Location: FCU_ExcitationContraction_Coupling @ cd9dc957bef0 / parameter_finder / output / TEMP.cellml.txt

Author:
Shelley Fong <s.fong@auckland.ac.nz>
Date:
2022-05-05 15:47:50+12:00
Desc:
updating exposure files
Permanent Source URI:
https://models.cellml.org/workspace/7a8/rawfile/cd9dc957bef01d968377cbc4452e1fadc1addb56/parameter_finder/output/TEMP.cellml.txt
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def model FCU_EC_coupling as
 def import using "units_and_constants/units_BG.cellml" for
            unit mM using unit mM;
unit fmol using unit fmol;
unit per_fmol using unit per_fmol;
            unit J_per_mol using unit J_per_mol;
unit fmol_per_sec using unit fmol_per_sec;
            unit C_per_mol using unit C_per_mol;
  unit J_per_C using unit J_per_C;
            unit microm3 using unit microm3;
  unit fF using unit fF;
            unit fC using unit fC;
  unit fA using unit fA;
            unit per_second using unit per_second;
  unit millivolt using unit millivolt;
            unit per_sec using unit per_sec;
  unit J_per_K_per_mol using unit J_per_K_per_mol;
            unit fmol_per_L using unit fmol_per_L;
  unit fmol_per_L_per_sec using unit fmol_per_L_per_sec;
            unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L;
  unit uM using unit uM;
            unit mM_per_sec using unit mM_per_sec;
  unit uM_per_sec using unit uM_per_sec;
            unit pL using unit pL;
  unit m_to_u using unit m_to_u;
 enddef;
def import using "units_and_constants/constants_BG.cellml" for
                comp constants using comp constants;
enddef;

def import using "crossbridge_TRPN/BG_crossbridge_TRPN.cellml" for
comp crossbridge_TRPN using comp crossbridge_TRPN;
enddef;
def import using "LCC/BG_LCC.cellml" for
comp LCC using comp LCC;
enddef;
def import using "PLB/BG_PLB.cellml" for
comp PLB using comp PLB;
enddef;
def import using "RyR/BG_RyR.cellml" for
comp RyR using comp RyR;
enddef;
def import using "SERCA/BG_SERCA.cellml" for
comp SERCA using comp SERCA;
enddef;

