Location: Calcium Dynamics Annotations @ 4d6408caaf3e / chay_1997 / model / chay_1997.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-26 14:35:03+13:00
Desc:
modifying rdf files
Permanent Source URI:
https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/chay_1997/model/chay_1997.rdf
Compare... Download Source 

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.n_infinity">
    <dcterms:description>steady state function of delayed rectifier potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cytosolic_calcium.k_pump">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>rate of calcium release from endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current_i_NS">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>cationic nonselective inward current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cytosolic_calcium.k_Ca">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>sequestration rate of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cytosolic_calcium_Ca_lum">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./chay_1997.cellml#entity_4">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./chay_1997.cellml#entity_5">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:63842"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of luminal calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#ATP_sensitive_K_current.g_K_ATP">
    <dcterms:description>ATP-sensitive potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.i_fast">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.d">
    <dcterms:description>calcium current D-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.tau_h">
    <dcterms:description>activation time constant of fast current H-gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane_V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_m_gate.Vm">
    <dcterms:description>half-maximal activation potential of fast current M-gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cytosolic_calcium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.Cm">
    <dcterms:description>membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.i_K_ATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>ATP-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.Sh">
    <dcterms:description>saturation potential of fast current H-gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cytosolic_calcium.i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_i_fast">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_i_K_dr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>delayed-rectifying potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Na_leak_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current_i_K_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.tau_n">
    <dcterms:description>activation time constant of delayed rectifier potassium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Na_leak_current.g_NaL">
    <dcterms:description>sodium leak current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.tau_d">
    <dcterms:description>activation time constant of calcium current D-gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.lamda_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.h_infinity">
    <dcterms:description>steady state function of fast current H-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.Sn">
    <dcterms:description>saturation potential of delayed rectifier potassium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#ATP_sensitive_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.K_NS">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./chay_1997.cellml#entity_0">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./chay_1997.cellml#entity_1">
            <bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005829"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant of cationic nonselective inward current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cytosolic_calcium_Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.h">
    <dcterms:description>fast current H-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_m_gate.Sm">
    <dcterms:description>saturation potential of fast current M-gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.lamda_n">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current.n">
    <dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Na_leak_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.g_K_Ca">
    <dcterms:description>calcium-sensitive potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current.m_infinity">
    <dcterms:description>steady state function of fast current M-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#chay_1997"
     bqmodel:isDescribedBy="9284334"
     semsim:modelName="chay_1997">
    <semsim:unknown>Pancreatic Beta-cell</semsim:unknown>
    <semsim:unknown>The Chay et al 1997 mathematical model of the effects of extracellular 
        and intracellular calcium on pancreatic beta cells.</semsim:unknown>
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;Extracellular And Intracellular Calcium Effects On Pancreatic Beta-Cells&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Auckland Bioengineering Institute, The university of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This CellML model runs in both OpenCell and COR to reproduce the published results. The value for the variable 'Ca_o' in the component 'calcium_current' can be altered to 0, 2.5, 5 or 7.5 mM to reproduce figures 5 a,b,c,d, respectively.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;ABSTRACT: The extracellular calcium concentration has interesting effects on bursting of pancreatic beta-cells. The mechanism underlying the extracellular Ca2+ effect is not well understood. By incorporating a low-threshold transient inward current to the store-operated bursting model of Chay, this paper elucidates the role of the extracellular Ca2+ concentration in influencing electrical activity, intracellular Ca2+ concentration, and the luminal Ca2+ concentration in the intracellular Ca2+ store. The possibility that this inward current is a carbachol-sensitive and TTX-insensitive Na+ current discovered by others is discussed. In addition, this paper explains how these three variables respond when various pharmacological agents are applied to the store-operated model.&lt;/para&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Effects of extracellular Calcium on Electrical Bursting and Intracellular and Luminal Calcium Oscillations in Insulin Secreting Pancreatic Beta-Cells, Teresa Ree Chay, 1997,&#xD;
        &lt;emphasis&gt;Biophysical Journal&lt;/emphasis&gt;&#xD;
