Location: BG_GPCR_B1AR_reduced @ 5ff72e51dee7 / BG_GPCR_B1AR_reduced.cellml

Author:
Shelley Fong <s.fong@auckland.ac.nz>
Date:
2022-01-19 15:45:38+13:00
Desc:
formatting
Permanent Source URI:
https://models.cellml.org/workspace/7dc/rawfile/5ff72e51dee7e4a21d5196b717ccb0a19e8172f3/BG_GPCR_B1AR_reduced.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="individual_GPCR_B1AR_reduced" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="units_and_constants/units_BG.cellml">
        <units name="mM" units_ref="mM"/>
        <units name="fmol" units_ref="fmol"/>
        <units name="per_fmol" units_ref="per_fmol"/>
        <units name="J_per_mol" units_ref="J_per_mol"/>
        <units name="fmol_per_sec" units_ref="fmol_per_sec"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="J_per_C" units_ref="J_per_C"/>
        <units name="microm3" units_ref="microm3"/>
        <units name="fF" units_ref="fF"/>
        <units name="fC" units_ref="fC"/>
        <units name="fA" units_ref="fA"/>
        <units name="per_second" units_ref="per_second"/>
        <units name="millivolt" units_ref="millivolt"/>
        <units name="per_sec" units_ref="per_sec"/>
        <units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
        <units name="fmol_per_L" units_ref="fmol_per_L"/>
        <units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
        <units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
        <units name="uM" units_ref="uM"/>
        <units name="mM_per_sec" units_ref="mM_per_sec"/>
        <units name="uM_per_sec" units_ref="uM_per_sec"/>
        <units name="pL" units_ref="pL"/>
        <units name="m_to_u" units_ref="m_to_u"/>
    </import>
    <import xlink:href="units_and_constants/constants_BG.cellml">
        <component component_ref="constants" name="constants"/>
    </import>
    <component name="environment">
        <variable name="time" public_interface="out" units="second"/>
        <!-- initial values-->
        <variable initial_value="0.0004579000e0" name="q_RB1_inactive_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RB1_inactive_init" units="fmol"/>
        <variable name="q_LB1_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_RB1_init" units="fmol"/>
        <variable initial_value="0.1455400000" name="q_Gs_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_RB1_Gs_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RB1_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RB1_Gs_init" units="fmol"/>
        <variable initial_value="0.01" name="q_Gsa_GTP_init" units="fmol"/>
        <variable initial_value="0.02" name="q_Gsbetagamma_init" units="fmol"/>
        <variable initial_value="0.01" name="q_Gsa_GDP_init" units="fmol"/>
        <variable initial_value="2.2" name="q_GTP_init" units="fmol"/>
        <variable initial_value="1.1" name="q_GDP_init" units="fmol"/>
        <variable initial_value="570" name="q_Pi_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_RB1_tag_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RB1_tag_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_RB1_GRKArr_init" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RB1_GRKArr_init" units="fmol"/>
        <variable initial_value="1e-3" name="q_GRKArr_init" units="fmol"/>
        <!-- stimulus-->
        <variable initial_value="2.5" name="stimSt" units="second"/>
        <variable initial_value="5e-1" name="stimDur" units="second"/>
        <variable initial_value="5e0" name="tR" units="second"/>
        <variable initial_value="1e1" name="stimMag" units="fmol"/>
        <variable initial_value="1e-8" name="stimHolding" units="fmol"/>
        <variable name="m" units="fmol_per_sec"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>m</ci>
                <apply>
                    <divide/>
                    <ci>stimMag</ci>
                    <ci>tR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LB1_init</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimHolding</ci>
                            <apply>
                                <times/>
                                <ci>m</ci>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <minus/>
                                        <ci>time</ci>
                                        <ci>stimSt</ci>
                                    </apply>
                                    <ci>tR</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <ci>stimSt</ci>
                            </apply>
                            <apply>
                                <gt/>
                                <ci>time</ci>
                                <apply>
                                    <minus/>
                                    <ci>stimSt</ci>
                                    <ci>tR</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimMag</ci>
                            <ci>stimHolding</ci>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <geq/>
                                <ci>time</ci>
                                <ci>stimSt</ci>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimHolding</ci>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>m</ci>
                                </apply>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <ci>time</ci>
                                            <ci>stimSt</ci>
                                        </apply>
                                        <ci>tR</ci>
                                    </apply>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <leq/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt</ci>
                                    <ci>tR</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                            <apply>
