- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2022-01-28 09:32:45+13:00
- Desc:
- Adding combined crossbridge_TRPN module
- Permanent Source URI:
- https://models.cellml.org/workspace/75f/rawfile/3bc405a7c9215edb27f452c85b8b8e939dd50dbc/composite_whole_B1AR/whole.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="BG_whole" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="mM" units_ref="mM"/>
<units name="fmol" units_ref="fmol"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="microm3" units_ref="microm3"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
<units name="per_second" units_ref="per_second"/>
<units name="millivolt" units_ref="millivolt"/>
<units name="per_sec" units_ref="per_sec"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="fmol_per_L" units_ref="fmol_per_L"/>
<units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
<units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
<units name="uM" units_ref="uM"/>
<units name="mM_per_sec" units_ref="mM_per_sec"/>
<units name="uM_per_sec" units_ref="uM_per_sec"/>
<units name="pL" units_ref="pL"/>
<units name="m_to_u" units_ref="m_to_u"/>
</import>
<import xlink:href="units_and_constants/constants_BG.cellml">
<component component_ref="constants" name="constants"/>
</import>
<import xlink:href="cAMP/BG_cAMP.cellml">
<component component_ref="cAMP" name="cAMP"/>
</import>
<import xlink:href="beta1AR/BG_beta1AR.cellml">
<component component_ref="B1AR" name="beta1AR"/>
</import>
<import xlink:href="LRGbinding/BG_LRGbinding.cellml">
<component component_ref="LRGbinding" name="LRGbinding"/>
</import>
<import xlink:href="GsProtein/BG_GsProtein.cellml">
<component component_ref="GsProtein" name="GsProtein"/>
</import>
<import xlink:href="PKA/BG_PKA.cellml">
<component component_ref="PKA" name="PKA"/>
</import>
<import xlink:href="Inhib1/BG_Inhib1.cellml">
<component component_ref="Inhib1" name="Inhib1"/>
</import>
<import xlink:href="PLB/BG_PLB.cellml">
<component component_ref="PLB" name="PLB"/>
</import>
<component name="BG_parameters">
<variable initial_value="756623" name="kappa_1a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000157975" name="kappa_1b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="90661.5" name="kappa_2a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0244642" name="kappa_2b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="4.05153e+07" name="kappa_3a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="4.71108e-18" name="kappa_3b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="46279.3" name="kappa_4a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.177998" name="kappa_4b" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="647.331" name="kappa_5" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="159417" name="kappa_6" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="7.12413e+06" name="kappa_7" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="143475" name="kappa_sig1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="52.5633" name="kappa_sig2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="77.1867" name="kappa_sig3" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="9827.69" name="kappa_sig4" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.45993e-05" name="kappa_B11" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="29363.3" name="kappa_B12" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.45993e-05" name="kappa_B21" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="29363.3" name="kappa_B22" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0128353" name="kappa_P1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00123477" name="kappa_P2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="21.3896" name="kappa_aI" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="74.1732" name="kappa_bI" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="16.9539" name="kappa_dI" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="165.552" name="kappa_iI" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="21.3896" name="kappa_aII" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="74.1732" name="kappa_bII" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="16.9539" name="kappa_dII" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="165.552" name="kappa_iII" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="93.6916" name="kappa_PLBph1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="13.4983" name="kappa_PLBph2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.190625" name="kappa_PLBd1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.597838" name="kappa_PLBd2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1756.06" name="kappa_Inh" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.3198" name="kappa_PKAi1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.71479" name="kappa_PKAi2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3.60316" name="kappa_PP2ai1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3.54084" name="kappa_PP2ai2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0073331" name="kappa_act1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="9.10152e-05" name="kappa_act2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00782619" name="kappa_hyd" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="443.387" name="kappa_reassoc" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00511157" name="K_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00511157" name="K_cAMP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.203204" name="K_AC" public_interface="out" units="per_fmol"/>
<variable initial_value="36.8029" name="K_AC_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.18235" name="K_a_GTP_AC" public_interface="out" units="per_fmol"/>
