- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-26 14:35:03+13:00
- Desc:
- modifying rdf files
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/magnus_keizer_1997/model/magnus_keizer_1997.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.proton_motive_force">
<dcterms:description>proton motive force</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.ADP_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_12">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_1">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_2">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:85704"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:260691"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.J_uni">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux into mitochondrial matrix through uniporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_leak.g_H">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
<dcterms:description>proton leakage conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.na">
<dcterms:description>calcium uniporter activation cooperativity</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.ATP4_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_14">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_4">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_2"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:66864"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:30616"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial ATP(4-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.Pi_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_10">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:24838"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial inorganic phosphate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.ADP3_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_16">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:456216"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial ADP(3-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.ADP_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_9">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.K_F1">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_0">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_1"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium equilibrium constant of F1F0-ATPase</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.pb">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_leak.JH_leak">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>proton leakage flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.J_uni">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux into mitochondrial matrix through uniporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.rc1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_leak.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.J_ant">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>adenine nucleotide translocator flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.Na_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_18">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_1"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.n">
<dcterms:description>sodium-calcium exchanger cooperativity parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.ra">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.JH_res">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>proton flux via respiration driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.K_Ca">
<dcterms:description>sodium half-saturation constant of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.Jmax_uni">
<dcterms:description>maximum calcium flux through uniporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.rho_res">
<dcterms:description>proton pump density</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_leak.proton_motive_force">
<dcterms:description>proton motive force</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.rc2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.pc1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.Jmax_ant">
<dcterms:description>maximum adenine nucleotide translocator flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.p1">
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.r2">
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.Jmax_Na_Ca">
<dcterms:description>maximum sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.L">
<dcterms:description>equilibrium constant for calcium uniporter conformations</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.J_ant">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>adenine nucleotide translocator flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.V_offset">
<dcterms:description>calcium uniporter voltage offset for calcium transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.pc2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.J_uni">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux into mitochondrial matrix through uniporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.V_B">
<dcterms:description>total phase boundary potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.p2">
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.K_trans">
<bqbiol:isPropertyOf rdf:resource="./magnus_keizer_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium dissociation constant of uniporter transportation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.JH_F1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>proton flux through F1F0-ATPase driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#magnus_keizer_1997_version01"
semsim:modelName="magnus_keizer_1997"
bqmodel:isDescribedBy="9277370">
<semsim:modelName>magnus_keizer_1997_version01</semsim:modelName>
<semsim:unknown>Pancreatic Beta-cell</semsim:unknown>
<semsim:unknown>Minimal model of beta-cell mitochondrial Ca2+ handling</semsim:unknown>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Mitochondrial Ca2+ Handling</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
In 1997 Gerhard Magnus and Joel Keizer published a minimal mathematical model to describe Ca
<superscript>2+</superscript>
handling by mitochondria in the pancreatic beta-cell. Their kinetic model includes six transport mechanisms in the inner mitochondrial membrane, including proton pumping via respiration and proton pumping by the F0F1-ATPase, a proton leak, adenine nucleotide exchange, the Ca
<superscript>2+</superscript>
uniporter and Na
<superscript>+</superscript>
/Ca
<superscript>2+</superscript>
exchange (see
<xref linkend="fig_cell_diagram" />
below).
</para>
<para>The complete original paper reference is cited below:</para>
<para>
Minimal model of beta-cell mitochondrial Ca
<superscript>2+</superscript>
handling, Gerhard Magnus and Joel Keizer, 1997,
<ulink url="http://ajpcell.physiology.org/">
<emphasis>American Journal of Physiology</emphasis>
</ulink>
, 273, C717-C733.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9277370&amp;dopt=Abstract">PubMed ID: 9277370</ulink>
</para>
<para>
The raw CellML description of the mitochondrial Ca
<superscript>2+</superscript>
handling model can be downloaded in various formats as described in
<xref linkend="sec_download_this_model" />
. For an example of a more complete documentation for an electrophysiological model, see
<ulink url="${HTML_EXMPL_HHSA_INTRO}">The Hodgkin-Huxley Squid Axon Model, 1952</ulink>
.