def comp BG_parameters as
var kappa_R_TRPNCa: fmol_per_sec {init: 52.0453, pub: out};
var kappa_R_BU: fmol_per_sec {init: 2.90875, pub: out};
var kappa_R_UW: fmol_per_sec {init: 0.332501, pub: out};
var kappa_R_WS: fmol_per_sec {init: 0.00782356, pub: out};
var kappa_R_SU: fmol_per_sec {init: 140824, pub: out};
var kappa_LCC_Ca1: fmol_per_sec {init: 0.756518, pub: out};
var kappa_LCC_Ca2: fmol_per_sec {init: 0.996063, pub: out};
var kappa_LCC_K1: fmol_per_sec {init: 0.0247377, pub: out};
var kappa_LCC_K2: fmol_per_sec {init: 0.0325707, pub: out};
var kappa_d000: fmol_per_sec {init: 329.349, pub: out};
var kappa_d010: fmol_per_sec {init: 16.6321, pub: out};
var kappa_d020: fmol_per_sec {init: 21.8985, pub: out};
var kappa_d001: fmol_per_sec {init: 0.141736, pub: out};
var kappa_d011: fmol_per_sec {init: 0.00715766, pub: out};
var kappa_d021: fmol_per_sec {init: 0.00942408, pub: out};
var kappa_f1_000: fmol_per_sec {init: 31.7244, pub: out};
var kappa_f1_100: fmol_per_sec {init: 157.535, pub: out};
var kappa_f1_001: fmol_per_sec {init: 0.0136527, pub: out};
var kappa_f1_101: fmol_per_sec {init: 0.0677958, pub: out};
var kappa_f2_000: fmol_per_sec {init: 2.06197, pub: out};
var kappa_f2_100: fmol_per_sec {init: 10.2392, pub: out};
var kappa_f2_001: fmol_per_sec {init: 0.000887375, pub: out};
var kappa_f2_101: fmol_per_sec {init: 0.00440648, pub: out};
var kappa_f3_010: fmol_per_sec {init: 4498.81, pub: out};
var kappa_f3_110: fmol_per_sec {init: 22339.9, pub: out};
var kappa_f3_011: fmol_per_sec {init: 1.93608, pub: out};
var kappa_f3_111: fmol_per_sec {init: 9.61406, pub: out};
var kappa_fCa000: fmol_per_sec {init: 48530.3, pub: out};
var kappa_fCa100: fmol_per_sec {init: 240989, pub: out};
var kappa_fCa010: fmol_per_sec {init: 2450.77, pub: out};
var kappa_fCa110: fmol_per_sec {init: 12169.9, pub: out};
var kappa_fCa020: fmol_per_sec {init: 3226.79, pub: out};
var kappa_fCa120: fmol_per_sec {init: 16023.4, pub: out};
var kappa_PLBph1: fmol_per_sec {init: 45.5263, pub: out};
var kappa_PLBph2: fmol_per_sec {init: 6.55904, pub: out};
var kappa_PLBd1: fmol_per_sec {init: 0.386674, pub: out};
var kappa_PLBd2: fmol_per_sec {init: 1.21269, pub: out};
var kappa_Inh: fmol_per_sec {init: 431.435, pub: out};
var kappa_RyR: fmol_per_sec {init: 2.85549e+06, pub: out};
var kappa_OC: fmol_per_sec {init: 8.83262, pub: out};
var kappa_CCI: fmol_per_sec {init: 0.12618, pub: out};
var kappa_CII: fmol_per_sec {init: 883.262, pub: out};
var kappa_IO: fmol_per_sec {init: 73.6052, pub: out};
var kappa_SERCA_R1_2: fmol_per_sec {init: 1.57289e-05, pub: out};
var kappa_SERCA_R2_4: fmol_per_sec {init: 175018, pub: out};
var kappa_SERCA_R2_2a: fmol_per_sec {init: 2.44679e+06, pub: out};
var kappa_SERCA_R4_5: fmol_per_sec {init: 175018, pub: out};
var kappa_SERCA_R5_6: fmol_per_sec {init: 3487.81, pub: out};
var kappa_SERCA_R6_8: fmol_per_sec {init: 4.39557e+06, pub: out};
var kappa_SERCA_R8_9: fmol_per_sec {init: 1.01676e+07, pub: out};
var kappa_SERCA_R9_10: fmol_per_sec {init: 1.01676e+07, pub: out};
var kappa_SERCA_R10_1: fmol_per_sec {init: 0.00441447, pub: out};
var K_TRPN: per_fmol {init: 1.27424, pub: out};
var K_Cai: per_fmol {init: 1.27424, pub: out};
var K_Ca_TRPN: per_fmol {init: 0.11171, pub: out};
var K_B: per_fmol {init: 6.06164, pub: out};
var K_U: per_fmol {init: 2.27312, pub: out};
var K_W: per_fmol {init: 14.8627, pub: out};
var K_S: per_fmol {init: 3.71567e-06, pub: out};
var K_Ca_i: per_fmol {init: 0.0343245, pub: out};
var K_Ca_o: per_fmol {init: 0.227859, pub: out};
var K_K_i: per_fmol {init: 0.000825154, pub: out};
var K_K_o: per_fmol {init: 0.00547767, pub: out};
var K_000_LCC: per_fmol {init: 1.47795, pub: out};
var K_010_LCC: per_fmol {init: 29.2665, pub: out};
var K_020_LCC: per_fmol {init: 22.2281, pub: out};
var K_100_LCC: per_fmol {init: 0.297629, pub: out};
var K_110_LCC: per_fmol {init: 5.89367, pub: out};
var K_120_LCC: per_fmol {init: 4.47629, pub: out};
var K_001_LCC: per_fmol {init: 3434.28, pub: out};
