Location: BG_GPCR_M2_reduced @ e831afee2206 / BG_GPCR_M2_reduced.cellml

Author:
Shelley Fong <s.fong@auckland.ac.nz>
Date:
2022-02-18 13:28:26+13:00
Desc:
Updating way cellml is written
Permanent Source URI:
https://models.cellml.org/workspace/7dd/rawfile/e831afee220663860fb5e91083cf1d4805d59f5f/BG_GPCR_M2_reduced.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="individual_GPCR_M2_reduced" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="units_and_constants/units_BG.cellml">
        <units name="mM" units_ref="mM"/>
        <units name="fmol" units_ref="fmol"/>
        <units name="per_fmol" units_ref="per_fmol"/>
        <units name="J_per_mol" units_ref="J_per_mol"/>
        <units name="fmol_per_sec" units_ref="fmol_per_sec"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="J_per_C" units_ref="J_per_C"/>
        <units name="microm3" units_ref="microm3"/>
        <units name="fF" units_ref="fF"/>
        <units name="fC" units_ref="fC"/>
        <units name="fA" units_ref="fA"/>
        <units name="per_second" units_ref="per_second"/>
        <units name="millivolt" units_ref="millivolt"/>
        <units name="per_sec" units_ref="per_sec"/>
        <units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
        <units name="fmol_per_L" units_ref="fmol_per_L"/>
        <units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
        <units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
        <units name="uM" units_ref="uM"/>
        <units name="mM_per_sec" units_ref="mM_per_sec"/>
        <units name="uM_per_sec" units_ref="uM_per_sec"/>
        <units name="pL" units_ref="pL"/>
        <units name="m_to_u" units_ref="m_to_u"/>
    </import>
    <import xlink:href="units_and_constants/constants_BG.cellml">
        <component component_ref="constants" name="constants"/>
    </import>
    <component name="environment">
        <variable name="time" public_interface="out" units="second"/>
        <!-- initial values-->
        <variable initial_value="0.00072162" name="q_RM2_inactive" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RM2_inactive" public_interface="out" units="fmol"/>
        <variable name="q_LM2" public_interface="out" units="fmol"/>
        <variable name="q_LM2_stim" units="fmol"/>
        <variable initial_value="0" name="q_LM2_ode" units="fmol"/>
        <variable initial_value="1e-18" name="q_RM2" public_interface="out" units="fmol"/>
        <variable initial_value="0.00836" name="q_Gi" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_RM2_Gi" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RM2" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RM2_Gi" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_Gia_GTP" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_Gibetagamma" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_Gia_GDP" public_interface="out" units="fmol"/>
        <variable initial_value="2.2" name="q_GTP" public_interface="out" units="fmol"/>
        <variable initial_value="1.1" name="q_GDP" public_interface="out" units="fmol"/>
        <variable initial_value="570" name="q_Pi" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_RM2_tag" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RM2_tag" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_RM2_GRKArr" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_L_RM2_GRKArr" public_interface="out" units="fmol"/>
        <variable initial_value="1e-18" name="q_GRKArr" public_interface="out" units="fmol"/>
        <!-- stimulus-->
        <variable initial_value="7e1" name="stimSt" units="second"/>
        <variable initial_value="5e1" name="stimDur" units="second"/>
        <variable initial_value="5e1" name="tR" units="second"/>
        <variable initial_value="0e2" name="stimMag" units="fmol"/>
        <variable initial_value="1e-8" name="stimHolding" units="fmol"/>
        <variable name="m" units="fmol_per_sec"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>m</ci>
                <apply>
                    <divide/>
                    <ci>stimMag</ci>
                    <ci>tR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LM2_stim</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimHolding</ci>
                            <apply>
                                <times/>
                                <ci>m</ci>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <minus/>
                                        <ci>time</ci>
                                        <ci>stimSt</ci>
                                    </apply>
                                    <ci>tR</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <ci>stimSt</ci>
                            </apply>
                            <apply>
                                <gt/>
                                <ci>time</ci>
                                <apply>
                                    <minus/>
                                    <ci>stimSt</ci>
                                    <ci>tR</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimMag</ci>
                            <ci>stimHolding</ci>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <geq/>
                                <ci>time</ci>
                                <ci>stimSt</ci>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <plus/>
                            <ci>stimHolding</ci>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>m</ci>
                                </apply>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <ci>time</ci>