<variable initial_value="10.1002" name="K_a_GTP_AC_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00408046" name="K_FSK_AC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.617051" name="K_FSK_AC_ATP" public_interface="out" units="per_fmol"/>
<variable initial_value="3.57225" name="K_PDE" public_interface="out" units="per_fmol"/>
<variable initial_value="0.816575" name="K_PDE_cAMP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00511157" name="K_five_AMP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0121813" name="K_IBMX" public_interface="out" units="per_fmol"/>
<variable initial_value="44.9071" name="K_PDEinh" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0652161" name="K_a_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="1.32668e-05" name="K_FSK" public_interface="out" units="per_fmol"/>
<variable initial_value="0.356212" name="K_L" public_interface="out" units="per_fmol"/>
<variable initial_value="0.407286" name="K_R" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00361468" name="K_G" public_interface="out" units="per_fmol"/>
<variable initial_value="265.938" name="K_LR" public_interface="out" units="per_fmol"/>
<variable initial_value="26.7494" name="K_RG" public_interface="out" units="per_fmol"/>
<variable initial_value="265.938" name="K_LRG" public_interface="out" units="per_fmol"/>
<variable initial_value="3.19126e-10" name="K_B1d" public_interface="out" units="per_fmol"/>
<variable initial_value="9.01813e-05" name="K_BARK" public_interface="out" units="per_fmol"/>
<variable initial_value="0.990003" name="K_LR_BARK" public_interface="out" units="per_fmol"/>
<variable initial_value="0.990003" name="K_LRG_BARK" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0131111" name="K_B1p" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0131111" name="K_B1tot" public_interface="out" units="per_fmol"/>
<variable initial_value="0.187914" name="K_PKACI" public_interface="out" units="per_fmol"/>
<variable initial_value="2.26483e-06" name="K_PKACI_B1p" public_interface="out" units="per_fmol"/>
<variable initial_value="21.8362" name="K_PKI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.845627" name="K_RCI" public_interface="out" units="per_fmol"/>
<variable initial_value="1.35906" name="K_ARCI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.391918" name="K_A2RCI" public_interface="out" units="per_fmol"/>
<variable initial_value="1.1688" name="K_CI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0426455" name="K_A2RI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.175593" name="K_PKACI_PKI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.845627" name="K_RCII" public_interface="out" units="per_fmol"/>
<variable initial_value="1.35906" name="K_ARCII" public_interface="out" units="per_fmol"/>
<variable initial_value="0.391918" name="K_A2RCII" public_interface="out" units="per_fmol"/>
<variable initial_value="1.1688" name="K_CII" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0426455" name="K_A2RII" public_interface="out" units="per_fmol"/>
<variable initial_value="0.175593" name="K_PKACII_PKI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00240905" name="K_PLB" public_interface="out" units="per_fmol"/>
<variable initial_value="0.310271" name="K_PLB_PKACI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.718539" name="K_PP1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.413311" name="K_PLBp_PP1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.333155" name="K_PLBp" public_interface="out" units="per_fmol"/>
<variable initial_value="0.669719" name="K_Ip" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0165539" name="K_Ip_PP1" public_interface="out" units="per_fmol"/>
<variable initial_value="4.59979" name="K_Ip_PKACI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0210116" name="K_PP2a" public_interface="out" units="per_fmol"/>
<variable initial_value="0.513115" name="K_Ip_PP2a" public_interface="out" units="per_fmol"/>
<variable initial_value="0.754271" name="K_I" public_interface="out" units="per_fmol"/>
<variable initial_value="0.000299049" name="K_beta_gamma" public_interface="out" units="per_fmol"/>
<variable initial_value="0.169246" name="K_a_GDP" public_interface="out" units="per_fmol"/>
</component>
<component name="B1AR_environment">
<variable name="time" units="second"/>
<variable initial_value="153400" name="C_m" public_interface="out" units="fF"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable initial_value="34.4" name="vol_myo" public_interface="out" units="pL"/>
<!-- stimulus-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_L_init</ci>
<piecewise>
<piece>
<cn cellml:units="fmol" type="e-notation">1<sep/>-1</cn>
<apply>
<lt/>
<ci>time</ci>
<cn cellml:units="second" type="e-notation">1<sep/>-1</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="fmol" type="e-notation">1<sep/>-6</cn>
</otherwise>
</piecewise>
</apply>
</math>
<!-- initial conditions for every variable-->
<variable name="q_L_init" units="fmol"/>
<variable initial_value="0.0000508778" name="q_R_init" units="fmol"/>
<variable initial_value="0.0290876489" name="q_G_init" units="fmol"/>
<variable initial_value="0.0000508778" name="q_RG_init" units="fmol"/>
<variable initial_value="0.0000508778" name="q_LRG_init" units="fmol"/>
<variable initial_value="0.0009519" name="q_a_GTP_init" units="fmol"/>
<variable initial_value="0.00097622" name="q_beta_gamma_init" units="fmol"/>
<variable initial_value="2.44948e-05" name="q_a_GDP_init" units="fmol"/>
<variable initial_value="0.0000508778" name="q_LR_BARK_init" units="fmol"/>
<variable initial_value="0.0000508778" name="q_LRG_BARK_init" units="fmol"/>
<variable initial_value="1e-16" name="q_B1d_init" units="fmol"/>
<variable initial_value="1e-16" name="q_B1p_init" units="fmol"/>
<variable initial_value="0.008778" name="q_PKACI_B1p_init" units="fmol"/>