var K_011_LCC: per_fmol {init: 68005.7, pub: out};
var K_021_LCC: per_fmol {init: 51650.9, pub: out};
var K_101_LCC: per_fmol {init: 691.593, pub: out};
var K_111_LCC: per_fmol {init: 13695, pub: out};
var K_121_LCC: per_fmol {init: 10401.4, pub: out};
var K_PLB: per_fmol {init: 0.00235741, pub: out};
var K_PKACI: per_fmol {init: 0.395191, pub: out};
var K_PLB_PKACI: per_fmol {init: 0.638527, pub: out};
var K_PP1: per_fmol {init: 0.361989, pub: out};
var K_PLBp_PP1: per_fmol {init: 0.203757, pub: out};
var K_PLBp: per_fmol {init: 0.326014, pub: out};
var K_Ip: per_fmol {init: 5.41093, pub: out};
var K_Ip_PP1: per_fmol {init: 0.0673793, pub: out};
var K_Ca_SR: per_fmol {init: 0.980701, pub: out};
var K_C_RyR: per_fmol {init: 3962.58, pub: out};
var K_CI_RyR: per_fmol {init: 39.6258, pub: out};
var K_I_RyR: per_fmol {init: 0.06793, pub: out};
var K_O_RyR: per_fmol {init: 6.793, pub: out};
var K_P1_SERCA: per_fmol {init: 38162.5, pub: out};
var K_P2_SERCA: per_fmol {init: 128177, pub: out};
var K_P2a_SERCA: per_fmol {init: 10585.3, pub: out};
var K_P4_SERCA: per_fmol {init: 147985, pub: out};
var K_P5_SERCA: per_fmol {init: 0.728251, pub: out};
var K_P6_SERCA: per_fmol {init: 29565.2, pub: out};
var K_P8_SERCA: per_fmol {init: 4226.28, pub: out};
var K_P9_SERCA: per_fmol {init: 2547.31, pub: out};
var K_P10_SERCA: per_fmol {init: 4643.82, pub: out};
var K_H: per_fmol {init: 212.798, pub: out};
var K_MgATP: per_fmol {init: 1254.32, pub: out};
var K_MgADP: per_fmol {init: 1.89443e-05, pub: out};
var K_Pi: per_fmol {init: 0.0257106, pub: out};
enddef;
    def comp environment as
                var time: second {pub: out};
                var vol_myo: pL {init: 34.4, pub: out};
                var freq: dimensionless {init: 500};
var q_TRPN: fmol {init: 1e-888, pub: out};
var q_Cai: fmol {init: 1e-888, pub: out};
var q_Ca_TRPN: fmol {init: 1e-888, pub: out};
var q_B: fmol {init: 1e-888, pub: out};
var q_U: fmol {init: 1e-888, pub: out};
var q_W: fmol {init: 1e-888, pub: out};
var q_S: fmol {init: 1e-888, pub: out};
var q_Ca_i: fmol {init: 1e-888, pub: out};
var q_Ca_o: fmol {init: 1e-888, pub: out};
var q_K_i: fmol {init: 1e-888, pub: out};
var q_K_o: fmol {init: 1e-888, pub: out};
var q_000_LCC: fmol {init: 1e-888, pub: out};
var q_010_LCC: fmol {init: 1e-888, pub: out};
var q_020_LCC: fmol {init: 1e-888, pub: out};
var q_100_LCC: fmol {init: 1e-888, pub: out};
var q_110_LCC: fmol {init: 1e-888, pub: out};
var q_120_LCC: fmol {init: 1e-888, pub: out};
var q_001_LCC: fmol {init: 1e-888, pub: out};
var q_011_LCC: fmol {init: 1e-888, pub: out};
var q_021_LCC: fmol {init: 1e-888, pub: out};
var q_101_LCC: fmol {init: 1e-888, pub: out};
var q_111_LCC: fmol {init: 1e-888, pub: out};
var q_121_LCC: fmol {init: 1e-888, pub: out};
var q_PLB: fmol {init: 1e-888, pub: out};
var q_PKACI: fmol {init: 1e-888, pub: out};
var q_PLB_PKACI: fmol {init: 1e-888, pub: out};
var q_PP1: fmol {init: 1e-888, pub: out};
var q_PLBp_PP1: fmol {init: 1e-888, pub: out};
var q_PLBp: fmol {init: 1e-888, pub: out};
var q_Ip: fmol {init: 1e-888, pub: out};
var q_Ip_PP1: fmol {init: 1e-888, pub: out};
var q_Ca_SR: fmol {init: 1e-888, pub: out};
var q_C_RyR: fmol {init: 1e-888, pub: out};
var q_CI_RyR: fmol {init: 1e-888, pub: out};
var q_I_RyR: fmol {init: 1e-888, pub: out};
var q_O_RyR: fmol {init: 1e-888, pub: out};
var q_P1_SERCA: fmol {init: 1e-888, pub: out};
var q_P2_SERCA: fmol {init: 1e-888, pub: out};
var q_P2a_SERCA: fmol {init: 1e-888, pub: out};
var q_P4_SERCA: fmol {init: 1e-888, pub: out};
var q_P5_SERCA: fmol {init: 1e-888, pub: out};
var q_P6_SERCA: fmol {init: 1e-888, pub: out};
var q_P8_SERCA: fmol {init: 1e-888, pub: out};
var q_P9_SERCA: fmol {init: 1e-888, pub: out};
var q_P10_SERCA: fmol {init: 1e-888, pub: out};
var q_H: fmol {init: 1e-888, pub: out};
var q_MgATP: fmol {init: 1e-888, pub: out};
var q_MgADP: fmol {init: 1e-888, pub: out};
var q_Pi: fmol {init: 1e-888, pub: out};

