- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-12-03 10:26:09+13:00
- Desc:
- Init
- Permanent Source URI:
- https://models.cellml.org/workspace/7dd/rawfile/11c2bfce41f9ce7654eaf5658c8bc5cdc6f2fb31/BG_GPCR_B1AR_reduced_withRswitch.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="individual_GPCR_B1AR_reduced" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="mM" units_ref="mM"/>
<units name="fmol" units_ref="fmol"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="microm3" units_ref="microm3"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
<units name="per_second" units_ref="per_second"/>
<units name="millivolt" units_ref="millivolt"/>
<units name="per_sec" units_ref="per_sec"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="fmol_per_L" units_ref="fmol_per_L"/>
<units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
<units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
<units name="uM" units_ref="uM"/>
<units name="mM_per_sec" units_ref="mM_per_sec"/>
<units name="uM_per_sec" units_ref="uM_per_sec"/>
<units name="pL" units_ref="pL"/>
<units name="m_to_u" units_ref="m_to_u"/>
</import>
<import xlink:href="units_and_constants/constants_BG.cellml">
<component component_ref="constants" name="constants"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
<!-- initial values-->
<variable initial_value="0.0004579000e0" name="q_RB1_inactive_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_inactive_init" units="fmol"/>
<variable name="q_LB1_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_init" units="fmol"/>
<variable initial_value="0.1455400000" name="q_Gs_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_Gs_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_Gs_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gsa_GTP_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gsbetagamma_init" units="fmol"/>
<variable initial_value="1e-18" name="q_Gsa_GDP_init" units="fmol"/>
<variable initial_value="2.2" name="q_GTP_init" units="fmol"/>
<variable initial_value="1.1" name="q_GDP_init" units="fmol"/>
<variable initial_value="570" name="q_Pi_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_tag_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_tag_init" units="fmol"/>
<variable initial_value="1e-18" name="q_RB1_GRKArr_init" units="fmol"/>
<variable initial_value="1e-18" name="q_L_RB1_GRKArr_init" units="fmol"/>
<variable initial_value="1e-18" name="q_GRKArr_init" units="fmol"/>
<!-- stimulus-->
<variable initial_value="2e2" name="stimSt" units="second"/>
<variable initial_value="5e1" name="stimDur" units="second"/>
<variable initial_value="8e1" name="tR" units="second"/>
<variable initial_value="4e-1" name="stimMag" units="fmol"/>
<variable initial_value="1e-8" name="stimHolding" units="fmol"/>
<variable name="m" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m</ci>
<apply>
<divide/>
<ci>stimMag</ci>
<ci>tR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LB1_init</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<ci>m</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<ci>tR</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<apply>
<gt/>
<ci>time</ci>
<apply>
<minus/>
<ci>stimSt</ci>
<ci>tR</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimMag</ci>
<ci>stimHolding</ci>
</apply>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>stimHolding</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stimSt</ci>
</apply>
<ci>tR</ci>
</apply>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>tR</ci>
<ci>stimDur</ci>
</apply>
</apply>
<apply>
<geq/>
<ci>time</ci>
<apply>
<plus/>
<ci>stimSt</ci>
<ci>stimDur</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>stimHolding</ci>
</otherwise>
</piecewise>
</apply>
</math>
<!-- Global value-->
<variable name="q_RB1_inactive" public_interface="out" units="fmol"/>
<variable name="q_L_RB1_inactive" public_interface="out" units="fmol"/>