<variable initial_value="0.0000508778" name="q_B1tot_init" units="fmol"/>
<variable initial_value="0.00221209" name="q_PKACI_init" units="fmol"/>
<variable initial_value="0.0228" name="q_BARK_init" units="fmol"/>
<variable initial_value="0" name="q_LR_init" units="fmol"/>
<variable initial_value="189.99905570" name="q_ATP_init" units="fmol"/>
<variable initial_value="0.0006143333" name="q_AC_init" units="fmol"/>
<variable initial_value="0.0314042742" name="q_cAMP_init" units="fmol"/>
<variable initial_value="0.000614333" name="q_AC_ATP_init" units="fmol"/>
<variable initial_value="0.0000126667" name="q_FSK_init" units="fmol"/>
<variable initial_value="0.0000126667" name="q_FSK_AC_init" units="fmol"/>
<variable initial_value="0.0000126667" name="q_FSK_AC_ATP_init" units="fmol"/>
<variable initial_value="0.00031730" name="q_a_GTP_init" units="fmol"/>
<variable initial_value="0.00031730" name="q_a_GTP_AC_init" units="fmol"/>
<variable initial_value="0.00031730" name="q_a_GTP_AC_ATP_init" units="fmol"/>
<variable initial_value="0.0007171258" name="q_PDE_init" units="fmol"/>
<variable initial_value="1e-13" name="q_PDEinh_init" units="fmol"/>
<variable initial_value="0.0007171258" name="q_PDE_cAMP_init" units="fmol"/>
<variable initial_value="3.80E-06" name="q_IBMX_init" units="fmol"/>
<variable initial_value="1e-18" name="q_five_AMP_init" units="fmol"/>
<variable initial_value="6.840E-03" name="q_PKI_init" units="fmol"/>
<variable initial_value="2.242E-02" name="q_RCI_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_ARCI_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_A2RCI_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_CI_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_A2RI_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_PKACI_PKI_init" units="fmol"/>
<variable initial_value="9.500E-04" name="q_RCII_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_ARCII_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_A2RCII_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_CII_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_A2RII_init" units="fmol"/>
<variable initial_value="3.800E-15" name="q_PKACII_PKI_init" units="fmol"/>
<variable initial_value="4.028E+00" name="q_PLB_init" units="fmol"/>
<variable initial_value="1e-13" name="q_PLB_PKACI_init" units="fmol"/>
<variable initial_value="3.382E-02" name="q_PP1_init" units="fmol"/>
<variable initial_value="1e-13" name="q_PLBp_PP1_init" units="fmol"/>
<variable initial_value="1.560E-01" name="q_PLBp_init" units="fmol"/>
<variable initial_value="9.994E-04" name="q_Ip_init" units="fmol"/>
<variable initial_value="1e-13" name="q_Ip_PP1_init" units="fmol"/>
<variable initial_value="1e-13" name="q_Ip_PKACI_init" units="fmol"/>
<variable initial_value="8.512E-03" name="q_PP2a_init" units="fmol"/>
<variable initial_value="1e-13" name="q_Ip_PP2a_init" units="fmol"/>
<variable initial_value="1.140E-02" name="q_I_init" units="fmol"/>
<!-- concentrations - for plotting-->
<variable name="c_cAMP" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>c_cAMP</ci>
<apply>
<divide/>
<ci>q_cAMP</ci>
<ci>vol_myo</ci>
</apply>
</apply>
</math>
<!-- total value-->
<variable name="q_L" public_interface="out" units="fmol"/>
<variable name="q_R" public_interface="out" units="fmol"/>
<variable name="q_G" public_interface="out" units="fmol"/>
<variable name="q_RG" public_interface="out" units="fmol"/>
<variable name="q_LR" public_interface="out" units="fmol"/>
<variable name="q_LRG" public_interface="out" units="fmol"/>
<variable name="q_LR_BARK" public_interface="out" units="fmol"/>
<variable name="q_LRG_BARK" public_interface="out" units="fmol"/>
<variable name="q_B1d" public_interface="out" units="fmol"/>
<variable name="q_B1p" public_interface="out" units="fmol"/>
<variable name="q_PKACI_B1p" public_interface="out" units="fmol"/>
<variable name="q_B1tot" public_interface="out" units="fmol"/>
<variable name="q_PKACI" public_interface="out" units="fmol"/>
<variable name="q_BARK" public_interface="out" units="fmol"/>
<variable name="q_a_GTP" public_interface="out" units="fmol"/>
<variable name="q_beta_gamma" public_interface="out" units="fmol"/>
<variable name="q_a_GDP" public_interface="out" units="fmol"/>
<variable name="q_ATP" public_interface="out" units="fmol"/>
<variable name="q_cAMP" public_interface="out" units="fmol"/>
<variable name="q_AC" public_interface="out" units="fmol"/>
<variable name="q_AC_ATP" public_interface="out" units="fmol"/>
<variable name="q_a_GTP_AC" public_interface="out" units="fmol"/>
<variable name="q_a_GTP_AC_ATP" public_interface="out" units="fmol"/>
<variable name="q_FSK_AC" public_interface="out" units="fmol"/>
<variable name="q_FSK_AC_ATP" public_interface="out" units="fmol"/>
<variable name="q_PDE" public_interface="out" units="fmol"/>
<variable name="q_PDE_cAMP" public_interface="out" units="fmol"/>
<variable name="q_five_AMP" public_interface="out" units="fmol"/>
<variable name="q_IBMX" public_interface="out" units="fmol"/>
<variable name="q_PDEinh" public_interface="out" units="fmol"/>
<variable name="q_FSK" public_interface="out" units="fmol"/>
<variable name="q_PKI" public_interface="out" units="fmol"/>
<variable name="q_RCI" public_interface="out" units="fmol"/>
<variable name="q_ARCI" public_interface="out" units="fmol"/>
<variable name="q_A2RCI" public_interface="out" units="fmol"/>
<variable name="q_CI" public_interface="out" units="fmol"/>
<variable name="q_A2RI" public_interface="out" units="fmol"/>
<variable name="q_PKACI_PKI" public_interface="out" units="fmol"/>
<variable name="q_RCII" public_interface="out" units="fmol"/>
<variable name="q_ARCII" public_interface="out" units="fmol"/>
<variable name="q_A2RCII" public_interface="out" units="fmol"/>
<variable name="q_CII" public_interface="out" units="fmol"/>