// crossbridge_TRPN imports
var v_R_TRPNCa: fmol_per_sec {pub: in};
var v_R_BU: fmol_per_sec {pub: in};
var v_R_UW: fmol_per_sec {pub: in};
var v_R_WS: fmol_per_sec {pub: in};
var v_R_SU: fmol_per_sec {pub: in};


// LCC imports
var v_LCC_Ca1: fmol_per_sec {pub: in};
var v_LCC_Ca2: fmol_per_sec {pub: in};
var v_LCC_K1: fmol_per_sec {pub: in};
var v_LCC_K2: fmol_per_sec {pub: in};
var v_d000: fmol_per_sec {pub: in};
var v_d010: fmol_per_sec {pub: in};
var v_d020: fmol_per_sec {pub: in};
var v_d001: fmol_per_sec {pub: in};
var v_d011: fmol_per_sec {pub: in};
var v_d021: fmol_per_sec {pub: in};
var v_f1_000: fmol_per_sec {pub: in};
var v_f1_100: fmol_per_sec {pub: in};
var v_f1_001: fmol_per_sec {pub: in};
var v_f1_101: fmol_per_sec {pub: in};
var v_f2_000: fmol_per_sec {pub: in};
var v_f2_100: fmol_per_sec {pub: in};
var v_f2_001: fmol_per_sec {pub: in};
var v_f2_101: fmol_per_sec {pub: in};
var v_f3_010: fmol_per_sec {pub: in};
var v_f3_110: fmol_per_sec {pub: in};
var v_f3_011: fmol_per_sec {pub: in};
var v_f3_111: fmol_per_sec {pub: in};
var v_fCa000: fmol_per_sec {pub: in};
var v_fCa100: fmol_per_sec {pub: in};
var v_fCa010: fmol_per_sec {pub: in};
var v_fCa110: fmol_per_sec {pub: in};
var v_fCa020: fmol_per_sec {pub: in};
var v_fCa120: fmol_per_sec {pub: in};


