- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-26 14:35:03+13:00
- Desc:
- modifying rdf files
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/gall_susa_1999_a/model/gall_susa_1999_a.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="gall_susa_1999_a" cmeta:id="gall_1999">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Na/Ca Exchange in Models for Pancreatic Beta-Cells</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model represents Model I from the published paper. The CellML matches the published equations and the model runs in OpenCell and COR but it does not replicate the published results.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: In the presence of an insulinotropic glucose concentration, beta-cells, in intact pancreatic islets, exhibit periodic bursting electrical activity consisting of an alternation of active and silent phases. The fraction of time spent in the active phase over a period is called the plateau fraction and is correlated with the rate of insulin release. However, the mechanisms that regulate the plateau fraction remain unclear. In this paper we investigate the possible role of the plasma membrane Na+/Ca2+ exchange of the beta-cell in controlling the plateau fraction. We have extended different single-cell models to incorporate this Ca2+-activated electrogenic Ca2+ transporter. We find that the Na+/Ca2+ exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. In addition, we show theoretically that the Na+/Ca2+ exchanger is a key regulator of the cytoplasmic calcium concentration in clusters of heterogeneous cells with gap-junctional electrical coupling.</para>
<para>The original paper reference is cited below:</para>
<para>
Effect of Na/Ca Exchange on Plateau Fraction and [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
in Models for Bursting in Pancreatic Beta-Cells, David Gall and Isabella Susa, 1999,
<emphasis>Biophysical Journal</emphasis>
, 77, 45-53.
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/10388739">PubMed ID: 10388739</ulink>
</para>
</sect1>
</article>
</documentation>
<units name="picoS">
<unit prefix="pico" units="siemens" />
</units>
<units name="femtoF">
<unit prefix="femto" units="farad" />
</units>
<units name="mole_per_microlitre_coulomb">
<unit exponent="-1.0" prefix="micro" units="litre" />
<unit units="mole" />
<unit exponent="-1.0" units="coulomb" />
</units>
<units name="per_millisecond">
<unit exponent="-1.0" units="millisecond" />
</units>
<units name="micromolar">
<unit exponent="-1.0" units="litre" />
<unit prefix="micro" units="mole" />
</units>
<units name="millivolt">
<unit prefix="milli" units="volt" />
</units>
<units name="picoA">
<unit prefix="pico" units="ampere" />
</units>
<units name="millisecond">
<unit prefix="milli" units="second" />
</units>
<units name="millimolar">
<unit exponent="-1.0" units="litre" />
<unit prefix="milli" units="mole" />
</units>
<component name="environment">
<variable cmeta:id="environment.time" name="time" public_interface="out" units="millisecond" />
</component>
<component name="membrane">
<variable cmeta:id="membrane.V" initial_value="-76.0" name="V" public_interface="out" units="millivolt" />
<variable cmeta:id="membrane.Cm" initial_value="5310.0" name="Cm" units="femtoF" />
<variable cmeta:id="membrane.time" name="time" public_interface="in" units="millisecond" />
<variable cmeta:id="membrane.i_Ca" name="i_Ca" public_interface="in" units="picoA" />
<variable cmeta:id="membrane.i_K" name="i_K" public_interface="in" units="picoA" />
<variable cmeta:id="membrane.i_K_Ca" name="i_K_Ca" public_interface="in" units="picoA" />
<variable cmeta:id="membrane.i_Na_Ca" name="i_Na_Ca" public_interface="in" units="picoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="membrane_voltage_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<ci>i_K</ci>
<ci>i_Ca</ci>
<ci>i_K_Ca</ci>
<ci>i_Na_Ca</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
</component>
<component name="rapidly_activating_K_current">
<variable cmeta:id="rapidly_activating_K_current.i_K" name="i_K" public_interface="out" units="picoA" />
<variable cmeta:id="rapidly_activating_K_current.V_K" initial_value="-75.0" name="V_K" public_interface="out" units="millivolt" />
<variable cmeta:id="rapidly_activating_K_current.g_K" initial_value="2500.0" name="g_K" units="picoS" />
<variable cmeta:id="rapidly_activating_K_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
<variable cmeta:id="rapidly_activating_K_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="rapidly_activating_K_current.n" name="n" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_K_calculation">
<eq />
<ci>i_K</ci>
<apply>
<times />
<ci>g_K</ci>
<ci>n</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapidly_activating_K_current_n_gate">
