- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-26 14:35:03+13:00
- Desc:
- modifying rdf files
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/shorten_robson_mckinnon_wall_2000/model/shorten_robson_mckinnon_wall_2000.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="shorten_robson_mckinnon_wall_2000" cmeta:id="shorten_robson_mckinnon_wall_2000_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>CRH-induced Electrical Activity and Calcium Signalling in Pituitary Corticotrophs</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Corticotroph releasing hormone (CRH) is one of the major regulatory hormones associated with the neuroendocrine response to stress. Pituitary corticotroph cells generate repetitive action potentials and associated Ca
<superscript>2+</superscript>
transients in response to the agonist CRH. The mechanisms underlying this process are complex. CRH is known to activate the adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase A (PKA) pathway. PKA phosphorylates L-type voltage-sensitive Ca
<superscript>2+</superscript>
channels, activating them and contributing to the generation of an action potential and Ca
<superscript>2+</superscript>
transients.
</para>
<para>
In an earlier Hodgkin-Huxley type mathematical model of this process, LeBeau
<emphasis>et al.</emphasis>
showed than an increase in the L-type current was sufficient to generate repetitive action potentials from a resting state in the model (LeBeau
<emphasis>et al.</emphasis>
, 1997). However, they found that the action potential frequency of the model was much higher than the observed experimental action potential frequency. This problem was addressed in the current model described here (the complete original paper reference is cited below).
</para>
<para>
In addition to the activation of the L-type current, CRH also inhibits an inwardly rectifying K
<superscript>+</superscript>
current. This current helps to maintain a negative membrane resting potential. Inhibition of this inward rectifying K
<superscript>+</superscript>
current enhances membrane depolarisation and increases membrane excitability. By adding a component that represents the inward rectifying K
<superscript>+</superscript>
current to the original model, the new model simulates the dual modulatory action of CRH on inward rectifier and voltage-gated Ca
<superscript>2+</superscript>
channels better describes the experimentally observed CHR-induced effects (see the figure below).
</para>
<para>
<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMD-45CWWS4-26&_user=140507&_coverDate=10%2F07%2F2000&_alid=68313992&_rdoc=1&_fmt=summary&_orig=search&_qd=1&_cdi=6932&_sort=d&_docanchor=&wchp=dGLbVzb-lSztz&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=08c1a4ab23ba3610c703cc5ce5ee4944">CRH-induced Electrical Activity and Calcium Signalling in Pituitary Corticotrophs</ulink>
, Paul R. Shorten, A. Bruce Robson, Alan E. McKinnon and David J.N. Wall, 2000,
<ulink url="http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=6932&_auth=y&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=c8e64d20ff203cda2255f4b6b7affe4f">
<emphasis>Journal of Theoretical Biology</emphasis>
</ulink>
, 206, 395-405. (A PDF version of the article is available for Journal Members on the Journal of Theoretical Biology website.)
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell schematic for the model</title>
</objectinfo>
<imagedata fileref="shorten_robson_2000.png" />
</imageobject>
</mediaobject>
<caption>
Schematic diagram of a pituitary corticotroph cell showing the transmembrane ionic currents captured by the mathematical model. Arrows indicate ionic channels and pumps.
<emphasis>
I
<subscript>Ca-L</subscript>
</emphasis>
represents an L-type Ca
<superscript>2+</superscript>
current responsible for most of the Ca
<superscript>2+</superscript>
influx during an action potential.
<emphasis>
I
<subscript>Ca-T</subscript>
</emphasis>
is a T-type voltage-sensitive Ca
<superscript>2+</superscript>
current. A voltage-sensitive K
<superscript>+</superscript>
current,
<emphasis>
I
<subscript>K-DR</subscript>
</emphasis>
, is mainly responsible for action potential repolarisation. A Ca
<superscript>2+</superscript>
-activated K
<superscript>+</superscript>
current,
<emphasis>
I
<subscript>K-Ca</subscript>
</emphasis>
, is essential for bursting behaviour. The remaining leak current,
<emphasis>
I
<subscript>K-IR</subscript>
</emphasis>
, represents an inwardly rectifying K
<superscript>+</superscript>
current which helps to maintain a negative resting potential.
<emphasis>
J
<subscript>eff</subscript>
</emphasis>
is a plasma membrane Ca
<superscript>2+</superscript>
-ATPase pump. Within the cytosol, significant portions of Ca
<superscript>2+</superscript>
are bound to buffers. This is denoted by B
<subscript>c</subscript>
.