                                <geq/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>stimHolding</ci>
                    </otherwise>
                </piecewise>
            </apply>
        </math>
        <!-- Global value-->
        <variable name="q_RB1_inactive" public_interface="out" units="fmol"/>
        <variable name="q_L_RB1_inactive" public_interface="out" units="fmol"/>
        <variable name="q_LB1" public_interface="out" units="fmol"/>
        <variable name="q_RB1" public_interface="out" units="fmol"/>
        <variable name="q_Gs" public_interface="out" units="fmol"/>
        <variable name="q_RB1_Gs" public_interface="out" units="fmol"/>
        <variable name="q_L_RB1" public_interface="out" units="fmol"/>
        <variable name="q_L_RB1_Gs" public_interface="out" units="fmol"/>
        <variable name="q_Gsa_GTP" public_interface="out" units="fmol"/>
        <variable name="q_Gsbetagamma" public_interface="out" units="fmol"/>
        <variable name="q_Gsa_GDP" public_interface="out" units="fmol"/>
        <variable name="q_GTP" public_interface="out" units="fmol"/>
        <variable name="q_GDP" public_interface="out" units="fmol"/>
        <variable name="q_Pi" public_interface="out" units="fmol"/>
        <variable name="q_RB1_tag" public_interface="out" units="fmol"/>
        <variable name="q_L_RB1_tag" public_interface="out" units="fmol"/>
        <variable name="q_RB1_GRKArr" public_interface="out" units="fmol"/>
        <variable name="q_L_RB1_GRKArr" public_interface="out" units="fmol"/>
        <variable name="q_GRKArr" public_interface="out" units="fmol"/>
        <!-- From submodule-->
        <variable name="q_RB1_inactive_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_inactive_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_LB1_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_RB1_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_Gs_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_RB1_Gs_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_Gs_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_Gsa_GTP_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_Gsbetagamma_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_Gsa_GDP_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_GTP_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_GDP_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_Pi_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_RB1_tag_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_tag_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_RB1_GRKArr_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_GRKArr_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <variable name="q_GRKArr_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>q_RB1_inactive</ci>
                <apply>
                    <plus/>
                    <ci>q_RB1_inactive_mGPCR_B1AR_reduced</ci>
                    <ci>q_RB1_inactive_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_L_RB1_inactive</ci>
                <apply>
                    <plus/>
                    <ci>q_L_RB1_inactive_mGPCR_B1AR_reduced</ci>
                    <ci>q_L_RB1_inactive_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LB1</ci>
                <apply>
                    <plus/>
                    <ci>q_LB1_mGPCR_B1AR_reduced</ci>
                    <ci>q_LB1_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_RB1</ci>
                <apply>
                    <plus/>
                    <ci>q_RB1_mGPCR_B1AR_reduced</ci>
                    <ci>q_RB1_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Gs</ci>
                <apply>
                    <plus/>
                    <ci>q_Gs_mGPCR_B1AR_reduced</ci>
                    <ci>q_Gs_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_RB1_Gs</ci>
                <apply>
                    <plus/>
                    <ci>q_RB1_Gs_mGPCR_B1AR_reduced</ci>
                    <ci>q_RB1_Gs_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_L_RB1</ci>
                <apply>
                    <plus/>
                    <ci>q_L_RB1_mGPCR_B1AR_reduced</ci>
                    <ci>q_L_RB1_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_L_RB1_Gs</ci>
                <apply>
                    <plus/>
                    <ci>q_L_RB1_Gs_mGPCR_B1AR_reduced</ci>
                    <ci>q_L_RB1_Gs_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Gsa_GTP</ci>
                <apply>
                    <plus/>
                    <ci>q_Gsa_GTP_mGPCR_B1AR_reduced</ci>
                    <ci>q_Gsa_GTP_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Gsbetagamma</ci>
                <apply>
                    <plus/>
                    <ci>q_Gsbetagamma_mGPCR_B1AR_reduced</ci>
                    <ci>q_Gsbetagamma_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Gsa_GDP</ci>
                <apply>
                    <plus/>
                    <ci>q_Gsa_GDP_mGPCR_B1AR_reduced</ci>
                    <ci>q_Gsa_GDP_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_GTP</ci>
                <apply>
                    <plus/>
                    <ci>q_GTP_mGPCR_B1AR_reduced</ci>
                    <ci>q_GTP_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_GDP</ci>
                <apply>
                    <plus/>
                    <ci>q_GDP_mGPCR_B1AR_reduced</ci>
                    <ci>q_GDP_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_Pi</ci>
                <apply>
                    <plus/>
                    <ci>q_Pi_mGPCR_B1AR_reduced</ci>
                    <ci>q_Pi_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_RB1_tag</ci>
