Location: Calcium Dynamics Annotations @ 4d6408caaf3e / purvis_butera_2005 / model / purvis_butera_2005.cellml

Author:

neilstephen2001 <npar276@aucklanduni.ac.nz>

Date:

2021-01-26 14:35:03+13:00

Desc:

modifying rdf files

Permanent Source URI:

https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/purvis_butera_2005/model/purvis_butera_2005.cellml

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  <documentation xmlns="http://cellml.org/tmp-documentation">
    <article>
      <articleinfo>
        <title>Ionic current model of a hypoglossal motoneuron</title>
        <author>
          <firstname>Geoffrey</firstname>
          <surname>Nunns</surname>
          <affiliation>
            <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
          </affiliation>
        </author>
      </articleinfo>
      <section id="sec_status">
        <title>Model Status</title>
        <para>This CellML model is known to run in both OpenCell and COR and the units have been checked and are consistent. The model recreates the published results.</para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        <para>ABSTRACT: We have developed a single-compartment, electrophysiological, hypoglossal motoneuron (HM) model based primarily on experimental data from neonatal rat HMs. The model is able to reproduce the fine features of the HM action potential: the fast afterhyperpolarization, the afterdepolarization, and the medium-duration afterhyperpolarization (mAHP). The model also reproduces the repetitive firing properties seen in neonatal HMs and replicates the neuron's response to pharmacological experiments. The model was used to study the role of specific ionic currents in HM firing and how variations in the densities of these currents may account for age-dependent changes in excitability seen in HMs. By varying the density of a fast inactivating calcium current, the model alternates between accelerating and adapting firing patterns. Modeling the age-dependent increase in H current density accounts for the decrease in mAHP duration observed experimentally, but does not fully account for the decrease in input resistance. An increase in the density of the voltage-dependent potassium currents and the H current is required to account for the decrease in input resistance. These changes also account for the age-dependent decrease in action potential duration.</para>
        <informalfigure float="0" id="fig_reaction_diagram">
          <mediaobject>
            <imageobject>
              <objectinfo>
                <title>model diagram</title>
              </objectinfo>
              <imagedata fileref="purvis_2005.png" />
            </imageobject>
          </mediaobject>
          <caption>A schematic diagram of the cell model.  It is composed of ten ionic currents across the plasma membrane: a fast sodium current, INa; a delayed rectifier potassium current, IK; a persistent sodium current,  INaP; a passive leakage current, IL; a LVA calcium current, IT; an N-type HVA calcium current, IN; a P-type HVA calcium current, IP; a calcium-dependent potassium current, ISK; a fast-transient potassium current, IA; and finally, a hyperpolarisation-activated current, IH.</caption>
        </informalfigure>
        <para>The original paper reference is cited below:</para>
        <para>
          Ionic current model of a hypoglossal motoneuron, Robert J. Butera, Jr., Liston K. Purvis, 2005,
          <emphasis>Journal of Neurophysiology</emphasis>
          , 93, 723-733.
          <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=15653786&amp;dopt=Abstract">PubMed ID: 15653786</ulink>
        </para>
      </sect1>
    </article>
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            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <apply>
                    <plus />
                    <ci>V</ci>
                    <ci>theta_n</ci>
                  </apply>
                </apply>
                <ci>sigma_n</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>n</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>n_infinity</ci>
            <ci>n</ci>
          </apply>
          <ci>tau_n</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="leak_current">
    <variable cmeta:id="leak_current_i_leak" name="i_leak" public_interface="out" units="nanoA" />
    <variable cmeta:id="leak_current.g_leak" initial_value="0.005" name="g_leak" units="uS" />
    <variable cmeta:id="leak_current.E_leak" initial_value="-50" name="E_leak" units="millivolt" />
    <variable cmeta:id="leak_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="leak_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_leak</ci>
        <apply>
          <times />
          <ci>g_leak</ci>
          <apply>
            <minus />
            <ci>V</ci>
            <ci>E_leak</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="LVA_calcium_current">
    <variable cmeta:id="LVA_calcium_current_i_T" name="i_T" public_interface="out" units="nanoA" />
    <variable cmeta:id="LVA_calcium_current.g_T" initial_value="0.1" name="g_T" units="uS" />
    <variable cmeta:id="LVA_calcium_current.E_Ca" initial_value="40" name="E_Ca" public_interface="out" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <variable cmeta:id="LVA_calcium_current.m" name="m" private_interface="in" units="dimensionless" />
    <variable cmeta:id="LVA_calcium_current.h" name="h" private_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_T</ci>
        <apply>
          <times />
          <ci>g_T</ci>
          <ci>m</ci>
          <ci>h</ci>
          <apply>
            <minus />
            <ci>V</ci>
            <ci>E_Ca</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="LVA_calcium_current_m_gate">
    <variable cmeta:id="LVA_calcium_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_m_gate.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="LVA_calcium_current_m_gate.m" initial_value="0.001" name="m" public_interface="out" units="dimensionless" />
    <variable cmeta:id="LVA_calcium_current_m_gate.theta_m" initial_value="38" name="theta_m" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_m_gate.sigma_m" initial_value="5" name="sigma_m" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_m_gate.theta_1" initial_value="28" name="theta_1" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_m_gate.sigma_1" initial_value="25" name="sigma_1" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_m_gate.sigma_2" initial_value="70" name="sigma_2" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_m_gate.tau_m" name="tau_m" units="millisecond" />
    <variable cmeta:id="LVA_calcium_current_m_gate.m_infinity" name="m_infinity" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>tau_m</ci>
        <apply>
          <plus />
          <apply>
            <divide />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">5</cn>
            <apply>
              <plus />
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <plus />
                    <ci>V</ci>
                    <ci>theta_1</ci>
                  </apply>
                  <ci>sigma_1</ci>
                </apply>
              </apply>
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <minus />
                    <apply>
                      <plus />
                      <ci>V</ci>
                      <ci>theta_1</ci>
                    </apply>
                  </apply>
                  <ci>sigma_2</ci>
                </apply>
              </apply>
            </apply>
          </apply>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2</cn>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>m_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <apply>
                    <plus />
                    <ci>V</ci>
                    <ci>theta_m</ci>
                  </apply>
                </apply>
                <ci>sigma_m</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>m</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>m_infinity</ci>
            <ci>m</ci>
          </apply>
          <ci>tau_m</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="LVA_calcium_current_h_gate">
    <variable cmeta:id="LVA_calcium_current_h_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_h_gate.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="LVA_calcium_current_h_gate.h" initial_value="0.562" name="h" public_interface="out" units="dimensionless" />
    <variable cmeta:id="LVA_calcium_current_h_gate.theta_h" initial_value="70.1" name="theta_h" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_h_gate.sigma_h" initial_value="7" name="sigma_h" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_h_gate.theta_1" initial_value="70" name="theta_1" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_h_gate.sigma_1" initial_value="65" name="sigma_1" units="millivolt" />
    <variable cmeta:id="LVA_calcium_current_h_gate.tau_h" name="tau_h" units="millisecond" />
    <variable cmeta:id="LVA_calcium_current_h_gate.h_infinity" name="h_infinity" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>tau_h</ci>
        <apply>
          <plus />
          <apply>
            <divide />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">20</cn>
            <apply>
              <plus />
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <plus />
                    <ci>V</ci>
                    <ci>theta_1</ci>
                  </apply>
                  <ci>sigma_1</ci>
                </apply>
              </apply>
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <minus />
                    <apply>
                      <plus />
                      <ci>V</ci>
                      <ci>theta_1</ci>
                    </apply>
                  </apply>
                  <ci>sigma_1</ci>
                </apply>
              </apply>
            </apply>
          </apply>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>h_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <plus />
                  <ci>V</ci>
                  <ci>theta_h</ci>
                </apply>
                <ci>sigma_h</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>h</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>h_infinity</ci>
            <ci>h</ci>
          </apply>
          <ci>tau_h</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="N_HVA_calcium_current">
    <variable cmeta:id="N_HVA_calcium_current_i_N" name="i_N" public_interface="out" units="nanoA" />
    <variable cmeta:id="N_HVA_calcium_current.g_N" initial_value="0.05" name="g_N" units="uS" />
    <variable cmeta:id="N_HVA_calcium_current.E_Ca" name="E_Ca" public_interface="in" units="millivolt" />
    <variable cmeta:id="N_HVA_calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="N_HVA_calcium_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <variable cmeta:id="N_HVA_calcium_current.m" name="m" private_interface="in" units="dimensionless" />
    <variable cmeta:id="N_HVA_calcium_current.h" name="h" private_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_N</ci>