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>diagram of the mitochondrial Ca2+ handling model showing ionic currents across the mitochondrial membrane</title>
</objectinfo>
<imagedata fileref="magnus_1997.png" />
</imageobject>
</mediaobject>
<caption>A schematic representation of the ion fluxes through the mitochondrial inner membrane that are included in the Magnus-Keizer minimal model.</caption>
</informalfigure>
<informalfigure float="0" id="fig_cellml_rendering">
<mediaobject>
<imageobject>
<objectinfo>
<title>the cellml rendering of the mitochondrial Ca2+ handling model</title>
</objectinfo>
<imagedata fileref="cellml_rendering.gif" />
</imageobject>
</mediaobject>
<caption>
The network defined in the CellML description of the mitochondrial Ca
<superscript>2+</superscript>
handling model.
</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.r1">
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.rb">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.p3">
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.ATP_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_11">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_1"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.g">
<dcterms:description>voltage fitting factor for respiratory driven proton pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.pH_m">
<dcterms:description>pH of mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.ATP4_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_13">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_1"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:30616"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ATP(4-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.Jo">
<dcterms:description>half proton flux via respiration driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.total_mitochondrial_adenosine_phosphate">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_7">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:22256"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of total mitochondrial adenosine phosphate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.ADP3_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_15">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_1"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:456216"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ADP(3-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.V_offset">
<dcterms:description>calcium uniporter voltage offset for calcium transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.ADP_m">
<bqbiol:isPropertyOf rdf:resource="./magnus_keizer_1997.cellml#entity_9"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.f">
<dcterms:description>fraction of effective voltage difference</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.V_B">
<dcterms:description>total phase boundary potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.delta_pH">
<dcterms:description>pH difference between cytosol and mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.total_NAD_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_3">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:13389"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of total mitochondrial NAD</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.J_Na_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>sodium-calcium exchanger flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.b">
<dcterms:description>sodium-calcium exchanger voltage dependence</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.g_H">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
<dcterms:description>proton leakage conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.NADH_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_6">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16908"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial NADH</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.JH_leak">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>proton leakage flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.r3">
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.K_act">
<bqbiol:isPropertyOf rdf:resource="./magnus_keizer_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium dissociation constant of uniporter activation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.Ca_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_17">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.JH_F1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>proton flux through F1F0-ATPase driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.rho_F1">
<dcterms:description>F1F0-ATPase pump concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.V_B">
<dcterms:description>total phase boundary potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Ca_uniporter.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./magnus_keizer_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.fm">
<dcterms:description>fraction of free mitochondrial matrix calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.delta_pH">
<dcterms:description>pH difference between cytosol and mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.Cmito">
<dcterms:description>inner mitochondrial membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.A_res">
<dcterms:description>driving reaction affinity of respiratory driven proton pump </dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#Na_Ca_exchanger.K_Na">
<bqbiol:isPropertyOf rdf:resource="./magnus_keizer_1997.cellml#entity_18"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>sodium half-saturation constant of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.ADP_m_free">
<bqbiol:isPropertyOf rdf:resource="./magnus_keizer_1997.cellml#entity_9"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free mitochondrial matrix ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.K_res">
<bqbiol:isPropertyOf rdf:resource="./magnus_keizer_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium equilibrium constant of respiration driven proton pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.Jp_F1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>phosphate flux through F1F0-ATPase driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.Jp_F1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>phosphate flux through F1F0-ATPase driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.NAD_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_5">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15846"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial NAD</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.pa">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#proton_pump.JH_res">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>proton flux via respiration driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.A_F1">
<dcterms:description>driving reaction affinity of F1F0-ATPase</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#ATP_ADP_exchange.ATP_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#entity_8">
<bqbiol:isPartOf rdf:resource="./magnus_keizer_1997.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.pH_i">
<dcterms:description>pH of cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#membrane.delta_pH">
<dcterms:description>pH difference between cytosol and mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./magnus_keizer_1997.cellml#F0_F1_ATPase.ATP_m">
<bqbiol:isPropertyOf rdf:resource="./magnus_keizer_1997.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of mitochondrial ATP</dcterms:description>
</rdf:Description>
</rdf:RDF>