                <apply>
                    <plus/>
                    <ci>q_RB1_tag_mGPCR_B1AR_reduced</ci>
                    <ci>q_RB1_tag_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_L_RB1_tag</ci>
                <apply>
                    <plus/>
                    <ci>q_L_RB1_tag_mGPCR_B1AR_reduced</ci>
                    <ci>q_L_RB1_tag_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_RB1_GRKArr</ci>
                <apply>
                    <plus/>
                    <ci>q_RB1_GRKArr_mGPCR_B1AR_reduced</ci>
                    <ci>q_RB1_GRKArr_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_L_RB1_GRKArr</ci>
                <apply>
                    <plus/>
                    <ci>q_L_RB1_GRKArr_mGPCR_B1AR_reduced</ci>
                    <ci>q_L_RB1_GRKArr_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_GRKArr</ci>
                <apply>
                    <plus/>
                    <ci>q_GRKArr_mGPCR_B1AR_reduced</ci>
                    <ci>q_GRKArr_init</ci>
                </apply>
            </apply>
        </math>
        <!-- mass conservation checks-->
        <variable name="conserv_R_T" units="fmol"/>
        <variable name="conserv_L_T" units="fmol"/>
        <variable name="conserv_G_T" units="fmol"/>
        <variable name="total_R_init" units="fmol"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>conserv_R_T</ci>
                <apply>
                    <plus/>
                    <ci>q_RB1_inactive</ci>
                    <ci>q_L_RB1_inactive</ci>
                    <ci>q_RB1</ci>
                    <ci>q_RB1_Gs</ci>
                    <ci>q_L_RB1</ci>
                    <ci>q_L_RB1_Gs</ci>
                    <ci>q_RB1_tag</ci>
                    <ci>q_L_RB1_tag</ci>
                    <ci>q_RB1_GRKArr</ci>
                    <ci>q_L_RB1_GRKArr</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>total_R_init</ci>
                <apply>
                    <plus/>
                    <ci>q_RB1_inactive_init</ci>
                    <ci>q_L_RB1_inactive_init</ci>
                    <ci>q_RB1_init</ci>
                    <ci>q_RB1_Gs_init</ci>
                    <ci>q_L_RB1_init</ci>
                    <ci>q_L_RB1_Gs_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>conserv_L_T</ci>
                <apply>
                    <plus/>
                    <ci>q_L_RB1_inactive</ci>
                    <ci>q_LB1</ci>
                    <ci>q_L_RB1</ci>
                    <ci>q_L_RB1_Gs</ci>
                    <ci>q_L_RB1_tag</ci>
                    <ci>q_L_RB1_GRKArr</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>conserv_G_T</ci>
                <apply>
                    <plus/>
                    <ci>q_Gs</ci>
                    <ci>q_RB1_Gs</ci>
                    <ci>q_L_RB1_Gs</ci>
                    <ci>q_Gsa_GTP</ci>
                    <ci>q_Gsa_GDP</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="GPCR_B1AR_reduced_parameters">
        <!-- A - with v_L_B1. without PiPhos
        var kappa_Rswitch_B1: fmol_per_sec {init: 128.165, pub: out};
        var kappa_LRswitch_B1: fmol_per_sec {init: 0.00270724, pub: out};
        var kappa_C_B1: fmol_per_sec {init: 3051.24, pub: out};
        var kappa_R_B1: fmol_per_sec {init: 64451.7, pub: out};
        var kappa_L_B1: fmol_per_sec {init: 0.000771563, pub: out};
        var kappa_Act1_Gs: fmol_per_sec {init: 0.000901275, pub: out};
        var kappa_Act2_Gs: fmol_per_sec {init: 10.133, pub: out};
        var kappa_Hyd_Gs: fmol_per_sec {init: 0.651714e-4, pub: out};
        var kappa_Reassoc_Gs: fmol_per_sec {init: 0.00238072, pub: out};
        var kappa_InternR_B1: fmol_per_sec {init: 0.00136649, pub: out};
        var kappa_InternLR_B1: fmol_per_sec {init: 15.3633, pub: out};
        var K_RB1_inactive: per_fmol {init: 2.26815, pub: out};
        var K_L_RB1_inactive: per_fmol {init: 107378, pub: out};
        var K_LB1: per_fmol {init: 4828.8, pub: out};
        var K_RB1: per_fmol {init: 0.0226815, pub: out};
        var K_Gs: per_fmol {init: 0.122105, pub: out};
        var K_RB1_Gs: per_fmol {init: 3.14397, pub: out};
        var K_L_RB1: per_fmol {init: 0.00107378, pub: out};
        var K_L_RB1_Gs: per_fmol {init: 0.00027964, pub: out};
        var K_Gsa_GTP: per_fmol {init: 0.0356841, pub: out};
        var K_Gsbetagamma: per_fmol {init: 28.4425, pub: out};
        var K_Gsa_GDP: per_fmol {init: 15.1005, pub: out};
        var K_GTP: per_fmol {init: 4.77164, pub: out};
        var K_GDP: per_fmol {init: 1.61737e-06, pub: out};
        var K_Pi: per_fmol {init: 8.58685e-07, pub: out};
        var K_RB1_tag: per_fmol {init: 4.82676, pub: out};
        var K_L_RB1_tag: per_fmol {init: 0.000429315, pub: out};
        var K_RB1_GRKArr: per_fmol {init: 0.00212734, pub: out};
        var K_L_RB1_GRKArr: per_fmol {init: 1.89216e-07, pub: out};
        var K_GRKArr: per_fmol {init: 1281.21, pub: out};-->
        <!-- B - without PiPhos and v_L_B1-->
        <!--        var kappa_Rswitch_B1: fmol_per_sec {init: 1063.65, pub: out};
        var kappa_LRswitch_B1: fmol_per_sec {init: 1.88351e-07, pub: out};
        var kappa_C_B1: fmol_per_sec {init: 1.39309e+06, pub: out};
        var kappa_R_B1: fmol_per_sec {init: 2.46689e+06, pub: out};
        var kappa_L_B1: fmol_per_sec {init: 0, pub: out};
        var kappa_L_actR: fmol_per_sec {init: 53680.1, pub: out};
        var kappa_Act1_Gs: fmol_per_sec {init: 0.000168285, pub: out};
        var kappa_Act2_Gs: fmol_per_sec {init: 0.158613, pub: out};
        var kappa_Hyd_Gs: fmol_per_sec {init: 0.325272, pub: out};
        var kappa_Reassoc_Gs: fmol_per_sec {init: 1.30973e-05, pub: out};