<variable name="q_LB1" public_interface="out" units="fmol"/>
<variable name="q_RB1" public_interface="out" units="fmol"/>
<variable name="q_Gs" public_interface="out" units="fmol"/>
<variable name="q_RB1_Gs" public_interface="out" units="fmol"/>
<variable name="q_L_RB1" public_interface="out" units="fmol"/>
<variable name="q_L_RB1_Gs" public_interface="out" units="fmol"/>
<variable name="q_Gsa_GTP" public_interface="out" units="fmol"/>
<variable name="q_Gsbetagamma" public_interface="out" units="fmol"/>
<variable name="q_Gsa_GDP" public_interface="out" units="fmol"/>
<variable name="q_GTP" public_interface="out" units="fmol"/>
<variable name="q_GDP" public_interface="out" units="fmol"/>
<variable name="q_Pi" public_interface="out" units="fmol"/>
<variable name="q_RB1_tag" public_interface="out" units="fmol"/>
<variable name="q_L_RB1_tag" public_interface="out" units="fmol"/>
<variable name="q_RB1_GRKArr" public_interface="out" units="fmol"/>
<variable name="q_L_RB1_GRKArr" public_interface="out" units="fmol"/>
<variable name="q_GRKArr" public_interface="out" units="fmol"/>
<!-- From submodule-->
<variable name="q_RB1_inactive_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_inactive_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_LB1_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_RB1_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_Gs_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_RB1_Gs_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_Gs_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GTP_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_Gsbetagamma_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GDP_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_GTP_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_GDP_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_Pi_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_RB1_tag_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_tag_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_RB1_GRKArr_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_GRKArr_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<variable name="q_GRKArr_mGPCR_B1AR_reduced" public_interface="in" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_RB1_inactive</ci>
<apply>
<plus/>
<ci>q_RB1_inactive_mGPCR_B1AR_reduced</ci>
<ci>q_RB1_inactive_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1_inactive</ci>
<apply>
<plus/>
<ci>q_L_RB1_inactive_mGPCR_B1AR_reduced</ci>
<ci>q_L_RB1_inactive_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_LB1</ci>
<apply>
<plus/>
<ci>q_LB1_mGPCR_B1AR_reduced</ci>
<ci>q_LB1_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1</ci>
<apply>
<plus/>
<ci>q_RB1_mGPCR_B1AR_reduced</ci>
<ci>q_RB1_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gs</ci>
<apply>
<plus/>
<ci>q_Gs_mGPCR_B1AR_reduced</ci>
<ci>q_Gs_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1_Gs</ci>
<apply>
<plus/>
<ci>q_RB1_Gs_mGPCR_B1AR_reduced</ci>
<ci>q_RB1_Gs_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1</ci>
<apply>
<plus/>
<ci>q_L_RB1_mGPCR_B1AR_reduced</ci>
<ci>q_L_RB1_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1_Gs</ci>
<apply>
<plus/>
<ci>q_L_RB1_Gs_mGPCR_B1AR_reduced</ci>
<ci>q_L_RB1_Gs_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gsa_GTP</ci>
<apply>
<plus/>
<ci>q_Gsa_GTP_mGPCR_B1AR_reduced</ci>
<ci>q_Gsa_GTP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gsbetagamma</ci>
<apply>
<plus/>
<ci>q_Gsbetagamma_mGPCR_B1AR_reduced</ci>
<ci>q_Gsbetagamma_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Gsa_GDP</ci>
<apply>
<plus/>
<ci>q_Gsa_GDP_mGPCR_B1AR_reduced</ci>
<ci>q_Gsa_GDP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_GTP</ci>
<apply>
<plus/>
<ci>q_GTP_mGPCR_B1AR_reduced</ci>
<ci>q_GTP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_GDP</ci>
<apply>
<plus/>
<ci>q_GDP_mGPCR_B1AR_reduced</ci>
