- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-26 14:35:03+13:00
- Desc:
- modifying rdf files
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/dupont_1991a/model/dupont_1991a.cellml
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<title>Signal-induced Ca2+ oscillations: Properties of a model based on (Ca2+)-induced Ca2+ release</title>
<author>
<firstname>Ethan</firstname>
<surname>Choi</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model has been built with the differential expressions in Dupont's 1991 paper. This file is known to run in PCEnv and COR, and parameters for constants (beta) can be altered to produce all diagrams of figure 2 in the paper. The current parameterization is set to reproduce beta = 60% (0.6). The initial conditions Z = 0.52 and Y = 0.93 were found by allowing the model to run till steady state at 100 seconds.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>We consider a simple, minimal model for signal-induced Ca2+ oscillations based on Ca(2+)-induced Ca2+ release. The model takes into account the existence of two pools of intracellular Ca2+, namely, one sensitive to inositol 1,4,5 trisphosphate (InsP3) whose synthesis is elicited by the stimulus, and one insensitive to InsP3. The discharge of the latter pool into the cytosol is activated by cytosolic Ca2+. Oscillations in cytosolic Ca2+ arise in this model either spontaneously or in an appropriate range of external stimulation; these oscillations do not require the concomitant, periodic variation of InsP3. The following properties of the model are reviewed and compared with experimental observations: (a) Control of the frequency of Ca2+ oscillations by the external stimulus or extracellular Ca2+; (b) correlation of latency with period of Ca2+ oscillations obtained at different levels of stimulation; (c) effect of a transient increase in InsP3; (d) phase shift and transient suppression of Ca2+ oscillations by Ca2+ pulses, and (e) propagation of Ca2+ waves. It is shown that on all these counts the model provides a simple, unified explanation for a number of experimental observations in a variety of cell types. The model based on Ca(2+)-induced Ca2+ release can be extended to incorporate variations in the level of InsP3 as well as desensitization of the InsP3 receptor; besides accounting for the phenomena described by the minimal model, the extended model might also account for the occurrence of complex Ca2+ oscillations.</para>
<informalfigure float="0" id="fig_reaction_diagram">
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<title>model diagram</title>
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<caption>Schematic diagram of the cell model for signal-induced, intracellular calcium oscillations.</caption>
</informalfigure>
<para>The complete original paper reference is cited below:</para>
<para>
Signal-induced Ca2+ oscillations: properties of a model based on Ca(2+)-induced Ca2+ release, Dupont G, Berridge M.J, Goldbeter A, 1991,
<emphasis>Cell Calcium</emphasis>
12, 73-85.
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/1647878">PubMedID: 1647878</ulink>
</para>
</sect1>
</article>
</documentation>
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<dcterms:description>threshold constant for calcium activation of IP3-insensitive store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.n">
<dcterms:description>Hill coefficient for calcium pumping into IP3-insensitive store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#insensitive_pool.v2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux from cytosol into the IP3-insensitive intracellular store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#parameters_p">
<dcterms:description>Hill coefficient for calcium activation of IP3-insensitive store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#insensitive_pool.kf">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of passive leak of calcium from IP3-insensitive intracellular store into cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#parameters.v3">
<dcterms:description>calcium flux from IP3-insensitive intracellular store into the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#cytosol.v3">
<dcterms:description>calcium flux from IP3-insensitive intracellular store into the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.KR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>threshold constant for calcium release from IP3-insensitive store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.kf">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of passive leak of calcium from IP3-insensitive intracellular store into cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#parameters.m">
<dcterms:description>Hill coefficient for calcium release from IP3-insensitive store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosol.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#parameters.Z">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.v2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux from cytosol into the IP3-insensitive intracellular store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosol.v2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux from cytosol into the IP3-insensitive intracellular store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosol.kf">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of passive leak of calcium from IP3-insensitive intracellular store into cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.VM3">
<dcterms:description>maximum rate of calcium pumping from IP3-insensitive intracellular store into the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#cytosol.Y">
<bqbiol:isPropertyOf rdf:resource="dupont_1991a.cellml#entity_0" />
<dcterms:description>concentration of calcium in IP3-insensitive intracellular store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#insensitive_pool.v3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux from IP3-insensitive intracellular store into the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#parameters.k">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of transport of cytosolic calcium out of the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#cytosol.beta">
<dcterms:description>stimulation factor of IP3 receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#parameters.v0">
<dcterms:description>rate of influx of extracellular calcium into the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#parameters.beta">
<dcterms:description>stimulation factor of IP3 receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#cytosol.kf">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of passive leak of calcium from IP3-insensitive intracellular store into cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#cytosol.v2">
<dcterms:description>calcium flux from cytosol into the IP3-insensitive intracellular store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.K2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>threshold constant for calcium pumping into IP3-insensitive store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="dupont_1991a.cellml#Y">
<bqbiol:isPropertyOf rdf:resource="dupont_1991a.cellml#entity_0" />
<dcterms:description>concentration of calcium in IP3-insensitive intracellular store</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
