- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-26 14:35:03+13:00
- Desc:
- modifying rdf files
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/yi_fogelson_keener_peskin_2003/model/yi_fogelson_keener_peskin_2003.cellml
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling Volume Shifts and Ionic Concentration Changes during Ischemia and Hypoxia</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>Ischemia arises when both blood flow and oxygen transport to a tissue stop, while hypoxia describes a condition where normal blood flow continues but there is a reduction in the supply of oxygen to the tissue. For both hypoxia and ischemia, depriving the tissue of oxygen causes cells to switch from aerobic to anaerobic respiration. This results in reduced ATP synthesis, which in turn decreases the effectiveness of the cell membrane ion pumps, especially the Na-K-ATPase pump. Additionally, in the case of ischemia, reduced blood flow has the effect of reducing the tissue's supply of metabolic substrates, and it also reduces the efficiency of waste product removal.</para>
<para>
Ischemia and hypoxia have been experimentally studied in a wide variety of species and different tissue types. Tissue responses to ischemia include swelling of the intracellular space, shrinkage of the extracellular space, and an increase in the extracellular potassium concentration ([K
<superscript>+</superscript>
]
<subscript>e</subscript>
). In neural tissue, this increase in extracellular potassium concentration occurs in two stages; an initial rapid increase from about 5 mM to 55 mM, followed by a slower increase up to 80 mM. In cardiac myocytes, there are generally three phases observed: a rapid increase, a relative plateau, and a second, slower increase. These increases in extracellular potassium concentration may have important pathological consequences. For example, in cardiac ischemia, the increased [K
<superscript>+</superscript>
]
<subscript>e</subscript>
may cause arrhythmias.
</para>
<para>In 2003, Chung-Seon Yi, Aaron L. Fogelson, James P. Keener, and Charles S. Peskin studied the possible mechanisms underlying extracellular potassium accumulation during ischemia. They developed a simple Hodgkin-Huxley type ionic model, which unlike other previously published models of cardiac myocytes, includes extracellular volume, capillary flow and the influence of nearby healthy tissue as variables (see figure 1 and figure 2 below). The model describes events in a tissue consisting of a collection of homogeneous cells subject to ischemia or hypoxia, a homogeneous extracellular space surrounding three cells, a capillary compartment representing the vasculature for this piece of tissue, and another compartment corresponding to the healthy tissue surrounding the ischemic or hypoxic tissue. The first three compartments combine to form the damaged tissue.</para>
<para>
Model simulations produce a response to ischemia similar to that seen in neural tissue, and the mechanisms underlying this process in the model is elucidated. However, Yi
<emphasis>et al.</emphasis>
found that the same underlying mechanism is not present in the cardiac ion model, and they suggest that this difference may explain the qualitative difference in response observed in cardiac tissue.
</para>
<para>The complete original paper reference is cited below:</para>
<para>
<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMD-4789XHH-8&_user=140507&_coverDate=01%2F07%2F2003&_rdoc=8&_fmt=summary&_orig=browse&_srch=%23toc%236932%232003%23997799998%23365817!&_cdi=6932&_sort=d&_docanchor=&wchp=dGLbVzz-lSztz&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=d49670d50ea95b76f07fd616d782751a">A Mathematical Study of Volume Shifts and Ionic Concentration Changes during Ischemia and Hypoxia</ulink>
, Chung-Seon Yi, Aaron L. Fogelson, James P. Keener, and Charles S. Peskin, 2003,
<ulink url="http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=6932&_auth=y&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=c8e64d20ff203cda2255f4b6b7affe4f">
<emphasis>Theoretical Journal of Biology</emphasis>
</ulink>
, 220, 83-106. (A PDF version of the article is available to subscribers of the Theoretical Journal of Biology.)
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12453453&dopt=Abstract">PubMed ID: 12453453</ulink>
</para>
<informalfigure float="0" id="fig_schematic_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>schematic diagram</title>
</objectinfo>
<imagedata fileref="yi_2003a.png" />
</imageobject>
</mediaobject>
<caption>
A schematic diagram of the Yi
<emphasis>et al.</emphasis>
2003 mathematical model. In the tissue damaged by ischemia or hypoxia there are three compartments: an intracellular space within a collection of homogeneous cells; the extracellular space surrounding these cells; and the capillary space serving the cells. In addition there is a fourth compartment which represents the extracellular space of the undamaged tissue. The cell membrane separates the intracellular and extracellular compartments, and the capillary wall separates the extracellular space from the capillary space.
