- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-26 14:35:03+13:00
- Desc:
- modifying rdf files
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/wierschem_2004/model/wierschem_2004.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="wierschem_2004" cmeta:id="wierschem_2004">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Complex bursting in pancreatic islets: a potential glycolytic mechanism</title>
<author>
<firstname>Ethan</firstname>
<surname>Choi</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model has been built with the differential expressions in Wierschem's 2004 paper and also the XPPAUT code from Richard Bertram. This file is known to run in PCEnv and COR, however the model works in milliseconds, and must be run for at least 600000 time units or more (to simulate 10 minutes) and could not be changed to portray minutes instead. Due to the large iterations, and large point density required to run the model, problems were found in PCEnv and COR where the model would crash or not display properly giving an memory exceded error. Current parameterization of the model replicates Figure 9 of the paper. The initial conditions for all variables were provided in the Bertram code (given as V=-66, n=0, c=0.17, ATP=2.4, ADP=0.05) however these figures still required a warmup period for the functions so they were changed by running the model to steady state then cloning to the output to better replicate the figures from the paper.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: The electrical activity of insulin-secreting pancreatic islets of Langerhans is characterized by bursts of action potentials. Most often this bursting is periodic, but in some cases it is modulated by an underlying slower rhythm. We suggest that the modulatory rhythm for this complex bursting pattern is due to oscillations in glycolysis, while the bursting itself is generated by some other slow process. To demonstrate this hypothesis, we couple a minimal model of glycolytic oscillations to a minimal model for activity-dependent bursting in islets. We show that the combined model can reproduce several complex bursting patterns from mouse islets published in the literature, and we illustrate how these complex oscillations are produced through the use of a fast/slow analysis.</para>
<para>
Complex bursting in pancreatic islets: a potential glycolytic mechanism, Wierschem, Bertram, 2004,
<emphasis>Journal of Theoretical Biology</emphasis>
, 228, 513-521.
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/15178199">PubMed ID: 15178199</ulink>
</para>
<informalfigure>
<mediaobject>
<imageobject>
<objectinfo>
<title>Model Diagram</title>
</objectinfo>
<imagedata fileref="wierschem_2004.png" />
</imageobject>
</mediaobject>
<caption>Schematic diagram of the composite model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="per_millisecond">
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</units>
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<dcterms:description>current to flux conversion variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_influx.f">
<dcterms:description>ratio of free to total cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_current.g_Ca_">
<dcterms:description>calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_current.g_Ca_">
<dcterms:description>calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_current.n">
<dcterms:description>potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_Ca.time">
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<rdf:Description rdf:about="#ATP_sensitive_K_current.g_KATP_">
<dcterms:description>ATP-sensitive potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_activated_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
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<dcterms:description>potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cytosolic_Ca.J_mem">
<semsim:isComputationalComponentFor>
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium influx into the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_channel_activation.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#wierschem_2004" semsim:modelName="wierschem_2004" bqmodel:isDescribedBy="15178199">
<semsim:unknown>pancreatic beta cell@en</semsim:unknown>
</rdf:Description>
<rdf:Description rdf:about="#K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_channel_activation.tau_n">
<dcterms:description>activation time constant for potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_sensitive_K_current.ATP">
<dcterms:description>concentration of ATP nucleotides</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_activated_K_current.c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_0">
<ro:part_of>
<rdf:Description rdf:about="#entity_1">
<ro:part_of>
<rdf:Description rdf:about="#entity_2">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:85704" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:260691" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_KATP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>ATP-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_channel_activation.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_15">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#membrane.C_m">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_influx.I_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_activated_K_current.k_D">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="wierschem_2004.cellml#entity_0">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>calcium dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_current.n">
<dcterms:description>potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_influx.f">
<dcterms:description>ratio of free to total cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#cytosolic_Ca.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#K_current.g_K_">
<dcterms:description>potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_current.s_m">
<dcterms:description>calcium channel saturation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#ATP">
<dcterms:description>concentration of ATP nucleotides</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#membrane.I_Ca">
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#membrane.I_K">
<dcterms:description>potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_sensitive_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#I_KCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_channel_activation.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_influx.I_Ca">
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#ADP">
<dcterms:description>concentration of ADP nucleotides</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#nucleotides.tau_c">
<dcterms:description>time constant of phosphofructokinase reaction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#m_infinity">