                                            <ci>stimSt</ci>
                                        </apply>
                                        <ci>tR</ci>
                                    </apply>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt</ci>
                                    <ci>tR</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                            <apply>
                                <geq/>
                                <ci>time</ci>
                                <apply>
                                    <plus/>
                                    <ci>stimSt</ci>
                                    <ci>stimDur</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>stimHolding</ci>
                    </otherwise>
                </piecewise>
            </apply>
        </math>
        <!-- mass conservation checks-->
        <variable name="conserv_R_T" units="fmol"/>
        <variable name="conserv_L_T" units="fmol"/>
        <variable name="conserv_G_T" units="fmol"/>
        <variable name="total_R" units="fmol"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>conserv_R_T</ci>
                <apply>
                    <plus/>
                    <ci>q_RM2_inactive</ci>
                    <ci>q_L_RM2_inactive</ci>
                    <ci>q_RM2</ci>
                    <ci>q_RM2_Gi</ci>
                    <ci>q_L_RM2</ci>
                    <ci>q_L_RM2_Gi</ci>
                    <ci>q_RM2_tag</ci>
                    <ci>q_L_RM2_tag</ci>
                    <ci>q_RM2_GRKArr</ci>
                    <ci>q_L_RM2_GRKArr</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>total_R</ci>
                <apply>
                    <plus/>
                    <ci>q_RM2_inactive</ci>
                    <ci>q_L_RM2_inactive</ci>
                    <ci>q_RM2</ci>
                    <ci>q_RM2_Gi</ci>
                    <ci>q_L_RM2</ci>
                    <ci>q_L_RM2_Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>conserv_L_T</ci>
                <apply>
                    <plus/>
                    <ci>q_L_RM2_inactive</ci>
                    <ci>q_LM2</ci>
                    <ci>q_L_RM2</ci>
                    <ci>q_L_RM2_Gi</ci>
                    <ci>q_L_RM2_tag</ci>
                    <ci>q_L_RM2_GRKArr</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>conserv_G_T</ci>
                <apply>
                    <plus/>
                    <ci>q_Gi</ci>
                    <ci>q_RM2_Gi</ci>
                    <ci>q_L_RM2_Gi</ci>
                    <ci>q_Gia_GTP</ci>
                    <ci>q_Gia_GDP</ci>
                </apply>
            </apply>
        </math>
        <!-- From submodule-->
        <variable name="v_Rswitch_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_LRswitch_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_C_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_L_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_Act1_Gi" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_Act2_Gi" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_Hyd_Gi" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_Reassoc_Gi" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_InternR_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_InternLR_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_Rsynthesis" units="fmol_per_sec"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>v_Rsynthesis</ci>
                <apply>
                    <plus/>
                    <apply>
                        <plus/>
                        <ci>v_C_M2</ci>
                    </apply>
                    <ci>v_L_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RM2_inactive</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_Rswitch_M2</ci>
                    </apply>
                    <ci>v_L_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RM2_inactive</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_LRswitch_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_LM2_ode</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_L_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RM2</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <ci>v_Rswitch_M2</ci>
                        <ci>v_C_M2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">1.0</cn>
                        <ci>v_Rsynthesis</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Gi</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <apply>
                            <minus/>
                            <ci>v_C_M2</ci>
                        </apply>
                        <ci>v_R_M2</ci>
                    </apply>
                    <ci>v_Reassoc_Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RM2_Gi</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_C_M2</ci>
                    <ci>v_Act1_Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RM2</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <ci>v_LRswitch_M2</ci>
                        <ci>v_R_M2</ci>
                    </apply>
                    <ci>v_L_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RM2_Gi</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_R_M2</ci>
                    <ci>v_Act2_Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Gia_GTP</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <ci>v_Act1_Gi</ci>
                        <ci>v_Act2_Gi</ci>
                    </apply>