<ci>q_GDP_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Pi</ci>
<apply>
<plus/>
<ci>q_Pi_mGPCR_B1AR_reduced</ci>
<ci>q_Pi_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1_tag</ci>
<apply>
<plus/>
<ci>q_RB1_tag_mGPCR_B1AR_reduced</ci>
<ci>q_RB1_tag_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1_tag</ci>
<apply>
<plus/>
<ci>q_L_RB1_tag_mGPCR_B1AR_reduced</ci>
<ci>q_L_RB1_tag_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_RB1_GRKArr</ci>
<apply>
<plus/>
<ci>q_RB1_GRKArr_mGPCR_B1AR_reduced</ci>
<ci>q_RB1_GRKArr_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_L_RB1_GRKArr</ci>
<apply>
<plus/>
<ci>q_L_RB1_GRKArr_mGPCR_B1AR_reduced</ci>
<ci>q_L_RB1_GRKArr_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_GRKArr</ci>
<apply>
<plus/>
<ci>q_GRKArr_mGPCR_B1AR_reduced</ci>
<ci>q_GRKArr_init</ci>
</apply>
</apply>
</math>
<!-- mass conservation checks-->
<variable name="conserv_R_T" units="fmol"/>
<variable name="conserv_L_T" units="fmol"/>
<variable name="conserv_G_T" units="fmol"/>
<variable name="total_R_init" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>conserv_R_T</ci>
<apply>
<plus/>
<ci>q_RB1_inactive</ci>
<ci>q_L_RB1_inactive</ci>
<ci>q_RB1</ci>
<ci>q_RB1_Gs</ci>
<ci>q_L_RB1</ci>
<ci>q_L_RB1_Gs</ci>
<ci>q_RB1_tag</ci>
<ci>q_L_RB1_tag</ci>
<ci>q_RB1_GRKArr</ci>
<ci>q_L_RB1_GRKArr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>total_R_init</ci>
<apply>
<plus/>
<ci>q_RB1_inactive_init</ci>
<ci>q_L_RB1_inactive_init</ci>
<ci>q_RB1_init</ci>
<ci>q_RB1_Gs_init</ci>
<ci>q_L_RB1_init</ci>
<ci>q_L_RB1_Gs_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>conserv_L_T</ci>
<apply>
<plus/>
<ci>q_L_RB1_inactive</ci>
<ci>q_LB1</ci>
<ci>q_L_RB1</ci>
<ci>q_L_RB1_Gs</ci>
<ci>q_L_RB1_tag</ci>
<ci>q_L_RB1_GRKArr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>conserv_G_T</ci>
<apply>
<plus/>
<ci>q_Gs</ci>
<ci>q_RB1_Gs</ci>
<ci>q_L_RB1_Gs</ci>
<ci>q_Gsa_GTP</ci>
<ci>q_Gsa_GDP</ci>
</apply>
</apply>
</math>
</component>
<component name="GPCR_B1AR_reduced_parameters">
<variable initial_value="128.165" name="kappa_Rswitch" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00270724" name="kappa_LRswitch" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3051.24" name="kappa_C_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="64451.7" name="kappa_R_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000771563" name="kappa_L_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000901275" name="kappa_Act1_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="10.133" name="kappa_Act2_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.651714" name="kappa_Hyd_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00238072" name="kappa_Reassoc_Gs" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00136649" name="kappa_InternR_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="15.3633" name="kappa_InternLR_B1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.26815" name="K_RB1_inactive" public_interface="out" units="per_fmol"/>
<variable initial_value="107378" name="K_L_RB1_inactive" public_interface="out" units="per_fmol"/>
<variable initial_value="4828.8" name="K_LB1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0226815" name="K_RB1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.122105" name="K_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="3.14397" name="K_RB1_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00107378" name="K_L_RB1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00027964" name="K_L_RB1_Gs" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0356841" name="K_Gsa_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="28.4425" name="K_Gsbetagamma" public_interface="out" units="per_fmol"/>
<variable initial_value="15.1005" name="K_Gsa_GDP" public_interface="out" units="per_fmol"/>
<variable initial_value="4.77164" name="K_GTP" public_interface="out" units="per_fmol"/>
