- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2022-02-18 13:27:41+13:00
- Desc:
- Updating way cellml is written
- Permanent Source URI:
- https://models.cellml.org/workspace/7dc/rawfile/27738c8bd7e535b72ec3ad5073fc326dd3e96855/BG_GPCR_B1AR_reduced.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="individual_GPCR_B1AR_reduced" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="mM" units_ref="mM"/>
<units name="fmol" units_ref="fmol"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="microm3" units_ref="microm3"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
<units name="per_second" units_ref="per_second"/>
<units name="millivolt" units_ref="millivolt"/>
<units name="per_sec" units_ref="per_sec"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="fmol_per_L" units_ref="fmol_per_L"/>
<units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
<units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
<units name="uM" units_ref="uM"/>
<units name="mM_per_sec" units_ref="mM_per_sec"/>
<units name="uM_per_sec" units_ref="uM_per_sec"/>
<units name="pL" units_ref="pL"/>
<units name="m_to_u" units_ref="m_to_u"/>
</import>
<import xlink:href="units_and_constants/constants_BG.cellml">
<component component_ref="constants" name="constants"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
<!-- initial values-->
<variable initial_value="0.0004579000e0" name="q_RB1_inactive" public_interface="out" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_inactive" public_interface="out" units="fmol"/>
<variable initial_value="0" name="q_LB1_ode" units="fmol"/>
<variable name="q_LB1_stim" units="fmol"/>
<variable name="q_LB1" public_interface="out" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1" public_interface="out" units="fmol"/>
<variable initial_value="0.1455400000" name="q_Gs" public_interface="out" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_Gs" public_interface="out" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1" public_interface="out" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_Gs" public_interface="out" units="fmol"/>
<variable initial_value="0.01" name="q_Gsa_GTP" public_interface="out" units="fmol"/>
<variable initial_value="0.02" name="q_Gsbetagamma" public_interface="out" units="fmol"/>
<variable initial_value="0.01" name="q_Gsa_GDP" public_interface="out" units="fmol"/>
<variable initial_value="2.2" name="q_GTP" public_interface="out" units="fmol"/>
<variable initial_value="1.1" name="q_GDP" public_interface="out" units="fmol"/>
<variable initial_value="570" name="q_Pi" public_interface="out" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_tag" public_interface="out" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_tag" public_interface="out" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_GRKArr" public_interface="out" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_GRKArr" public_interface="out" units="fmol"/>
<variable initial_value="1e-3" name="q_GRKArr" public_interface="out" units="fmol"/>
<!-- stimulus-->
<variable initial_value="2.5" name="stimSt" units="second"/>
<variable initial_value="5e-1" name="stimDur" units="second"/>
<variable initial_value="5e0" name="tR" units="second"/>
<variable initial_value="1e1" name="stimMag" units="fmol"/>
<variable initial_value="1e-8" name="stimHolding" units="fmol"/>
<variable name="m" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m</ci>
<apply>
<divide/>
<ci>stimMag</ci>
<ci>tR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LB1_stim</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<ci>m</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<ci>tR</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<apply>
<gt/>
<ci>time</ci>
<apply>
<minus/>
<ci>stimSt</ci>
<ci>tR</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimMag</ci>
<ci>stimHolding</ci>
</apply>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<ci>tR</ci>
</apply>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<leq/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>tR</ci>
<ci>stimDur</ci>
</apply>
</apply>
<apply>
<geq/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>stimHolding</ci>
</otherwise>
</piecewise>
</apply>
</math>
<!-- From submodule-->
<variable name="v_Rswitch_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="v_LRswitch_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="v_C_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="v_R_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="v_L_actR" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Act1_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Act2_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Hyd_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Reassoc_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="v_InternR_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="v_InternLR_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Rsynthesis" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>v_Rsynthesis</ci>