<variable name="q_A2RII" public_interface="out" units="fmol"/>
<variable name="q_PKACII_PKI" public_interface="out" units="fmol"/>
<variable name="q_PLB" public_interface="out" units="fmol"/>
<variable name="q_PLB_PKACI" public_interface="out" units="fmol"/>
<variable name="q_PP1" public_interface="out" units="fmol"/>
<variable name="q_PLBp_PP1" public_interface="out" units="fmol"/>
<variable name="q_PLBp" public_interface="out" units="fmol"/>
<variable name="q_Ip" public_interface="out" units="fmol"/>
<variable name="q_Ip_PP1" public_interface="out" units="fmol"/>
<variable name="q_Ip_PKACI" public_interface="out" units="fmol"/>
<variable name="q_PP2a" public_interface="out" units="fmol"/>
<variable name="q_Ip_PP2a" public_interface="out" units="fmol"/>
<variable name="q_I" public_interface="out" units="fmol"/>
<!-- beta1AR imports-->
<variable name="q_LR_mbeta1AR" public_interface="in" units="fmol"/>
<variable name="q_LRG_mbeta1AR" public_interface="in" units="fmol"/>
<variable name="q_B1d_mbeta1AR" public_interface="in" units="fmol"/>
<variable name="q_BARK_mbeta1AR" public_interface="in" units="fmol"/>
<variable name="q_LR_BARK_mbeta1AR" public_interface="in" units="fmol"/>
<variable name="q_LRG_BARK_mbeta1AR" public_interface="in" units="fmol"/>
<variable name="q_B1p_mbeta1AR" public_interface="in" units="fmol"/>
<variable name="q_B1tot_mbeta1AR" public_interface="in" units="fmol"/>
<variable name="q_PKACI_mbeta1AR" public_interface="in" units="fmol"/>
<variable name="q_PKACI_B1p_mbeta1AR" public_interface="in" units="fmol"/>
<!-- LRGbinding imports-->
<variable name="q_L_mLRGbinding" public_interface="in" units="fmol"/>
<variable name="q_R_mLRGbinding" public_interface="in" units="fmol"/>
<variable name="q_G_mLRGbinding" public_interface="in" units="fmol"/>
<variable name="q_LR_mLRGbinding" public_interface="in" units="fmol"/>
<variable name="q_RG_mLRGbinding" public_interface="in" units="fmol"/>
<variable name="q_LRG_mLRGbinding" public_interface="in" units="fmol"/>
<!-- cAMP imports-->
<variable name="q_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_cAMP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_AC_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_a_GTP_AC_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_a_GTP_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_FSK_AC_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_FSK_AC_ATP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PDE_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PDE_cAMP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_five_AMP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_IBMX_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_PDEinh_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_a_GTP_mcAMP" public_interface="in" units="fmol"/>
<variable name="q_FSK_mcAMP" public_interface="in" units="fmol"/>
<!-- GsProtein imports-->
<variable name="q_R_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_G_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_RG_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_LR_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_LRG_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_a_GTP_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_beta_gamma_mGsProtein" public_interface="in" units="fmol"/>
<variable name="q_a_GDP_mGsProtein" public_interface="in" units="fmol"/>
<!-- PKA imports-->
<variable name="q_cAMP_mPKA" public_interface="in" units="fmol"/>
<variable name="q_PKI_mPKA" public_interface="in" units="fmol"/>
<variable name="q_RCI_mPKA" public_interface="in" units="fmol"/>
<variable name="q_ARCI_mPKA" public_interface="in" units="fmol"/>
<variable name="q_A2RCI_mPKA" public_interface="in" units="fmol"/>
<variable name="q_CI_mPKA" public_interface="in" units="fmol"/>
<variable name="q_A2RI_mPKA" public_interface="in" units="fmol"/>
<variable name="q_PKACI_PKI_mPKA" public_interface="in" units="fmol"/>
<variable name="q_RCII_mPKA" public_interface="in" units="fmol"/>
<variable name="q_ARCII_mPKA" public_interface="in" units="fmol"/>
<variable name="q_A2RCII_mPKA" public_interface="in" units="fmol"/>
<variable name="q_CII_mPKA" public_interface="in" units="fmol"/>
<variable name="q_A2RII_mPKA" public_interface="in" units="fmol"/>
<variable name="q_PKACII_PKI_mPKA" public_interface="in" units="fmol"/>
<!-- PLB imports-->
<variable name="q_PLB_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PKACI_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PLB_PKACI_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PP1_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PLBp_PP1_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PLBp_mPLB" public_interface="in" units="fmol"/>
<variable name="q_Ip_mPLB" public_interface="in" units="fmol"/>
<variable name="q_Ip_PP1_mPLB" public_interface="in" units="fmol"/>
<!-- Inhib1 imports-->
<variable name="q_PKACI_mInhib1" public_interface="in" units="fmol"/>
<variable name="q_Ip_mInhib1" public_interface="in" units="fmol"/>
<variable name="q_Ip_PKACI_mInhib1" public_interface="in" units="fmol"/>
<variable name="q_PP2a_mInhib1" public_interface="in" units="fmol"/>
<variable name="q_Ip_PP2a_mInhib1" public_interface="in" units="fmol"/>
<variable name="q_I_mInhib1" public_interface="in" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_L</ci>
<apply>
<plus/>
<ci>q_L_mLRGbinding</ci>
<ci>q_L_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_R</ci>
<apply>
<plus/>
<ci>q_R_mLRGbinding</ci>
<ci>q_R_mGsProtein</ci>
<ci>q_R_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_G</ci>
<apply>
<plus/>
<ci>q_G_mLRGbinding</ci>
<ci>q_G_mGsProtein</ci>
<ci>q_G_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LR</ci>
<apply>
<plus/>
<ci>q_LR_mLRGbinding</ci>
<ci>q_LR_mbeta1AR</ci>
<ci>q_LR_mGsProtein</ci>