                    <ci>v_Hyd_Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Gibetagamma</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <ci>v_Act1_Gi</ci>
                        <ci>v_Act2_Gi</ci>
                    </apply>
                    <ci>v_Reassoc_Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Gia_GDP</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Hyd_Gi</ci>
                    <ci>v_Reassoc_Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_GTP</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_Act1_Gi</ci>
                    </apply>
                    <ci>v_Act2_Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_GDP</ci>
                </apply>
                <apply>
                    <plus/>
                    <ci>v_Act1_Gi</ci>
                    <ci>v_Act2_Gi</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Pi</ci>
                </apply>
                <ci>v_Hyd_Gi</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RM2_tag</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Act1_Gi</ci>
                    <ci>v_InternR_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RM2_tag</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Act2_Gi</ci>
                    <ci>v_InternLR_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_RM2_GRKArr</ci>
                </apply>
                <ci>v_InternR_M2</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_L_RM2_GRKArr</ci>
                </apply>
                <ci>v_InternLR_M2</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_GRKArr</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_InternR_M2</ci>
                    </apply>
                    <ci>v_InternLR_M2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>q_LM2</ci>
                <apply>
                    <plus/>
                    <ci>q_LM2_stim</ci>
                    <ci>q_LM2_ode</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="GPCR_M2_reduced_parameters">
        <variable initial_value="77.8337" name="kappa_Rswitch_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.00321972" name="kappa_LRswitch_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="4441.42" name="kappa_C_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="183727" name="kappa_R_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0354169" name="kappa_L_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.00199813" name="kappa_Act1_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.08204" name="kappa_Act2_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.604042" name="kappa_Hyd_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0057063" name="kappa_Reassoc_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.00590542" name="kappa_InternR_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="3.19794" name="kappa_InternLR_M2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="3.73486" name="K_RM2_inactive" public_interface="out" units="per_fmol"/>
        <variable initial_value="90286.7" name="K_L_RM2_inactive" public_interface="out" units="per_fmol"/>
        <variable initial_value="63.8849" name="K_LM2" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0373486" name="K_RM2" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0509433" name="K_Gi" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.96354" name="K_RM2_Gi" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000902867" name="K_L_RM2" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00362594" name="K_L_RM2_Gi" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0385003" name="K_Gia_GTP" public_interface="out" units="per_fmol"/>
        <variable initial_value="19.8214" name="K_Gibetagamma" public_interface="out" units="per_fmol"/>
        <variable initial_value="9.04022" name="K_Gia_GDP" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.538466" name="K_GTP" public_interface="out" units="per_fmol"/>
        <variable initial_value="3.39308e-06" name="K_GDP" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.54752e-06" name="K_Pi" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.38022" name="K_RM2_tag" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00254876" name="K_L_RM2_tag" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000492256" name="K_RM2_GRKArr" public_interface="out" units="per_fmol"/>
        <variable initial_value="9.09015e-07" name="K_L_RM2_GRKArr" public_interface="out" units="per_fmol"/>
        <variable initial_value="1036.77" name="K_GRKArr" public_interface="out" units="per_fmol"/>
    </component>
    <component name="GPCR_M2_reduced">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="R" public_interface="in" units="J_per_K_per_mol"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <!-- parameters-->
        <variable name="kappa_Rswitch_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_LRswitch_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_C_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_R_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_L_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_Act1_Gi" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_Act2_Gi" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_Hyd_Gi" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_Reassoc_Gi" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_InternR_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_InternLR_M2" public_interface="in" units="fmol_per_sec"/>
