOR with current r_endo
p_LV[i] =-data1.algebraic()["main/p_LV"] # obtain LV pressure from OpenCOR
l_LV[i] = data1.constants()["main/lambda_a"] # obtain extension ratio from OpenCOR
data2.constants()["Heart/u_LV"] = p_LV[i] # update u_LV in CV model with LV pressure from wall calculation
data2.set_starting_point(t[i-1]) # set start time in s for OpenCOR CV model (module 2)
data2.set_ending_point(t[i]) # set end time
s2.run() # run CV model
q_LV[i] = data2.states()["Heart/q_LV"] # update q_LV from CV model
p_LA[i] = data2.algebraic()["Heart/u_LA"] # update p_LA from CV model
r_LV[i] = (q_LV[i]/(l_LV[i]*math.pi))**0.5 # calculate LV radius from LV volume
p_AA[i] = data2.states()["Systemic/u_AA"] # update p_LA from CV model
print("Phase V: t[%3d]=%8.4f To=%7.2f p_LV=%7.2f p_LA=%7.2f p_AA=%7.2f r_LV=%7.3f q_LV=%9.6f"
% (i, t[i], To[i], p_LV[i], p_LA[i], p_AA[i], r_LV[i], q_LV[i]))