<apply>
<plus/>
<ci>v_Rswitch_B1</ci>
<ci>v_L_actR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1_inactive</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_Rswitch_B1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0</cn>
<ci>v_Rsynthesis</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1_inactive</ci>
</apply>
<apply>
<minus/>
<ci>v_LRswitch_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_LB1_ode</ci>
</apply>
<apply>
<minus/>
<ci>v_L_actR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_Rswitch_B1</ci>
<ci>v_C_B1</ci>
</apply>
<ci>v_L_actR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Gs</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_C_B1</ci>
</apply>
<ci>v_R_B1</ci>
</apply>
<ci>v_Reassoc_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1_Gs</ci>
</apply>
<apply>
<minus/>
<ci>v_C_B1</ci>
<ci>v_Act1_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_LRswitch_B1</ci>
<ci>v_R_B1</ci>
</apply>
<ci>v_L_actR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1_Gs</ci>
</apply>
<apply>
<minus/>
<ci>v_R_B1</ci>
<ci>v_Act2_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Gsa_GTP</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_Act1_Gs</ci>
<ci>v_Act2_Gs</ci>
</apply>
<ci>v_Hyd_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Gsbetagamma</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_Act1_Gs</ci>
<ci>v_Act2_Gs</ci>
</apply>
<ci>v_Reassoc_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Gsa_GDP</ci>
</apply>
<apply>
<minus/>
<ci>v_Hyd_Gs</ci>
<ci>v_Reassoc_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_GTP</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_Act1_Gs</ci>
</apply>
<ci>v_Act2_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_GDP</ci>
</apply>
<apply>
<plus/>
<ci>v_Act1_Gs</ci>
<ci>v_Act2_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Pi</ci>
</apply>
<ci>v_Hyd_Gs</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1_tag</ci>
</apply>
<apply>
<minus/>
<ci>v_Act1_Gs</ci>
<ci>v_InternR_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1_tag</ci>
</apply>
<apply>
<minus/>
<ci>v_Act2_Gs</ci>
<ci>v_InternLR_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1_GRKArr</ci>
</apply>
<ci>v_InternR_B1</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1_GRKArr</ci>
</apply>
<ci>v_InternLR_B1</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_GRKArr</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_InternR_B1</ci>
</apply>
<ci>v_InternLR_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LB1</ci>
<apply>
<plus/>
<ci>q_LB1_stim</ci>
<ci>q_LB1_ode</ci>
</apply>
</apply>
</math>
</component>
<component name="GPCR_B1AR_reduced_parameters">
<variable initial_value="1036.38" name="kappa_Rswitch_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.83921e-07" name="kappa_LRswitch_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="891573" name="kappa_C_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.58222e+06" name="kappa_R_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="52417.5" name="kappa_L_actR" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000610519" name="kappa_Act1_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.576677" name="kappa_Act2_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0661821" name="kappa_Hyd_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="8.60273e-06" name="kappa_Reassoc_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00230556" name="kappa_InternR_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.17775" name="kappa_InternLR_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="28.0492" name="K_RB1_inactive" public_interface="out" units="per_fmol"/>
<variable initial_value="1.58056e+11" name="K_L_RB1_inactive" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0574759" name="K_LB1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.280492" name="K_RB1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00337913" name="K_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="1.07597" name="K_RB1_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="0.158056" name="K_L_RB1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00113911" name="K_L_RB1_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00878478" name="K_Gsa_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="736.699" name="K_Gsbetagamma" public_interface="out" units="per_fmol"/>
<variable initial_value="161.34" name="K_Gsa_GDP" public_interface="out" units="per_fmol"/>
<variable initial_value="823.314" name="K_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="3.61368e-10" name="K_GDP" public_interface="out" units="per_fmol"/>