        <variable name="K_RM2_inactive" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RM2_inactive" public_interface="in" units="per_fmol"/>
        <variable name="K_LM2" public_interface="in" units="per_fmol"/>
        <variable name="K_RM2" public_interface="in" units="per_fmol"/>
        <variable name="K_Gi" public_interface="in" units="per_fmol"/>
        <variable name="K_RM2_Gi" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RM2" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RM2_Gi" public_interface="in" units="per_fmol"/>
        <variable name="K_Gia_GTP" public_interface="in" units="per_fmol"/>
        <variable name="K_Gibetagamma" public_interface="in" units="per_fmol"/>
        <variable name="K_Gia_GDP" public_interface="in" units="per_fmol"/>
        <variable name="K_GTP" public_interface="in" units="per_fmol"/>
        <variable name="K_GDP" public_interface="in" units="per_fmol"/>
        <variable name="K_Pi" public_interface="in" units="per_fmol"/>
        <variable name="K_RM2_tag" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RM2_tag" public_interface="in" units="per_fmol"/>
        <variable name="K_RM2_GRKArr" public_interface="in" units="per_fmol"/>
        <variable name="K_L_RM2_GRKArr" public_interface="in" units="per_fmol"/>
        <variable name="K_GRKArr" public_interface="in" units="per_fmol"/>
        <!-- Input from global environment-->
        <variable name="q_RM2_inactive" public_interface="in" units="fmol"/>
        <variable name="q_L_RM2_inactive" public_interface="in" units="fmol"/>
        <variable name="q_LM2" public_interface="in" units="fmol"/>
        <variable name="q_RM2" public_interface="in" units="fmol"/>
        <variable name="q_Gi" public_interface="in" units="fmol"/>
        <variable name="q_RM2_Gi" public_interface="in" units="fmol"/>
        <variable name="q_L_RM2" public_interface="in" units="fmol"/>
        <variable name="q_L_RM2_Gi" public_interface="in" units="fmol"/>
        <variable name="q_Gia_GTP" public_interface="in" units="fmol"/>
        <variable name="q_Gibetagamma" public_interface="in" units="fmol"/>
        <variable name="q_Gia_GDP" public_interface="in" units="fmol"/>
        <variable name="q_GTP" public_interface="in" units="fmol"/>
        <variable name="q_GDP" public_interface="in" units="fmol"/>
        <variable name="q_Pi" public_interface="in" units="fmol"/>
        <variable name="q_RM2_tag" public_interface="in" units="fmol"/>
        <variable name="q_L_RM2_tag" public_interface="in" units="fmol"/>
        <variable name="q_RM2_GRKArr" public_interface="in" units="fmol"/>
        <variable name="q_L_RM2_GRKArr" public_interface="in" units="fmol"/>
        <variable name="q_GRKArr" public_interface="in" units="fmol"/>
        <!-- Constitutive parameters-->
        <variable name="mu_RM2_inactive" units="J_per_mol"/>
        <variable name="mu_L_RM2_inactive" units="J_per_mol"/>
        <variable name="mu_LM2" units="J_per_mol"/>
        <variable name="mu_RM2" units="J_per_mol"/>
        <variable name="mu_Gi" units="J_per_mol"/>
        <variable name="mu_RM2_Gi" units="J_per_mol"/>
        <variable name="mu_L_RM2" units="J_per_mol"/>
        <variable name="mu_L_RM2_Gi" units="J_per_mol"/>
        <variable name="mu_Gia_GTP" units="J_per_mol"/>
        <variable name="mu_Gibetagamma" units="J_per_mol"/>
        <variable name="mu_Gia_GDP" units="J_per_mol"/>
        <variable name="mu_GTP" units="J_per_mol"/>
        <variable name="mu_GDP" units="J_per_mol"/>
        <variable name="mu_Pi" units="J_per_mol"/>
        <variable name="mu_RM2_tag" units="J_per_mol"/>
        <variable name="mu_L_RM2_tag" units="J_per_mol"/>
        <variable name="mu_RM2_GRKArr" units="J_per_mol"/>
        <variable name="mu_L_RM2_GRKArr" units="J_per_mol"/>
        <variable name="mu_GRKArr" units="J_per_mol"/>
        <variable name="v_Rswitch_M2" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_LRswitch_M2" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_C_M2" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_R_M2" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_L_M2" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_Act1_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_Act2_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_Hyd_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_Reassoc_Gi" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_InternR_M2" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_InternLR_M2" public_interface="out" units="fmol_per_sec"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>mu_RM2_inactive</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RM2_inactive</ci>
                            <ci>q_RM2_inactive</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RM2_inactive</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RM2_inactive</ci>
                            <ci>q_L_RM2_inactive</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_LM2</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_LM2</ci>
                            <ci>q_LM2</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_RM2</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RM2</ci>
                            <ci>q_RM2</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Gi</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Gi</ci>
                            <ci>q_Gi</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_RM2_Gi</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RM2_Gi</ci>