<variable cmeta:id="rapidly_activating_K_current_n_gate.n" initial_value="0.1" name="n" public_interface="out" units="dimensionless" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.n_infinity" name="n_infinity" units="dimensionless" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.lamda" initial_value="1.6" name="lamda" units="dimensionless" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.tau_n" name="tau_n" units="millisecond" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.V_n" initial_value="-15.0" name="V_n" units="millivolt" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.S_n" initial_value="5.6" name="S_n" units="millivolt" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.a" initial_value="65.0" name="a" units="millivolt" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.b" initial_value="20.0" name="b" units="millivolt" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.c" initial_value="6.0" name="c" units="millisecond" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.V_" initial_value="-75.0" name="V_" units="millivolt" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="rapidly_activating_K_current_n_gate.time" name="time" public_interface="in" units="millisecond" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="n_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>n</ci>
</apply>
<apply>
<times />
<ci>lamda</ci>
<apply>
<divide />
<apply>
<minus />
<ci>n_infinity</ci>
<ci>n</ci>
</apply>
<ci>tau_n</ci>
</apply>
</apply>
</apply>
<apply id="n_infinity_calculation">
<eq />
<ci>n_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V_n</ci>
<ci>V</ci>
</apply>
<ci>S_n</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="tau_n_calculation">
<eq />
<ci>tau_n</ci>
<apply>
<divide />
<ci>c</ci>
<apply>
<plus />
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V</ci>
<ci>V_</ci>
</apply>
<ci>a</ci>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V_</ci>
<ci>V</ci>
</apply>
<ci>b</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_current">
<variable cmeta:id="calcium_current.i_Ca" name="i_Ca" public_interface="out" units="picoA" />
<variable cmeta:id="calcium_current.V_Ca" initial_value="110.0" name="V_Ca" units="millivolt" />
<variable cmeta:id="calcium_current.g_Ca" initial_value="1400.0" name="g_Ca" units="picoS" />
<variable cmeta:id="calcium_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
<variable cmeta:id="calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="calcium_current.m_infinity" name="m_infinity" private_interface="in" units="dimensionless" />
<variable cmeta:id="calcium_current.h" name="h" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_Ca_calculation">
<eq />
<ci>i_Ca</ci>
<apply>
<times />
<ci>g_Ca</ci>
<ci>m_infinity</ci>
<ci>h</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_current_m_gate">
<variable cmeta:id="calcium_current_m_gate.m_infinity" name="m_infinity" public_interface="out" units="dimensionless" />
<variable cmeta:id="calcium_current_m_gate.V_m" initial_value="4.0" name="V_m" units="millivolt" />
<variable cmeta:id="calcium_current_m_gate.S_m" initial_value="14.0" name="S_m" units="millivolt" />
<variable cmeta:id="calcium_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_current_m_gate.time" name="time" public_interface="in" units="millisecond" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="m_infinity_calculation">
<eq />
<ci>m_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V_m</ci>
<ci>V</ci>
</apply>
<ci>S_m</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_current_h_gate">
<variable cmeta:id="calcium_current_h_gate.h" name="h" public_interface="out" units="dimensionless" />
<variable cmeta:id="calcium_current_h_gate.V_h" initial_value="-10.0" name="V_h" units="millivolt" />
<variable cmeta:id="calcium_current_h_gate.S_h" initial_value="-10.0" name="S_h" units="millivolt" />
<variable cmeta:id="calcium_current_h_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_current_h_gate.time" name="time" public_interface="in" units="millisecond" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="h_calculation">
<eq />
<ci>h</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V_h</ci>
<ci>V</ci>
</apply>
<ci>S_h</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_activated_K_current">
<variable cmeta:id="calcium_activated_K_current.i_K_Ca" name="i_K_Ca" public_interface="out" units="picoA" />
<variable cmeta:id="calcium_activated_K_current.g_K_Ca" initial_value="30000.0" name="g_K_Ca" units="picoS" />
<variable cmeta:id="calcium_activated_K_current.K_d" initial_value="100.0" name="K_d" units="micromolar" />
<variable cmeta:id="calcium_activated_K_current.V_K" name="V_K" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_activated_K_current.time" name="time" public_interface="in" units="millisecond" />
<variable cmeta:id="calcium_activated_K_current.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_activated_K_current.Ca_i" name="Ca_i" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_K_Ca_calculation">
<eq />
<ci>i_K_Ca</ci>
<apply>
<times />
<ci>g_K_Ca</ci>
<apply>
<divide />
<ci>Ca_i</ci>
<apply>
<plus />
<ci>K_d</ci>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<minus />
<ci>V</ci>
<ci>V_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_exchanger_current">
<variable cmeta:id="Na_Ca_exchanger_current.i_Na_Ca" name="i_Na_Ca" public_interface="out" units="picoA" />
<variable cmeta:id="Na_Ca_exchanger_current.g_Na_Ca" initial_value="234.0" name="g_Na_Ca" units="picoS" />
<variable cmeta:id="Na_Ca_exchanger_current.K_1_2" initial_value="1.5" name="K_1_2" units="micromolar" />
<variable cmeta:id="Na_Ca_exchanger_current.V_Na_Ca" name="V_Na_Ca" units="millivolt" />
<variable cmeta:id="Na_Ca_exchanger_current.RT_F" initial_value="26.54" name="RT_F" units="millivolt" />
<variable cmeta:id="Na_Ca_exchanger_current.nH" initial_value="5.0" name="nH" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger_current.time" name="time" public_interface="in" units="millisecond" />