</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="per_micrometre">
<unit exponent="-1.0" units="micrometre" />
</units>
<units name="picoL">
<unit prefix="pico" units="litre" />
</units>
<units name="picoA">
<unit prefix="pico" units="ampere" />
</units>
<units name="micromolar_micrometre_per_millisecond_per_picoA">
<unit exponent="-1.0" prefix="pico" units="ampere" />
<unit units="micrometre" />
<unit units="micromolar" />
<unit exponent="-1.0" units="millisecond" />
</units>
<units name="joule_per_kilomole_kelvin">
<unit exponent="-1.0" units="kelvin" />
<unit exponent="-1.0" prefix="kilo" units="mole" />
<unit units="joule" />
</units>
<units name="picoF">
<unit prefix="pico" units="farad" />
</units>
<units name="picoL_per_millisecond">
<unit exponent="-1.0" units="millisecond" />
<unit units="picoL" />
</units>
<units name="micrometre">
<unit prefix="micro" units="metre" />
</units>
<units name="nanoS">
<unit prefix="nano" units="siemens" />
</units>
<units name="molar">
<unit units="mole" />
<unit exponent="-1.0" units="litre" />
</units>
<units name="micromolar_micrometre_per_millisecond">
<unit units="micromolar" />
<unit exponent="-1.0" units="millisecond" />
<unit units="micrometre" />
</units>
<units name="millivolt">
<unit prefix="milli" units="volt" />
</units>
<units name="millimolar">
<unit prefix="milli" units="mole" />
<unit exponent="-1.0" units="litre" />
</units>
<units name="millimolar_per_millisecond">
<unit exponent="-1.0" units="millisecond" />
<unit units="millimolar" />
</units>
<units name="millisecond">
<unit prefix="milli" units="second" />
</units>
<units name="micromolar">
<unit prefix="micro" units="mole" />
<unit exponent="-1.0" units="litre" />
</units>
<units name="micromolar_picoL_per_millisecond">
<unit units="picoL" />
<unit exponent="-1.0" units="millisecond" />
<unit units="micromolar" />
</units>
<units name="coulomb_per_mole">
<unit exponent="-1.0" units="mole" />
<unit units="coulomb" />
</units>
<component name="environment">
<variable cmeta:id="environment.time" name="time" public_interface="out" units="second" />
<variable cmeta:id="environment.Ca_e" initial_value="20.0" name="Ca_e" public_interface="out" units="millimolar" />
<variable cmeta:id="environment.K_e" initial_value="5.6" name="K_e" public_interface="out" units="millimolar" />
<variable cmeta:id="environment.K_i" initial_value="140.0" name="K_i" public_interface="out" units="millimolar" />
<variable cmeta:id="environment.V_tau" initial_value="-60.0" name="V_tau" public_interface="out" units="millivolt" />
<variable cmeta:id="environment.k_tau" initial_value="22.0" name="k_tau" public_interface="out" units="millivolt" />
</component>
<component name="membrane">
<variable cmeta:id="membrane.V" name="V" public_interface="out" units="millivolt" />
<variable cmeta:id="membrane.R" initial_value="8.314" name="R" public_interface="out" units="joule_per_kilomole_kelvin" />
<variable cmeta:id="membrane.T" initial_value="310.0" name="T" public_interface="out" units="kelvin" />
<variable cmeta:id="membrane.F" initial_value="96845.0" name="F" public_interface="out" units="coulomb_per_mole" />
<variable cmeta:id="membrane.Cm" initial_value="7.0" name="Cm" units="picoF" />
<variable cmeta:id="membrane.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="membrane.i_Ca_L" name="i_Ca_L" public_interface="in" units="picoA" />
<variable cmeta:id="membrane.i_Ca_T" name="i_Ca_T" public_interface="in" units="picoA" />
<variable cmeta:id="membrane.i_K_DR" name="i_K_DR" public_interface="in" units="picoA" />
<variable cmeta:id="membrane.i_K_Ca" name="i_K_Ca" public_interface="in" units="picoA" />
<variable cmeta:id="membrane.i_K_IR" name="i_K_IR" public_interface="in" units="picoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="membrane_voltage_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<ci>i_Ca_L</ci>
<ci>i_Ca_T</ci>
<ci>i_K_DR</ci>
<ci>i_K_Ca</ci>
<ci>i_K_IR</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_calcium_current">
<variable cmeta:id="L_type_calcium_current.i_Ca_L" name="i_Ca_L" public_interface="out" units="picoA" />
<variable cmeta:id="L_type_calcium_current.V_Ca" name="V_Ca" public_interface="out" units="millivolt" />
<variable cmeta:id="L_type_calcium_current.g_Ca_L" initial_value="9.0" name="g_Ca_L" units="nanoS" />
<variable cmeta:id="L_type_calcium_current.time" name="time" public_interface="in" private_interface="out" units="second" />
<variable cmeta:id="L_type_calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="L_type_calcium_current.V_tau" name="V_tau" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="L_type_calcium_current.k_tau" name="k_tau" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="L_type_calcium_current.R" name="R" public_interface="in" units="joule_per_kilomole_kelvin" />
<variable cmeta:id="L_type_calcium_current.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="L_type_calcium_current.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="L_type_calcium_current.Ca_e" name="Ca_e" public_interface="in" units="millimolar" />
<variable cmeta:id="L_type_calcium_current.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<variable cmeta:id="L_type_calcium_current.m_L" name="m_L" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_Ca_L_calculation">
<eq />
<ci>i_Ca_L</ci>
<apply>
<times />
<ci>g_Ca_L</ci>
<apply>
<power />
<ci>m_L</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<ci>V_Ca</ci>
</apply>
</apply>
