Location: Calcium Dynamics Annotations @ 4d6408caaf3e / shorten_robson_mckinnon_wall_2000 / model / shorten_robson_mckinnon_wall_2000.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-26 14:35:03+13:00
Desc:
modifying rdf files
Permanent Source URI:
https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/shorten_robson_mckinnon_wall_2000/model/shorten_robson_mckinnon_wall_2000.rdf
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<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#environment.K_e">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#entity_2">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#entity_1">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>half-maximal activity constant of calcium-activated potassium current</dcterms:description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium flux out of the cell</dcterms:description>
  </rdf:Description>
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    <dcterms:description>calcium-activated potassium current conductance</dcterms:description>
  </rdf:Description>
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    <dcterms:description>voltage-sensitive potassium current</dcterms:description>
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    <bqbiol:isPropertyOf rdf:resource="./shorten_robson_mckinnon_wall_2000.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
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    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#environment.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#environment.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
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    <bqbiol:isPropertyOf rdf:resource="./shorten_robson_mckinnon_wall_2000.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
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    <dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
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  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_h_gate.h_T">
    <dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
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  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.V_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.i_K_IR">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>inward rectifier current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.tau_m_L">
    <dcterms:description>L-type calcium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.m_T">
    <dcterms:description>T-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.i_Ca_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>T-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.f_cyt">
    <dcterms:description>cytosolic calcium buffering factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.i_Ca_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>T-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
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    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#environment.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_h_gate.h_T_infinity">
    <dcterms:description>steady state function of T-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.J_in">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium flux into the cell</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.n_infinity">
    <dcterms:description>steady state function of voltage-sensitive potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.n">
    <dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.g_K_IR">
    <dcterms:description>inward rectifier current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.K_p">
    <bqbiol:isPropertyOf rdf:resource="./shorten_robson_mckinnon_wall_2000.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>half-maximal activity constant of SERCA pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.V_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#Ca_activated_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.alpha">
    <dcterms:description>calcium current to flux proportionality constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.i_K_IR">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>inward rectifier current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.m_L_infinity">
    <dcterms:description>steady state function of L-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.g_Ca_L">
    <dcterms:description>L-type calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./shorten_robson_mckinnon_wall_2000.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.m_L">
    <dcterms:description>L-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.v_p">
    <dcterms:description>maximum plasma membrane pump rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#shorten_robson_mckinnon_wall_2000_version01">
    <semsim:modelName>shorten_robson_mckinnon_wall_2000_version01</semsim:modelName>
    <semsim:unknown>Shorten et al's 2000 mathematical model of CRH-induced electrical 
        activity and calcium signalling in pituitary corticotrophs.</semsim:unknown>
    <semsim:unknown>Pituitary Corticotrophs</semsim:unknown>
    <semsim:modelName>shorten_robson_mckinnon_wall_2000</semsim:modelName>
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;CRH-induced Electrical Activity and Calcium Signalling in Pituitary Corticotrophs&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Bioengineering Institute, University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This is the original unchecked version of the model imported from the previous&#xD;
            CellML model repository, 24-Jan-2006.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;&#xD;
        Corticotroph releasing hormone (CRH) is one of the major regulatory hormones associated with the neuroendocrine response to stress.  Pituitary corticotroph cells generate repetitive action potentials and associated Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        transients in response to the agonist CRH.  The mechanisms underlying this process are complex.  CRH is known to activate the adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase A (PKA) pathway.  PKA phosphorylates L-type voltage-sensitive Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        channels, activating them and contributing to the generation of an action potential and Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        transients.&#xD;
      &lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        In an earlier Hodgkin-Huxley type mathematical model of this process, LeBeau&#xD;
        &lt;emphasis&gt;et al.&lt;/emphasis&gt;&#xD;
        showed than an increase in the L-type current was sufficient to generate repetitive action potentials from a resting state in the model (LeBeau&#xD;
        &lt;emphasis&gt;et al.&lt;/emphasis&gt;&#xD;
        , 1997).  However, they found that the action potential frequency of the model was much higher than the observed experimental action potential frequency.  This problem was addressed in the current model described here (the complete original paper reference is cited below).&#xD;
      &lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        In addition to the activation of the L-type current, CRH also inhibits an inwardly rectifying K&#xD;
        &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
        current.  This current helps to maintain a negative membrane resting potential.  Inhibition of this inward rectifying K&#xD;
        &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
        current enhances membrane depolarisation and increases membrane excitability.  By adding a component that represents the inward rectifying K&#xD;
        &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
        current to the original model, the new model simulates the dual modulatory action of CRH on inward rectifier and voltage-gated Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        channels better describes the experimentally observed CHR-induced effects (see the figure below).&#xD;