<variable cmeta:id="Na_Ca_exchanger_current.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="Na_Ca_exchanger_current.Ca_i" name="Ca_i" public_interface="in" units="micromolar" />
<variable cmeta:id="Na_Ca_exchanger_current.Ca_o" name="Ca_o" public_interface="in" units="micromolar" />
<variable cmeta:id="Na_Ca_exchanger_current.Na_i" name="Na_i" public_interface="in" units="millimolar" />
<variable cmeta:id="Na_Ca_exchanger_current.Na_o" name="Na_o" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_Na_Ca_calculation">
<eq />
<ci>i_Na_Ca</ci>
<apply>
<times />
<ci>g_Na_Ca</ci>
<apply>
<divide />
<apply>
<power />
<ci>Ca_i</ci>
<ci>nH</ci>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>K_1_2</ci>
<ci>nH</ci>
</apply>
<apply>
<power />
<ci>Ca_i</ci>
<ci>nH</ci>
</apply>
</apply>
</apply>
<apply>
<minus />
<ci>V</ci>
<ci>V_Na_Ca</ci>
</apply>
</apply>
</apply>
<apply id="V_Na_Ca_calculation">
<eq />
<ci>V_Na_Ca</ci>
<apply>
<times />
<ci>RT_F</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<apply>
<ln />
<apply>
<minus />
<apply>
<divide />
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ionic_concentrations">
<variable cmeta:id="ionic_concentrations.Ca_i" initial_value="0.52" name="Ca_i" public_interface="out" units="micromolar" />
<variable cmeta:id="ionic_concentrations.Ca_o" initial_value="2600.0" name="Ca_o" public_interface="out" units="micromolar" />
<variable cmeta:id="ionic_concentrations.Na_i" initial_value="10.0" name="Na_i" public_interface="out" units="millimolar" />
<variable cmeta:id="ionic_concentrations.Na_o" initial_value="140.0" name="Na_o" public_interface="out" units="millimolar" />
<variable cmeta:id="ionic_concentrations.f" initial_value="0.001" name="f" units="dimensionless" />
<variable cmeta:id="ionic_concentrations.k_Ca" initial_value="0.03" name="k_Ca" units="per_millisecond" />
<variable cmeta:id="ionic_concentrations.alpha" initial_value="0.0000045055" name="alpha" units="mole_per_microlitre_coulomb" />
<variable cmeta:id="ionic_concentrations.time" name="time" public_interface="in" units="millisecond" />
<variable cmeta:id="ionic_concentrations.i_Ca" name="i_Ca" public_interface="in" units="picoA" />
<variable cmeta:id="ionic_concentrations.i_Na_Ca" name="i_Na_Ca" public_interface="in" units="picoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Ca_i_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times />
<ci>f</ci>
<apply>
<minus />
<apply>
<times />
<apply>
<minus />
<ci>alpha</ci>
</apply>
<apply>
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<apply>
<times />
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<apply>
<times />
<ci>k_Ca</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="calcium_current">
<component_ref component="calcium_current_h_gate" />
<component_ref component="calcium_current_m_gate" />
</component_ref>
<component_ref component="rapidly_activating_K_current">
<component_ref component="rapidly_activating_K_current_n_gate" />
</component_ref>
</group>
<connection>
<map_components component_1="ionic_concentrations" component_2="Na_Ca_exchanger_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="rapidly_activating_K_current_n_gate" component_2="rapidly_activating_K_current" />
<map_variables variable_1="n" variable_2="n" />
</connection>
<connection>
<map_components component_1="calcium_current" component_2="membrane" />
<map_variables variable_1="i_Ca" variable_2="i_Ca" />
</connection>
<connection>
<map_components component_1="calcium_current_h_gate" component_2="calcium_current" />
<map_variables variable_1="h" variable_2="h" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger_current" component_2="membrane" />
<map_variables variable_1="i_Na_Ca" variable_2="i_Na_Ca" />
</connection>
<connection>
<map_components component_1="environment" component_2="Na_Ca_exchanger_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="rapidly_activating_K_current" component_2="membrane" />
<map_variables variable_1="i_K" variable_2="i_K" />
</connection>
<connection>
<map_components component_1="environment" component_2="membrane" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="calcium_current" component_2="ionic_concentrations" />
<map_variables variable_1="i_Ca" variable_2="i_Ca" />
</connection>
<connection>
<map_components component_1="environment" component_2="rapidly_activating_K_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_activated_K_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger_current" component_2="ionic_concentrations" />
<map_variables variable_1="i_Na_Ca" variable_2="i_Na_Ca" />
</connection>
<connection>
<map_components component_1="calcium_current" component_2="calcium_current_h_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_exchanger_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="ionic_concentrations" component_2="calcium_activated_K_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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</rdf:Description>
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<dcterms:description>saturation potential of M-gate calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.Cm">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#Na_Ca_exchanger_current.g_Na_Ca">