<apply id="V_Ca_calculation">
<eq />
<ci>V_Ca</ci>
<apply>
<times />
<ci>V</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>Ca_i</ci>
<ci>Ca_e</ci>
</apply>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
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<apply>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
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<apply>
<times />
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_calcium_current_m_gate">
<variable cmeta:id="L_type_calcium_current_m_gate.m_L" name="m_L" public_interface="out" units="dimensionless" />
<variable cmeta:id="L_type_calcium_current_m_gate.m_L_infinity" name="m_L_infinity" units="dimensionless" />
<variable cmeta:id="L_type_calcium_current_m_gate.tau_m_L" name="tau_m_L" units="millisecond" />
<variable cmeta:id="L_type_calcium_current_m_gate.tau_m_L_max" initial_value="27.0" name="tau_m_L_max" units="millisecond" />
<variable cmeta:id="L_type_calcium_current_m_gate.V_m_L" initial_value="-12.0" name="V_m_L" units="millivolt" />
<variable cmeta:id="L_type_calcium_current_m_gate.k_m_L" initial_value="12.0" name="k_m_L" units="millivolt" />
<variable cmeta:id="L_type_calcium_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="L_type_calcium_current_m_gate.V_tau" name="V_tau" public_interface="in" units="millivolt" />
<variable cmeta:id="L_type_calcium_current_m_gate.k_tau" name="k_tau" public_interface="in" units="millivolt" />
<variable cmeta:id="L_type_calcium_current_m_gate.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="m_L_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>m_L</ci>
</apply>
<apply>
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<ci>m_L</ci>
</apply>
<ci>tau_m_L</ci>
</apply>
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<ci>V</ci>
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</apply>
</apply>
</apply>
</apply>
<apply id="tau_m_L_calculation">
<eq />
<ci>tau_m_L</ci>
<apply>
<divide />
<ci>tau_m_L_max</ci>
<apply>
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<apply>
<exp />
<apply>
<divide />
<apply>
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<ci>V</ci>
<ci>V_tau</ci>
</apply>
<ci>k_tau</ci>
</apply>
</apply>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<apply>
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</apply>
</apply>
<ci>k_tau</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_calcium_current">
<variable cmeta:id="T_type_calcium_current.i_Ca_T" name="i_Ca_T" public_interface="out" units="picoA" />
<variable cmeta:id="T_type_calcium_current.g_Ca_T" initial_value="10.0" name="g_Ca_T" units="nanoS" />
<variable cmeta:id="T_type_calcium_current.time" name="time" public_interface="in" private_interface="out" units="second" />
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<variable cmeta:id="T_type_calcium_current.k_tau" name="k_tau" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="T_type_calcium_current.V_Ca" name="V_Ca" public_interface="in" units="millivolt" />
<variable cmeta:id="T_type_calcium_current.m_T" name="m_T" private_interface="in" units="dimensionless" />
<variable cmeta:id="T_type_calcium_current.h_T" name="h_T" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
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</apply>
</apply>
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</component>
<component name="T_type_calcium_current_m_gate">
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<variable cmeta:id="T_type_calcium_current_m_gate.V_m_T" initial_value="-30.0" name="V_m_T" units="millivolt" />
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<variable cmeta:id="T_type_calcium_current_m_gate.V_tau" name="V_tau" public_interface="in" units="millivolt" />
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<apply>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
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</apply>
</apply>
<ci>k_tau</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_calcium_current_h_gate">
<variable cmeta:id="T_type_calcium_current_h_gate.h_T" name="h_T" public_interface="out" units="dimensionless" />
<variable cmeta:id="T_type_calcium_current_h_gate.h_T_infinity" name="h_T_infinity" units="dimensionless" />
<variable cmeta:id="T_type_calcium_current_h_gate.tau_h_T" initial_value="15.0" name="tau_h_T" units="millisecond" />
<variable cmeta:id="T_type_calcium_current_h_gate.V_h_T" initial_value="-57.0" name="V_h_T" units="millivolt" />
<variable cmeta:id="T_type_calcium_current_h_gate.k_h_T" initial_value="5.0" name="k_h_T" units="millivolt" />
<variable cmeta:id="T_type_calcium_current_h_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="T_type_calcium_current_h_gate.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="h_T_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>h_T</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>h_T_infinity</ci>
<ci>h_T</ci>
</apply>
<ci>tau_h_T</ci>
</apply>
</apply>
<apply id="h_T_infinity_calculation">
<eq />
<ci>h_T_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V</ci>
<ci>V_h_T</ci>
</apply>
<ci>k_h_T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="voltage_sensitive_K_current">
<variable cmeta:id="voltage_sensitive_K_current.i_K_DR" name="i_K_DR" public_interface="out" units="picoA" />
<variable cmeta:id="voltage_sensitive_K_current.V_K" name="V_K" public_interface="out" units="millivolt" />
<variable cmeta:id="voltage_sensitive_K_current.g_K_DR" initial_value="0.1" name="g_K_DR" units="nanoS" />