</caption>
</informalfigure>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="yi_2003b.png" />
</imageobject>
</mediaobject>
<caption>
A schematic diagram describing the ionic components of the Yi
<emphasis>et al.</emphasis>
2003 mathematical model. Sodium, chloride and potassium ions are exchanged between the intracellular and extracellular environments through channels and via the sodium-potassium pump. Water is also passed between the various components.
</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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</component>
<component name="intracellular_potassium">
<variable cmeta:id="intracellular_potassium.K_i" initial_value="139.0" name="K_i" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_potassium.g_K" name="g_K" public_interface="out" units="milliC_per_volt_per_minute" />
<variable cmeta:id="intracellular_potassium.delta_K" name="delta_K" public_interface="out" units="millivolt" />
<variable cmeta:id="intracellular_potassium.g_b_K" initial_value="8.33E-4" name="g_b_K" units="milliC_per_volt_per_minute" />
<variable cmeta:id="intracellular_potassium.g_K_max" initial_value="1.28E-2" name="g_K_max" units="milliC_per_volt_per_minute" />
<variable cmeta:id="intracellular_potassium.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="intracellular_potassium.K_e" name="K_e" public_interface="in" units="millimolar" />
<variable cmeta:id="intracellular_potassium.P" name="P" public_interface="in" units="micromole_per_minute" />
<variable cmeta:id="intracellular_potassium.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="intracellular_potassium.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="intracellular_potassium.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="intracellular_potassium.delta" name="delta" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="intracellular_potassium.delta_eq" name="delta_eq" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="intracellular_potassium.n_infinity" name="n_infinity" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="K_i_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<times />
<apply>
<divide />
<ci>g_K</ci>
<ci>F</ci>
</apply>
<apply>
<minus />
<ci>delta</ci>
<ci>delta_K</ci>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>P</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="g_K_calculation">
<eq />
<ci>g_K</ci>
<apply>
<plus />
<ci>g_b_K</ci>
<apply>
<times />
<ci>g_K_max</ci>
<apply>
<power />
<ci>n_infinity</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="delta_K_calculation">
<eq />
<ci>delta_K</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>K_e</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_potassium_n_gate">
<variable cmeta:id="intracellular_potassium_n_gate.n_infinity" name="n_infinity" public_interface="out" units="dimensionless" />
<variable cmeta:id="intracellular_potassium_n_gate.A_n" name="A_n" units="first_order_rate_constant" />
<variable cmeta:id="intracellular_potassium_n_gate.B_n" name="B_n" units="first_order_rate_constant" />
<variable cmeta:id="intracellular_potassium_n_gate.delta" name="delta" public_interface="in" units="millivolt" />
<variable cmeta:id="intracellular_potassium_n_gate.delta_eq" name="delta_eq" public_interface="in" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="A_n_calculation">
<eq />
<ci>A_n</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01</cn>
<apply>
<plus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.0</cn>
<ci>delta</ci>
</apply>
<ci>delta_eq</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
<apply>
<plus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.0</cn>
<ci>delta</ci>
</apply>
<ci>delta_eq</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply id="B_n_calculation">
<eq />
<ci>B_n</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="first_order_rate_constant">0.125</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<apply>
<minus />
<ci>delta</ci>
</apply>
<ci>delta_eq</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="n_infinity_calculation">
<eq />
<ci>n_infinity</ci>
<apply>
<divide />
<ci>A_n</ci>
<apply>
<plus />
<ci>A_n</ci>
<ci>B_n</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_chloride">
<variable cmeta:id="intracellular_chloride.Cl_i" initial_value="4.95" name="Cl_i" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_chloride.g_Cl" initial_value="2.81E-4" name="g_Cl" public_interface="out" units="milliC_per_volt_per_minute" />
<variable cmeta:id="intracellular_chloride.delta_Cl" name="delta_Cl" public_interface="out" units="millivolt" />