<dcterms:description>maximum sodium-calcium exchanger current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_Na_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger_current.V_Na_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>reversal potential of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#Na_Ca_exchanger_current.i_Na_Ca">
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#calcium_activated_K_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#calcium_activated_K_current.g_K_Ca">
<dcterms:description>calcium-activated potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ionic_concentrations.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_26">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_5">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free cytosolic sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#calcium_current_m_gate.m_infinity">
<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_current_h_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#calcium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#rapidly_activating_K_current.i_K">
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#calcium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#Na_Ca_exchanger_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="gall_susa_1999_a.cellml#entity_0" />
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#rapidly_activating_K_current.g_K">
<dcterms:description>rapid potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_activated_K_current.K_d">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#rapidly_activating_K_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ionic_concentrations.i_Na_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_29">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#gall_1999" semsim:modelName="gall_1999" bqmodel:isDescribedBy="10388739">
<semsim:unknown>Pancreatic Beta-Cell</semsim:unknown>
<semsim:unknown>The Gall and Susa 1999 model of Na/Ca exchange in Model I for pancreatic beta-cells.</semsim:unknown>
<semsim:modelName>gall_susa_1999_a</semsim:modelName>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger_current.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#membrane.i_K_Ca">
<dcterms:description>calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger_current.g_Na_Ca">
<dcterms:description>maximum sodium-calcium exchanger current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#Na_Ca_exchanger_current.V_Na_Ca">
<dcterms:description>reversal potential of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger_current.K_1_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium half-saturation constant of the sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#rapidly_activating_K_current_n_gate.tau_n">
<dcterms:description>activation time constant of delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_current.m_infinity">
<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#ionic_concentrations.k_Ca">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>calcium removal rate in the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#Na_Ca_exchanger_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#ionic_concentrations.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#calcium_current.i_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_activated_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rapidly_activating_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#membrane.i_K">
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#Na_Ca_exchanger_current.Na_i">
<bqbiol:isPropertyOf rdf:resource="gall_susa_1999_a.cellml#entity_4" />
<dcterms:description>concentration of free cytosolic sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#entity_3">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022" />
</rdf:Description>
<rdf:Description rdf:about="#rapidly_activating_K_current_n_gate.n">
<dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#rapidly_activating_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#ionic_concentrations.f">
<dcterms:description>fraction of free cytoplasmic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#ionic_concentrations.Na_o">
<bqbiol:isPropertyOf rdf:resource="gall_susa_1999_a.cellml#entity_5" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rapidly_activating_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#rapidly_activating_K_current_n_gate.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#ionic_concentrations.i_Na_Ca">
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#Na_Ca_exchanger_current.nH">
<dcterms:description>Hill coefficient of sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#calcium_activated_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#ionic_concentrations.Ca_o">
<bqbiol:isPropertyOf rdf:resource="gall_susa_1999_a.cellml#entity_2" />
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rapidly_activating_K_current.i_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger_current.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free cytosolic sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#membrane.i_Na_Ca">
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="gall_susa_1999_a.cellml#calcium_current_h_gate.V_h">
<dcterms:description>half-maximal activation potential of H-gate calcium channel</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
