- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-26 14:35:03+13:00
- Desc:
- modifying rdf files
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/saftenku_williams_sitsapesan_2001_low_model/model/saftenku_williams_sitsapesan_2001_low_model.cellml
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<article>
<articleinfo>
<title>Markovian Models of Low and High Activity Levels of Cardiac Ryanodine Receptors</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model represents the 'low' Markovian model of the RyR channel activity. The model runs in both OpenCell and COR and the units are consistent. Unfortunately, there are no comparable figures in the published paper for a curation check of the CellML model results.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: The modal gating behavior of single sheep cardiac sarcoplasmic reticulum (SR) Ca2+-release/ryanodine receptor (RyR) channels was assessed. We find that the gating of RyR channels spontaneously shifts between high (H) and low (L) levels of activity and inactive periods where no channel openings are detected (I). Moreover, we find that there is evidence for multiple gating modes within H activity, which we term H1 and H2 mode. Our results demonstrate that the underlying mechanisms regulating gating are similar in native and purified channels. Dwell-time distributions of L activity were best fitted by three open and five closed significant exponential components whereas dwell-time distributions of H1 activity were best fitted by two to three open and four closed significant exponential components. Increases in cytosolic [Ca2+] cause an increase in open probability (Po) within L activity and an increase in the probability of occurrence of H activity. Open lifetime distributions within L activity were Ca2+ independent whereas open lifetime distributions within H activity were Ca2+ dependent. This study is the first attempt to estimate RyR single-channel kinetic parameters from sequences of idealized dwell-times and to develop kinetic models of RyR gating using the criterion of maximum likelihood. We propose distinct kinetic schemes for L, H1, and H2 activity that describe the major features of sheep cardiac RyR channel gating at these levels of activity.</para>
<para>The original paper reference is cited below:</para>
<para>
Markovian Models Of Low And High Activity Levels Of Cardiac Ryanodine Receptors, Elena Saftenku, Alan J. Williams and Rebecca Sitsapesan, 2001,
<emphasis>Biophysical Journal</emphasis>
, 80, 2727-2741.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11371448&dopt=Abstract">PubMed ID: 11371448</ulink>
</para>
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<title>Schematic diagrams of the RyR models</title>
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</mediaobject>
<caption>Kinetic models of the gating of cardiac ryanodine receptors at low and high levels of activity.</caption>
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</sect1>
</article>
</documentation>
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<map_variables variable_1="C4O2" variable_2="C4O2" />
<map_variables variable_1="C4O3" variable_2="C4O3" />
</connection>
<connection>
<map_components component_1="environment" component_2="O2" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="C3" component_2="O1" />
<map_variables variable_1="C3" variable_2="C3" />
</connection>
<connection>
<map_components component_1="O1" component_2="C3" />
<map_variables variable_1="O1" variable_2="O1" />
</connection>
<connection>
<map_components component_1="environment" component_2="C5" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="C1" />
<map_variables variable_1="C2C1" variable_2="C2C1" />
<map_variables variable_1="C1C2" variable_2="C1C2" />
<map_variables variable_1="Ca" variable_2="Ca" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="O2" />
<map_variables variable_1="O2C3" variable_2="O2C3" />
<map_variables variable_1="C3O2" variable_2="C3O2" />
<map_variables variable_1="O2C4" variable_2="O2C4" />
<map_variables variable_1="C4O2" variable_2="C4O2" />
</connection>
<connection>
<map_components component_1="C1" component_2="C2" />
<map_variables variable_1="C1" variable_2="C1" />
</connection>
<connection>
<map_components component_1="C3" component_2="O2" />
<map_variables variable_1="C3" variable_2="C3" />
</connection>
<connection>
<map_components component_1="environment" component_2="C1" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="C5" component_2="C2" />
<map_variables variable_1="C5" variable_2="C5" />
</connection>
<connection>
<map_components component_1="O3" component_2="C3" />
<map_variables variable_1="O3" variable_2="O3" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="C3" />
<map_variables variable_1="C3O1" variable_2="C3O1" />
<map_variables variable_1="C3O3" variable_2="C3O3" />
<map_variables variable_1="O2C3" variable_2="O2C3" />
<map_variables variable_1="O3C3" variable_2="O3C3" />
<map_variables variable_1="C2C3" variable_2="C2C3" />
<map_variables variable_1="C3O2" variable_2="C3O2" />
<map_variables variable_1="O1C3" variable_2="O1C3" />
<map_variables variable_1="C3C2" variable_2="C3C2" />
<map_variables variable_1="Ca" variable_2="Ca" />
</connection>
<connection>
<map_components component_1="environment" component_2="C2" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="C4" component_2="O2" />
<map_variables variable_1="C4" variable_2="C4" />
</connection>
<connection>
<map_components component_1="O2" component_2="C4" />
<map_variables variable_1="O2" variable_2="O2" />
</connection>
<connection>
<map_components component_1="C3" component_2="C2" />
<map_variables variable_1="C3" variable_2="C3" />
</connection>
<connection>
<map_components component_1="C4" component_2="O3" />
<map_variables variable_1="C4" variable_2="C4" />
</connection>
<rdf:RDF xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#">
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C1C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.O2C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C3O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.O2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C4.C4O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.O1C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C1.C2">
<dcterms:description>fraction of ryanodine receptors in the closed C2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C5.C2C5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C2.C2C1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O2.O2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O2.O2C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C3C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C1.Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_0">
<ro:part_of>
<rdf:Description rdf:about="#entity_1">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:62390" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C2C5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O1.C3O1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C5.C2">
<dcterms:description>fraction of ryanodine receptors in the closed C2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.C5">
<dcterms:description>fraction of ryanodine receptors in the closed C5 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C3C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O3.C3O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O2.C4">
<dcterms:description>fraction of ryanodine receptors in the closed C4 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.O2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.C3O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.O3">
<dcterms:description>fraction of ryanodine receptors in the open O3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O3.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#C1.C1">
<dcterms:description>fraction of ryanodine receptors in the closed C1 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C3O1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O1.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#entity_1">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62390" />
</rdf:Description>
<rdf:Description rdf:about="#O1.O1">
<dcterms:description>fraction of ryanodine receptors in the open O1 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O2.C3O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.C3C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O3.O3">
<dcterms:description>fraction of ryanodine receptors in the open O3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C5.C2">
<dcterms:description>fraction of ryanodine receptors in the closed C2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.O3C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C1.C1C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.C2">
<dcterms:description>fraction of ryanodine receptors in the closed C2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O1.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#C1.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O3.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C3O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.C3O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.O2">
<dcterms:description>fraction of ryanodine receptors in the open O2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C4.O3C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C2C1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O3.O3C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C1.C2">