<variable cmeta:id="voltage_sensitive_K_current.time" name="time" public_interface="in" private_interface="out" units="second" />
<variable cmeta:id="voltage_sensitive_K_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="voltage_sensitive_K_current.R" name="R" public_interface="in" units="joule_per_kilomole_kelvin" />
<variable cmeta:id="voltage_sensitive_K_current.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="voltage_sensitive_K_current.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="voltage_sensitive_K_current.K_e" name="K_e" public_interface="in" units="millimolar" />
<variable cmeta:id="voltage_sensitive_K_current.K_i" name="K_i" public_interface="in" units="millimolar" />
<variable cmeta:id="voltage_sensitive_K_current.n" name="n" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_K_DR_calculation">
<eq />
<ci>i_K_DR</ci>
<apply>
<times />
<ci>g_K_DR</ci>
<ci>n</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_K</ci>
</apply>
</apply>
</apply>
<apply id="V_K_calculation">
<eq />
<ci>V_K</ci>
<apply>
<times />
<ci>V</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>K_i</ci>
<ci>K_e</ci>
</apply>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="voltage_sensitive_K_current_n_gate">
<variable cmeta:id="voltage_sensitive_K_current_n_gate.n" name="n" public_interface="out" units="dimensionless" />
<variable cmeta:id="voltage_sensitive_K_current_n_gate.n_infinity" name="n_infinity" units="dimensionless" />
<variable cmeta:id="voltage_sensitive_K_current_n_gate.tau_n" initial_value="20.0" name="tau_n" units="millisecond" />
<variable cmeta:id="voltage_sensitive_K_current_n_gate.V_n" initial_value="-20.0" name="V_n" units="millivolt" />
<variable cmeta:id="voltage_sensitive_K_current_n_gate.k_n" initial_value="4.5" name="k_n" units="millivolt" />
<variable cmeta:id="voltage_sensitive_K_current_n_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="voltage_sensitive_K_current_n_gate.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="n_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>n</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>n_infinity</ci>
<ci>n</ci>
</apply>
<ci>tau_n</ci>
</apply>
</apply>
<apply id="n_infinity_calculation">
<eq />
<ci>n_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V_n</ci>
<ci>V</ci>
</apply>
<ci>k_n</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_activated_K_current">
<variable cmeta:id="Ca_activated_K_current.i_K_Ca" name="i_K_Ca" public_interface="out" units="picoA" />
<variable cmeta:id="Ca_activated_K_current.g_K_Ca" initial_value="0.09" name="g_K_Ca" units="nanoS" />
<variable cmeta:id="Ca_activated_K_current.Kc" initial_value="0.5" name="Kc" units="micromolar" />
<variable cmeta:id="Ca_activated_K_current.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="Ca_activated_K_current.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="Ca_activated_K_current.V_K" name="V_K" public_interface="in" units="millivolt" />
<variable cmeta:id="Ca_activated_K_current.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_K_Ca_calculation">
<eq />
<ci>i_K_Ca</ci>
<apply>
<times />
<ci>g_K_Ca</ci>
<apply>
<divide />
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<power />
<ci>Kc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
<ci>V_K</ci>
</apply>
</apply>
</math>
</component>
<component name="inward_rectifier_current">
<variable cmeta:id="inward_rectifier_current.i_K_IR" name="i_K_IR" public_interface="out" units="picoA" />
<variable cmeta:id="inward_rectifier_current.I_max" initial_value="2.7" name="I_max" units="picoA" />
<variable cmeta:id="inward_rectifier_current.g_K_IR" initial_value="0.3" name="g_K_IR" units="nanoS" />
<variable cmeta:id="inward_rectifier_current.V_K_IR" initial_value="-71.5" name="V_K_IR" units="millivolt" />
<variable cmeta:id="inward_rectifier_current.ks" initial_value="6.5" name="ks" units="millivolt" />
<variable cmeta:id="inward_rectifier_current.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="inward_rectifier_current.V" name="V" public_interface="in" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_K_IR_calculation">
<eq />
<ci>i_K_IR</ci>
<piecewise>
<piece>
<apply>
<times />
<ci>I_max</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V_K_IR</ci>
<ci>V</ci>
</apply>
<ci>ks</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt />
<ci>V</ci>
<ci>V_K_IR</ci>
</apply>
</piece>
<otherwise>
<apply>
<times />
<ci>g_K_IR</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_K_IR</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="cytosolic_calcium">
<variable cmeta:id="cytosolic_calcium.Ca_i" name="Ca_i" public_interface="out" units="millimolar" />
<variable cmeta:id="cytosolic_calcium.K_p" initial_value="0.08" name="K_p" units="micromolar" />
<variable cmeta:id="cytosolic_calcium.f_cyt" initial_value="0.005" name="f_cyt" units="dimensionless" />
<variable cmeta:id="cytosolic_calcium.v_p" initial_value="0.025" name="v_p" units="micromolar_micrometre_per_millisecond" />
<variable cmeta:id="cytosolic_calcium.J_in" name="J_in" units="millimolar_per_millisecond" />
<variable cmeta:id="cytosolic_calcium.J_eff" name="J_eff" units="millimolar_per_millisecond" />
<variable cmeta:id="cytosolic_calcium.alpha" initial_value="0.0074" name="alpha" units="micromolar_micrometre_per_millisecond_per_picoA" />
<variable cmeta:id="cytosolic_calcium.beta" initial_value="0.4" name="beta" units="per_micrometre" />