<variable cmeta:id="intracellular_chloride.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="intracellular_chloride.Cl_e" name="Cl_e" public_interface="in" units="millimolar" />
<variable cmeta:id="intracellular_chloride.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="intracellular_chloride.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="intracellular_chloride.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="intracellular_chloride.delta" name="delta" public_interface="in" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Cl_i_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Cl_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<ci>g_Cl</ci>
<ci>F</ci>
</apply>
<apply>
<plus />
<ci>delta</ci>
<ci>delta_Cl</ci>
</apply>
</apply>
</apply>
<apply id="delta_Cl_calculation">
<eq />
<ci>delta_Cl</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">-1.0</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>Cl_e</ci>
<ci>Cl_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="extracellular_sodium">
<variable cmeta:id="extracellular_sodium.Na_e" initial_value="140.0" name="Na_e" public_interface="out" units="millimolar" />
<variable cmeta:id="extracellular_sodium.delta_Na" name="delta_Na" public_interface="in" units="millivolt" />
<variable cmeta:id="extracellular_sodium.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="extracellular_sodium.g_Na" name="g_Na" public_interface="in" units="milliC_per_volt_per_minute" />
<variable cmeta:id="extracellular_sodium.P" name="P" public_interface="in" units="micromole_per_minute" />
<variable cmeta:id="extracellular_sodium.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="extracellular_sodium.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="extracellular_sodium.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="extracellular_sodium.delta" name="delta" public_interface="in" units="millivolt" />
<variable cmeta:id="extracellular_sodium.Jv_Na" name="Jv_Na" public_interface="in" units="cm3_millimolar_per_minute" />
<variable cmeta:id="extracellular_sodium.Jh_Na" name="Jh_Na" public_interface="in" units="cm3_millimolar_per_minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Na_e_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_e</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<apply>
<divide />
<ci>g_Na</ci>
<ci>F</ci>
</apply>
<apply>
<minus />
<ci>delta</ci>
<ci>delta_Na</ci>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>P</ci>
</apply>
</apply>
<apply>
<plus />
<ci>Jv_Na</ci>
<ci>Jh_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="extracellular_potassium">
<variable cmeta:id="extracellular_potassium.K_e" initial_value="5.4" name="K_e" public_interface="out" units="millimolar" />
<variable cmeta:id="extracellular_potassium.g_K" name="g_K" public_interface="in" units="milliC_per_volt_per_minute" />
<variable cmeta:id="extracellular_potassium.delta_K" name="delta_K" public_interface="in" units="millivolt" />
<variable cmeta:id="extracellular_potassium.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="extracellular_potassium.P" name="P" public_interface="in" units="micromole_per_minute" />
<variable cmeta:id="extracellular_potassium.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="extracellular_potassium.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="extracellular_potassium.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="extracellular_potassium.delta" name="delta" public_interface="in" units="millivolt" />
<variable cmeta:id="extracellular_potassium.Jv_K" name="Jv_K" public_interface="in" units="cm3_millimolar_per_minute" />
<variable cmeta:id="extracellular_potassium.Jh_K" name="Jh_K" public_interface="in" units="cm3_millimolar_per_minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="K_e_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K_e</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<times />
<apply>
<divide />
<ci>g_K</ci>
<ci>F</ci>
</apply>
<apply>
<minus />
<ci>delta</ci>
<ci>delta_K</ci>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>P</ci>
</apply>
</apply>
<apply>
<plus />
<ci>Jv_K</ci>
<ci>Jh_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="extracellular_chloride">
<variable cmeta:id="extracellular_chloride.Cl_e" initial_value="110.0" name="Cl_e" public_interface="out" units="millimolar" />
<variable cmeta:id="extracellular_chloride.g_Cl" name="g_Cl" public_interface="in" units="milliC_per_volt_per_minute" />
<variable cmeta:id="extracellular_chloride.delta_Cl" name="delta_Cl" public_interface="in" units="millivolt" />