        <apply>
          <times />
          <ci>g_N</ci>
          <ci>m</ci>
          <ci>h</ci>
          <apply>
            <minus />
            <ci>V</ci>
            <ci>E_Ca</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="N_HVA_calcium_current_m_gate">
    <variable cmeta:id="N_HVA_calcium_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="N_HVA_calcium_current_m_gate.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="N_HVA_calcium_current_m_gate.m" initial_value="0.001" name="m" public_interface="out" units="dimensionless" />
    <variable cmeta:id="N_HVA_calcium_current_m_gate.theta_m" initial_value="30" name="theta_m" units="millivolt" />
    <variable cmeta:id="N_HVA_calcium_current_m_gate.sigma_m" initial_value="6" name="sigma_m" units="millivolt" />
    <variable cmeta:id="N_HVA_calcium_current_m_gate.tau_m" initial_value="5" name="tau_m" units="millisecond" />
    <variable cmeta:id="N_HVA_calcium_current_m_gate.m_infinity" name="m_infinity" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>m_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <apply>
                    <plus />
                    <ci>V</ci>
                    <ci>theta_m</ci>
                  </apply>
                </apply>
                <ci>sigma_m</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>m</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>m_infinity</ci>
            <ci>m</ci>
          </apply>
          <ci>tau_m</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="N_HVA_calcium_current_h_gate">
    <variable cmeta:id="N_HVA_calcium_current_h_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="N_HVA_calcium_current_h_gate.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="N_HVA_calcium_current_h_gate.h" initial_value="0.649" name="h" public_interface="out" units="dimensionless" />
    <variable cmeta:id="N_HVA_calcium_current_h_gate.theta_h" initial_value="70" name="theta_h" units="millivolt" />
    <variable cmeta:id="N_HVA_calcium_current_h_gate.sigma_h" initial_value="3" name="sigma_h" units="millivolt" />
    <variable cmeta:id="N_HVA_calcium_current_h_gate.tau_h" initial_value="25" name="tau_h" units="millisecond" />
    <variable cmeta:id="N_HVA_calcium_current_h_gate.h_infinity" name="h_infinity" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>h_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <plus />
                  <ci>V</ci>
                  <ci>theta_h</ci>
                </apply>
                <ci>sigma_h</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>h</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>h_infinity</ci>
            <ci>h</ci>
          </apply>
          <ci>tau_h</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="P_HVA_calcium_current">
    <variable cmeta:id="P_HVA_calcium_current_i_P" name="i_P" public_interface="out" units="nanoA" />
    <variable cmeta:id="P_HVA_calcium_current.g_P" initial_value="0.05" name="g_P" units="uS" />
    <variable cmeta:id="P_HVA_calcium_current.E_Ca" name="E_Ca" public_interface="in" units="millivolt" />
    <variable cmeta:id="P_HVA_calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="P_HVA_calcium_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <variable cmeta:id="P_HVA_calcium_current.m" name="m" private_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_P</ci>
        <apply>
          <times />
          <ci>g_P</ci>
          <ci>m</ci>
          <apply>
            <minus />
            <ci>V</ci>
            <ci>E_Ca</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="P_HVA_calcium_current_m_gate">
    <variable cmeta:id="P_HVA_calcium_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="P_HVA_calcium_current_m_gate.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="P_HVA_calcium_current_m_gate.m" initial_value="0" name="m" public_interface="out" units="dimensionless" />
    <variable cmeta:id="P_HVA_calcium_current_m_gate.theta_m" initial_value="17" name="theta_m" units="millivolt" />
    <variable cmeta:id="P_HVA_calcium_current_m_gate.sigma_m" initial_value="3" name="sigma_m" units="millivolt" />
    <variable cmeta:id="P_HVA_calcium_current_m_gate.tau_m" initial_value="10" name="tau_m" units="millisecond" />
    <variable cmeta:id="P_HVA_calcium_current_m_gate.m_infinity" name="m_infinity" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>m_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <apply>
                    <plus />
                    <ci>V</ci>
                    <ci>theta_m</ci>
                  </apply>
                </apply>
                <ci>sigma_m</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>m</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>m_infinity</ci>
            <ci>m</ci>
          </apply>
          <ci>tau_m</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="calcium_dependent_potassium_current">
    <variable cmeta:id="calcium_dependent_potassium_current_i_SK" name="i_SK" public_interface="out" units="nanoA" />
    <variable cmeta:id="calcium_dependent_potassium_current.g_SK" initial_value="0.3" name="g_SK" units="uS" />
    <variable cmeta:id="calcium_dependent_potassium_current.E_K" name="E_K" public_interface="in" units="millivolt" />
    <variable cmeta:id="calcium_dependent_potassium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="calcium_dependent_potassium_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <variable cmeta:id="calcium_dependent_potassium_current.i_T" name="i_T" public_interface="in" private_interface="out" units="nanoA" />
    <variable cmeta:id="calcium_dependent_potassium_current.i_N" name="i_N" public_interface="in" private_interface="out" units="nanoA" />
    <variable cmeta:id="calcium_dependent_potassium_current.i_P" name="i_P" public_interface="in" private_interface="out" units="nanoA" />
    <variable cmeta:id="calcium_dependent_potassium_current.z" name="z" private_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_SK</ci>
        <apply>
          <times />
          <ci>g_SK</ci>
          <apply>
            <power />
            <ci>z</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
          </apply>
          <apply>
            <minus />
            <ci>V</ci>
            <ci>E_K</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="calcium_dependent_potassium_current_z_gate">
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.i_T" name="i_T" public_interface="in" units="nanoA" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.i_N" name="i_N" public_interface="in" units="nanoA" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.i_P" name="i_P" public_interface="in" units="nanoA" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.z" initial_value="0" name="z" public_interface="out" units="dimensionless" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.K1" initial_value="-500" name="K1" units="uM_per_nanocoulomb" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.K2" initial_value="0.04" name="K2" units="per_ms" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.Ca_conc" initial_value="0.0604" name="Ca_conc" units="uM" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.tau_z" initial_value="1" name="tau_z" units="millisecond" />
    <variable cmeta:id="calcium_dependent_potassium_current_z_gate.z_infinity" name="z_infinity" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>Ca_conc</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <times />
            <apply>
              <divide />
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1000</cn>
            </apply>
            <ci>K1</ci>
            <apply>
              <plus />
              <ci>i_T</ci>
              <ci>i_N</ci>
              <ci>i_P</ci>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>K2</ci>
            <ci>Ca_conc</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>z_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <power />
              <apply>
                <divide />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uM">0.003</cn>
                <ci>Ca_conc</ci>
              </apply>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>z</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>z_infinity</ci>
            <ci>z</ci>
          </apply>
          <ci>tau_z</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="fast_transient_potassium_current">
    <variable cmeta:id="fast_transient_potassium_current_i_A" name="i_A" public_interface="out" units="nanoA" />
    <variable cmeta:id="fast_transient_potassium_current.g_A" initial_value="1" name="g_A" units="uS" />
    <variable cmeta:id="fast_transient_potassium_current.E_K" name="E_K" public_interface="in" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <variable cmeta:id="fast_transient_potassium_current.m" name="m" private_interface="in" units="dimensionless" />
    <variable cmeta:id="fast_transient_potassium_current.h" name="h" private_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_A</ci>
        <apply>
          <times />
          <ci>g_A</ci>
          <ci>m</ci>
          <ci>h</ci>
          <apply>
            <minus />
            <ci>V</ci>
            <ci>E_K</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="fast_transient_potassium_current_m_gate">
    <variable cmeta:id="fast_transient_potassium_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.m" initial_value="0.057" name="m" public_interface="out" units="dimensionless" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.theta_m" initial_value="27" name="theta_m" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.sigma_m" initial_value="16" name="sigma_m" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.theta_1" initial_value="40" name="theta_1" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.theta_2" initial_value="74" name="theta_2" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.sigma_1" initial_value="5" name="sigma_1" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.sigma_2" initial_value="7.5" name="sigma_2" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.tau_m" name="tau_m" units="millisecond" />
    <variable cmeta:id="fast_transient_potassium_current_m_gate.m_infinity" name="m_infinity" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>tau_m</ci>
        <apply>
          <plus />
          <apply>
            <divide />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
            <apply>
              <plus />
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <plus />
                    <ci>V</ci>
                    <ci>theta_1</ci>
                  </apply>
                  <ci>sigma_1</ci>
                </apply>
              </apply>
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <minus />
                    <apply>
                      <plus />
                      <ci>V</ci>
                      <ci>theta_2</ci>
                    </apply>
                  </apply>