<variable cmeta:id="cytosolic_calcium.i_Ca_L" name="i_Ca_L" public_interface="in" units="picoA" />
<variable cmeta:id="cytosolic_calcium.i_Ca_T" name="i_Ca_T" public_interface="in" units="picoA" />
<variable cmeta:id="cytosolic_calcium.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Ca_i_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times />
<ci>f_cyt</ci>
<ci>beta</ci>
<apply>
<minus />
<ci>J_in</ci>
<ci>J_eff</ci>
</apply>
</apply>
</apply>
<apply id="J_in_calculation">
<eq />
<ci>J_in</ci>
<apply>
<times />
<apply>
<minus />
<ci>alpha</ci>
</apply>
<apply>
<plus />
<ci>i_Ca_L</ci>
<ci>i_Ca_T</ci>
</apply>
</apply>
</apply>
<apply id="J_eff_calculation">
<eq />
<ci>J_eff</ci>
<apply>
<divide />
<apply>
<times />
<ci>v_p</ci>
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<power />
<ci>K_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment" />
<component_ref component="membrane">
<component_ref component="cytosolic_calcium" />
<component_ref component="Ca_activated_K_current" />
<component_ref component="L_type_calcium_current">
<component_ref component="L_type_calcium_current_m_gate" />
</component_ref>
<component_ref component="T_type_calcium_current">
<component_ref component="T_type_calcium_current_m_gate" />
<component_ref component="T_type_calcium_current_h_gate" />
</component_ref>
<component_ref component="inward_rectifier_current" />
<component_ref component="voltage_sensitive_K_current">
<component_ref component="voltage_sensitive_K_current_n_gate" />
</component_ref>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="L_type_calcium_current">
<component_ref component="L_type_calcium_current_m_gate" />
</component_ref>
<component_ref component="T_type_calcium_current">
<component_ref component="T_type_calcium_current_m_gate" />
<component_ref component="T_type_calcium_current_h_gate" />
</component_ref>
<component_ref component="voltage_sensitive_K_current">
<component_ref component="voltage_sensitive_K_current_n_gate" />
</component_ref>
</group>
<connection>
<map_components component_1="L_type_calcium_current" component_2="membrane" />
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L" />
</connection>
<connection>
<map_components component_1="T_type_calcium_current" component_2="T_type_calcium_current_m_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="k_tau" variable_2="k_tau" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V_tau" variable_2="V_tau" />
</connection>
<connection>
<map_components component_1="T_type_calcium_current_m_gate" component_2="T_type_calcium_current" />
<map_variables variable_1="m_T" variable_2="m_T" />
</connection>
<connection>
<map_components component_1="voltage_sensitive_K_current_n_gate" component_2="voltage_sensitive_K_current" />
<map_variables variable_1="n" variable_2="n" />
</connection>
<connection>
<map_components component_1="membrane" component_2="Ca_activated_K_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_calcium_current" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="T" variable_2="T" />
</connection>
<connection>
<map_components component_1="membrane" component_2="T_type_calcium_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="L_type_calcium_current" component_2="L_type_calcium_current_m_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="k_tau" variable_2="k_tau" />
<map_variables variable_1="V_tau" variable_2="V_tau" />
</connection>
<connection>
<map_components component_1="membrane" component_2="inward_rectifier_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="L_type_calcium_current_m_gate" component_2="L_type_calcium_current" />
<map_variables variable_1="m_L" variable_2="m_L" />
</connection>
<connection>
<map_components component_1="environment" component_2="cytosolic_calcium" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="Ca_activated_K_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="T_type_calcium_current" component_2="T_type_calcium_current_h_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="T_type_calcium_current" component_2="cytosolic_calcium" />
<map_variables variable_1="i_Ca_T" variable_2="i_Ca_T" />
</connection>
<connection>
<map_components component_1="L_type_calcium_current" component_2="cytosolic_calcium" />
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L" />
</connection>
<connection>
<map_components component_1="environment" component_2="T_type_calcium_current" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="k_tau" variable_2="k_tau" />
<map_variables variable_1="V_tau" variable_2="V_tau" />
</connection>
<connection>
<map_components component_1="Ca_activated_K_current" component_2="membrane" />
<map_variables variable_1="i_K_Ca" variable_2="i_K_Ca" />
</connection>
<connection>
<map_components component_1="inward_rectifier_current" component_2="membrane" />
<map_variables variable_1="i_K_IR" variable_2="i_K_IR" />
</connection>
<connection>
<map_components component_1="L_type_calcium_current" component_2="T_type_calcium_current" />
<map_variables variable_1="V_Ca" variable_2="V_Ca" />
</connection>
<connection>
<map_components component_1="cytosolic_calcium" component_2="Ca_activated_K_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="voltage_sensitive_K_current" component_2="voltage_sensitive_K_current_n_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="T_type_calcium_current_h_gate" component_2="T_type_calcium_current" />
<map_variables variable_1="h_T" variable_2="h_T" />
</connection>
<connection>