<variable cmeta:id="extracellular_chloride.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="extracellular_chloride.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="extracellular_chloride.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="extracellular_chloride.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="extracellular_chloride.delta" name="delta" public_interface="in" units="millivolt" />
<variable cmeta:id="extracellular_chloride.Jv_Cl" name="Jv_Cl" public_interface="in" units="cm3_millimolar_per_minute" />
<variable cmeta:id="extracellular_chloride.Jh_Cl" name="Jh_Cl" public_interface="in" units="cm3_millimolar_per_minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Cl_e_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Cl_e</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<times />
<apply>
<divide />
<ci>g_Cl</ci>
<ci>F</ci>
</apply>
<apply>
<plus />
<ci>delta</ci>
<ci>delta_Cl</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<ci>Jv_Cl</ci>
<ci>Jh_Cl</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="extracellular_space">
<variable cmeta:id="extracellular_space.V_e" initial_value="9.50E-9" name="V_e" public_interface="out" units="cm3" />
<variable cmeta:id="extracellular_space.delta_e" name="delta_e" public_interface="out" units="millivolt" />
<variable cmeta:id="extracellular_space.X_e" initial_value="3.94E-9" name="X_e" public_interface="out" units="micromole" />
<variable cmeta:id="extracellular_space.z_e" initial_value="85.4" name="z_e" units="dimensionless" />
<variable cmeta:id="extracellular_space.Lie_p" name="Lie_p" public_interface="in" units="cm3_per_Pa_per_minute" />
<variable cmeta:id="extracellular_space.pi_i" name="pi_i" public_interface="in" units="Pa" />
<variable cmeta:id="extracellular_space.pi_e" name="pi_e" public_interface="in" units="Pa" />
<variable cmeta:id="extracellular_space.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="extracellular_space.Jv_H2O" name="Jv_H2O" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="extracellular_space.Jh_H2O" name="Jh_H2O" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="extracellular_space.Cl_e" name="Cl_e" public_interface="in" units="millimolar" />
<variable cmeta:id="extracellular_space.Na_e" name="Na_e" public_interface="in" units="millimolar" />
<variable cmeta:id="extracellular_space.K_e" name="K_e" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_e_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>V_e</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Lie_p</ci>
<apply>
<minus />
<ci>pi_e</ci>
<ci>pi_i</ci>
</apply>
</apply>
<apply>
<plus />
<ci>Jv_H2O</ci>
<ci>Jh_H2O</ci>
</apply>
</apply>
</apply>
<apply id="X_e_calculation">
<eq />
<ci>X_e</ci>
<apply>
<divide />
<apply>
<times />
<ci>V_e</ci>
<apply>
<minus />
<apply>
<plus />
<ci>Na_e</ci>
<ci>K_e</ci>
</apply>
<ci>Cl_e</ci>
</apply>
</apply>
<ci>z_e</ci>
</apply>
</apply>
</math>
</component>
<component name="water_flux">
<variable cmeta:id="water_flux.Jh_H2O" initial_value="0.0" name="Jh_H2O" public_interface="out" units="cm3_per_minute" />
<variable cmeta:id="water_flux.V_infinity_e" name="V_infinity_e" units="cm3" />
<variable cmeta:id="water_flux.V_infinity_T" name="V_infinity_T" units="cm3" />
<variable cmeta:id="water_flux.tau_1" initial_value="3.3" name="tau_1" units="minute" />
<variable cmeta:id="water_flux.tau_2" initial_value="33.0" name="tau_2" units="minute" />
<variable cmeta:id="water_flux.V_i" name="V_i" public_interface="in" units="cm3" />
<variable cmeta:id="water_flux.V_e" name="V_e" public_interface="in" units="cm3" />
<variable cmeta:id="water_flux.time" name="time" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Jh_H2O_calculation">
<eq />
<ci>Jh_H2O</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<ci>tau_1</ci>
</apply>
<apply>
<minus />
<ci>V_infinity_e</ci>
<ci>V_e</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<ci>tau_2</ci>
</apply>
<apply>
<minus />
<ci>V_infinity_T</ci>
<apply>
<plus />
<ci>V_i</ci>
<ci>V_e</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_flux">
<variable cmeta:id="sodium_flux.Jh_Na" initial_value="0.0" name="Jh_Na" public_interface="out" units="cm3_millimolar_per_minute" />
<variable cmeta:id="sodium_flux.Na_infinity_e" name="Na_infinity_e" units="millimolar" />
<variable cmeta:id="sodium_flux.alpha_Na" name="alpha_Na" units="dimensionless" />
<variable cmeta:id="sodium_flux.Na_e" name="Na_e" public_interface="in" units="millimolar" />
<variable cmeta:id="sodium_flux.delta_eh" name="delta_eh" public_interface="in" units="millivolt" />