                  <ci>sigma_2</ci>
                </apply>
              </apply>
            </apply>
          </apply>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.37</cn>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>m_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <apply>
                    <plus />
                    <ci>V</ci>
                    <ci>theta_m</ci>
                  </apply>
                </apply>
                <ci>sigma_m</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>m</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>m_infinity</ci>
            <ci>m</ci>
          </apply>
          <ci>tau_m</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="fast_transient_potassium_current_h_gate">
    <variable cmeta:id="fast_transient_potassium_current_h_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_h_gate.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="fast_transient_potassium_current_h_gate.h" initial_value="0.287" name="h" public_interface="out" units="dimensionless" />
    <variable cmeta:id="fast_transient_potassium_current_h_gate.theta_h" initial_value="80" name="theta_h" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_h_gate.sigma_h" initial_value="11" name="sigma_h" units="millivolt" />
    <variable cmeta:id="fast_transient_potassium_current_h_gate.tau_h" initial_value="20" name="tau_h" units="millisecond" />
    <variable cmeta:id="fast_transient_potassium_current_h_gate.h_infinity" name="h_infinity" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>h_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <plus />
                  <ci>V</ci>
                  <ci>theta_h</ci>
                </apply>
                <ci>sigma_h</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>h</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>h_infinity</ci>
            <ci>h</ci>
          </apply>
          <ci>tau_h</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="hyperpolarization_activated_current">
    <variable cmeta:id="hyperpolarization_activated_current_i_H" name="i_H" public_interface="out" units="nanoA" />
    <variable cmeta:id="hyperpolarization_activated_current.g_H" initial_value="0.005" name="g_H" units="uS" />
    <variable cmeta:id="hyperpolarization_activated_current.E_H" initial_value="-38.8" name="E_H" units="millivolt" />
    <variable cmeta:id="hyperpolarization_activated_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="hyperpolarization_activated_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <variable cmeta:id="hyperpolarization_activated_current.m" name="m" private_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_H</ci>
        <apply>
          <times />
          <ci>g_H</ci>
          <ci>m</ci>
          <apply>
            <minus />
            <ci>V</ci>
            <ci>E_H</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="hyperpolarization_activated_current_m_gate">
    <variable cmeta:id="hyperpolarization_activated_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="hyperpolarization_activated_current_m_gate.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="hyperpolarization_activated_current_m_gate.m" initial_value="0.182" name="m" public_interface="out" units="dimensionless" />
    <variable cmeta:id="hyperpolarization_activated_current_m_gate.theta_m" initial_value="79.8" name="theta_m" units="millivolt" />
    <variable cmeta:id="hyperpolarization_activated_current_m_gate.sigma_m" initial_value="5.3" name="sigma_m" units="millivolt" />
    <variable cmeta:id="hyperpolarization_activated_current_m_gate.theta_1" initial_value="70" name="theta_1" units="millivolt" />
    <variable cmeta:id="hyperpolarization_activated_current_m_gate.sigma_1" initial_value="11" name="sigma_1" units="millivolt" />
    <variable cmeta:id="hyperpolarization_activated_current_m_gate.tau_m" name="tau_m" units="millisecond" />
    <variable cmeta:id="hyperpolarization_activated_current_m_gate.m_infinity" name="m_infinity" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>tau_m</ci>
        <apply>
          <plus />
          <apply>
            <divide />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
            <apply>
              <plus />
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <plus />
                    <ci>V</ci>
                    <ci>theta_1</ci>
                  </apply>
                  <ci>sigma_1</ci>
                </apply>
              </apply>
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <minus />
                    <apply>
                      <plus />
                      <ci>V</ci>
                      <ci>theta_1</ci>
                    </apply>
                  </apply>
                  <ci>sigma_1</ci>
                </apply>
              </apply>
            </apply>
          </apply>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">50</cn>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>m_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <plus />
                  <ci>V</ci>
                  <ci>theta_m</ci>
                </apply>
                <ci>sigma_m</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>m</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>m_infinity</ci>
            <ci>m</ci>
          </apply>
          <ci>tau_m</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="stimulus_protocol">
    <variable cmeta:id="stimulus_protocol.i_app" name="i_app" public_interface="out" units="nanoA" />
    <variable cmeta:id="stimulus_protocol.i_stimStart" initial_value="10" name="i_stimStart" units="millisecond" />
    <variable cmeta:id="stimulus_protocol.i_stimEnd" initial_value="11" name="i_stimEnd" units="millisecond" />
    <variable cmeta:id="stimulus_protocol.i_stimAmplitude" initial_value="10" name="i_stimAmplitude" units="nanoA" />
    <variable cmeta:id="stimulus_protocol.time" name="time" public_interface="in" units="millisecond" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_app</ci>
        <piecewise>
          <piece>
            <ci>i_stimAmplitude</ci>
            <apply>
              <and />
              <apply>
                <geq />
                <ci>time</ci>
                <ci>i_stimStart</ci>
              </apply>
              <apply>
                <leq />
                <ci>time</ci>
                <ci>i_stimEnd</ci>
              </apply>
            </apply>
          </piece>
          <otherwise>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoA">0</cn>
          </otherwise>
        </piecewise>
      </apply>
    </math>
  </component>
  <group>
    <relationship_ref relationship="encapsulation" />
    <component_ref component="LVA_calcium_current">
      <component_ref component="LVA_calcium_current_m_gate" />
      <component_ref component="LVA_calcium_current_h_gate" />
    </component_ref>
    <component_ref component="P_HVA_calcium_current">
      <component_ref component="P_HVA_calcium_current_m_gate" />
    </component_ref>
    <component_ref component="delayed_rectifier_current">
      <component_ref component="delayed_rectifier_current_n_gate" />
    </component_ref>
    <component_ref component="hyperpolarization_activated_current">
      <component_ref component="hyperpolarization_activated_current_m_gate" />
    </component_ref>
    <component_ref component="calcium_dependent_potassium_current">
      <component_ref component="calcium_dependent_potassium_current_z_gate" />
    </component_ref>
    <component_ref component="sodium_current">
      <component_ref component="sodium_current_m_gate" />
      <component_ref component="sodium_current_h_gate" />
    </component_ref>
    <component_ref component="persistent_sodium_current">
      <component_ref component="persistent_sodium_current_m_gate" />
      <component_ref component="persistent_sodium_current_h_gate" />
    </component_ref>
    <component_ref component="fast_transient_potassium_current">
      <component_ref component="fast_transient_potassium_current_h_gate" />
      <component_ref component="fast_transient_potassium_current_m_gate" />
    </component_ref>
    <component_ref component="N_HVA_calcium_current">
      <component_ref component="N_HVA_calcium_current_m_gate" />
      <component_ref component="N_HVA_calcium_current_h_gate" />
    </component_ref>
  </group>
  <connection>
    <map_components component_1="leak_current" component_2="membrane" />
    <map_variables variable_1="i_leak" variable_2="i_leak" />
  </connection>
  <connection>
    <map_components component_1="LVA_calcium_current" component_2="calcium_dependent_potassium_current" />
    <map_variables variable_1="i_T" variable_2="i_T" />
  </connection>
  <connection>
    <map_components component_1="LVA_calcium_current_m_gate" component_2="LVA_calcium_current" />
    <map_variables variable_1="m" variable_2="m" />
  </connection>
  <connection>
    <map_components component_1="sodium_current" component_2="persistent_sodium_current" />
    <map_variables variable_1="E_Na" variable_2="E_Na" />
  </connection>
  <connection>
    <map_components component_1="fast_transient_potassium_current_m_gate" component_2="fast_transient_potassium_current" />
    <map_variables variable_1="m" variable_2="m" />
  </connection>
  <connection>
    <map_components component_1="delayed_rectifier_current" component_2="membrane" />
    <map_variables variable_1="i_K" variable_2="i_K" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="hyperpolarization_activated_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="sodium_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="delayed_rectifier_current" component_2="fast_transient_potassium_current" />
    <map_variables variable_1="E_K" variable_2="E_K" />
  </connection>
  <connection>
    <map_components component_1="fast_transient_potassium_current" component_2="fast_transient_potassium_current_m_gate" />
    <map_variables variable_1="V" variable_2="V" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="delayed_rectifier_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="N_HVA_calcium_current_h_gate" component_2="N_HVA_calcium_current" />
    <map_variables variable_1="h" variable_2="h" />
  </connection>
  <connection>
    <map_components component_1="LVA_calcium_current" component_2="N_HVA_calcium_current" />
    <map_variables variable_1="E_Ca" variable_2="E_Ca" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="delayed_rectifier_current" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="persistent_sodium_current" component_2="persistent_sodium_current_h_gate" />
    <map_variables variable_1="time" variable_2="time" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="sodium_current" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="fast_transient_potassium_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="stimulus_protocol" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="persistent_sodium_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="P_HVA_calcium_current_m_gate" component_2="P_HVA_calcium_current" />