<variable initial_value="1.61737e-06" name="K_GDP" public_interface="out" units="per_fmol"/>
<variable initial_value="8.58685e-07" name="K_Pi" public_interface="out" units="per_fmol"/>
<variable initial_value="4.82676" name="K_RB1_tag" public_interface="out" units="per_fmol"/>
<variable initial_value="0.000429315" name="K_L_RB1_tag" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00212734" name="K_RB1_GRKArr" public_interface="out" units="per_fmol"/>
<variable initial_value="1.89216e-07" name="K_L_RB1_GRKArr" public_interface="out" units="per_fmol"/>
<variable initial_value="1281.21" name="K_GRKArr" public_interface="out" units="per_fmol"/>
</component>
<component name="GPCR_B1AR_reduced">
<variable name="time" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<!-- parameters-->
<variable name="kappa_Rswitch" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_LRswitch" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_C_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_R_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_L_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Act1_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Act2_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Hyd_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Reassoc_Gs" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_InternR_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_InternLR_B1" public_interface="in" units="fmol_per_sec"/>
<variable name="K_RB1_inactive" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1_inactive" public_interface="in" units="per_fmol"/>
<variable name="K_LB1" public_interface="in" units="per_fmol"/>
<variable name="K_RB1" public_interface="in" units="per_fmol"/>
<variable name="K_Gs" public_interface="in" units="per_fmol"/>
<variable name="K_RB1_Gs" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1_Gs" public_interface="in" units="per_fmol"/>
<variable name="K_Gsa_GTP" public_interface="in" units="per_fmol"/>
<variable name="K_Gsbetagamma" public_interface="in" units="per_fmol"/>
<variable name="K_Gsa_GDP" public_interface="in" units="per_fmol"/>
<variable name="K_GTP" public_interface="in" units="per_fmol"/>
<variable name="K_GDP" public_interface="in" units="per_fmol"/>
<variable name="K_Pi" public_interface="in" units="per_fmol"/>
<variable name="K_RB1_tag" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1_tag" public_interface="in" units="per_fmol"/>
<variable name="K_RB1_GRKArr" public_interface="in" units="per_fmol"/>
<variable name="K_L_RB1_GRKArr" public_interface="in" units="per_fmol"/>
<variable name="K_GRKArr" public_interface="in" units="per_fmol"/>
<!-- Input from global environment-->
<variable name="q_RB1_inactive_global" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_inactive_global" public_interface="in" units="fmol"/>
<variable name="q_LB1_global" public_interface="in" units="fmol"/>
<variable name="q_RB1_global" public_interface="in" units="fmol"/>
<variable name="q_Gs_global" public_interface="in" units="fmol"/>
<variable name="q_RB1_Gs_global" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_global" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_Gs_global" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GTP_global" public_interface="in" units="fmol"/>
<variable name="q_Gsbetagamma_global" public_interface="in" units="fmol"/>
<variable name="q_Gsa_GDP_global" public_interface="in" units="fmol"/>
<variable name="q_GTP_global" public_interface="in" units="fmol"/>
<variable name="q_GDP_global" public_interface="in" units="fmol"/>
<variable name="q_Pi_global" public_interface="in" units="fmol"/>
<variable name="q_RB1_tag_global" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_tag_global" public_interface="in" units="fmol"/>
<variable name="q_RB1_GRKArr_global" public_interface="in" units="fmol"/>
<variable name="q_L_RB1_GRKArr_global" public_interface="in" units="fmol"/>