      &lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        &lt;ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;amp;_udi=B6WMD-45CWWS4-26&amp;amp;_user=140507&amp;amp;_coverDate=10%2F07%2F2000&amp;amp;_alid=68313992&amp;amp;_rdoc=1&amp;amp;_fmt=summary&amp;amp;_orig=search&amp;amp;_qd=1&amp;amp;_cdi=6932&amp;amp;_sort=d&amp;amp;_docanchor=&amp;amp;wchp=dGLbVzb-lSztz&amp;amp;_acct=C000011498&amp;amp;_version=1&amp;amp;_urlVersion=0&amp;amp;_userid=140507&amp;amp;md5=08c1a4ab23ba3610c703cc5ce5ee4944"&gt;CRH-induced Electrical Activity and Calcium Signalling in Pituitary Corticotrophs&lt;/ulink&gt;&#xD;
        , Paul R. Shorten, A. Bruce Robson, Alan E. McKinnon and David J.N. Wall, 2000,&#xD;
        &lt;ulink url="http://www.sciencedirect.com/science?_ob=JournalURL&amp;amp;_cdi=6932&amp;amp;_auth=y&amp;amp;_acct=C000011498&amp;amp;_version=1&amp;amp;_urlVersion=0&amp;amp;_userid=140507&amp;amp;md5=c8e64d20ff203cda2255f4b6b7affe4f"&gt;&#xD;
          &lt;emphasis&gt;Journal of Theoretical Biology&lt;/emphasis&gt;&#xD;
        &lt;/ulink&gt;&#xD;
        , 206, 395-405.  (A PDF version of the article is available for Journal Members on the Journal of Theoretical Biology website.)&#xD;
      &lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_cell_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;cell schematic for the model&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="shorten_robson_2000.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;&#xD;
          Schematic diagram of a pituitary corticotroph cell showing the transmembrane ionic currents captured by the mathematical model.  Arrows indicate ionic channels and pumps.&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;Ca-L&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          represents an L-type Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          current responsible for most of the Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          influx during an action potential.&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;Ca-T&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          is a T-type voltage-sensitive Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          current.  A voltage-sensitive K&#xD;
          &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
          current,&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;K-DR&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          , is mainly responsible for action potential repolarisation.  A Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          -activated K&#xD;
          &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
          current,&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;K-Ca&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          , is essential for bursting behaviour.  The remaining leak current,&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;K-IR&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          , represents an inwardly rectifying K&#xD;
          &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
          current which helps to maintain a negative resting potential.&#xD;
          &lt;emphasis&gt;&#xD;
            J&#xD;
            &lt;subscript&gt;eff&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          is a plasma membrane Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          -ATPase pump.  Within the cytosol, significant portions of Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          are bound to buffers.  This is denoted by B&#xD;
          &lt;subscript&gt;c&lt;/subscript&gt;&#xD;
          .&#xD;
        &lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.m_T">
    <dcterms:description>T-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#environment.K_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#entity_3">
        <bqbiol:isPartOf rdf:resource="./shorten_robson_mckinnon_wall_2000.cellml#entity_4"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.K_i">
    <bqbiol:isPropertyOf rdf:resource="./shorten_robson_mckinnon_wall_2000.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./shorten_robson_mckinnon_wall_2000.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#environment.Ca_e">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#entity_0">
        <bqbiol:isPartOf rdf:resource="./shorten_robson_mckinnon_wall_2000.cellml#entity_1"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.i_K_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.g_Ca_T">
    <dcterms:description>T-type calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_h_gate.tau_h_T">
    <dcterms:description>T-type calcium channel inactivation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.n">
    <dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.Cm">
    <dcterms:description>membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.k_n">
    <dcterms:description>slope factor for voltage-sensitive potassium channel activation</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.V_n">
    <dcterms:description>voltage-sensitive potassium channel half-activation potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#membrane.i_K_DR">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>voltage-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.m_L">
    <dcterms:description>L-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#Ca_activated_K_current.i_K_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.tau_m_T_max">
    <dcterms:description>maximum T-type calcium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#Ca_activated_K_current.V_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.g_K_DR">
    <dcterms:description>voltage-sensitive potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.V_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.tau_m_T">
    <dcterms:description>T-type calcium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.V_m_L">
    <dcterms:description>L-type calcium channel half-activation potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.beta">
    <dcterms:description>ratio of cell surface area to cytosolic volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.I_max">
    <dcterms:description>maximum inward rectifier current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.m_T_infinity">
    <dcterms:description>steady state function of T-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current_n_gate.tau_n">
    <dcterms:description>voltage-sensitive potassium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.k_m_T">
    <dcterms:description>slope factor for T-type calcium channel activation</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.V_m_T">
    <dcterms:description>T-type calcium channel half-activation potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_h_gate.V_h_T">
    <dcterms:description>T-type calcium channel half-inactivation potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#inward_rectifier_current.V_K_IR">
    <dcterms:description>half-maximal activation potential of inward rectifier current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#cytosolic_calcium.i_Ca_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>T-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current.Ca_e">
    <bqbiol:isPropertyOf rdf:resource="./shorten_robson_mckinnon_wall_2000.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#Ca_activated_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.tau_m_L_max">
    <dcterms:description>maximum L-type calcium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_m_gate.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#T_type_calcium_current_h_gate.k_h_T">
    <dcterms:description>slope factor for T-type calcium channel inactivation</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#voltage_sensitive_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_robson_mckinnon_wall_2000.cellml#L_type_calcium_current_m_gate.k_m_L">
    <dcterms:description>slope factor for L-type calcium channel activation</dcterms:description>
  </rdf:Description>
</rdf:RDF>