    <map_variables variable_1="m" variable_2="m" />
  </connection>
  <connection>
    <map_components component_1="persistent_sodium_current" component_2="persistent_sodium_current_m_gate" />
    <map_variables variable_1="time" variable_2="time" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="calcium_dependent_potassium_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="N_HVA_calcium_current" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="delayed_rectifier_current" component_2="delayed_rectifier_current_n_gate" />
    <map_variables variable_1="V" variable_2="V" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="delayed_rectifier_current_n_gate" component_2="delayed_rectifier_current" />
    <map_variables variable_1="n" variable_2="n" />
  </connection>
  <connection>
    <map_components component_1="persistent_sodium_current" component_2="membrane" />
    <map_variables variable_1="i_NaP" variable_2="i_NaP" />
  </connection>
  <connection>
    <map_components component_1="hyperpolarization_activated_current" component_2="membrane" />
    <map_variables variable_1="i_H" variable_2="i_H" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="fast_transient_potassium_current" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="N_HVA_calcium_current" component_2="membrane" />
    <map_variables variable_1="i_N" variable_2="i_N" />
  </connection>
  <connection>
    <map_components component_1="P_HVA_calcium_current" component_2="calcium_dependent_potassium_current" />
    <map_variables variable_1="i_P" variable_2="i_P" />
  </connection>
  <connection>
    <map_components component_1="calcium_dependent_potassium_current" component_2="calcium_dependent_potassium_current_z_gate" />
    <map_variables variable_1="i_P" variable_2="i_P" />
    <map_variables variable_1="i_N" variable_2="i_N" />
    <map_variables variable_1="time" variable_2="time" />
    <map_variables variable_1="i_T" variable_2="i_T" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="LVA_calcium_current" component_2="P_HVA_calcium_current" />
    <map_variables variable_1="E_Ca" variable_2="E_Ca" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="leak_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="hyperpolarization_activated_current_m_gate" component_2="hyperpolarization_activated_current" />
    <map_variables variable_1="m" variable_2="m" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="N_HVA_calcium_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="N_HVA_calcium_current_m_gate" component_2="N_HVA_calcium_current" />
    <map_variables variable_1="m" variable_2="m" />
  </connection>
  <connection>
    <map_components component_1="P_HVA_calcium_current" component_2="P_HVA_calcium_current_m_gate" />
    <map_variables variable_1="time" variable_2="time" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
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  <connection>
    <map_components component_1="membrane" component_2="LVA_calcium_current" />
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  <connection>
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    <map_variables variable_1="time" variable_2="time" />
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  <connection>
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    <map_components component_1="P_HVA_calcium_current" component_2="membrane" />
    <map_variables variable_1="i_P" variable_2="i_P" />
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  <connection>
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  </connection>
  <connection>
    <map_components component_1="persistent_sodium_current_m_gate" component_2="persistent_sodium_current" />
    <map_variables variable_1="m" variable_2="m" />
  </connection>
  <connection>
    <map_components component_1="stimulus_protocol" component_2="membrane" />
    <map_variables variable_1="i_app" variable_2="i_app" />
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  <connection>
    <map_components component_1="sodium_current" component_2="sodium_current_h_gate" />
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    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="calcium_dependent_potassium_current" component_2="membrane" />
    <map_variables variable_1="i_SK" variable_2="i_SK" />
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  <connection>
    <map_components component_1="sodium_current_m_gate" component_2="sodium_current" />
    <map_variables variable_1="m" variable_2="m" />
  </connection>
  <connection>
    <map_components component_1="delayed_rectifier_current" component_2="calcium_dependent_potassium_current" />
    <map_variables variable_1="E_K" variable_2="E_K" />
  </connection>
  <connection>
    <map_components component_1="N_HVA_calcium_current" component_2="calcium_dependent_potassium_current" />
    <map_variables variable_1="i_N" variable_2="i_N" />
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  <connection>
    <map_components component_1="environment" component_2="calcium_dependent_potassium_current" />
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  <connection>
    <map_components component_1="environment" component_2="membrane" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="sodium_current" component_2="membrane" />
    <map_variables variable_1="i_Na" variable_2="i_Na" />
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  <connection>
    <map_components component_1="LVA_calcium_current_h_gate" component_2="LVA_calcium_current" />
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  <connection>
    <map_components component_1="membrane" component_2="P_HVA_calcium_current" />
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  <connection>
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    <map_variables variable_1="h" variable_2="h" />
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  <connection>
    <map_components component_1="environment" component_2="persistent_sodium_current" />
    <map_variables variable_1="time" variable_2="time" />
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  <connection>
    <map_components component_1="N_HVA_calcium_current" component_2="N_HVA_calcium_current_m_gate" />
    <map_variables variable_1="V" variable_2="V" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="persistent_sodium_current_h_gate" component_2="persistent_sodium_current" />
    <map_variables variable_1="h" variable_2="h" />
  </connection>
  <connection>
    <map_components component_1="LVA_calcium_current" component_2="membrane" />
    <map_variables variable_1="i_T" variable_2="i_T" />
  </connection>
  <connection>
    <map_components component_1="fast_transient_potassium_current" component_2="membrane" />
    <map_variables variable_1="i_A" variable_2="i_A" />
  </connection>
  <connection>
    <map_components component_1="sodium_current" component_2="sodium_current_m_gate" />
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    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="LVA_calcium_current" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="leak_current" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="P_HVA_calcium_current" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="hyperpolarization_activated_current" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="LVA_calcium_current" component_2="LVA_calcium_current_h_gate" />
    <map_variables variable_1="V" variable_2="V" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="calcium_dependent_potassium_current_z_gate" component_2="calcium_dependent_potassium_current" />
    <map_variables variable_1="z" variable_2="z" />
  </connection>
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    <rdf:Description rdf:about="#LVA_calcium_current_m_gate.sigma_1">
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      <dcterms:description>membrane potential</dcterms:description>
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      <dcterms:description>T-type calcium current conductance</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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      <dcterms:description>N-type calcium current activation variable</dcterms:description>
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      <dcterms:description>sodium reversal potential</dcterms:description>
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      <dcterms:description>fast transient potassium current</dcterms:description>
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      <dcterms:description>steady state function of fast transient potassium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of persistent sodium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_h_gate.h">
      <dcterms:description>T-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current_m_gate.theta_m">
      <dcterms:description>saturation potential of hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#delayed_rectifier_current_n_gate.theta_1">
      <dcterms:description>saturation potential of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current.g_N">
      <dcterms:description>N-type calcium current conductance</dcterms:description>
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      <dcterms:description>half-maximal potential of N-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_h_gate.h_infinity">
      <dcterms:description>steady state function of T-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.tau_m">
      <dcterms:description>activation time constant of hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_h_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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    <rdf:Description rdf:about="#persistent_sodium_current_h_gate.V">
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      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_h_gate.sigma_h">
      <dcterms:description>half-maximal potential of sodium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_m_gate.tau_m">
      <dcterms:description>time constant of sodium current activation gate</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.i_H">
      <dcterms:description>hyperpolarisation-activated current</dcterms:description>
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    <rdf:Description rdf:about="#sodium_current_h_gate.sigma_1">
      <dcterms:description>half-maximal potential of sodium current inactivation gate</dcterms:description>
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    <rdf:Description rdf:about="#N_HVA_calcium_current_h_gate.time">
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    <rdf:Description rdf:about="#LVA_calcium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of T-type calcium current activation gate</dcterms:description>
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    <rdf:Description rdf:about="#calcium_dependent_potassium_current_z_gate.i_T">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_57">