        var kappa_InternR_B1: fmol_per_sec {init: 0.00241351, pub: out};
        var kappa_InternLR_B1: fmol_per_sec {init: 2.2748, pub: out};
        var K_RB1_inactive: per_fmol {init: 27.3303, pub: out};
        var K_L_RB1_inactive: per_fmol {init: 1.54338e+11, pub: out};
        var K_LB1: per_fmol {init: 0.0576004, pub: out};
        var K_RB1: per_fmol {init: 0.273303, pub: out};
        var K_Gs: per_fmol {init: 0.00221952, pub: out};
        var K_RB1_Gs: per_fmol {init: 0.688616, pub: out};
        var K_L_RB1: per_fmol {init: 0.154338, pub: out};
        var K_L_RB1_Gs: per_fmol {init: 0.000730606, pub: out};
        var K_Gsa_GTP: per_fmol {init: 0.0714965, pub: out};
        var K_Gsbetagamma: per_fmol {init: 768.32, pub: out};
        var K_Gsa_GDP: per_fmol {init: 101.612, pub: out};
        var K_GTP: per_fmol {init: 116.676, pub: out};
        var K_GDP: per_fmol {init: 1.93325e-10, pub: out};
        var K_Pi: per_fmol {init: 2.55677e-11, pub: out};
        var K_RB1_tag: per_fmol {init: 0.399581, pub: out};
        var K_L_RB1_tag: per_fmol {init: 0.000423947, pub: out};
        var K_RB1_GRKArr: per_fmol {init: 1.20446e-05, pub: out};
        var K_L_RB1_GRKArr: per_fmol {init: 1.2779e-08, pub: out};
        var K_GRKArr: per_fmol {init: 876250, pub: out};-->
        <!-- C - B + artificially increased kAct1p and kAct2p 40x and decrease kHydp 40x-->
        <variable initial_value="1036.38" name="kappa_Rswitch_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.83921e-07" name="kappa_LRswitch_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="891573" name="kappa_C_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.58222e+06" name="kappa_R_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0" name="kappa_L_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="52417.5" name="kappa_L_actR" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.000610519" name="kappa_Act1_Gs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.576677" name="kappa_Act2_Gs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0661821" name="kappa_Hyd_Gs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="8.60273e-06" name="kappa_Reassoc_Gs" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.00230556" name="kappa_InternR_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.17775" name="kappa_InternLR_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="28.0492" name="K_RB1_inactive" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.58056e+11" name="K_L_RB1_inactive" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0574759" name="K_LB1" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.280492" name="K_RB1" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00337913" name="K_Gs" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.07597" name="K_RB1_Gs" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.158056" name="K_L_RB1" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00113911" name="K_L_RB1_Gs" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00878478" name="K_Gsa_GTP" public_interface="out" units="per_fmol"/>
        <variable initial_value="736.699" name="K_Gsbetagamma" public_interface="out" units="per_fmol"/>
        <variable initial_value="161.34" name="K_Gsa_GDP" public_interface="out" units="per_fmol"/>
        <variable initial_value="823.314" name="K_GTP" public_interface="out" units="per_fmol"/>
        <variable initial_value="3.61368e-10" name="K_GDP" public_interface="out" units="per_fmol"/>
        <variable initial_value="7.91408e-11" name="K_Pi" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.500146" name="K_RB1_tag" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000529497" name="K_L_RB1_tag" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.26086e-05" name="K_RB1_GRKArr" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.33485e-08" name="K_L_RB1_GRKArr" public_interface="out" units="per_fmol"/>
        <variable initial_value="732843" name="K_GRKArr" public_interface="out" units="per_fmol"/>
    </component>
    <component name="GPCR_B1AR_reduced">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="R" public_interface="in" units="J_per_K_per_mol"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <!-- parameters-->
        <variable name="kappa_Rswitch_B1" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_LRswitch_B1" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_C_B1" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_R_B1" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_L_B1" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_L_actR" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_Act1_Gs" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_Act2_Gs" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_Hyd_Gs" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_Reassoc_Gs" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_InternR_B1" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_InternLR_B1" public_interface="in" units="fmol_per_sec"/>
        <variable name="K_RB1_inactive" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RB1_inactive" public_interface="in" units="per_fmol"/>
        <variable name="K_LB1" public_interface="in" units="per_fmol"/>
        <variable name="K_RB1" public_interface="in" units="per_fmol"/>
        <variable name="K_Gs" public_interface="in" units="per_fmol"/>
        <variable name="K_RB1_Gs" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RB1" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RB1_Gs" public_interface="in" units="per_fmol"/>
        <variable name="K_Gsa_GTP" public_interface="in" units="per_fmol"/>
        <variable name="K_Gsbetagamma" public_interface="in" units="per_fmol"/>