<variable initial_value="7.91408e-11" name="K_Pi" public_interface="out" units="per_fmol"/>
<variable initial_value="0.500146" name="K_RB1_tag" public_interface="out" units="per_fmol"/>
<variable initial_value="0.000529497" name="K_L_RB1_tag" public_interface="out" units="per_fmol"/>
<variable initial_value="1.26086e-05" name="K_RB1_GRKArr" public_interface="out" units="per_fmol"/>
<variable initial_value="1.33485e-08" name="K_L_RB1_GRKArr" public_interface="out" units="per_fmol"/>
<variable initial_value="732843" name="K_GRKArr" public_interface="out" units="per_fmol"/>
</component>
<component name="GPCR_B1AR_reduced">
<variable name="time" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<!-- parameters-->
<variable name="kappa_Rswitch_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_LRswitch_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_C_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_R_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_L_actR" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Act1_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Act2_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Hyd_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Reassoc_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_InternR_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_InternLR_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="K_RB1_inactive" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1_inactive" public_interface="in" units="per_fmol"/>
<variable name="K_LB1" public_interface="in" units="per_fmol"/>
<variable name="K_RB1" public_interface="in" units="per_fmol"/>
<variable name="K_Gs" public_interface="in" units="per_fmol"/>
<variable name="K_RB1_Gs" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1_Gs" public_interface="in" units="per_fmol"/>
<variable name="K_Gsa_GTP" public_interface="in" units="per_fmol"/>
<variable name="K_Gsbetagamma" public_interface="in" units="per_fmol"/>
<variable name="K_Gsa_GDP" public_interface="in" units="per_fmol"/>
<variable name="K_GTP" public_interface="in" units="per_fmol"/>
<variable name="K_GDP" public_interface="in" units="per_fmol"/>
<variable name="K_Pi" public_interface="in" units="per_fmol"/>
<variable name="K_RB1_tag" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1_tag" public_interface="in" units="per_fmol"/>
<variable name="K_RB1_GRKArr" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1_GRKArr" public_interface="in" units="per_fmol"/>
<variable name="K_GRKArr" public_interface="in" units="per_fmol"/>
<!-- Input from global environment-->
<variable name="q_RB1_inactive" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_inactive" public_interface="in" units="fmol"/>
<variable name="q_LB1" public_interface="in" units="fmol"/>
<variable name="q_RB1" public_interface="in" units="fmol"/>
<variable name="q_Gs" public_interface="in" units="fmol"/>
<variable name="q_RB1_Gs" public_interface="in" units="fmol"/>
<variable name="q_L_RB1" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_Gs" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GTP" public_interface="in" units="fmol"/>
<variable name="q_Gsbetagamma" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GDP" public_interface="in" units="fmol"/>
<variable name="q_GTP" public_interface="in" units="fmol"/>
<variable name="q_GDP" public_interface="in" units="fmol"/>
<variable name="q_Pi" public_interface="in" units="fmol"/>
<variable name="q_RB1_tag" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_tag" public_interface="in" units="fmol"/>
<variable name="q_RB1_GRKArr" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_GRKArr" public_interface="in" units="fmol"/>
<variable name="q_GRKArr" public_interface="in" units="fmol"/>
<!-- Constitutive parameters-->
<variable name="mu_RB1_inactive" units="J_per_mol"/>
<variable name="mu_L_RB1_inactive" units="J_per_mol"/>
<variable name="mu_LB1" units="J_per_mol"/>
<variable name="mu_RB1" units="J_per_mol"/>
<variable name="mu_Gs" units="J_per_mol"/>
<variable name="mu_RB1_Gs" units="J_per_mol"/>
<variable name="mu_L_RB1" units="J_per_mol"/>
<variable name="mu_L_RB1_Gs" units="J_per_mol"/>
<variable name="mu_Gsa_GTP" units="J_per_mol"/>
<variable name="mu_Gsbetagamma" units="J_per_mol"/>
<variable name="mu_Gsa_GDP" units="J_per_mol"/>
<variable name="mu_GTP" units="J_per_mol"/>
<variable name="mu_GDP" units="J_per_mol"/>
<variable name="mu_Pi" units="J_per_mol"/>
<variable name="mu_RB1_tag" units="J_per_mol"/>
<variable name="mu_L_RB1_tag" units="J_per_mol"/>
<variable name="mu_RB1_GRKArr" units="J_per_mol"/>
<variable name="mu_L_RB1_GRKArr" units="J_per_mol"/>
<variable name="mu_GRKArr" units="J_per_mol"/>
<variable name="v_Rswitch_B1" public_interface="out" units="fmol_per_sec"/>
<variable name="v_LRswitch_B1" public_interface="out" units="fmol_per_sec"/>