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      <dcterms:description>T-type calcium current</dcterms:description>
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    <rdf:Description rdf:about="#LVA_calcium_current_h_gate.time">
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    <rdf:Description rdf:about="#calcium_dependent_potassium_current.z">
      <dcterms:description>calcium-dependent potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current_z_gate.K2">
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      <dcterms:description>calcium decay rate constant</dcterms:description>
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      <dcterms:description>saturation potential of fast transient potassium current activation gate</dcterms:description>
    </rdf:Description>
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      <dcterms:description>persistent sodium current</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.C">
      <dcterms:description>whole cell capacitance</dcterms:description>
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      <dcterms:description>T-type calcium current activation variable</dcterms:description>
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      <dcterms:description>steady state function of sodium current inactivation variable</dcterms:description>
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      <dcterms:description>half-maximal potential of T-type calcium current activation gate</dcterms:description>
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      <dcterms:description>half-maximal potential of sodium current inactivation gate</dcterms:description>
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      <semsim:isComputationalComponentFor>
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      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
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    <rdf:Description rdf:about="#calcium_dependent_potassium_current_z_gate.K1">
      <dcterms:description>accumulation scaling factor</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.i_T">
      <dcterms:description>T-type calcium current</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_h_gate.time">
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      <dcterms:description>saturation potential of fast transient potassium current activation gate</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of P-type calcium current</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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      <dcterms:description>fast transient potassium current inactivation variable</dcterms:description>
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      <dcterms:description>time constant of sodium current inactivation gate</dcterms:description>
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    <rdf:Description rdf:about="#calcium_dependent_potassium_current_z_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current.E_Na">
      <semsim:isComputationalComponentFor>
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      </semsim:isComputationalComponentFor>
      <dcterms:description>sodium reversal potential</dcterms:description>
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    <rdf:Description rdf:about="#environment_time">
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_h_gate.theta_1">
      <dcterms:description>saturation potential of sodium current inactivation gate</dcterms:description>
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      <dcterms:description>saturation potential of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#stimulus_protocol.i_stimAmplitude">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_h_gate.theta_h">
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      <semsim:modelName>purvis_butera_2005</semsim:modelName>
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    <rdf:Description rdf:about="#persistent_sodium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#delayed_rectifier_current_n_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_27">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current.E_K">
      <dcterms:description>potassium reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_h_gate.theta_h">
      <dcterms:description>saturation potential of sodium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_h_gate.theta_h">
      <dcterms:description>saturation potential of fast transient potassium current inactivation gate</dcterms:description>
    </rdf:Description>
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      <dcterms:description>half-maximal potential of N-type calcium current activation gate</dcterms:description>
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      <dcterms:description>time constant of sodium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current.h">
      <dcterms:description>persistent sodium current inactivation variable</dcterms:description>
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      <dcterms:description>half-maximal potential of fast transient potassium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of N-type calcium current activation gate</dcterms:description>
    </rdf:Description>
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      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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    <rdf:Description rdf:about="#sodium_current_h_gate.V">
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        <rdf:Description rdf:about="#property_15">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_m_gate.m">
      <dcterms:description>persistent sodium current activation variable</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_h_gate.tau_h">
      <dcterms:description>time constant of T-type calcium current inactivation gate</dcterms:description>
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    <rdf:Description rdf:about="#N_HVA_calcium_current_h_gate.V">
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        <rdf:Description rdf:about="#property_43">
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      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current_i_H">
      <dcterms:description>hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.sigma_n">
      <dcterms:description>half-maximal activation potential of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#leak_current.E_leak">
      <dcterms:description>leakage reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#delayed_rectifier_current_n_gate.tau_n">
      <dcterms:description>activation time constant of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current.m">
      <dcterms:description>T-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.sigma_1">
      <dcterms:description>half-maximal potential of fast transient potassium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.K2">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
      <dcterms:description>calcium decay rate constant</dcterms:description>
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    <rdf:Description rdf:about="#calcium_dependent_potassium_current_z_gate.i_P">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_59">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.n_infinity">
      <dcterms:description>steady state function of delayed rectifier potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current_m_gate.tau_m">
      <dcterms:description>activation time constant of hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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    <rdf:Description rdf:about="#N_HVA_calcium_current.g_N">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_39">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>N-type calcium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.i_K">
      <dcterms:description>delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current_i_P">
      <dcterms:description>P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#leak_current.E_leak">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_30">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>leakage reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current_m_gate.sigma_1">
      <dcterms:description>half-maximal activation potential of hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.sigma_m">
      <dcterms:description>half-maximal activation potential of hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#stimulus_protocol.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_m_gate.theta_1">
      <dcterms:description>saturation potential of T-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_70">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_m_gate.tau_m">
      <dcterms:description>time constant of T-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.K1">
      <dcterms:description>accumulation scaling factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.m_infinity">
      <dcterms:description>steady state function of hyperpolarisation-activated current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current_z_gate.i_N">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_58">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>N-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#stimulus_protocol.i_stimEnd">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.m">
      <dcterms:description>hyperpolarisation-activated current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current_h_gate.tau_h">
      <dcterms:description>time constant of N-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_47">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of T-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_m_gate.sigma_2">
      <dcterms:description>half-maximal potential of T-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_m_gate.sigma_m">
      <dcterms:description>half-maximal potential of sodium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_h_gate.sigma_h">
      <dcterms:description>half-maximal potential of fast transient potassium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of fast transient potassium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current.i_P">
      <dcterms:description>P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_m_gate.m">
      <dcterms:description>fast transient potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#delayed_rectifier_current.n">
      <dcterms:description>delayed rectifier potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_h_gate.h_infinity">
      <dcterms:description>steady state function of persistent sodium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.h">
      <dcterms:description>N-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of N-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_m_gate.sigma_2">