<ci>q_LR_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RG</ci>
<apply>
<plus/>
<ci>q_RG_mLRGbinding</ci>
<ci>q_RG_mGsProtein</ci>
<ci>q_RG_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LRG</ci>
<apply>
<plus/>
<ci>q_LRG_mLRGbinding</ci>
<ci>q_LRG_mbeta1AR</ci>
<ci>q_LRG_mGsProtein</ci>
<ci>q_LRG_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_B1d</ci>
<apply>
<plus/>
<ci>q_B1d_mbeta1AR</ci>
<ci>q_B1d_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_BARK</ci>
<apply>
<plus/>
<ci>q_BARK_mbeta1AR</ci>
<ci>q_BARK_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LR_BARK</ci>
<apply>
<plus/>
<ci>q_LR_BARK_mbeta1AR</ci>
<ci>q_LR_BARK_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LRG_BARK</ci>
<apply>
<plus/>
<ci>q_LRG_BARK_mbeta1AR</ci>
<ci>q_LRG_BARK_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_B1p</ci>
<apply>
<plus/>
<ci>q_B1p_mbeta1AR</ci>
<ci>q_B1p_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_B1tot</ci>
<apply>
<plus/>
<ci>q_B1tot_mbeta1AR</ci>
<ci>q_B1tot_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PKACI</ci>
<apply>
<plus/>
<ci>q_PKACI_mbeta1AR</ci>
<ci>q_PKACI_mPLB</ci>
<ci>q_PKACI_mInhib1</ci>
<ci>q_PKACI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PKACI_B1p</ci>
<apply>
<plus/>
<ci>q_PKACI_B1p_mbeta1AR</ci>
<ci>q_PKACI_B1p_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_ATP</ci>
<apply>
<plus/>
<ci>q_ATP_mcAMP</ci>
<ci>q_ATP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_cAMP</ci>
<apply>
<plus/>
<ci>q_cAMP_mcAMP</ci>
<ci>q_cAMP_mPKA</ci>
<ci>q_cAMP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_AC</ci>
<apply>
<plus/>
<ci>q_AC_mcAMP</ci>
<ci>q_AC_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_AC_ATP</ci>
<apply>
<plus/>
<ci>q_AC_ATP_mcAMP</ci>
<ci>q_AC_ATP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_a_GTP_AC</ci>
<apply>
<plus/>
<ci>q_a_GTP_AC_mcAMP</ci>
<ci>q_a_GTP_AC_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_a_GTP_AC_ATP</ci>
<apply>
<plus/>
<ci>q_a_GTP_AC_ATP_mcAMP</ci>
<ci>q_a_GTP_AC_ATP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_FSK_AC</ci>
<apply>
<plus/>
<ci>q_FSK_AC_mcAMP</ci>
<ci>q_FSK_AC_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_FSK_AC_ATP</ci>
<apply>
<plus/>
<ci>q_FSK_AC_ATP_mcAMP</ci>
<ci>q_FSK_AC_ATP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PDE</ci>
<apply>
<plus/>
<ci>q_PDE_mcAMP</ci>
<ci>q_PDE_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PDE_cAMP</ci>
<apply>
<plus/>
<ci>q_PDE_cAMP_mcAMP</ci>
<ci>q_PDE_cAMP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_five_AMP</ci>
<apply>
<plus/>
<ci>q_five_AMP_mcAMP</ci>
<ci>q_five_AMP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_IBMX</ci>
<apply>
<plus/>
<ci>q_IBMX_mcAMP</ci>
<ci>q_IBMX_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PDEinh</ci>
<apply>
<plus/>
<ci>q_PDEinh_mcAMP</ci>
<ci>q_PDEinh_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_a_GTP</ci>
<apply>
<plus/>
<ci>q_a_GTP_mcAMP</ci>
<ci>q_a_GTP_mGsProtein</ci>
<ci>q_a_GTP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_FSK</ci>
<apply>
<plus/>
<ci>q_FSK_mcAMP</ci>
<ci>q_FSK_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_beta_gamma</ci>
<apply>
<plus/>
<ci>q_beta_gamma_mGsProtein</ci>
<ci>q_beta_gamma_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_a_GDP</ci>
<apply>
<plus/>
<ci>q_a_GDP_mGsProtein</ci>
<ci>q_a_GDP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PKI</ci>
<apply>
<plus/>
<ci>q_PKI_mPKA</ci>
<ci>q_PKI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RCI</ci>
<apply>
<plus/>
<ci>q_RCI_mPKA</ci>
<ci>q_RCI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_ARCI</ci>
<apply>
<plus/>
<ci>q_ARCI_mPKA</ci>
<ci>q_ARCI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_A2RCI</ci>
<apply>
<plus/>
<ci>q_A2RCI_mPKA</ci>
<ci>q_A2RCI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_CI</ci>
<apply>
<plus/>
<ci>q_CI_mPKA</ci>
<ci>q_CI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_A2RI</ci>
<apply>
<plus/>
<ci>q_A2RI_mPKA</ci>
<ci>q_A2RI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PKACI_PKI</ci>
<apply>
<plus/>
<ci>q_PKACI_PKI_mPKA</ci>
<ci>q_PKACI_PKI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RCII</ci>
<apply>
<plus/>
<ci>q_RCII_mPKA</ci>
<ci>q_RCII_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_ARCII</ci>
<apply>
<plus/>
<ci>q_ARCII_mPKA</ci>
<ci>q_ARCII_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_A2RCII</ci>
<apply>
<plus/>
<ci>q_A2RCII_mPKA</ci>
<ci>q_A2RCII_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_CII</ci>
<apply>
<plus/>
<ci>q_CII_mPKA</ci>
<ci>q_CII_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_A2RII</ci>
<apply>
<plus/>
<ci>q_A2RII_mPKA</ci>
<ci>q_A2RII_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PKACII_PKI</ci>
<apply>
<plus/>
<ci>q_PKACII_PKI_mPKA</ci>
<ci>q_PKACII_PKI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PLB</ci>
<apply>
<plus/>
<ci>q_PLB_mPLB</ci>
<ci>q_PLB_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PLB_PKACI</ci>
<apply>
<plus/>
<ci>q_PLB_PKACI_mPLB</ci>
<ci>q_PLB_PKACI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PP1</ci>
<apply>
<plus/>
<ci>q_PP1_mPLB</ci>
<ci>q_PP1_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PLBp_PP1</ci>
<apply>
<plus/>
<ci>q_PLBp_PP1_mPLB</ci>
<ci>q_PLBp_PP1_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PLBp</ci>
<apply>
<plus/>
<ci>q_PLBp_mPLB</ci>
<ci>q_PLBp_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ip</ci>
<apply>
<plus/>
<ci>q_Ip_mPLB</ci>
<ci>q_Ip_mInhib1</ci>
<ci>q_Ip_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ip_PP1</ci>
<apply>
<plus/>
<ci>q_Ip_PP1_mPLB</ci>
<ci>q_Ip_PP1_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ip_PKACI</ci>
<apply>
<plus/>
<ci>q_Ip_PKACI_mInhib1</ci>
<ci>q_Ip_PKACI_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PP2a</ci>