<variable name="q_GRKArr_global" public_interface="in" units="fmol"/>
<!-- Output to global environment-->
<variable initial_value="1e-16" name="q_RB1_inactive" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_L_RB1_inactive" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_LB1" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_RB1" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Gs" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_RB1_Gs" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_L_RB1" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_L_RB1_Gs" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Gsa_GTP" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Gsbetagamma" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Gsa_GDP" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_GTP" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_GDP" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Pi" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_RB1_tag" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_L_RB1_tag" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_RB1_GRKArr" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_L_RB1_GRKArr" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_GRKArr" public_interface="out" units="fmol"/>
<!-- Constitutive parameters-->
<variable name="mu_RB1_inactive" units="J_per_mol"/>
<variable name="mu_L_RB1_inactive" units="J_per_mol"/>
<variable name="mu_LB1" units="J_per_mol"/>
<variable name="mu_RB1" units="J_per_mol"/>
<variable name="mu_Gs" units="J_per_mol"/>
<variable name="mu_RB1_Gs" units="J_per_mol"/>
<variable name="mu_L_RB1" units="J_per_mol"/>
<variable name="mu_L_RB1_Gs" units="J_per_mol"/>
<variable name="mu_Gsa_GTP" units="J_per_mol"/>
<variable name="mu_Gsbetagamma" units="J_per_mol"/>
<variable name="mu_Gsa_GDP" units="J_per_mol"/>
<variable name="mu_GTP" units="J_per_mol"/>
<variable name="mu_GDP" units="J_per_mol"/>
<variable name="mu_Pi" units="J_per_mol"/>
<variable name="mu_RB1_tag" units="J_per_mol"/>
<variable name="mu_L_RB1_tag" units="J_per_mol"/>
<variable name="mu_RB1_GRKArr" units="J_per_mol"/>
<variable name="mu_L_RB1_GRKArr" units="J_per_mol"/>
<variable name="mu_GRKArr" units="J_per_mol"/>
<variable name="v_Rswitch" units="fmol_per_sec"/>
<variable name="v_LRswitch" units="fmol_per_sec"/>
<variable name="v_C_B1" units="fmol_per_sec"/>
<variable name="v_R_B1" units="fmol_per_sec"/>
<variable name="v_L_B1" units="fmol_per_sec"/>
<variable name="v_Act1_Gs" units="fmol_per_sec"/>
<variable name="v_Act2_Gs" units="fmol_per_sec"/>
<variable name="v_Hyd_Gs" units="fmol_per_sec"/>
<variable name="v_Reassoc_Gs" units="fmol_per_sec"/>
<variable name="v_InternR_B1" units="fmol_per_sec"/>
<variable name="v_InternLR_B1" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_RB1_inactive</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1_inactive</ci>
<ci>q_RB1_inactive_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1_inactive</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1_inactive</ci>
<ci>q_L_RB1_inactive_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_LB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_LB1</ci>
<ci>q_LB1_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_RB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1</ci>
<ci>q_RB1_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Gs</ci>
<ci>q_Gs_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_RB1_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1_Gs</ci>
<ci>q_RB1_Gs_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1</ci>
<ci>q_L_RB1_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1_Gs</ci>
<ci>q_L_RB1_Gs_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Gsa_GTP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Gsa_GTP</ci>
<ci>q_Gsa_GTP_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Gsbetagamma</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Gsbetagamma</ci>