        <variable name="K_Gsa_GDP" public_interface="in" units="per_fmol"/>
        <variable name="K_GTP" public_interface="in" units="per_fmol"/>
        <variable name="K_GDP" public_interface="in" units="per_fmol"/>
        <variable name="K_Pi" public_interface="in" units="per_fmol"/>
        <variable name="K_RB1_tag" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RB1_tag" public_interface="in" units="per_fmol"/>
        <variable name="K_RB1_GRKArr" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RB1_GRKArr" public_interface="in" units="per_fmol"/>
        <variable name="K_GRKArr" public_interface="in" units="per_fmol"/>
        <!-- Input from global environment-->
        <variable name="q_RB1_inactive_global" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_inactive_global" public_interface="in" units="fmol"/>
        <variable name="q_LB1_global" public_interface="in" units="fmol"/>
        <variable name="q_RB1_global" public_interface="in" units="fmol"/>
        <variable name="q_Gs_global" public_interface="in" units="fmol"/>
        <variable name="q_RB1_Gs_global" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_global" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_Gs_global" public_interface="in" units="fmol"/>
        <variable name="q_Gsa_GTP_global" public_interface="in" units="fmol"/>
        <variable name="q_Gsbetagamma_global" public_interface="in" units="fmol"/>
        <variable name="q_Gsa_GDP_global" public_interface="in" units="fmol"/>
        <variable name="q_GTP_global" public_interface="in" units="fmol"/>
        <variable name="q_GDP_global" public_interface="in" units="fmol"/>
        <variable name="q_Pi_global" public_interface="in" units="fmol"/>
        <variable name="q_RB1_tag_global" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_tag_global" public_interface="in" units="fmol"/>
        <variable name="q_RB1_GRKArr_global" public_interface="in" units="fmol"/>
        <variable name="q_L_RB1_GRKArr_global" public_interface="in" units="fmol"/>
        <variable name="q_GRKArr_global" public_interface="in" units="fmol"/>
        <!-- Output to global environment-->
        <variable initial_value="1e-16" name="q_RB1_inactive" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_L_RB1_inactive" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_LB1" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_RB1" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_Gs" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_RB1_Gs" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_L_RB1" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_L_RB1_Gs" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_Gsa_GTP" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_Gsbetagamma" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_Gsa_GDP" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_GTP" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_GDP" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_Pi" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_RB1_tag" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_L_RB1_tag" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_RB1_GRKArr" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_L_RB1_GRKArr" public_interface="out" units="fmol"/>
        <variable initial_value="1e-16" name="q_GRKArr" public_interface="out" units="fmol"/>
        <!-- Constitutive parameters-->
        <variable name="mu_RB1_inactive" units="J_per_mol"/>
        <variable name="mu_L_RB1_inactive" units="J_per_mol"/>
        <variable name="mu_LB1" units="J_per_mol"/>
        <variable name="mu_RB1" units="J_per_mol"/>
        <variable name="mu_Gs" units="J_per_mol"/>
        <variable name="mu_RB1_Gs" units="J_per_mol"/>
        <variable name="mu_L_RB1" units="J_per_mol"/>
        <variable name="mu_L_RB1_Gs" units="J_per_mol"/>
        <variable name="mu_Gsa_GTP" units="J_per_mol"/>
        <variable name="mu_Gsbetagamma" units="J_per_mol"/>
        <variable name="mu_Gsa_GDP" units="J_per_mol"/>
        <variable name="mu_GTP" units="J_per_mol"/>
        <variable name="mu_GDP" units="J_per_mol"/>
        <variable name="mu_Pi" units="J_per_mol"/>
        <variable name="mu_RB1_tag" units="J_per_mol"/>
        <variable name="mu_L_RB1_tag" units="J_per_mol"/>
        <variable name="mu_RB1_GRKArr" units="J_per_mol"/>
        <variable name="mu_L_RB1_GRKArr" units="J_per_mol"/>
        <variable name="mu_GRKArr" units="J_per_mol"/>
        <variable name="v_Rswitch_B1" units="fmol_per_sec"/>
        <variable name="v_LRswitch_B1" units="fmol_per_sec"/>
        <variable name="v_C_B1" units="fmol_per_sec"/>
        <variable name="v_R_B1" units="fmol_per_sec"/>
        <variable name="v_L_B1" units="fmol_per_sec"/>
        <variable name="v_L_actR" units="fmol_per_sec"/>
        <variable name="v_Act1_Gs" units="fmol_per_sec"/>
        <variable name="v_Act2_Gs" units="fmol_per_sec"/>
        <variable name="v_Hyd_Gs" units="fmol_per_sec"/>
        <variable name="v_Reassoc_Gs" units="fmol_per_sec"/>
        <variable name="v_InternR_B1" units="fmol_per_sec"/>
        <variable name="v_InternLR_B1" units="fmol_per_sec"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>mu_RB1_inactive</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RB1_inactive</ci>
                            <ci>q_RB1_inactive_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RB1_inactive</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RB1_inactive</ci>
                            <ci>q_L_RB1_inactive_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_LB1</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_LB1</ci>