      <dcterms:description>half-maximal potential of fast transient potassium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of T-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_m_gate.sigma_1">
      <dcterms:description>half-maximal potential of T-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current_m_gate.tau_m">
      <dcterms:description>time constant of N-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_h_gate.sigma_1">
      <dcterms:description>half-maximal potential of T-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current_m_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_71">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.i_NaP">
      <dcterms:description>persistent sodium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current.g_P">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_45">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>P-type calcium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current.g_H">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_68">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>hyperpolarisation-activated current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current.m">
      <dcterms:description>P-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_m_gate.theta_1">
      <dcterms:description>saturation potential of T-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.i_P">
      <dcterms:description>P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_h_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_h_gate.theta_1">
      <dcterms:description>saturation potential of T-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of sodium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_H">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_10">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>hyperpolarisation-activated current</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_h_gate.h">
      <dcterms:description>persistent sodium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_m_gate.sigma_1">
      <dcterms:description>half-maximal potential of fast transient potassium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current.i_T">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_53">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_h_gate.h_infinity">
      <dcterms:description>steady state function of sodium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_i_SK">
      <dcterms:description>calcium-dependent potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current.i_N">
      <dcterms:description>N-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_h_gate.theta_h">
      <dcterms:description>saturation potential of sodium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current_i_K">
      <dcterms:description>delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_leak">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_4">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>leak current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current.m">
      <dcterms:description>sodium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.i_leak">
      <dcterms:description>leak current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current_h_gate.theta_h">
      <dcterms:description>saturation potential of N-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.i_N">
      <dcterms:description>N-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_h_gate.tau_h">
      <dcterms:description>time constant of fast transient potassium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_m_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#stimulus_protocol.i_stimStart">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current.i_N">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_54">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>N-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current_i_SK">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_49">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium-dependent potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane_V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_m_gate.m">
      <dcterms:description>persistent sodium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of P-type calcium current activation variable</dcterms:description>
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      <dcterms:description>sodium reversal potential</dcterms:description>
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      <dcterms:description>sodium current inactivation variable</dcterms:description>
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      <dcterms:description>saturation potential of hyperpolarisation-activated current</dcterms:description>
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      <dcterms:description>sodium current</dcterms:description>
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      <dcterms:description>P-type calcium current activation variable</dcterms:description>
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      <dcterms:description>hyperpolarisation-activated current</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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      <dcterms:description>delayed rectifier potassium current activation variable</dcterms:description>
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      <dcterms:description>P-type calcium current activation variable</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_m_gate.time">
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      <dcterms:description>T-type calcium current inactivation variable</dcterms:description>
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      <dcterms:description>T-type calcium current</dcterms:description>
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      <dcterms:description>half-maximal potential of sodium current inactivation gate</dcterms:description>
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      <dcterms:description>time constant of N-type calcium current inactivation gate</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of persistent sodium current activation variable</dcterms:description>
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      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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      <dcterms:description>steady state function of hyperpolarisation-activated current activation variable</dcterms:description>
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      <dcterms:description>persistent sodium current activation variable</dcterms:description>
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      <dcterms:description>potassium reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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    <rdf:Description rdf:about="#P_HVA_calcium_current.E_Ca">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_46">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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      <dcterms:description>calcium reversal potential</dcterms:description>
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      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_55">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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      <dcterms:description>P-type calcium current</dcterms:description>
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        <rdf:Description rdf:about="#property_69">
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      <dcterms:description>hyperpolarisation-activated current reversal potential</dcterms:description>
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      <dcterms:description>saturation potential of sodium current inactivation gate</dcterms:description>
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      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
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      <dcterms:description>half-maximal potential of sodium current activation gate</dcterms:description>
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      <dcterms:description>steady state function of sodium current activation variable</dcterms:description>
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    <rdf:Description rdf:about="#persistent_sodium_current.E_Na">
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        <rdf:Description rdf:about="#property_19">
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      </semsim:isComputationalComponentFor>
      <dcterms:description>sodium reversal potential</dcterms:description>
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      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_K">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_3">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>delayed rectifier potassium current</dcterms:description>
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    <rdf:Description rdf:about="#delayed_rectifier_current_i_K">
      <semsim:isComputationalComponentFor>
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      <dcterms:description>delayed rectifier potassium current</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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      <dcterms:description>time constant of fast transient potassium current inactivation gate</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_h_gate.h_infinity">
      <dcterms:description>steady state function of fast transient potassium current inactivation variable</dcterms:description>
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      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_66">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
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    <rdf:Description rdf:about="#N_HVA_calcium_current.E_Ca">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_40">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium reversal potential</dcterms:description>
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    <rdf:Description rdf:about="#leak_current.g_leak">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_29">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
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      <dcterms:description>leak current conductance</dcterms:description>
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    <rdf:Description rdf:about="#fast_transient_potassium_current.g_A">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_62">
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      <dcterms:description>fast transient potassium current conductance</dcterms:description>
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    <rdf:Description rdf:about="#delayed_rectifier_current.E_K">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_25">