<map_components component_1="membrane" component_2="voltage_sensitive_K_current" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="T" variable_2="T" />
</connection>
<connection>
<map_components component_1="cytosolic_calcium" component_2="L_type_calcium_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="membrane" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="L_type_calcium_current" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="k_tau" variable_2="k_tau" />
<map_variables variable_1="V_tau" variable_2="V_tau" />
<map_variables variable_1="Ca_e" variable_2="Ca_e" />
</connection>
<connection>
<map_components component_1="voltage_sensitive_K_current" component_2="Ca_activated_K_current" />
<map_variables variable_1="V_K" variable_2="V_K" />
</connection>
<connection>
<map_components component_1="T_type_calcium_current" component_2="membrane" />
<map_variables variable_1="i_Ca_T" variable_2="i_Ca_T" />
</connection>
<connection>
<map_components component_1="voltage_sensitive_K_current" component_2="membrane" />
<map_variables variable_1="i_K_DR" variable_2="i_K_DR" />
</connection>
<connection>
<map_components component_1="environment" component_2="voltage_sensitive_K_current" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="K_e" variable_2="K_e" />
<map_variables variable_1="K_i" variable_2="K_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="inward_rectifier_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<rdf:RDF xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#">
<rdf:Description rdf:about="#L_type_calcium_current_m_gate.V_m_L">
<dcterms:description>L-type calcium channel half-activation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current_n_gate.tau_n">
<dcterms:description>voltage-sensitive potassium channel activation time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.i_Ca_T">
<dcterms:description>T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current_m_gate.tau_m_L">
<dcterms:description>L-type calcium channel activation time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.m_L">
<dcterms:description>L-type calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.Ca_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf>
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<ro:part_of>
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<dcterms:description>half-maximal activity constant of calcium-activated potassium current</dcterms:description>
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<dcterms:description>half-maximal activity constant of SERCA pump</dcterms:description>
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<dcterms:description>slope factor for T-type calcium channel activation</dcterms:description>
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<rdf:Description rdf:about="#inward_rectifier_current.I_max">
<dcterms:description>maximum inward rectifier current</dcterms:description>
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<dcterms:description>L-type calcium channel activation variable</dcterms:description>
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<dcterms:description>concentration of extracellular calcium</dcterms:description>
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<dcterms:description>absolute temperature</dcterms:description>
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
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<dcterms:description>membrane potential</dcterms:description>
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<dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
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<dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
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<dcterms:description>calcium flux out of the cell</dcterms:description>
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<dcterms:description>steady state function of voltage-sensitive potassium channel activation variable</dcterms:description>
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<dcterms:description>absolute temperature</dcterms:description>
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<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#membrane.i_K_DR">
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<dcterms:description>voltage-sensitive potassium current</dcterms:description>
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<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.V">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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<dcterms:description>potassium reversal potential</dcterms:description>
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<dcterms:description>calcium-activated potassium current</dcterms:description>
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<dcterms:description>membrane potential</dcterms:description>
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<ro:part_of>
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<dcterms:description>potassium reversal potential</dcterms:description>
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<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.m_L">
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<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
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<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.J_in">