<ci>q_Gsbetagamma_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Gsa_GDP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Gsa_GDP</ci>
<ci>q_Gsa_GDP_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_GTP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_GTP</ci>
<ci>q_GTP_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_GDP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_GDP</ci>
<ci>q_GDP_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Pi</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Pi</ci>
<ci>q_Pi_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_RB1_tag</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1_tag</ci>
<ci>q_RB1_tag_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1_tag</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1_tag</ci>
<ci>q_L_RB1_tag_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_RB1_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_RB1_GRKArr</ci>
<ci>q_RB1_GRKArr_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_L_RB1_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_L_RB1_GRKArr</ci>
<ci>q_L_RB1_GRKArr_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_GRKArr</ci>
<ci>q_GRKArr_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Rswitch</ci>
<apply>
<times/>
<ci>kappa_Rswitch</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_RB1_inactive</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_RB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_LRswitch</ci>
<apply>
<times/>
<ci>kappa_LRswitch</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1_inactive</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_C_B1</ci>
<apply>
<times/>
<ci>kappa_C_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_RB1</ci>
<ci>mu_Gs</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_RB1_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_R_B1</ci>
<apply>
<times/>
<ci>kappa_R_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_L_RB1</ci>
<ci>mu_Gs</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_L_B1</ci>
<apply>
<times/>
<ci>kappa_L_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_RB1_inactive</ci>
<ci>mu_LB1</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1_inactive</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Act1_Gs</ci>
<apply>
<times/>
<ci>kappa_Act1_Gs</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_RB1_Gs</ci>
<ci>mu_GTP</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_Gsa_GTP</ci>
<ci>mu_Gsbetagamma</ci>
<ci>mu_RB1_tag</ci>
<ci>mu_GDP</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Act2_Gs</ci>
<apply>
<times/>
<ci>kappa_Act2_Gs</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_L_RB1_Gs</ci>
<ci>mu_GTP</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_Gsa_GTP</ci>
<ci>mu_Gsbetagamma</ci>
<ci>mu_L_RB1_tag</ci>
<ci>mu_GDP</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Hyd_Gs</ci>
<apply>
<times/>
<ci>kappa_Hyd_Gs</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_Gsa_GTP</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_Gsa_GDP</ci>
<ci>mu_Pi</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Reassoc_Gs</ci>
<apply>
<times/>
<ci>kappa_Reassoc_Gs</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_Gsa_GDP</ci>
<ci>mu_Gsbetagamma</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_Gs</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_InternR_B1</ci>
<apply>
<times/>
<ci>kappa_InternR_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_RB1_tag</ci>
<ci>mu_GRKArr</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_RB1_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_InternLR_B1</ci>
<apply>
<times/>
<ci>kappa_InternLR_B1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_L_RB1_tag</ci>
<ci>mu_GRKArr</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_L_RB1_GRKArr</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<variable name="v_Rsynthesis" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>v_Rsynthesis</ci>