<variable name="v_C_B1" public_interface="out" units="fmol_per_sec"/>
<variable name="v_R_B1" public_interface="out" units="fmol_per_sec"/>
<variable name="v_L_actR" public_interface="out" units="fmol_per_sec"/>
<variable name="v_Act1_Gs" public_interface="out" units="fmol_per_sec"/>
<variable name="v_Act2_Gs" public_interface="out" units="fmol_per_sec"/>
<variable name="v_Hyd_Gs" public_interface="out" units="fmol_per_sec"/>
<variable name="v_Reassoc_Gs" public_interface="out" units="fmol_per_sec"/>
<variable name="v_InternR_B1" public_interface="out" units="fmol_per_sec"/>
<variable name="v_InternLR_B1" public_interface="out" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_RB1_inactive</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1_inactive</ci>
<ci>q_RB1_inactive</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1_inactive</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1_inactive</ci>
<ci>q_L_RB1_inactive</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_LB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_LB1</ci>
<ci>q_LB1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_RB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1</ci>
<ci>q_RB1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Gs</ci>
<ci>q_Gs</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_RB1_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1_Gs</ci>
<ci>q_RB1_Gs</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1</ci>
<ci>q_L_RB1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1_Gs</ci>
<ci>q_L_RB1_Gs</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Gsa_GTP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Gsa_GTP</ci>
<ci>q_Gsa_GTP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Gsbetagamma</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Gsbetagamma</ci>
<ci>q_Gsbetagamma</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Gsa_GDP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Gsa_GDP</ci>
<ci>q_Gsa_GDP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_GTP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_GTP</ci>
<ci>q_GTP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_GDP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_GDP</ci>
<ci>q_GDP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Pi</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Pi</ci>
<ci>q_Pi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_RB1_tag</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1_tag</ci>
<ci>q_RB1_tag</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1_tag</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1_tag</ci>
<ci>q_L_RB1_tag</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_RB1_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1_GRKArr</ci>
<ci>q_RB1_GRKArr</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1_GRKArr</ci>
<ci>q_L_RB1_GRKArr</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_GRKArr</ci>
<ci>q_GRKArr</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Rswitch_B1</ci>
<apply>
<times/>
<ci>kappa_Rswitch_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_RB1_inactive</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_RB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_LRswitch_B1</ci>
<apply>
<times/>
<ci>kappa_LRswitch_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1_inactive</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_C_B1</ci>
<apply>
<times/>
<ci>kappa_C_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_RB1</ci>
<ci>mu_Gs</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_RB1_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_R_B1</ci>
<apply>
<times/>
<ci>kappa_R_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_L_RB1</ci>
<ci>mu_Gs</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_L_actR</ci>
<apply>
<times/>
<ci>kappa_L_actR</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_RB1</ci>
<ci>mu_LB1</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Act1_Gs</ci>
<apply>
<times/>
<ci>kappa_Act1_Gs</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_RB1_Gs</ci>
<ci>mu_GTP</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_Gsa_GTP</ci>
<ci>mu_Gsbetagamma</ci>
<ci>mu_RB1_tag</ci>
<ci>mu_GDP</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Act2_Gs</ci>
<apply>
<times/>
<ci>kappa_Act2_Gs</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_L_RB1_Gs</ci>
<ci>mu_GTP</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_Gsa_GTP</ci>
<ci>mu_Gsbetagamma</ci>
<ci>mu_L_RB1_tag</ci>
<ci>mu_GDP</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Hyd_Gs</ci>
<apply>
<times/>
<ci>kappa_Hyd_Gs</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_Gsa_GTP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_Gsa_GDP</ci>
<ci>mu_Pi</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Reassoc_Gs</ci>