<apply>
<plus/>
<ci>q_PP2a_mInhib1</ci>
<ci>q_PP2a_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ip_PP2a</ci>
<apply>
<plus/>
<ci>q_Ip_PP2a_mInhib1</ci>
<ci>q_Ip_PP2a_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_I</ci>
<apply>
<plus/>
<ci>q_I_mInhib1</ci>
<ci>q_I_init</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="B1AR_environment" component_2="constants"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="B1AR_environment" component_2="cAMP"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_ATP_mcAMP" variable_2="q_ATP"/>
<map_variables variable_1="q_ATP" variable_2="q_ATP_global"/>
<map_variables variable_1="q_cAMP_mcAMP" variable_2="q_cAMP"/>
<map_variables variable_1="q_cAMP" variable_2="q_cAMP_global"/>
<map_variables variable_1="q_AC_mcAMP" variable_2="q_AC"/>
<map_variables variable_1="q_AC" variable_2="q_AC_global"/>
<map_variables variable_1="q_AC_ATP_mcAMP" variable_2="q_AC_ATP"/>
<map_variables variable_1="q_AC_ATP" variable_2="q_AC_ATP_global"/>
<map_variables variable_1="q_a_GTP_AC_mcAMP" variable_2="q_a_GTP_AC"/>
<map_variables variable_1="q_a_GTP_AC" variable_2="q_a_GTP_AC_global"/>
<map_variables variable_1="q_a_GTP_AC_ATP_mcAMP" variable_2="q_a_GTP_AC_ATP"/>
<map_variables variable_1="q_a_GTP_AC_ATP" variable_2="q_a_GTP_AC_ATP_global"/>
<map_variables variable_1="q_FSK_AC_mcAMP" variable_2="q_FSK_AC"/>
<map_variables variable_1="q_FSK_AC" variable_2="q_FSK_AC_global"/>
<map_variables variable_1="q_FSK_AC_ATP_mcAMP" variable_2="q_FSK_AC_ATP"/>
<map_variables variable_1="q_FSK_AC_ATP" variable_2="q_FSK_AC_ATP_global"/>
<map_variables variable_1="q_PDE_mcAMP" variable_2="q_PDE"/>
<map_variables variable_1="q_PDE" variable_2="q_PDE_global"/>
<map_variables variable_1="q_PDE_cAMP_mcAMP" variable_2="q_PDE_cAMP"/>
<map_variables variable_1="q_PDE_cAMP" variable_2="q_PDE_cAMP_global"/>
<map_variables variable_1="q_five_AMP_mcAMP" variable_2="q_five_AMP"/>
<map_variables variable_1="q_five_AMP" variable_2="q_five_AMP_global"/>
<map_variables variable_1="q_IBMX_mcAMP" variable_2="q_IBMX"/>
<map_variables variable_1="q_IBMX" variable_2="q_IBMX_global"/>
<map_variables variable_1="q_PDEinh_mcAMP" variable_2="q_PDEinh"/>
<map_variables variable_1="q_PDEinh" variable_2="q_PDEinh_global"/>
<map_variables variable_1="q_a_GTP_mcAMP" variable_2="q_a_GTP"/>
<map_variables variable_1="q_a_GTP" variable_2="q_a_GTP_global"/>
<map_variables variable_1="q_FSK_mcAMP" variable_2="q_FSK"/>
<map_variables variable_1="q_FSK" variable_2="q_FSK_global"/>
</connection>
<connection>
<map_components component_1="B1AR_environment" component_2="beta1AR"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_LR_mbeta1AR" variable_2="q_LR"/>
<map_variables variable_1="q_LR" variable_2="q_LR_global"/>
<map_variables variable_1="q_LRG_mbeta1AR" variable_2="q_LRG"/>
<map_variables variable_1="q_LRG" variable_2="q_LRG_global"/>
<map_variables variable_1="q_B1d_mbeta1AR" variable_2="q_B1d"/>
<map_variables variable_1="q_B1d" variable_2="q_B1d_global"/>
<map_variables variable_1="q_BARK_mbeta1AR" variable_2="q_BARK"/>
<map_variables variable_1="q_BARK" variable_2="q_BARK_global"/>
<map_variables variable_1="q_LR_BARK_mbeta1AR" variable_2="q_LR_BARK"/>
<map_variables variable_1="q_LR_BARK" variable_2="q_LR_BARK_global"/>
<map_variables variable_1="q_LRG_BARK_mbeta1AR" variable_2="q_LRG_BARK"/>
<map_variables variable_1="q_LRG_BARK" variable_2="q_LRG_BARK_global"/>
<map_variables variable_1="q_B1p_mbeta1AR" variable_2="q_B1p"/>
<map_variables variable_1="q_B1p" variable_2="q_B1p_global"/>
<map_variables variable_1="q_B1tot_mbeta1AR" variable_2="q_B1tot"/>
<map_variables variable_1="q_B1tot" variable_2="q_B1tot_global"/>
<map_variables variable_1="q_PKACI_mbeta1AR" variable_2="q_PKACI"/>
<map_variables variable_1="q_PKACI" variable_2="q_PKACI_global"/>
<map_variables variable_1="q_PKACI_B1p_mbeta1AR" variable_2="q_PKACI_B1p"/>
<map_variables variable_1="q_PKACI_B1p" variable_2="q_PKACI_B1p_global"/>
</connection>
<connection>
<map_components component_1="B1AR_environment" component_2="LRGbinding"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_L_mLRGbinding" variable_2="q_L"/>
<map_variables variable_1="q_L" variable_2="q_L_global"/>
<map_variables variable_1="q_R_mLRGbinding" variable_2="q_R"/>
<map_variables variable_1="q_R" variable_2="q_R_global"/>
<map_variables variable_1="q_G_mLRGbinding" variable_2="q_G"/>
<map_variables variable_1="q_G" variable_2="q_G_global"/>
<map_variables variable_1="q_LR_mLRGbinding" variable_2="q_LR"/>
<map_variables variable_1="q_LR" variable_2="q_LR_global"/>
<map_variables variable_1="q_RG_mLRGbinding" variable_2="q_RG"/>
<map_variables variable_1="q_RG" variable_2="q_RG_global"/>
<map_variables variable_1="q_LRG_mLRGbinding" variable_2="q_LRG"/>
<map_variables variable_1="q_LRG" variable_2="q_LRG_global"/>
</connection>
<connection>
<map_components component_1="B1AR_environment" component_2="GsProtein"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_R_mGsProtein" variable_2="q_R"/>
<map_variables variable_1="q_R" variable_2="q_R_global"/>
<map_variables variable_1="q_G_mGsProtein" variable_2="q_G"/>
<map_variables variable_1="q_G" variable_2="q_G_global"/>
<map_variables variable_1="q_RG_mGsProtein" variable_2="q_RG"/>
<map_variables variable_1="q_RG" variable_2="q_RG_global"/>
<map_variables variable_1="q_LR_mGsProtein" variable_2="q_LR"/>
<map_variables variable_1="q_LR" variable_2="q_LR_global"/>
<map_variables variable_1="q_LRG_mGsProtein" variable_2="q_LRG"/>
<map_variables variable_1="q_LRG" variable_2="q_LRG_global"/>
<map_variables variable_1="q_a_GTP_mGsProtein" variable_2="q_a_GTP"/>
<map_variables variable_1="q_a_GTP" variable_2="q_a_GTP_global"/>
<map_variables variable_1="q_beta_gamma_mGsProtein" variable_2="q_beta_gamma"/>