                            <ci>q_RM2_Gi</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RM2</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RM2</ci>
                            <ci>q_L_RM2</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RM2_Gi</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RM2_Gi</ci>
                            <ci>q_L_RM2_Gi</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Gia_GTP</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Gia_GTP</ci>
                            <ci>q_Gia_GTP</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Gibetagamma</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Gibetagamma</ci>
                            <ci>q_Gibetagamma</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Gia_GDP</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Gia_GDP</ci>
                            <ci>q_Gia_GDP</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_GTP</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_GTP</ci>
                            <ci>q_GTP</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_GDP</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_GDP</ci>
                            <ci>q_GDP</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Pi</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Pi</ci>
                            <ci>q_Pi</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_RM2_tag</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RM2_tag</ci>
                            <ci>q_RM2_tag</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RM2_tag</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RM2_tag</ci>
                            <ci>q_L_RM2_tag</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_RM2_GRKArr</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_RM2_GRKArr</ci>
                            <ci>q_RM2_GRKArr</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_L_RM2_GRKArr</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_L_RM2_GRKArr</ci>
                            <ci>q_L_RM2_GRKArr</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_GRKArr</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_GRKArr</ci>
                            <ci>q_GRKArr</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Rswitch_M2</ci>
                <apply>
                    <times/>
                    <ci>kappa_Rswitch_M2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_RM2_inactive</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_RM2</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_LRswitch_M2</ci>
                <apply>
                    <times/>
                    <ci>kappa_LRswitch_M2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RM2_inactive</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RM2</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_C_M2</ci>
                <apply>
                    <times/>
                    <ci>kappa_C_M2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_RM2</ci>
                                    <ci>mu_Gi</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_RM2_Gi</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_R_M2</ci>
                <apply>
                    <times/>
                    <ci>kappa_R_M2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_L_RM2</ci>
                                    <ci>mu_Gi</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RM2_Gi</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_L_M2</ci>
                <apply>
                    <times/>
                    <ci>kappa_L_M2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_RM2_inactive</ci>
                                    <ci>mu_LM2</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RM2_inactive</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Act1_Gi</ci>
                <apply>
                    <times/>
                    <ci>kappa_Act1_Gi</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_RM2_Gi</ci>
                                    <ci>mu_GTP</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_Gia_GTP</ci>
                                    <ci>mu_Gibetagamma</ci>
                                    <ci>mu_RM2_tag</ci>
                                    <ci>mu_GDP</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Act2_Gi</ci>
                <apply>
                    <times/>
                    <ci>kappa_Act2_Gi</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_L_RM2_Gi</ci>
                                    <ci>mu_GTP</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_Gia_GTP</ci>
                                    <ci>mu_Gibetagamma</ci>
                                    <ci>mu_L_RM2_tag</ci>
                                    <ci>mu_GDP</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Hyd_Gi</ci>
                <apply>
                    <times/>
                    <ci>kappa_Hyd_Gi</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_Gia_GTP</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_Gia_GDP</ci>
                                    <ci>mu_Pi</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Reassoc_Gi</ci>
                <apply>
                    <times/>
                    <ci>kappa_Reassoc_Gi</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_Gia_GDP</ci>