                            <ci>q_LB1_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_RB1</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RB1</ci>
                            <ci>q_RB1_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Gs</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Gs</ci>
                            <ci>q_Gs_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_RB1_Gs</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RB1_Gs</ci>
                            <ci>q_RB1_Gs_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RB1</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RB1</ci>
                            <ci>q_L_RB1_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RB1_Gs</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RB1_Gs</ci>
                            <ci>q_L_RB1_Gs_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Gsa_GTP</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Gsa_GTP</ci>
                            <ci>q_Gsa_GTP_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Gsbetagamma</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Gsbetagamma</ci>
                            <ci>q_Gsbetagamma_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Gsa_GDP</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Gsa_GDP</ci>
                            <ci>q_Gsa_GDP_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_GTP</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_GTP</ci>
                            <ci>q_GTP_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_GDP</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_GDP</ci>
                            <ci>q_GDP_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Pi</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Pi</ci>
                            <ci>q_Pi_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_RB1_tag</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RB1_tag</ci>
                            <ci>q_RB1_tag_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RB1_tag</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RB1_tag</ci>
                            <ci>q_L_RB1_tag_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_RB1_GRKArr</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RB1_GRKArr</ci>
                            <ci>q_RB1_GRKArr_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RB1_GRKArr</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RB1_GRKArr</ci>
                            <ci>q_L_RB1_GRKArr_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_GRKArr</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_GRKArr</ci>
                            <ci>q_GRKArr_global</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Rswitch_B1</ci>
                <apply>
                    <times/>
                    <ci>kappa_Rswitch_B1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_RB1_inactive</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_RB1</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_LRswitch_B1</ci>
                <apply>
                    <times/>
                    <ci>kappa_LRswitch_B1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RB1_inactive</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RB1</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_C_B1</ci>
                <apply>
                    <times/>
                    <ci>kappa_C_B1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_RB1</ci>
                                    <ci>mu_Gs</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_RB1_Gs</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_R_B1</ci>
                <apply>
                    <times/>
                    <ci>kappa_R_B1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_L_RB1</ci>
                                    <ci>mu_Gs</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RB1_Gs</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_L_B1</ci>
                <apply>
                    <times/>
                    <ci>kappa_L_B1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_RB1_inactive</ci>
                                    <ci>mu_LB1</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RB1_inactive</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_L_actR</ci>
                <apply>
                    <times/>
                    <ci>kappa_L_actR</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_RB1</ci>
                                    <ci>mu_LB1</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RB1</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Act1_Gs</ci>
                <apply>
                    <times/>
                    <ci>kappa_Act1_Gs</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_RB1_Gs</ci>
                                    <ci>mu_GTP</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_Gsa_GTP</ci>
                                    <ci>mu_Gsbetagamma</ci>
                                    <ci>mu_RB1_tag</ci>
                                    <ci>mu_GDP</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Act2_Gs</ci>
                <apply>
                    <times/>
                    <ci>kappa_Act2_Gs</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_L_RB1_Gs</ci>
                                    <ci>mu_GTP</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_Gsa_GTP</ci>
                                    <ci>mu_Gsbetagamma</ci>
                                    <ci>mu_L_RB1_tag</ci>
                                    <ci>mu_GDP</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Hyd_Gs</ci>