<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_activated_K_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_activated_K_current.k_D">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.I_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_current.v_m">
<dcterms:description>activation potential of calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#n_infinity">
<dcterms:description>steady state function of potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_current.v_m">
<dcterms:description>activation potential of calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_current.g_K_">
<dcterms:description>potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_activated_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#environment_time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#I_Ca">
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_channel_activation.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#ATP_sensitive_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#membrane.I_KCa">
<dcterms:description>calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_sensitive_K_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment_time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#nucleotides.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#K_channel_activation.s_n">
<dcterms:description>potassium channel saturation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#n_infinity">
<dcterms:description>steady state function of potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_influx.k_c">
<dcterms:description>rate of calcium pumping out of the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_current.s_m">
<dcterms:description>calcium channel saturation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#entity_1">
<bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005829" />
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#membrane.I_KATP">
<dcterms:description>ATP-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_sensitive_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.I_KCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_influx.k_c">
<dcterms:description>rate of calcium pumping out of the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_channel_activation.v_n">
<dcterms:description>activation potential of potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#nucleotides.phi">
<dcterms:description>phosphofructokinase-catalysed reaction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#ATP_sensitive_K_current.g_KATP_">
<dcterms:description>ATP-sensitive potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#nucleotides.v">
<dcterms:description>constant ATP influx into the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#J_mem">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium influx into the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_influx.c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#nucleotides.eta">
<dcterms:description>ATP degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.I_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#ATP_sensitive_K_current.ATP">
<dcterms:description>concentration of ATP nucleotides</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#omega">
<dcterms:description>activation variable of calcium-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#nucleotides.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#n">
<dcterms:description>potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#nucleotides.v">
<dcterms:description>constant ATP influx into the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#c">
<bqbiol:isPropertyOf rdf:resource="wierschem_2004.cellml#entity_0" />
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ADP">
<dcterms:description>concentration of ADP nucleotides</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#ATP_sensitive_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_current.V_Ca">
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_activated_K_current.g_KCa_">
<dcterms:description>calcium-dependent potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.I_KATP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>ATP-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP">
<dcterms:description>concentration of ATP nucleotides</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.C_m">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#m_infinity">
<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_influx.alpha">
<dcterms:description>current to flux conversion variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_channel_activation.s_n">
<dcterms:description>potassium channel saturation potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_activated_K_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_activated_K_current.c">
<bqbiol:isPropertyOf rdf:resource="wierschem_2004.cellml#entity_0" />
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#I_KCa">
<dcterms:description>calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#n">
<dcterms:description>potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_channel_activation.tau_n">
<dcterms:description>activation time constant for potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#nucleotides.k">
<dcterms:description>ratio of forward and reverse reaction rates of substrate ATP binding to phosphofructokinase</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_activated_K_current.g_KCa_">
<dcterms:description>calcium-dependent potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#nucleotides.eta">
<dcterms:description>ATP degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#J_mem">
<dcterms:description>calcium influx into the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#nucleotides.phi">
<dcterms:description>phosphofructokinase-catalysed reaction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#nucleotides.tau_c">
<dcterms:description>time constant of phosphofructokinase reaction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#K_channel_activation.v_n">
<dcterms:description>activation potential of potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#cytosolic_Ca.J_mem">
<dcterms:description>calcium influx into the cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#Ca_influx.c">
<bqbiol:isPropertyOf rdf:resource="wierschem_2004.cellml#entity_0" />
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#I_KATP">
<dcterms:description>ATP-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#omega">
<dcterms:description>activation variable of calcium-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_current.V_Ca">
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#nucleotides.k">
<dcterms:description>ratio of forward and reverse reaction rates of substrate ATP binding to phosphofructokinase</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="wierschem_2004.cellml#ATP_sensitive_K_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