<apply>
<plus/>
<ci>v_Rswitch</ci>
<ci>v_L_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1_inactive</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_Rswitch</ci>
</apply>
<ci>v_L_B1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>v_Rsynthesis</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1_inactive</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_LRswitch</ci>
</apply>
<ci>v_L_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_LB1</ci>
</apply>
<apply>
<minus/>
<ci>v_L_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1</ci>
</apply>
<apply>
<minus/>
<ci>v_Rswitch</ci>
<ci>v_C_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Gs</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_C_B1</ci>
</apply>
<ci>v_R_B1</ci>
</apply>
<ci>v_Reassoc_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1_Gs</ci>
</apply>
<apply>
<minus/>
<ci>v_C_B1</ci>
<ci>v_Act1_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1</ci>
</apply>
<apply>
<minus/>
<ci>v_LRswitch</ci>
<ci>v_R_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1_Gs</ci>
</apply>
<apply>
<minus/>
<ci>v_R_B1</ci>
<ci>v_Act2_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Gsa_GTP</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_Act1_Gs</ci>
<ci>v_Act2_Gs</ci>
</apply>
<ci>v_Hyd_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Gsbetagamma</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_Act1_Gs</ci>
<ci>v_Act2_Gs</ci>
</apply>
<ci>v_Reassoc_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Gsa_GDP</ci>
</apply>
<apply>
<minus/>
<ci>v_Hyd_Gs</ci>
<ci>v_Reassoc_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_GTP</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_Act1_Gs</ci>
</apply>
<ci>v_Act2_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_GDP</ci>
</apply>
<apply>
<plus/>
<ci>v_Act1_Gs</ci>
<ci>v_Act2_Gs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Pi</ci>
</apply>
<ci>v_Hyd_Gs</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1_tag</ci>
</apply>
<apply>
<minus/>
<ci>v_Act1_Gs</ci>
<ci>v_InternR_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1_tag</ci>
</apply>
<apply>
<minus/>
<ci>v_Act2_Gs</ci>
<ci>v_InternLR_B1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_RB1_GRKArr</ci>
</apply>
<ci>v_InternR_B1</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_L_RB1_GRKArr</ci>
</apply>
<ci>v_InternLR_B1</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_GRKArr</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_InternR_B1</ci>
</apply>
<ci>v_InternLR_B1</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="GPCR_B1AR_reduced"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_RB1_inactive_mGPCR_B1AR_reduced" variable_2="q_RB1_inactive"/>
<map_variables variable_1="q_RB1_inactive" variable_2="q_RB1_inactive_global"/>
<map_variables variable_1="q_L_RB1_inactive_mGPCR_B1AR_reduced" variable_2="q_L_RB1_inactive"/>
<map_variables variable_1="q_L_RB1_inactive" variable_2="q_L_RB1_inactive_global"/>
<map_variables variable_1="q_LB1_mGPCR_B1AR_reduced" variable_2="q_LB1"/>
<map_variables variable_1="q_LB1" variable_2="q_LB1_global"/>
<map_variables variable_1="q_RB1_mGPCR_B1AR_reduced" variable_2="q_RB1"/>
<map_variables variable_1="q_RB1" variable_2="q_RB1_global"/>
<map_variables variable_1="q_Gs_mGPCR_B1AR_reduced" variable_2="q_Gs"/>
<map_variables variable_1="q_Gs" variable_2="q_Gs_global"/>
<map_variables variable_1="q_RB1_Gs_mGPCR_B1AR_reduced" variable_2="q_RB1_Gs"/>
<map_variables variable_1="q_RB1_Gs" variable_2="q_RB1_Gs_global"/>
<map_variables variable_1="q_L_RB1_mGPCR_B1AR_reduced" variable_2="q_L_RB1"/>
<map_variables variable_1="q_L_RB1" variable_2="q_L_RB1_global"/>
<map_variables variable_1="q_L_RB1_Gs_mGPCR_B1AR_reduced" variable_2="q_L_RB1_Gs"/>
<map_variables variable_1="q_L_RB1_Gs" variable_2="q_L_RB1_Gs_global"/>