<map_variables variable_1="q_beta_gamma" variable_2="q_beta_gamma_global"/>
<map_variables variable_1="q_a_GDP_mGsProtein" variable_2="q_a_GDP"/>
<map_variables variable_1="q_a_GDP" variable_2="q_a_GDP_global"/>
</connection>
<connection>
<map_components component_1="B1AR_environment" component_2="PKA"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_cAMP_mPKA" variable_2="q_cAMP"/>
<map_variables variable_1="q_cAMP" variable_2="q_cAMP_global"/>
<map_variables variable_1="q_PKI_mPKA" variable_2="q_PKI"/>
<map_variables variable_1="q_PKI" variable_2="q_PKI_global"/>
<map_variables variable_1="q_RCI_mPKA" variable_2="q_RCI"/>
<map_variables variable_1="q_RCI" variable_2="q_RCI_global"/>
<map_variables variable_1="q_ARCI_mPKA" variable_2="q_ARCI"/>
<map_variables variable_1="q_ARCI" variable_2="q_ARCI_global"/>
<map_variables variable_1="q_A2RCI_mPKA" variable_2="q_A2RCI"/>
<map_variables variable_1="q_A2RCI" variable_2="q_A2RCI_global"/>
<map_variables variable_1="q_CI_mPKA" variable_2="q_CI"/>
<map_variables variable_1="q_CI" variable_2="q_CI_global"/>
<map_variables variable_1="q_A2RI_mPKA" variable_2="q_A2RI"/>
<map_variables variable_1="q_A2RI" variable_2="q_A2RI_global"/>
<map_variables variable_1="q_PKACI_PKI_mPKA" variable_2="q_PKACI_PKI"/>
<map_variables variable_1="q_PKACI_PKI" variable_2="q_PKACI_PKI_global"/>
<map_variables variable_1="q_RCII_mPKA" variable_2="q_RCII"/>
<map_variables variable_1="q_RCII" variable_2="q_RCII_global"/>
<map_variables variable_1="q_ARCII_mPKA" variable_2="q_ARCII"/>
<map_variables variable_1="q_ARCII" variable_2="q_ARCII_global"/>
<map_variables variable_1="q_A2RCII_mPKA" variable_2="q_A2RCII"/>
<map_variables variable_1="q_A2RCII" variable_2="q_A2RCII_global"/>
<map_variables variable_1="q_CII_mPKA" variable_2="q_CII"/>
<map_variables variable_1="q_CII" variable_2="q_CII_global"/>
<map_variables variable_1="q_A2RII_mPKA" variable_2="q_A2RII"/>
<map_variables variable_1="q_A2RII" variable_2="q_A2RII_global"/>
<map_variables variable_1="q_PKACII_PKI_mPKA" variable_2="q_PKACII_PKI"/>
<map_variables variable_1="q_PKACII_PKI" variable_2="q_PKACII_PKI_global"/>
</connection>
<connection>
<map_components component_1="B1AR_environment" component_2="Inhib1"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_PKACI_mInhib1" variable_2="q_PKACI"/>
<map_variables variable_1="q_PKACI" variable_2="q_PKACI_global"/>
<map_variables variable_1="q_Ip_mInhib1" variable_2="q_Ip"/>
<map_variables variable_1="q_Ip" variable_2="q_Ip_global"/>
<map_variables variable_1="q_Ip_PKACI_mInhib1" variable_2="q_Ip_PKACI"/>
<map_variables variable_1="q_Ip_PKACI" variable_2="q_Ip_PKACI_global"/>
<map_variables variable_1="q_PP2a_mInhib1" variable_2="q_PP2a"/>
<map_variables variable_1="q_PP2a" variable_2="q_PP2a_global"/>
<map_variables variable_1="q_Ip_PP2a_mInhib1" variable_2="q_Ip_PP2a"/>
<map_variables variable_1="q_Ip_PP2a" variable_2="q_Ip_PP2a_global"/>
<map_variables variable_1="q_I_mInhib1" variable_2="q_I"/>
<map_variables variable_1="q_I" variable_2="q_I_global"/>
</connection>
<connection>
<map_components component_1="B1AR_environment" component_2="PLB"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_PLB_mPLB" variable_2="q_PLB"/>
<map_variables variable_1="q_PLB" variable_2="q_PLB_global"/>
<map_variables variable_1="q_PKACI_mPLB" variable_2="q_PKACI"/>
<map_variables variable_1="q_PKACI" variable_2="q_PKACI_global"/>
<map_variables variable_1="q_PLB_PKACI_mPLB" variable_2="q_PLB_PKACI"/>
<map_variables variable_1="q_PLB_PKACI" variable_2="q_PLB_PKACI_global"/>
<map_variables variable_1="q_PP1_mPLB" variable_2="q_PP1"/>
<map_variables variable_1="q_PP1" variable_2="q_PP1_global"/>
<map_variables variable_1="q_PLBp_PP1_mPLB" variable_2="q_PLBp_PP1"/>
<map_variables variable_1="q_PLBp_PP1" variable_2="q_PLBp_PP1_global"/>
<map_variables variable_1="q_PLBp_mPLB" variable_2="q_PLBp"/>
<map_variables variable_1="q_PLBp" variable_2="q_PLBp_global"/>
<map_variables variable_1="q_Ip_mPLB" variable_2="q_Ip"/>
<map_variables variable_1="q_Ip" variable_2="q_Ip_global"/>
<map_variables variable_1="q_Ip_PP1_mPLB" variable_2="q_Ip_PP1"/>
<map_variables variable_1="q_Ip_PP1" variable_2="q_Ip_PP1_global"/>
</connection>
<connection>
<map_components component_1="constants" component_2="cAMP"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="beta1AR"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="LRGbinding"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="GsProtein"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="Inhib1"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="PLB"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="PKA"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="cAMP"/>
<map_variables variable_1="kappa_1a" variable_2="kappa_1a"/>
<map_variables variable_1="kappa_1b" variable_2="kappa_1b"/>
<map_variables variable_1="kappa_2a" variable_2="kappa_2a"/>
<map_variables variable_1="kappa_2b" variable_2="kappa_2b"/>
<map_variables variable_1="kappa_3a" variable_2="kappa_3a"/>
<map_variables variable_1="kappa_3b" variable_2="kappa_3b"/>
<map_variables variable_1="kappa_4a" variable_2="kappa_4a"/>
<map_variables variable_1="kappa_4b" variable_2="kappa_4b"/>
<map_variables variable_1="kappa_5" variable_2="kappa_5"/>
<map_variables variable_1="kappa_6" variable_2="kappa_6"/>
<map_variables variable_1="kappa_7" variable_2="kappa_7"/>
<map_variables variable_1="K_ATP" variable_2="K_ATP"/>
<map_variables variable_1="K_cAMP" variable_2="K_cAMP"/>
<map_variables variable_1="K_AC" variable_2="K_AC"/>
<map_variables variable_1="K_AC_ATP" variable_2="K_AC_ATP"/>
<map_variables variable_1="K_a_GTP_AC" variable_2="K_a_GTP_AC"/>
<map_variables variable_1="K_a_GTP_AC_ATP" variable_2="K_a_GTP_AC_ATP"/>
<map_variables variable_1="K_FSK_AC" variable_2="K_FSK_AC"/>
<map_variables variable_1="K_FSK_AC_ATP" variable_2="K_FSK_AC_ATP"/>