// PLB imports
var v_PLBph1: fmol_per_sec {pub: in};
var v_PLBph2: fmol_per_sec {pub: in};
var v_PLBd1: fmol_per_sec {pub: in};
var v_PLBd2: fmol_per_sec {pub: in};
var v_Inh: fmol_per_sec {pub: in};


// RyR imports
var v_RyR: fmol_per_sec {pub: in};
var v_OC: fmol_per_sec {pub: in};
var v_CCI: fmol_per_sec {pub: in};
var v_CII: fmol_per_sec {pub: in};
var v_IO: fmol_per_sec {pub: in};


// SERCA imports
var v_SERCA_R1_2: fmol_per_sec {pub: in};
var v_SERCA_R2_4: fmol_per_sec {pub: in};
var v_SERCA_R2_2a: fmol_per_sec {pub: in};
var v_SERCA_R4_5: fmol_per_sec {pub: in};
var v_SERCA_R5_6: fmol_per_sec {pub: in};
var v_SERCA_R6_8: fmol_per_sec {pub: in};
var v_SERCA_R8_9: fmol_per_sec {pub: in};
var v_SERCA_R9_10: fmol_per_sec {pub: in};
var v_SERCA_R10_1: fmol_per_sec {pub: in};


ode(q_TRPN, time) = + v_mcrossbridge_TRPN ;
ode(q_Cai, time) = + v_mcrossbridge_TRPN ;
ode(q_Ca_TRPN, time) = + v_mcrossbridge_TRPN ;
ode(q_B, time) = + v_mcrossbridge_TRPN ;
ode(q_U, time) = + v_mcrossbridge_TRPN ;
ode(q_W, time) = + v_mcrossbridge_TRPN ;
ode(q_S, time) = + v_mcrossbridge_TRPN ;
ode(q_Ca_i, time) = + v_mLCC  + v_mRyR  + v_mSERCA ;
ode(q_Ca_o, time) = + v_mLCC ;
ode(q_K_i, time) = + v_mLCC ;
ode(q_K_o, time) = + v_mLCC ;
ode(q_000_LCC, time) = + v_mLCC ;
ode(q_010_LCC, time) = + v_mLCC ;
ode(q_020_LCC, time) = + v_mLCC ;
ode(q_100_LCC, time) = + v_mLCC ;
ode(q_110_LCC, time) = + v_mLCC ;
ode(q_120_LCC, time) = + v_mLCC ;
ode(q_001_LCC, time) = + v_mLCC ;
ode(q_011_LCC, time) = + v_mLCC ;
ode(q_021_LCC, time) = + v_mLCC ;
ode(q_101_LCC, time) = + v_mLCC ;
ode(q_111_LCC, time) = + v_mLCC ;
ode(q_121_LCC, time) = + v_mLCC ;
ode(q_PLB, time) = + v_mPLB ;
ode(q_PKACI, time) = + v_mPLB ;
ode(q_PLB_PKACI, time) = + v_mPLB ;
ode(q_PP1, time) = + v_mPLB ;
ode(q_PLBp_PP1, time) = + v_mPLB ;
ode(q_PLBp, time) = + v_mPLB ;
ode(q_Ip, time) = + v_mPLB ;
ode(q_Ip_PP1, time) = + v_mPLB ;
ode(q_Ca_SR, time) = + v_mRyR  + v_mSERCA ;
ode(q_C_RyR, time) = + v_mRyR ;
ode(q_CI_RyR, time) = + v_mRyR ;
ode(q_I_RyR, time) = + v_mRyR ;
ode(q_O_RyR, time) = + v_mRyR ;
ode(q_P1_SERCA, time) = + v_mSERCA ;
ode(q_P2_SERCA, time) = + v_mSERCA ;
ode(q_P2a_SERCA, time) = + v_mSERCA ;
ode(q_P4_SERCA, time) = + v_mSERCA ;
ode(q_P5_SERCA, time) = + v_mSERCA ;
ode(q_P6_SERCA, time) = + v_mSERCA ;
ode(q_P8_SERCA, time) = + v_mSERCA ;
ode(q_P9_SERCA, time) = + v_mSERCA ;
ode(q_P10_SERCA, time) = + v_mSERCA ;
ode(q_H, time) = + v_mSERCA ;
ode(q_MgATP, time) = + v_mSERCA ;
ode(q_MgADP, time) = + v_mSERCA ;
ode(q_Pi, time) = + v_mSERCA ;
enddef;