<map_variables variable_1="q_Gsa_GTP_mGPCR_B1AR_reduced" variable_2="q_Gsa_GTP"/>
<map_variables variable_1="q_Gsa_GTP" variable_2="q_Gsa_GTP_global"/>
<map_variables variable_1="q_Gsbetagamma_mGPCR_B1AR_reduced" variable_2="q_Gsbetagamma"/>
<map_variables variable_1="q_Gsbetagamma" variable_2="q_Gsbetagamma_global"/>
<map_variables variable_1="q_Gsa_GDP_mGPCR_B1AR_reduced" variable_2="q_Gsa_GDP"/>
<map_variables variable_1="q_Gsa_GDP" variable_2="q_Gsa_GDP_global"/>
<map_variables variable_1="q_GTP_mGPCR_B1AR_reduced" variable_2="q_GTP"/>
<map_variables variable_1="q_GTP" variable_2="q_GTP_global"/>
<map_variables variable_1="q_GDP_mGPCR_B1AR_reduced" variable_2="q_GDP"/>
<map_variables variable_1="q_GDP" variable_2="q_GDP_global"/>
<map_variables variable_1="q_Pi_mGPCR_B1AR_reduced" variable_2="q_Pi"/>
<map_variables variable_1="q_Pi" variable_2="q_Pi_global"/>
<map_variables variable_1="q_RB1_tag_mGPCR_B1AR_reduced" variable_2="q_RB1_tag"/>
<map_variables variable_1="q_RB1_tag" variable_2="q_RB1_tag_global"/>
<map_variables variable_1="q_L_RB1_tag_mGPCR_B1AR_reduced" variable_2="q_L_RB1_tag"/>
<map_variables variable_1="q_L_RB1_tag" variable_2="q_L_RB1_tag_global"/>
<map_variables variable_1="q_RB1_GRKArr_mGPCR_B1AR_reduced" variable_2="q_RB1_GRKArr"/>
<map_variables variable_1="q_RB1_GRKArr" variable_2="q_RB1_GRKArr_global"/>
<map_variables variable_1="q_L_RB1_GRKArr_mGPCR_B1AR_reduced" variable_2="q_L_RB1_GRKArr"/>
<map_variables variable_1="q_L_RB1_GRKArr" variable_2="q_L_RB1_GRKArr_global"/>
<map_variables variable_1="q_GRKArr_mGPCR_B1AR_reduced" variable_2="q_GRKArr"/>
<map_variables variable_1="q_GRKArr" variable_2="q_GRKArr_global"/>
</connection>
<connection>
<map_components component_1="GPCR_B1AR_reduced" component_2="GPCR_B1AR_reduced_parameters"/>
<map_variables variable_1="kappa_Rswitch" variable_2="kappa_Rswitch"/>
<map_variables variable_1="kappa_LRswitch" variable_2="kappa_LRswitch"/>
<map_variables variable_1="kappa_C_B1" variable_2="kappa_C_B1"/>
<map_variables variable_1="kappa_R_B1" variable_2="kappa_R_B1"/>
<map_variables variable_1="kappa_L_B1" variable_2="kappa_L_B1"/>
<map_variables variable_1="kappa_Act1_Gs" variable_2="kappa_Act1_Gs"/>
<map_variables variable_1="kappa_Act2_Gs" variable_2="kappa_Act2_Gs"/>
<map_variables variable_1="kappa_Hyd_Gs" variable_2="kappa_Hyd_Gs"/>
<map_variables variable_1="kappa_Reassoc_Gs" variable_2="kappa_Reassoc_Gs"/>
<map_variables variable_1="kappa_InternR_B1" variable_2="kappa_InternR_B1"/>
<map_variables variable_1="kappa_InternLR_B1" variable_2="kappa_InternLR_B1"/>
<map_variables variable_1="K_RB1_inactive" variable_2="K_RB1_inactive"/>
<map_variables variable_1="K_L_RB1_inactive" variable_2="K_L_RB1_inactive"/>
<map_variables variable_1="K_LB1" variable_2="K_LB1"/>
<map_variables variable_1="K_RB1" variable_2="K_RB1"/>
<map_variables variable_1="K_Gs" variable_2="K_Gs"/>
<map_variables variable_1="K_RB1_Gs" variable_2="K_RB1_Gs"/>
<map_variables variable_1="K_L_RB1" variable_2="K_L_RB1"/>
<map_variables variable_1="K_L_RB1_Gs" variable_2="K_L_RB1_Gs"/>
<map_variables variable_1="K_Gsa_GTP" variable_2="K_Gsa_GTP"/>
<map_variables variable_1="K_Gsbetagamma" variable_2="K_Gsbetagamma"/>
<map_variables variable_1="K_Gsa_GDP" variable_2="K_Gsa_GDP"/>
<map_variables variable_1="K_GTP" variable_2="K_GTP"/>
<map_variables variable_1="K_GDP" variable_2="K_GDP"/>
<map_variables variable_1="K_Pi" variable_2="K_Pi"/>
<map_variables variable_1="K_RB1_tag" variable_2="K_RB1_tag"/>
<map_variables variable_1="K_L_RB1_tag" variable_2="K_L_RB1_tag"/>
<map_variables variable_1="K_RB1_GRKArr" variable_2="K_RB1_GRKArr"/>
<map_variables variable_1="K_L_RB1_GRKArr" variable_2="K_L_RB1_GRKArr"/>
<map_variables variable_1="K_GRKArr" variable_2="K_GRKArr"/>
</connection>
<connection>
<map_components component_1="constants" component_2="GPCR_B1AR_reduced"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
</model>