        , 73, 1673-1688.&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;list_uids=9284334&amp;amp;dopt=Abstract"&gt;PubMed ID: 9284334&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_cell_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;diagram of the mitochondrial Ca2+ handling model&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="chay_1997.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;&#xD;
          A schematic representation of the current and fluxes captured by the Chay 1997 pancreatic beta-cell model.  This diagram shows the plasma membrane currents associated with burst and spike oscillations: the fast current, I&#xD;
          &lt;subscript&gt;fast&lt;/subscript&gt;&#xD;
          ; the calcium current, I&#xD;
          &lt;subscript&gt;&#xD;
            Ca&#xD;
            &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          &lt;/subscript&gt;&#xD;
          ; the cationic nonselective inward current, I&#xD;
          &lt;subscript&gt;NS&lt;/subscript&gt;&#xD;
          ; the delayed-rectifying K&#xD;
          &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
          current, I&#xD;
          &lt;subscript&gt;K(dr)&lt;/subscript&gt;&#xD;
          , the calcium-sensitive K&#xD;
          &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
          current, I&#xD;
          &lt;subscript&gt;K(Ca)&lt;/subscript&gt;&#xD;
          ; the ATP-sensitive K&#xD;
          &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
          current, I&#xD;
          &lt;subscript&gt;K(ATP)&lt;/subscript&gt;&#xD;
          ; and the Na&#xD;
          &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
          leak current, I&#xD;
          &lt;subscript&gt;Na(L)&lt;/subscript&gt;&#xD;
          .  The ER intracellular Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          store is also shown with its associated transmembrane calcium fluxes: calcium release, J&#xD;
          &lt;subscript&gt;rel&lt;/subscript&gt;&#xD;
          ; and calcium uptake by the Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          -ATPase, J&#xD;
          &lt;subscript&gt;pump&lt;/subscript&gt;&#xD;
          .&#xD;
        &lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cytosolic_calcium.k_rel">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>rate of calcium pumping into endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.Ca_lum">
    <bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of luminal calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.Sd">
    <dcterms:description>saturation potential of calcium current D-gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Na_leak_current.V_Na">
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.K_Ca">
    <bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>half-saturation constant of calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.Vn">
    <dcterms:description>half-maximal activation potential of delayed rectifier potassium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Na_leak_current_i_NaL">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium leak current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current.g_K_dr">
    <dcterms:description>delayed rectifier potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current.g_fast">
    <dcterms:description>fast current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current.h">
    <dcterms:description>fast current H-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.i_NS">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>cationic nonselective inward current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.n">
    <dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.K_Ca">
    <bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>half-saturation constant of calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.i_K_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#ATP_sensitive_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.d_infinity">
    <dcterms:description>steady state function of calcium current D-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.Ca_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./chay_1997.cellml#entity_2">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./chay_1997.cellml#entity_3">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_f_gate.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.V_K">
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.f_infinity">
    <dcterms:description>steady state function of calcium current F-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.i_K_dr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>delayed-rectifying potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_m_gate.m_infinity">
    <dcterms:description>steady state function of fast current M-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.g_NS">
    <dcterms:description>cationic non-selective inward current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.Vd">
    <dcterms:description>half-maximal activation potential of calcium current D-gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#ATP_sensitive_K_current_i_K_ATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>ATP-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.VNS">
    <dcterms:description>half-maximal activation potential of cationic non-selective inward current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#ATP_sensitive_K_current.V_K">
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_f_gate.K_Ca">
    <bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>half-saturation constant of calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_f_gate.f_infinity">
    <dcterms:description>steady state function of calcium current F-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current.V_K">
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#environment_time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.d">
    <dcterms:description>calcium current D-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.Vh">
    <dcterms:description>half-maximal activation potential of fast current H-gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.i_NaL">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium leak current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#membrane.i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#fast_current.V_fast">
    <dcterms:description>fast current reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.lamda_d">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
</rdf:RDF>