def map between environment and crossbridge_TRPN for
vars time and time;
vars q_TRPN and q_TRPN;
vars q_Cai and q_Cai;
vars q_Ca_TRPN and q_Ca_TRPN;
vars q_B and q_B;
vars q_U and q_U;
vars q_W and q_W;
vars q_S and q_S;
vars v_R_TRPNCa and v_R_TRPNCa;
vars v_R_BU and v_R_BU;
vars v_R_UW and v_R_UW;
vars v_R_WS and v_R_WS;
vars v_R_SU and v_R_SU;
enddef;

def map between environment and LCC for
vars time and time;
vars q_Ca_i and q_Ca_i;
vars q_Ca_o and q_Ca_o;
vars q_K_i and q_K_i;
vars q_K_o and q_K_o;
vars q_000_LCC and q_000_LCC;
vars q_010_LCC and q_010_LCC;
vars q_020_LCC and q_020_LCC;
vars q_100_LCC and q_100_LCC;
vars q_110_LCC and q_110_LCC;
vars q_120_LCC and q_120_LCC;
vars q_001_LCC and q_001_LCC;
vars q_011_LCC and q_011_LCC;
vars q_021_LCC and q_021_LCC;
vars q_101_LCC and q_101_LCC;
vars q_111_LCC and q_111_LCC;
vars q_121_LCC and q_121_LCC;
vars v_LCC_Ca1 and v_LCC_Ca1;
vars v_LCC_Ca2 and v_LCC_Ca2;
vars v_LCC_K1 and v_LCC_K1;
vars v_LCC_K2 and v_LCC_K2;
vars v_d000 and v_d000;
vars v_d010 and v_d010;
vars v_d020 and v_d020;
vars v_d001 and v_d001;
vars v_d011 and v_d011;
vars v_d021 and v_d021;
vars v_f1_000 and v_f1_000;
vars v_f1_100 and v_f1_100;
vars v_f1_001 and v_f1_001;
vars v_f1_101 and v_f1_101;
vars v_f2_000 and v_f2_000;
vars v_f2_100 and v_f2_100;
vars v_f2_001 and v_f2_001;
vars v_f2_101 and v_f2_101;
vars v_f3_010 and v_f3_010;
vars v_f3_110 and v_f3_110;
vars v_f3_011 and v_f3_011;
vars v_f3_111 and v_f3_111;
vars v_fCa000 and v_fCa000;
vars v_fCa100 and v_fCa100;
vars v_fCa010 and v_fCa010;
vars v_fCa110 and v_fCa110;
vars v_fCa020 and v_fCa020;
vars v_fCa120 and v_fCa120;
enddef;

def map between environment and PLB for
vars time and time;
vars q_PLB and q_PLB;
vars q_PKACI and q_PKACI;
vars q_PLB_PKACI and q_PLB_PKACI;
vars q_PP1 and q_PP1;
vars q_PLBp_PP1 and q_PLBp_PP1;
vars q_PLBp and q_PLBp;
vars q_Ip and q_Ip;
vars q_Ip_PP1 and q_Ip_PP1;
vars v_PLBph1 and v_PLBph1;
vars v_PLBph2 and v_PLBph2;
vars v_PLBd1 and v_PLBd1;
vars v_PLBd2 and v_PLBd2;
vars v_Inh and v_Inh;
enddef;

def map between environment and RyR for
vars time and time;
vars q_Ca_SR and q_Ca_SR;
vars q_Ca_i and q_Ca_i;
vars q_C_RyR and q_C_RyR;
vars q_CI_RyR and q_CI_RyR;
vars q_I_RyR and q_I_RyR;
vars q_O_RyR and q_O_RyR;
vars v_RyR and v_RyR;
vars v_OC and v_OC;
vars v_CCI and v_CCI;
vars v_CII and v_CII;
vars v_IO and v_IO;
enddef;