                <apply>
                    <times/>
                    <ci>kappa_Hyd_Gs</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_Gsa_GTP</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_Gsa_GDP</ci>
                                    <ci>mu_Pi</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Reassoc_Gs</ci>
                <apply>
                    <times/>
                    <ci>kappa_Reassoc_Gs</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_Gsa_GDP</ci>
                                    <ci>mu_Gsbetagamma</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_Gs</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_InternR_B1</ci>
                <apply>
                    <times/>
                    <ci>kappa_InternR_B1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_RB1_tag</ci>
                                    <ci>mu_GRKArr</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_RB1_GRKArr</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_InternLR_B1</ci>
                <apply>
                    <times/>
                    <ci>kappa_InternLR_B1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_L_RB1_tag</ci>
                                    <ci>mu_GRKArr</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RB1_GRKArr</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
        <variable name="v_Rsynthesis" units="fmol_per_sec"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>v_Rsynthesis</ci>
                <apply>
                    <plus/>
                    <ci>v_Rswitch_B1</ci>
                    <ci>v_L_actR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RB1_inactive</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <apply>
                            <minus/>
                            <ci>v_Rswitch_B1</ci>
                        </apply>
                        <ci>v_L_B1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.0</cn>
                        <ci>v_Rsynthesis</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RB1_inactive</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <ci>v_LRswitch_B1</ci>
                    </apply>
                    <ci>v_L_B1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_LB1</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_L_B1</ci>
                    </apply>
                    <ci>v_L_actR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RB1</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_Rswitch_B1</ci>
                        <ci>v_C_B1</ci>
                    </apply>
                    <ci>v_L_actR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Gs</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <apply>
                            <minus/>
                            <ci>v_C_B1</ci>
                        </apply>
                        <ci>v_R_B1</ci>
                    </apply>
                    <ci>v_Reassoc_Gs</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RB1_Gs</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_C_B1</ci>
                    <ci>v_Act1_Gs</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RB1</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <ci>v_LRswitch_B1</ci>
                        <ci>v_R_B1</ci>
                    </apply>
                    <ci>v_L_actR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RB1_Gs</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_R_B1</ci>
                    <ci>v_Act2_Gs</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Gsa_GTP</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <ci>v_Act1_Gs</ci>
                        <ci>v_Act2_Gs</ci>
                    </apply>
                    <ci>v_Hyd_Gs</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Gsbetagamma</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <ci>v_Act1_Gs</ci>
                        <ci>v_Act2_Gs</ci>
                    </apply>
                    <ci>v_Reassoc_Gs</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Gsa_GDP</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Hyd_Gs</ci>
                    <ci>v_Reassoc_Gs</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_GTP</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_Act1_Gs</ci>
                    </apply>
                    <ci>v_Act2_Gs</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_GDP</ci>
                </apply>
                <apply>
                    <plus/>
                    <ci>v_Act1_Gs</ci>
                    <ci>v_Act2_Gs</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Pi</ci>
                </apply>
                <ci>v_Hyd_Gs</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RB1_tag</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Act1_Gs</ci>
                    <ci>v_InternR_B1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RB1_tag</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Act2_Gs</ci>
                    <ci>v_InternLR_B1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RB1_GRKArr</ci>
                </apply>
                <ci>v_InternR_B1</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RB1_GRKArr</ci>
                </apply>
                <ci>v_InternLR_B1</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_GRKArr</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_InternR_B1</ci>
                    </apply>
                    <ci>v_InternLR_B1</ci>
                </apply>
            </apply>
        </math>
    </component>
    <connection>
        <map_components component_1="environment" component_2="GPCR_B1AR_reduced"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_RB1_inactive_mGPCR_B1AR_reduced" variable_2="q_RB1_inactive"/>