<apply>
<times/>
<ci>kappa_Reassoc_Gs</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_Gsa_GDP</ci>
<ci>mu_Gsbetagamma</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_InternR_B1</ci>
<apply>
<times/>
<ci>kappa_InternR_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_RB1_tag</ci>
<ci>mu_GRKArr</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_RB1_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_InternLR_B1</ci>
<apply>
<times/>
<ci>kappa_InternLR_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_L_RB1_tag</ci>
<ci>mu_GRKArr</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="GPCR_B1AR_reduced"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_RB1_inactive" variable_2="q_RB1_inactive"/>
<map_variables variable_1="q_L_RB1_inactive" variable_2="q_L_RB1_inactive"/>
<map_variables variable_1="q_LB1" variable_2="q_LB1"/>
<map_variables variable_1="q_RB1" variable_2="q_RB1"/>
<map_variables variable_1="q_Gs" variable_2="q_Gs"/>
<map_variables variable_1="q_RB1_Gs" variable_2="q_RB1_Gs"/>
<map_variables variable_1="q_L_RB1" variable_2="q_L_RB1"/>
<map_variables variable_1="q_L_RB1_Gs" variable_2="q_L_RB1_Gs"/>
<map_variables variable_1="q_Gsa_GTP" variable_2="q_Gsa_GTP"/>
<map_variables variable_1="q_Gsbetagamma" variable_2="q_Gsbetagamma"/>
<map_variables variable_1="q_Gsa_GDP" variable_2="q_Gsa_GDP"/>
<map_variables variable_1="q_GTP" variable_2="q_GTP"/>
<map_variables variable_1="q_GDP" variable_2="q_GDP"/>
<map_variables variable_1="q_Pi" variable_2="q_Pi"/>
<map_variables variable_1="q_RB1_tag" variable_2="q_RB1_tag"/>
<map_variables variable_1="q_L_RB1_tag" variable_2="q_L_RB1_tag"/>
<map_variables variable_1="q_RB1_GRKArr" variable_2="q_RB1_GRKArr"/>
<map_variables variable_1="q_L_RB1_GRKArr" variable_2="q_L_RB1_GRKArr"/>
<map_variables variable_1="q_GRKArr" variable_2="q_GRKArr"/>
<map_variables variable_1="v_Rswitch_B1" variable_2="v_Rswitch_B1"/>
<map_variables variable_1="v_LRswitch_B1" variable_2="v_LRswitch_B1"/>
<map_variables variable_1="v_C_B1" variable_2="v_C_B1"/>
<map_variables variable_1="v_R_B1" variable_2="v_R_B1"/>
<map_variables variable_1="v_L_actR" variable_2="v_L_actR"/>
<map_variables variable_1="v_Act1_Gs" variable_2="v_Act1_Gs"/>
<map_variables variable_1="v_Act2_Gs" variable_2="v_Act2_Gs"/>
<map_variables variable_1="v_Hyd_Gs" variable_2="v_Hyd_Gs"/>
<map_variables variable_1="v_Reassoc_Gs" variable_2="v_Reassoc_Gs"/>
<map_variables variable_1="v_InternR_B1" variable_2="v_InternR_B1"/>
<map_variables variable_1="v_InternLR_B1" variable_2="v_InternLR_B1"/>
</connection>
<connection>
<map_components component_1="GPCR_B1AR_reduced" component_2="GPCR_B1AR_reduced_parameters"/>
<map_variables variable_1="kappa_Rswitch_B1" variable_2="kappa_Rswitch_B1"/>
<map_variables variable_1="kappa_LRswitch_B1" variable_2="kappa_LRswitch_B1"/>
<map_variables variable_1="kappa_C_B1" variable_2="kappa_C_B1"/>
<map_variables variable_1="kappa_R_B1" variable_2="kappa_R_B1"/>
<map_variables variable_1="kappa_L_actR" variable_2="kappa_L_actR"/>
<map_variables variable_1="kappa_Act1_Gs" variable_2="kappa_Act1_Gs"/>
<map_variables variable_1="kappa_Act2_Gs" variable_2="kappa_Act2_Gs"/>
<map_variables variable_1="kappa_Hyd_Gs" variable_2="kappa_Hyd_Gs"/>
<map_variables variable_1="kappa_Reassoc_Gs" variable_2="kappa_Reassoc_Gs"/>
<map_variables variable_1="kappa_InternR_B1" variable_2="kappa_InternR_B1"/>
<map_variables variable_1="kappa_InternLR_B1" variable_2="kappa_InternLR_B1"/>
<map_variables variable_1="K_RB1_inactive" variable_2="K_RB1_inactive"/>
<map_variables variable_1="K_L_RB1_inactive" variable_2="K_L_RB1_inactive"/>
<map_variables variable_1="K_LB1" variable_2="K_LB1"/>
<map_variables variable_1="K_RB1" variable_2="K_RB1"/>
<map_variables variable_1="K_Gs" variable_2="K_Gs"/>
<map_variables variable_1="K_RB1_Gs" variable_2="K_RB1_Gs"/>
<map_variables variable_1="K_L_RB1" variable_2="K_L_RB1"/>
<map_variables variable_1="K_L_RB1_Gs" variable_2="K_L_RB1_Gs"/>
<map_variables variable_1="K_Gsa_GTP" variable_2="K_Gsa_GTP"/>
<map_variables variable_1="K_Gsbetagamma" variable_2="K_Gsbetagamma"/>
<map_variables variable_1="K_Gsa_GDP" variable_2="K_Gsa_GDP"/>
<map_variables variable_1="K_GTP" variable_2="K_GTP"/>
<map_variables variable_1="K_GDP" variable_2="K_GDP"/>
<map_variables variable_1="K_Pi" variable_2="K_Pi"/>
<map_variables variable_1="K_RB1_tag" variable_2="K_RB1_tag"/>
<map_variables variable_1="K_L_RB1_tag" variable_2="K_L_RB1_tag"/>
<map_variables variable_1="K_RB1_GRKArr" variable_2="K_RB1_GRKArr"/>
<map_variables variable_1="K_L_RB1_GRKArr" variable_2="K_L_RB1_GRKArr"/>
<map_variables variable_1="K_GRKArr" variable_2="K_GRKArr"/>
</connection>
<connection>
<map_components component_1="constants" component_2="GPCR_B1AR_reduced"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
</model>