def map between environment and SERCA for
vars time and time;
vars q_P1_SERCA and q_P1_SERCA;
vars q_P2_SERCA and q_P2_SERCA;
vars q_P2a_SERCA and q_P2a_SERCA;
vars q_P4_SERCA and q_P4_SERCA;
vars q_P5_SERCA and q_P5_SERCA;
vars q_P6_SERCA and q_P6_SERCA;
vars q_P8_SERCA and q_P8_SERCA;
vars q_P9_SERCA and q_P9_SERCA;
vars q_P10_SERCA and q_P10_SERCA;
vars q_H and q_H;
vars q_Ca_i and q_Ca_i;
vars q_Ca_SR and q_Ca_SR;
vars q_MgATP and q_MgATP;
vars q_MgADP and q_MgADP;
vars q_Pi and q_Pi;
vars v_SERCA_R1_2 and v_SERCA_R1_2;
vars v_SERCA_R2_4 and v_SERCA_R2_4;
vars v_SERCA_R2_2a and v_SERCA_R2_2a;
vars v_SERCA_R4_5 and v_SERCA_R4_5;
vars v_SERCA_R5_6 and v_SERCA_R5_6;
vars v_SERCA_R6_8 and v_SERCA_R6_8;
vars v_SERCA_R8_9 and v_SERCA_R8_9;
vars v_SERCA_R9_10 and v_SERCA_R9_10;
vars v_SERCA_R10_1 and v_SERCA_R10_1;
enddef;