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      <dcterms:description>potassium reversal potential</dcterms:description>
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      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_h_gate.tau_h">
      <dcterms:description>time constant of sodium current inactivation gate</dcterms:description>
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    <rdf:Description rdf:about="#stimulus_protocol.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of sodium current activation gate</dcterms:description>
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    <rdf:Description rdf:about="#delayed_rectifier_current_n_gate.n_infinity">
      <dcterms:description>steady state function of delayed rectifier potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current.g_P">
      <dcterms:description>P-type calcium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_h_gate.h">
      <dcterms:description>T-type calcium current inactivation variable</dcterms:description>
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    <rdf:Description rdf:about="#delayed_rectifier_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current.m">
      <dcterms:description>T-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.h_infinity">
      <dcterms:description>steady state function of N-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_m_gate.sigma_m">
      <dcterms:description>half-maximal potential of fast transient potassium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_h_gate.sigma_h">
      <dcterms:description>half-maximal potential of sodium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_h_gate.theta_h">
      <dcterms:description>saturation potential of fast transient potassium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#leak_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current_m_gate.m">
      <dcterms:description>hyperpolarisation-activated current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_h_gate.sigma_1">
      <dcterms:description>half-maximal potential of T-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#delayed_rectifier_current.g_K">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_24">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>delayed rectifier potassium current conductance</dcterms:description>
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    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.m">
      <dcterms:description>P-type calcium current activation variable</dcterms:description>
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      <dcterms:description>leak current</dcterms:description>
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      <dcterms:description>saturation potential of delayed rectifier potassium current</dcterms:description>
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      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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    <rdf:Description rdf:about="#delayed_rectifier_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_26">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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      <dcterms:description>membrane potential</dcterms:description>
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      <dcterms:description>delayed rectifier potassium current activation variable</dcterms:description>
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    <rdf:Description rdf:about="#leak_current_i_leak">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_28">
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      <dcterms:description>fast transient potassium current inactivation variable</dcterms:description>
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      <dcterms:description>steady state function of calcium-dependent potassium current activation variable</dcterms:description>
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      <semsim:isComputationalComponentFor>
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          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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      <dcterms:description>N-type calcium current</dcterms:description>
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    <rdf:Description rdf:about="#sodium_current.g_Na">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_12">
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      <dcterms:description>sodium current conductance</dcterms:description>
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    <rdf:Description rdf:about="#membrane.i_P">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_7">
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      <dcterms:description>P-type calcium current</dcterms:description>
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      <dcterms:description>membrane potential</dcterms:description>
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          <semsim:physicalPropertyOf>
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              <ro:part_of>
                <rdf:Description rdf:about="#entity_1">
                  <ro:part_of>
                    <rdf:Description rdf:about="#entity_2">
                      <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:50871" />
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                  </ro:part_of>
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              </ro:part_of>
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          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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      <dcterms:description>sodium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.i_Na">
      <dcterms:description>sodium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.C">
      <dcterms:description>whole cell capacitance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current.E_Ca">
      <dcterms:description>calcium reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_m_gate.m">
      <dcterms:description>T-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_i_T">
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.m">
      <dcterms:description>fast transient potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_h_gate.theta_h">
      <dcterms:description>saturation potential of T-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_m_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_16">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current.g_A">
      <dcterms:description>fast transient potassium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_h_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_37">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current.g_NaP">
      <dcterms:description>persistent sodium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_h_gate.theta_1">
      <dcterms:description>saturation potential of T-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_m_gate.sigma_m">
      <dcterms:description>half-maximal potential of T-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current.E_K">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_63">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>potassium reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_N">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_6">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>N-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.i_SK">
      <dcterms:description>calcium-dependent potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current.m">
      <dcterms:description>sodium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_20">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_h_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current.i_T">
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_m_gate.sigma_m">
      <dcterms:description>half-maximal potential of sodium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.theta_1">
      <dcterms:description>saturation potential of hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current.m">
      <dcterms:description>fast transient potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#butera_purvis_2004" bqmodel:isDescribedBy="15653786" />
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of T-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of P-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_41">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_T">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_5">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_i_T">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_32">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_h_gate.h">
      <dcterms:description>persistent sodium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.theta_h">
      <dcterms:description>saturation potential of N-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.z">
      <dcterms:description>calcium-dependent potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_h_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_h_gate.tau_h">
      <dcterms:description>time constant of T-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current_h_gate.h_infinity">
      <dcterms:description>steady state function of N-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.n">
      <dcterms:description>delayed rectifier potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#stimulus_protocol.i_app">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318" />
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_m_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_22">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current_m_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_42">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_m_gate.tau_m">
      <dcterms:description>time constant of T-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_m_gate.m">
      <dcterms:description>sodium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_i_A">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_61">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>fast transient potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_i_N">
      <dcterms:description>N-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current.h">
      <dcterms:description>T-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.z_infinity">
      <dcterms:description>steady state function of calcium-dependent potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current_h_gate.h">
      <dcterms:description>N-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current.m">
      <dcterms:description>persistent sodium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current_z_gate.tau_z">
      <dcterms:description>activation time constant of calcium-dependent potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current.E_H">