                                    <ci>mu_Gibetagamma</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_Gi</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_InternR_M2</ci>
                <apply>
                    <times/>
                    <ci>kappa_InternR_M2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_RM2_tag</ci>
                                    <ci>mu_GRKArr</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_RM2_GRKArr</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_InternLR_M2</ci>
                <apply>
                    <times/>
                    <ci>kappa_InternLR_M2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_L_RM2_tag</ci>
                                    <ci>mu_GRKArr</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_L_RM2_GRKArr</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <connection>
        <map_components component_1="environment" component_2="GPCR_M2_reduced"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_RM2_inactive" variable_2="q_RM2_inactive"/>
        <map_variables variable_1="q_L_RM2_inactive" variable_2="q_L_RM2_inactive"/>
        <map_variables variable_1="q_LM2" variable_2="q_LM2"/>
        <map_variables variable_1="q_RM2" variable_2="q_RM2"/>
        <map_variables variable_1="q_Gi" variable_2="q_Gi"/>
        <map_variables variable_1="q_RM2_Gi" variable_2="q_RM2_Gi"/>
        <map_variables variable_1="q_L_RM2" variable_2="q_L_RM2"/>
        <map_variables variable_1="q_L_RM2_Gi" variable_2="q_L_RM2_Gi"/>
        <map_variables variable_1="q_Gia_GTP" variable_2="q_Gia_GTP"/>
        <map_variables variable_1="q_Gibetagamma" variable_2="q_Gibetagamma"/>
        <map_variables variable_1="q_Gia_GDP" variable_2="q_Gia_GDP"/>
        <map_variables variable_1="q_GTP" variable_2="q_GTP"/>
        <map_variables variable_1="q_GDP" variable_2="q_GDP"/>
        <map_variables variable_1="q_Pi" variable_2="q_Pi"/>
        <map_variables variable_1="q_RM2_tag" variable_2="q_RM2_tag"/>
        <map_variables variable_1="q_L_RM2_tag" variable_2="q_L_RM2_tag"/>
        <map_variables variable_1="q_RM2_GRKArr" variable_2="q_RM2_GRKArr"/>
        <map_variables variable_1="q_L_RM2_GRKArr" variable_2="q_L_RM2_GRKArr"/>
        <map_variables variable_1="q_GRKArr" variable_2="q_GRKArr"/>
        <map_variables variable_1="v_Rswitch_M2" variable_2="v_Rswitch_M2"/>
        <map_variables variable_1="v_LRswitch_M2" variable_2="v_LRswitch_M2"/>
        <map_variables variable_1="v_C_M2" variable_2="v_C_M2"/>
        <map_variables variable_1="v_R_M2" variable_2="v_R_M2"/>
        <map_variables variable_1="v_L_M2" variable_2="v_L_M2"/>
        <map_variables variable_1="v_Act1_Gi" variable_2="v_Act1_Gi"/>
        <map_variables variable_1="v_Act2_Gi" variable_2="v_Act2_Gi"/>
        <map_variables variable_1="v_Hyd_Gi" variable_2="v_Hyd_Gi"/>
        <map_variables variable_1="v_Reassoc_Gi" variable_2="v_Reassoc_Gi"/>
        <map_variables variable_1="v_InternR_M2" variable_2="v_InternR_M2"/>
        <map_variables variable_1="v_InternLR_M2" variable_2="v_InternLR_M2"/>
    </connection>
    <connection>
        <map_components component_1="GPCR_M2_reduced" component_2="GPCR_M2_reduced_parameters"/>
        <map_variables variable_1="kappa_Rswitch_M2" variable_2="kappa_Rswitch_M2"/>
        <map_variables variable_1="kappa_LRswitch_M2" variable_2="kappa_LRswitch_M2"/>
        <map_variables variable_1="kappa_C_M2" variable_2="kappa_C_M2"/>
        <map_variables variable_1="kappa_R_M2" variable_2="kappa_R_M2"/>
        <map_variables variable_1="kappa_L_M2" variable_2="kappa_L_M2"/>
        <map_variables variable_1="kappa_Act1_Gi" variable_2="kappa_Act1_Gi"/>
        <map_variables variable_1="kappa_Act2_Gi" variable_2="kappa_Act2_Gi"/>
        <map_variables variable_1="kappa_Hyd_Gi" variable_2="kappa_Hyd_Gi"/>
        <map_variables variable_1="kappa_Reassoc_Gi" variable_2="kappa_Reassoc_Gi"/>
        <map_variables variable_1="kappa_InternR_M2" variable_2="kappa_InternR_M2"/>
        <map_variables variable_1="kappa_InternLR_M2" variable_2="kappa_InternLR_M2"/>
        <map_variables variable_1="K_RM2_inactive" variable_2="K_RM2_inactive"/>
        <map_variables variable_1="K_L_RM2_inactive" variable_2="K_L_RM2_inactive"/>
        <map_variables variable_1="K_LM2" variable_2="K_LM2"/>
        <map_variables variable_1="K_RM2" variable_2="K_RM2"/>
        <map_variables variable_1="K_Gi" variable_2="K_Gi"/>
        <map_variables variable_1="K_RM2_Gi" variable_2="K_RM2_Gi"/>
        <map_variables variable_1="K_L_RM2" variable_2="K_L_RM2"/>
        <map_variables variable_1="K_L_RM2_Gi" variable_2="K_L_RM2_Gi"/>
        <map_variables variable_1="K_Gia_GTP" variable_2="K_Gia_GTP"/>
        <map_variables variable_1="K_Gibetagamma" variable_2="K_Gibetagamma"/>
        <map_variables variable_1="K_Gia_GDP" variable_2="K_Gia_GDP"/>
        <map_variables variable_1="K_GTP" variable_2="K_GTP"/>
        <map_variables variable_1="K_GDP" variable_2="K_GDP"/>
        <map_variables variable_1="K_Pi" variable_2="K_Pi"/>
        <map_variables variable_1="K_RM2_tag" variable_2="K_RM2_tag"/>
        <map_variables variable_1="K_L_RM2_tag" variable_2="K_L_RM2_tag"/>
        <map_variables variable_1="K_RM2_GRKArr" variable_2="K_RM2_GRKArr"/>
        <map_variables variable_1="K_L_RM2_GRKArr" variable_2="K_L_RM2_GRKArr"/>
        <map_variables variable_1="K_GRKArr" variable_2="K_GRKArr"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="GPCR_M2_reduced"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
</model>