def map between BG_parameters and crossbridge_TRPN for
vars kappa_R_TRPNCa and kappa_R_TRPNCa;
vars kappa_R_BU and kappa_R_BU;
vars kappa_R_UW and kappa_R_UW;
vars kappa_R_WS and kappa_R_WS;
vars kappa_R_SU and kappa_R_SU;
vars K_TRPN and K_TRPN;
vars K_Cai and K_Cai;
vars K_Ca_TRPN and K_Ca_TRPN;
vars K_B and K_B;
vars K_U and K_U;
vars K_W and K_W;
vars K_S and K_S;
enddef;
def map between BG_parameters and LCC for
vars kappa_LCC_Ca1 and kappa_LCC_Ca1;
vars kappa_LCC_Ca2 and kappa_LCC_Ca2;
vars kappa_LCC_K1 and kappa_LCC_K1;
vars kappa_LCC_K2 and kappa_LCC_K2;
vars kappa_d000 and kappa_d000;
vars kappa_d010 and kappa_d010;
vars kappa_d020 and kappa_d020;
vars kappa_d001 and kappa_d001;
vars kappa_d011 and kappa_d011;
vars kappa_d021 and kappa_d021;
vars kappa_f1_000 and kappa_f1_000;
vars kappa_f1_100 and kappa_f1_100;
vars kappa_f1_001 and kappa_f1_001;
vars kappa_f1_101 and kappa_f1_101;
vars kappa_f2_000 and kappa_f2_000;
vars kappa_f2_100 and kappa_f2_100;
vars kappa_f2_001 and kappa_f2_001;
vars kappa_f2_101 and kappa_f2_101;
vars kappa_f3_010 and kappa_f3_010;
vars kappa_f3_110 and kappa_f3_110;
vars kappa_f3_011 and kappa_f3_011;
vars kappa_f3_111 and kappa_f3_111;
vars kappa_fCa000 and kappa_fCa000;
vars kappa_fCa100 and kappa_fCa100;
vars kappa_fCa010 and kappa_fCa010;
vars kappa_fCa110 and kappa_fCa110;
vars kappa_fCa020 and kappa_fCa020;
vars kappa_fCa120 and kappa_fCa120;
vars K_Ca_i and K_Ca_i;
vars K_Ca_o and K_Ca_o;
vars K_K_i and K_K_i;
vars K_K_o and K_K_o;
vars K_000_LCC and K_000_LCC;
vars K_010_LCC and K_010_LCC;
vars K_020_LCC and K_020_LCC;
vars K_100_LCC and K_100_LCC;
vars K_110_LCC and K_110_LCC;
vars K_120_LCC and K_120_LCC;
vars K_001_LCC and K_001_LCC;
vars K_011_LCC and K_011_LCC;
vars K_021_LCC and K_021_LCC;
vars K_101_LCC and K_101_LCC;
vars K_111_LCC and K_111_LCC;
vars K_121_LCC and K_121_LCC;
enddef;
def map between BG_parameters and PLB for
vars kappa_PLBph1 and kappa_PLBph1;
vars kappa_PLBph2 and kappa_PLBph2;
vars kappa_PLBd1 and kappa_PLBd1;
vars kappa_PLBd2 and kappa_PLBd2;
vars kappa_Inh and kappa_Inh;
vars K_PLB and K_PLB;
vars K_PKACI and K_PKACI;
vars K_PLB_PKACI and K_PLB_PKACI;
vars K_PP1 and K_PP1;
vars K_PLBp_PP1 and K_PLBp_PP1;
vars K_PLBp and K_PLBp;
vars K_Ip and K_Ip;
vars K_Ip_PP1 and K_Ip_PP1;
enddef;
def map between BG_parameters and RyR for
vars kappa_RyR and kappa_RyR;
vars kappa_OC and kappa_OC;
vars kappa_CCI and kappa_CCI;
vars kappa_CII and kappa_CII;
vars kappa_IO and kappa_IO;
vars K_Ca_SR and K_Ca_SR;
vars K_Ca_i and K_Ca_i;
vars K_C_RyR and K_C_RyR;
vars K_CI_RyR and K_CI_RyR;
vars K_I_RyR and K_I_RyR;
vars K_O_RyR and K_O_RyR;
enddef;
def map between BG_parameters and SERCA for
vars kappa_SERCA_R1_2 and kappa_SERCA_R1_2;
vars kappa_SERCA_R2_4 and kappa_SERCA_R2_4;
vars kappa_SERCA_R2_2a and kappa_SERCA_R2_2a;
vars kappa_SERCA_R4_5 and kappa_SERCA_R4_5;
vars kappa_SERCA_R5_6 and kappa_SERCA_R5_6;
vars kappa_SERCA_R6_8 and kappa_SERCA_R6_8;
vars kappa_SERCA_R8_9 and kappa_SERCA_R8_9;
vars kappa_SERCA_R9_10 and kappa_SERCA_R9_10;
vars kappa_SERCA_R10_1 and kappa_SERCA_R10_1;
vars K_P1_SERCA and K_P1_SERCA;
vars K_P2_SERCA and K_P2_SERCA;
vars K_P2a_SERCA and K_P2a_SERCA;
vars K_P4_SERCA and K_P4_SERCA;
vars K_P5_SERCA and K_P5_SERCA;
vars K_P6_SERCA and K_P6_SERCA;
vars K_P8_SERCA and K_P8_SERCA;
vars K_P9_SERCA and K_P9_SERCA;
vars K_P10_SERCA and K_P10_SERCA;
vars K_H and K_H;
vars K_Ca_i and K_Ca_i;
vars K_Ca_SR and K_Ca_SR;
vars K_MgATP and K_MgATP;
vars K_MgADP and K_MgADP;
vars K_Pi and K_Pi;
enddef;

def map between constants and crossbridge_TRPN for
	vars R and R;
	vars T and T;
enddef;
def map between constants and LCC for
	vars R and R;
	vars T and T;
enddef;
def map between constants and PLB for
	vars R and R;
	vars T and T;
enddef;
def map between constants and RyR for
	vars R and R;
	vars T and T;
enddef;
def map between constants and SERCA for
	vars R and R;
	vars T and T;
enddef;

enddef;