      <dcterms:description>hyperpolarisation-activated current reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of fast transient potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current.g_SK">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_50">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium-dependent potassium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_h_gate.theta_h">
      <dcterms:description>saturation potential of sodium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_h_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.sigma_m">
      <dcterms:description>half-maximal activation potential of P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current_m_gate.tau_m">
      <dcterms:description>activation time constant of P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.sigma_1">
      <dcterms:description>half-maximal activation potential of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current.g_H">
      <dcterms:description>hyperpolarisation-activated current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#leak_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_SK">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_8">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium-dependent potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current.h">
      <dcterms:description>sodium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_m_gate.m">
      <dcterms:description>sodium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current_m_gate.sigma_m">
      <dcterms:description>half-maximal activation potential of hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_35">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#leak_current.g_leak">
      <dcterms:description>leak current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of sodium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current.E_K">
      <dcterms:description>potassium reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.tau_z">
      <dcterms:description>activation time constant of calcium-dependent potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current_m_gate.m_infinity">
      <dcterms:description>steady state function of N-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_h_gate.sigma_h">
      <dcterms:description>half-maximal potential of sodium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#delayed_rectifier_current_n_gate.sigma_2">
      <dcterms:description>half-maximal activation potential of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current.E_Ca">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_34">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_Na">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_1">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>sodium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_h_gate.tau_h">
      <dcterms:description>time constant of sodium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current.h">
      <dcterms:description>fast transient potassium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.Ca_conc">
      <bqbiol:isPropertyOf>
        <rdf:Description rdf:about="purvis_butera_2005.cellml#entity_0">
          <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
        </rdf:Description>
      </bqbiol:isPropertyOf>
      <dcterms:description>concentration of intracellular calcium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current_i_P">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_44">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_m_gate.sigma_m">
      <dcterms:description>half-maximal potential of T-type calcium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_i_A">
      <dcterms:description>fast transient potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current.z">
      <dcterms:description>calcium-dependent potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#stimulus_protocol.i_stimAmplitude">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_m_gate.m">
      <dcterms:description>N-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_h_gate.h">
      <dcterms:description>sodium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#delayed_rectifier_current_n_gate.sigma_1">
      <dcterms:description>half-maximal activation potential of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current.h">
      <dcterms:description>N-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_h_gate.h_infinity">
      <dcterms:description>steady state function of T-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current.g_K">
      <dcterms:description>delayed rectifier potassium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_m_gate.tau_m">
      <dcterms:description>time constant of sodium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LVA_calcium_current_h_gate.sigma_h">
      <dcterms:description>half-maximal potential of T-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_m_gate.sigma_m">
      <dcterms:description>half-maximal potential of sodium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current.g_SK">
      <dcterms:description>calcium-dependent potassium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#P_HVA_calcium_current.E_Ca">
      <dcterms:description>calcium reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#delayed_rectifier_current_n_gate.sigma_n">
      <dcterms:description>half-maximal activation potential of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.tau_m">
      <dcterms:description>time constant of fast transient potassium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_app">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current.h">
      <dcterms:description>persistent sodium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current_h_gate.sigma_h">
      <dcterms:description>half-maximal potential of T-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#hyperpolarization_activated_current.m">
      <dcterms:description>hyperpolarisation-activated current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.tau_n">
      <dcterms:description>activation time constant of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of sodium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#stimulus_protocol.i_stimEnd">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_m_gate.theta_m">
      <dcterms:description>saturation potential of sodium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current_m_gate.sigma_m">
      <dcterms:description>half-maximal activation potential of P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_14">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.i_N">
      <dcterms:description>N-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current_z_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_56">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#entity_1">
      <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:260693" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.theta_2">
      <dcterms:description>saturation potential of fast transient potassium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current.E_Ca">
      <dcterms:description>calcium reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_NaP">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_2">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>persistent sodium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_m_gate.tau_m">
      <dcterms:description>time constant of fast transient potassium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_h_gate.sigma_h">
      <dcterms:description>half-maximal potential of fast transient potassium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.sigma_1">
      <dcterms:description>half-maximal activation potential of hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_i_Na">
      <dcterms:description>sodium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_i_NaP">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_17">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>persistent sodium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#LVA_calcium_current.g_T">
      <dcterms:description>T-type calcium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#stimulus_protocol.i_app">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.theta_n">
      <dcterms:description>saturation potential of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#fast_transient_potassium_current_h_gate.h">
      <dcterms:description>fast transient potassium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.sigma_h">
      <dcterms:description>half-maximal potential of N-type calcium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#persistent_sodium_current_m_gate.tau_m">
      <dcterms:description>time constant of sodium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.theta_1">
      <dcterms:description>saturation potential of fast transient potassium current activation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current.m">
      <dcterms:description>fast transient potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.theta_m">
      <dcterms:description>saturation potential of hyperpolarisation-activated current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_HVA_calcium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_h_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current.E_K">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_51">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>potassium reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#membrane.i_A">
      <dcterms:description>fast transient potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.i_P">
      <dcterms:description>P-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_52">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#persistent_sodium_current_m_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#sodium_current_h_gate.h">
      <dcterms:description>sodium current inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#fast_transient_potassium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#N_HVA_calcium_current.m">
      <dcterms:description>N-type calcium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#hyperpolarization_activated_current.m">
      <dcterms:description>hyperpolarisation-activated current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calcium_dependent_potassium_current_z_gate.z">
      <dcterms:description>calcium-dependent potassium current activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.sigma_2">
      <dcterms:description>half-maximal activation potential of delayed rectifier potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sodium_current_h_gate.sigma_h">
      <dcterms:description>half-maximal potential of sodium current inactivation gate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="purvis_butera_2005.cellml#N_HVA_calcium_current.h">
      <dcterms:description>N-type calcium current inactivation variable</dcterms:description>
    </rdf:Description>
  </rdf:RDF>
</model>