<dcterms:description>fraction of ryanodine receptors in the closed C2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.O3">
<dcterms:description>fraction of ryanodine receptors in the open O3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O3.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.C4O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.C5C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C5.C5C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C2.C2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C5.C5">
<dcterms:description>fraction of ryanodine receptors in the closed C5 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O1.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.O2">
<dcterms:description>fraction of ryanodine receptors in the open O2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C5C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C4.C4">
<dcterms:description>fraction of ryanodine receptors in the closed C4 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C1C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.Ca">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#entity_0">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62492" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O3.O3">
<dcterms:description>fraction of ryanodine receptors in the open O3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C4O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.C3O1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C5.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O3.C4">
<dcterms:description>fraction of ryanodine receptors in the closed C4 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.O2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C1">
<dcterms:description>fraction of ryanodine receptors in the closed C1 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.C2">
<dcterms:description>fraction of ryanodine receptors in the closed C2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.C2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.O3C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O3.C3O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.O1">
<dcterms:description>fraction of ryanodine receptors in the open O1 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C1.C2C1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O2.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#saftenku_low_model_2001" bqmodel:isDescribedBy="11371448" />
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#O1.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O2.C4O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C4O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O1.O1C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.O2C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.O1C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C2">
<dcterms:description>fraction of ryanodine receptors in the closed C2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O3.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C4O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C5C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C2.C2C5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C4.O3">
<dcterms:description>fraction of ryanodine receptors in the open O3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.C3C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C4.O2C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C2C1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.C3O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O2.C3O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C2.C1">
<dcterms:description>fraction of ryanodine receptors in the closed C1 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C2C1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#saftenku_low_model_2001" bqmodel:isDescribedBy="11371448" semsim:modelName="saftenku_2001">
<semsim:unknown>Saftenku et al's 2001 markovian model of low activity levels of cardiac ryanodine receptors.</semsim:unknown>
<semsim:unknown>Cardiac Myocyte</semsim:unknown>
<semsim:modelName>saftenku_williams_sitsapesan_2001_low_model</semsim:modelName>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O2.O2">
<dcterms:description>fraction of ryanodine receptors in the open O2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.O3C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C4.O2">
<dcterms:description>fraction of ryanodine receptors in the open O2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O3.O3C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C2.Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C4.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#C3.O1C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O3.C4">
<dcterms:description>fraction of ryanodine receptors in the closed C4 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C4O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C4.C4O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C5C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C1.C1C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.O2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C1.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O2.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C4.O2">
<dcterms:description>fraction of ryanodine receptors in the open O2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O3.C4O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.O3">
<dcterms:description>fraction of ryanodine receptors in the open O3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.C3O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O3.C4O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C5.C5C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.O3C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.C3C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C2.C1C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.O3C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C5.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#C2.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C3C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C2C5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C1.Ca">
<bqbiol:isPropertyOf rdf:resource="saftenku_williams_sitsapesan_2001_low_model.cellml#entity_0" />
<dcterms:description>concentration of calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O1.O1C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O3.O3C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O2.O2">
<dcterms:description>fraction of ryanodine receptors in the open O2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.O3C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O2.C4">
<dcterms:description>fraction of ryanodine receptors in the closed C4 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C1C2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.C3O1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C2.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O3.O3C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C3O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O2.O2C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.O1">
<dcterms:description>fraction of ryanodine receptors in the open O1 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C4.C4">
<dcterms:description>fraction of ryanodine receptors in the closed C4 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O1.C3O1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.Ca">
<bqbiol:isPropertyOf rdf:resource="saftenku_williams_sitsapesan_2001_low_model.cellml#entity_0" />
<dcterms:description>concentration of calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C4.O2C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.O3C4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C1.C2C1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.C3O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C2C5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O2.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C4.C4O3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.Ca">
<bqbiol:isPropertyOf rdf:resource="saftenku_williams_sitsapesan_2001_low_model.cellml#entity_0" />
<dcterms:description>concentration of calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.C2">
<dcterms:description>fraction of ryanodine receptors in the closed C2 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#O1.O1">
<dcterms:description>fraction of ryanodine receptors in the open O1 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O2.C4O2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C1.C1">
<dcterms:description>fraction of ryanodine receptors in the closed C1 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O2.C3">
<dcterms:description>fraction of ryanodine receptors in the closed C3 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#reaction_constants.C3O1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C2.C5">
<dcterms:description>fraction of ryanodine receptors in the closed C5 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.O1C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C5.C5">
<dcterms:description>fraction of ryanodine receptors in the closed C5 state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O2.O2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C5.C2C5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="saftenku_williams_sitsapesan_2001_low_model.cellml#C3.C2C3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
</rdf:RDF>
</model>