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<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#property_6">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>voltage-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_h_gate.V_h_T">
<dcterms:description>T-type calcium channel half-inactivation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_m_gate.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current_n_gate.n_infinity">
<dcterms:description>steady state function of voltage-sensitive potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.g_K_IR">
<dcterms:description>inward rectifier current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_h_gate.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_m_gate.V_tau">
<dcterms:description>midpoint potential of time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current_n_gate.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.V_tau">
<dcterms:description>midpoint potential of time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.m_T">
<dcterms:description>T-type calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.V_n">
<dcterms:description>voltage-sensitive potassium channel half-activation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.i_Ca_L">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.k_tau">
<dcterms:description>slope factor for time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.V_tau">
<dcterms:description>midpoint potential of time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current.K_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_24">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_K_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#Ca_activated_K_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current.g_K_DR">
<dcterms:description>voltage-sensitive potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.K_e">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#entity_2">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
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</bqbiol:isPropertyOf>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.Ca_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#membrane.i_Ca_T">
<dcterms:description>T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#membrane.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_h_gate.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_calcium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#membrane.i_K_IR">
<dcterms:description>inward rectifier current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#membrane.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_m_gate.tau_m_T_max">
<dcterms:description>maximum T-type calcium channel activation time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_m_gate.k_m_T">
<dcterms:description>slope factor for T-type calcium channel activation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.tau_n">
<dcterms:description>voltage-sensitive potassium channel activation time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#shorten_robson_mckinnon_wall_2000_version01">
<semsim:modelName>shorten_robson_mckinnon_wall_2000_version01</semsim:modelName>
<semsim:unknown>Shorten et al's 2000 mathematical model of CRH-induced electrical
activity and calcium signalling in pituitary corticotrophs.</semsim:unknown>
<semsim:unknown>Pituitary Corticotrophs</semsim:unknown>
<semsim:modelName>shorten_robson_mckinnon_wall_2000</semsim:modelName>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.i_K_IR">
<dcterms:description>inward rectifier current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.k_tau">
<dcterms:description>slope factor for time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_calcium.Ca_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_33">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#environment.K_e">
<bqbiol:isPropertyOf rdf:resource="shorten_robson_mckinnon_wall_2000.cellml#entity_2" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#environment.V_tau">
<dcterms:description>midpoint potential of time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current.g_Ca_T">
<dcterms:description>T-type calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_calcium.i_Ca_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current.m_T">
<dcterms:description>T-type calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.V_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.g_Ca_T">
<dcterms:description>T-type calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.K_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#entity_3">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current_n_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.Ca_i">
<bqbiol:isPropertyOf rdf:resource="shorten_robson_mckinnon_wall_2000.cellml#entity_5" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current.V_tau">
<dcterms:description>midpoint potential of time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.V_Ca">
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.V_tau">
<dcterms:description>midpoint potential of time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current_m_gate.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_m_gate.m_T">
<dcterms:description>T-type calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_calcium.f_cyt">
<dcterms:description>cytosolic calcium buffering factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.V_tau">