<map_variables variable_1="K_PDE" variable_2="K_PDE"/>
<map_variables variable_1="K_PDE_cAMP" variable_2="K_PDE_cAMP"/>
<map_variables variable_1="K_five_AMP" variable_2="K_five_AMP"/>
<map_variables variable_1="K_IBMX" variable_2="K_IBMX"/>
<map_variables variable_1="K_PDEinh" variable_2="K_PDEinh"/>
<map_variables variable_1="K_a_GTP" variable_2="K_a_GTP"/>
<map_variables variable_1="K_FSK" variable_2="K_FSK"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="beta1AR"/>
<map_variables variable_1="kappa_B11" variable_2="kappa_B11"/>
<map_variables variable_1="kappa_B12" variable_2="kappa_B12"/>
<map_variables variable_1="kappa_B21" variable_2="kappa_B21"/>
<map_variables variable_1="kappa_B22" variable_2="kappa_B22"/>
<map_variables variable_1="kappa_P1" variable_2="kappa_P1"/>
<map_variables variable_1="kappa_P2" variable_2="kappa_P2"/>
<map_variables variable_1="K_B1d" variable_2="K_B1d"/>
<map_variables variable_1="K_BARK" variable_2="K_BARK"/>
<map_variables variable_1="K_LR_BARK" variable_2="K_LR_BARK"/>
<map_variables variable_1="K_LRG_BARK" variable_2="K_LRG_BARK"/>
<map_variables variable_1="K_B1p" variable_2="K_B1p"/>
<map_variables variable_1="K_B1tot" variable_2="K_B1tot"/>
<map_variables variable_1="K_PKACI" variable_2="K_PKACI"/>
<map_variables variable_1="K_PKACI_B1p" variable_2="K_PKACI_B1p"/>
<map_variables variable_1="K_LR" variable_2="K_LR"/>
<map_variables variable_1="K_LRG" variable_2="K_LRG"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="LRGbinding"/>
<map_variables variable_1="kappa_sig1" variable_2="kappa_sig1"/>
<map_variables variable_1="kappa_sig2" variable_2="kappa_sig2"/>
<map_variables variable_1="kappa_sig3" variable_2="kappa_sig3"/>
<map_variables variable_1="kappa_sig4" variable_2="kappa_sig4"/>
<map_variables variable_1="K_L" variable_2="K_L"/>
<map_variables variable_1="K_R" variable_2="K_R"/>
<map_variables variable_1="K_G" variable_2="K_G"/>
<map_variables variable_1="K_LR" variable_2="K_LR"/>
<map_variables variable_1="K_RG" variable_2="K_RG"/>
<map_variables variable_1="K_LRG" variable_2="K_LRG"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="PKA"/>
<map_variables variable_1="kappa_aI" variable_2="kappa_aI"/>
<map_variables variable_1="kappa_bI" variable_2="kappa_bI"/>
<map_variables variable_1="kappa_dI" variable_2="kappa_dI"/>
<map_variables variable_1="kappa_iI" variable_2="kappa_iI"/>
<map_variables variable_1="kappa_aII" variable_2="kappa_aII"/>
<map_variables variable_1="kappa_bII" variable_2="kappa_bII"/>
<map_variables variable_1="kappa_dII" variable_2="kappa_dII"/>
<map_variables variable_1="kappa_iII" variable_2="kappa_iII"/>
<map_variables variable_1="K_cAMP" variable_2="K_cAMP"/>
<map_variables variable_1="K_PKI" variable_2="K_PKI"/>
<map_variables variable_1="K_RCI" variable_2="K_RCI"/>
<map_variables variable_1="K_ARCI" variable_2="K_ARCI"/>
<map_variables variable_1="K_A2RCI" variable_2="K_A2RCI"/>
<map_variables variable_1="K_CI" variable_2="K_CI"/>
<map_variables variable_1="K_A2RI" variable_2="K_A2RI"/>
<map_variables variable_1="K_PKACI_PKI" variable_2="K_PKACI_PKI"/>
<map_variables variable_1="K_RCII" variable_2="K_RCII"/>
<map_variables variable_1="K_ARCII" variable_2="K_ARCII"/>
<map_variables variable_1="K_A2RCII" variable_2="K_A2RCII"/>
<map_variables variable_1="K_CII" variable_2="K_CII"/>
<map_variables variable_1="K_A2RII" variable_2="K_A2RII"/>
<map_variables variable_1="K_PKACII_PKI" variable_2="K_PKACII_PKI"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="PLB"/>
<map_variables variable_1="kappa_PLBph1" variable_2="kappa_PLBph1"/>
<map_variables variable_1="kappa_PLBph2" variable_2="kappa_PLBph2"/>
<map_variables variable_1="kappa_PLBd1" variable_2="kappa_PLBd1"/>
<map_variables variable_1="kappa_PLBd2" variable_2="kappa_PLBd2"/>
<map_variables variable_1="kappa_Inh" variable_2="kappa_Inh"/>
<map_variables variable_1="K_PLB" variable_2="K_PLB"/>
<map_variables variable_1="K_PKACI" variable_2="K_PKACI"/>
<map_variables variable_1="K_PLB_PKACI" variable_2="K_PLB_PKACI"/>
<map_variables variable_1="K_PP1" variable_2="K_PP1"/>
<map_variables variable_1="K_PLBp_PP1" variable_2="K_PLBp_PP1"/>
<map_variables variable_1="K_PLBp" variable_2="K_PLBp"/>
<map_variables variable_1="K_Ip" variable_2="K_Ip"/>
<map_variables variable_1="K_Ip_PP1" variable_2="K_Ip_PP1"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="Inhib1"/>
<map_variables variable_1="kappa_PKAi1" variable_2="kappa_PKAi1"/>
<map_variables variable_1="kappa_PKAi2" variable_2="kappa_PKAi2"/>
<map_variables variable_1="kappa_PP2ai1" variable_2="kappa_PP2ai1"/>
<map_variables variable_1="kappa_PP2ai2" variable_2="kappa_PP2ai2"/>
<map_variables variable_1="K_PKACI" variable_2="K_PKACI"/>
<map_variables variable_1="K_Ip" variable_2="K_Ip"/>
<map_variables variable_1="K_Ip_PKACI" variable_2="K_Ip_PKACI"/>
<map_variables variable_1="K_PP2a" variable_2="K_PP2a"/>
<map_variables variable_1="K_Ip_PP2a" variable_2="K_Ip_PP2a"/>
<map_variables variable_1="K_I" variable_2="K_I"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="GsProtein"/>
<map_variables variable_1="kappa_act1" variable_2="kappa_act1"/>
<map_variables variable_1="kappa_act2" variable_2="kappa_act2"/>
<map_variables variable_1="kappa_hyd" variable_2="kappa_hyd"/>
<map_variables variable_1="kappa_reassoc" variable_2="kappa_reassoc"/>
<map_variables variable_1="K_LRG" variable_2="K_LRG"/>
<map_variables variable_1="K_R" variable_2="K_R"/>
<map_variables variable_1="K_RG" variable_2="K_RG"/>
<map_variables variable_1="K_G" variable_2="K_G"/>
<map_variables variable_1="K_LR" variable_2="K_LR"/>
<map_variables variable_1="K_a_GTP" variable_2="K_a_GTP"/>
<map_variables variable_1="K_beta_gamma" variable_2="K_beta_gamma"/>
<map_variables variable_1="K_a_GDP" variable_2="K_a_GDP"/>
</connection>
</model>