        <map_variables variable_1="q_RB1_inactive" variable_2="q_RB1_inactive_global"/>
        <map_variables variable_1="q_L_RB1_inactive_mGPCR_B1AR_reduced" variable_2="q_L_RB1_inactive"/>
        <map_variables variable_1="q_L_RB1_inactive" variable_2="q_L_RB1_inactive_global"/>
        <map_variables variable_1="q_LB1_mGPCR_B1AR_reduced" variable_2="q_LB1"/>
        <map_variables variable_1="q_LB1" variable_2="q_LB1_global"/>
        <map_variables variable_1="q_RB1_mGPCR_B1AR_reduced" variable_2="q_RB1"/>
        <map_variables variable_1="q_RB1" variable_2="q_RB1_global"/>
        <map_variables variable_1="q_Gs_mGPCR_B1AR_reduced" variable_2="q_Gs"/>
        <map_variables variable_1="q_Gs" variable_2="q_Gs_global"/>
        <map_variables variable_1="q_RB1_Gs_mGPCR_B1AR_reduced" variable_2="q_RB1_Gs"/>
        <map_variables variable_1="q_RB1_Gs" variable_2="q_RB1_Gs_global"/>
        <map_variables variable_1="q_L_RB1_mGPCR_B1AR_reduced" variable_2="q_L_RB1"/>
        <map_variables variable_1="q_L_RB1" variable_2="q_L_RB1_global"/>
        <map_variables variable_1="q_L_RB1_Gs_mGPCR_B1AR_reduced" variable_2="q_L_RB1_Gs"/>
        <map_variables variable_1="q_L_RB1_Gs" variable_2="q_L_RB1_Gs_global"/>
        <map_variables variable_1="q_Gsa_GTP_mGPCR_B1AR_reduced" variable_2="q_Gsa_GTP"/>
        <map_variables variable_1="q_Gsa_GTP" variable_2="q_Gsa_GTP_global"/>
        <map_variables variable_1="q_Gsbetagamma_mGPCR_B1AR_reduced" variable_2="q_Gsbetagamma"/>
        <map_variables variable_1="q_Gsbetagamma" variable_2="q_Gsbetagamma_global"/>
        <map_variables variable_1="q_Gsa_GDP_mGPCR_B1AR_reduced" variable_2="q_Gsa_GDP"/>
        <map_variables variable_1="q_Gsa_GDP" variable_2="q_Gsa_GDP_global"/>
        <map_variables variable_1="q_GTP_mGPCR_B1AR_reduced" variable_2="q_GTP"/>
        <map_variables variable_1="q_GTP" variable_2="q_GTP_global"/>
        <map_variables variable_1="q_GDP_mGPCR_B1AR_reduced" variable_2="q_GDP"/>
        <map_variables variable_1="q_GDP" variable_2="q_GDP_global"/>
        <map_variables variable_1="q_Pi_mGPCR_B1AR_reduced" variable_2="q_Pi"/>
        <map_variables variable_1="q_Pi" variable_2="q_Pi_global"/>
        <map_variables variable_1="q_RB1_tag_mGPCR_B1AR_reduced" variable_2="q_RB1_tag"/>
        <map_variables variable_1="q_RB1_tag" variable_2="q_RB1_tag_global"/>
        <map_variables variable_1="q_L_RB1_tag_mGPCR_B1AR_reduced" variable_2="q_L_RB1_tag"/>
        <map_variables variable_1="q_L_RB1_tag" variable_2="q_L_RB1_tag_global"/>
        <map_variables variable_1="q_RB1_GRKArr_mGPCR_B1AR_reduced" variable_2="q_RB1_GRKArr"/>
        <map_variables variable_1="q_RB1_GRKArr" variable_2="q_RB1_GRKArr_global"/>
        <map_variables variable_1="q_L_RB1_GRKArr_mGPCR_B1AR_reduced" variable_2="q_L_RB1_GRKArr"/>
        <map_variables variable_1="q_L_RB1_GRKArr" variable_2="q_L_RB1_GRKArr_global"/>
        <map_variables variable_1="q_GRKArr_mGPCR_B1AR_reduced" variable_2="q_GRKArr"/>
        <map_variables variable_1="q_GRKArr" variable_2="q_GRKArr_global"/>
    </connection>
    <connection>
        <map_components component_1="GPCR_B1AR_reduced" component_2="GPCR_B1AR_reduced_parameters"/>
        <map_variables variable_1="kappa_Rswitch_B1" variable_2="kappa_Rswitch_B1"/>
        <map_variables variable_1="kappa_LRswitch_B1" variable_2="kappa_LRswitch_B1"/>
        <map_variables variable_1="kappa_C_B1" variable_2="kappa_C_B1"/>
        <map_variables variable_1="kappa_R_B1" variable_2="kappa_R_B1"/>
        <map_variables variable_1="kappa_L_B1" variable_2="kappa_L_B1"/>
        <map_variables variable_1="kappa_L_actR" variable_2="kappa_L_actR"/>
        <map_variables variable_1="kappa_Act1_Gs" variable_2="kappa_Act1_Gs"/>
        <map_variables variable_1="kappa_Act2_Gs" variable_2="kappa_Act2_Gs"/>
        <map_variables variable_1="kappa_Hyd_Gs" variable_2="kappa_Hyd_Gs"/>
        <map_variables variable_1="kappa_Reassoc_Gs" variable_2="kappa_Reassoc_Gs"/>
        <map_variables variable_1="kappa_InternR_B1" variable_2="kappa_InternR_B1"/>
        <map_variables variable_1="kappa_InternLR_B1" variable_2="kappa_InternLR_B1"/>
        <map_variables variable_1="K_RB1_inactive" variable_2="K_RB1_inactive"/>
        <map_variables variable_1="K_L_RB1_inactive" variable_2="K_L_RB1_inactive"/>
        <map_variables variable_1="K_LB1" variable_2="K_LB1"/>
        <map_variables variable_1="K_RB1" variable_2="K_RB1"/>
        <map_variables variable_1="K_Gs" variable_2="K_Gs"/>
        <map_variables variable_1="K_RB1_Gs" variable_2="K_RB1_Gs"/>
        <map_variables variable_1="K_L_RB1" variable_2="K_L_RB1"/>
        <map_variables variable_1="K_L_RB1_Gs" variable_2="K_L_RB1_Gs"/>
        <map_variables variable_1="K_Gsa_GTP" variable_2="K_Gsa_GTP"/>
        <map_variables variable_1="K_Gsbetagamma" variable_2="K_Gsbetagamma"/>
        <map_variables variable_1="K_Gsa_GDP" variable_2="K_Gsa_GDP"/>
        <map_variables variable_1="K_GTP" variable_2="K_GTP"/>
        <map_variables variable_1="K_GDP" variable_2="K_GDP"/>
        <map_variables variable_1="K_Pi" variable_2="K_Pi"/>
        <map_variables variable_1="K_RB1_tag" variable_2="K_RB1_tag"/>
        <map_variables variable_1="K_L_RB1_tag" variable_2="K_L_RB1_tag"/>
        <map_variables variable_1="K_RB1_GRKArr" variable_2="K_RB1_GRKArr"/>
        <map_variables variable_1="K_L_RB1_GRKArr" variable_2="K_L_RB1_GRKArr"/>
        <map_variables variable_1="K_GRKArr" variable_2="K_GRKArr"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="GPCR_B1AR_reduced"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
</model>