<dcterms:description>midpoint potential of time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#entity_1">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022" />
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current.i_Ca_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_15">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#Ca_activated_K_current.i_K_Ca">
<dcterms:description>calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current.h_T">
<dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.i_Ca_L">
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current_n_gate.n">
<dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_2">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_sensitive_K_current.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#environment.Ca_e">
<bqbiol:isPropertyOf rdf:resource="shorten_robson_mckinnon_wall_2000.cellml#entity_0" />
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_h_gate.tau_h_T">
<dcterms:description>T-type calcium channel inactivation time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#inward_rectifier_current.V_K_IR">
<dcterms:description>half-maximal activation potential of inward rectifier current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.Cm">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.beta">
<dcterms:description>ratio of cell surface area to cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#Ca_activated_K_current.g_K_Ca">
<dcterms:description>calcium-activated potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_K_IR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>inward rectifier current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.tau_m_L">
<dcterms:description>L-type calcium channel activation time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.n">
<dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_activated_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.g_Ca_L">
<dcterms:description>L-type calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.g_Ca_L">
<dcterms:description>L-type calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.i_K_DR">
<dcterms:description>voltage-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#environment.K_i">
<bqbiol:isPropertyOf rdf:resource="shorten_robson_mckinnon_wall_2000.cellml#entity_3" />
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.k_tau">
<dcterms:description>slope factor for time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_calcium.K_p">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_34">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>half-maximal activity constant of SERCA pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_m_gate.k_tau">
<dcterms:description>slope factor for time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.v_p">
<dcterms:description>maximum plasma membrane pump rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current_m_gate.k_m_L">
<dcterms:description>slope factor for L-type calcium channel activation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.tau_m_L_max">
<dcterms:description>maximum L-type calcium channel activation time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.k_tau">
<dcterms:description>slope factor for time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.n">
<dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_calcium.v_p">
<dcterms:description>maximum plasma membrane pump rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#Ca_activated_K_current.g_K_Ca">
<dcterms:description>calcium-activated potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.m_L">
<dcterms:description>L-type calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.V_m_T">
<dcterms:description>T-type calcium channel half-activation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.m_T_infinity">
<dcterms:description>steady state function of T-type calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.i_Ca_T">
<dcterms:description>T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current_m_gate.m_L_infinity">
<dcterms:description>steady state function of L-type calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#entity_4">
<bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005829" />
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current.V_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_h_gate.V_h_T">
<dcterms:description>T-type calcium channel half-inactivation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_Ca_L">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_calcium.J_eff">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_36">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux out of the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#T_type_calcium_current_h_gate.h_T_infinity">
<dcterms:description>steady state function of T-type calcium channel inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.V_m_L">
<dcterms:description>L-type calcium channel half-activation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#L_type_calcium_current_m_gate.V_tau">
<dcterms:description>midpoint potential of time factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.f_cyt">
<dcterms:description>cytosolic calcium buffering factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_calcium.beta">
<dcterms:description>ratio of cell surface area to cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.V_tau">
<dcterms:description>midpoint potential of time factor</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