<variable cmeta:id="sodium_flux.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="sodium_flux.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="sodium_flux.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="sodium_flux.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="sodium_flux.P_h" name="P_h" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="sodium_flux.Jh_H2O" name="Jh_H2O" public_interface="in" units="cm3_per_minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Jh_Na_calculation">
<eq />
<ci>Jh_Na</ci>
<apply>
<times />
<ci>P_h</ci>
<ci>alpha_Na</ci>
<apply>
<divide />
<apply>
<minus />
<ci>Na_infinity_e</ci>
<apply>
<times />
<ci>Na_e</ci>
<apply>
<exp />
<ci>alpha_Na</ci>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<ci>alpha_Na</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="alpha_Na_calculation">
<eq />
<ci>alpha_Na</ci>
<apply>
<minus />
<apply>
<divide />
<ci>Jh_H2O</ci>
<ci>P_h</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
<ci>delta_eh</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="potassium_flux">
<variable cmeta:id="potassium_flux.Jh_K" initial_value="0.0" name="Jh_K" public_interface="out" units="cm3_millimolar_per_minute" />
<variable cmeta:id="potassium_flux.K_infinity_e" name="K_infinity_e" units="millimolar" />
<variable cmeta:id="potassium_flux.alpha_K" name="alpha_K" units="dimensionless" />
<variable cmeta:id="potassium_flux.K_e" name="K_e" public_interface="in" units="millimolar" />
<variable cmeta:id="potassium_flux.delta_eh" name="delta_eh" public_interface="in" units="millivolt" />
<variable cmeta:id="potassium_flux.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="potassium_flux.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="potassium_flux.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="potassium_flux.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="potassium_flux.P_h" name="P_h" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="potassium_flux.Jh_H2O" name="Jh_H2O" public_interface="in" units="cm3_per_minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Jh_K_calculation">
<eq />
<ci>Jh_K</ci>
<apply>
<times />
<ci>P_h</ci>
<ci>alpha_K</ci>
<apply>
<divide />
<apply>
<minus />
<ci>K_infinity_e</ci>
<apply>
<times />
<ci>K_e</ci>
<apply>
<exp />
<ci>alpha_K</ci>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<ci>alpha_K</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="alpha_K_calculation">
<eq />
<ci>alpha_K</ci>
<apply>
<minus />
<apply>
<divide />
<ci>Jh_H2O</ci>
<ci>P_h</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
<ci>delta_eh</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="chloride_flux">
<variable cmeta:id="chloride_flux.Jh_Cl" initial_value="0.0" name="Jh_Cl" public_interface="out" units="cm3_millimolar_per_minute" />
<variable cmeta:id="chloride_flux.Cl_infinity_e" name="Cl_infinity_e" units="millimolar" />
<variable cmeta:id="chloride_flux.alpha_Cl" name="alpha_Cl" units="dimensionless" />
<variable cmeta:id="chloride_flux.Cl_e" name="Cl_e" public_interface="in" units="millimolar" />
<variable cmeta:id="chloride_flux.delta_eh" name="delta_eh" public_interface="in" units="millivolt" />
<variable cmeta:id="chloride_flux.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="chloride_flux.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="chloride_flux.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="chloride_flux.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="chloride_flux.P_h" name="P_h" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="chloride_flux.Jh_H2O" name="Jh_H2O" public_interface="in" units="cm3_per_minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Jh_Cl_calculation">
<eq />
<ci>Jh_Cl</ci>
<apply>
<times />
<ci>P_h</ci>
<ci>alpha_Cl</ci>
<apply>
<divide />
<apply>
<minus />
<ci>Cl_infinity_e</ci>
<apply>
<times />
<ci>Cl_e</ci>
<apply>
<exp />
<ci>alpha_Cl</ci>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<ci>alpha_Cl</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="alpha_Cl_calculation">
<eq />
<ci>alpha_Cl</ci>
<apply>
<minus />
<apply>
<divide />
<ci>Jh_H2O</ci>
<ci>P_h</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">-1.0</cn>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
<ci>delta_eh</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="capillary_compartment_sodium">
<variable cmeta:id="capillary_compartment_sodium.Na_v" initial_value="136.7" name="Na_v" public_interface="out" units="millimolar" />
<variable cmeta:id="capillary_compartment_sodium.delta_ev_Na" name="delta_ev_Na" public_interface="out" units="millivolt" />
<variable cmeta:id="capillary_compartment_sodium.Jv_Na" initial_value="0.0" name="Jv_Na" public_interface="out" units="cm3_millimolar_per_minute" />
<variable cmeta:id="capillary_compartment_sodium.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="capillary_compartment_sodium.Na_a" name="Na_a" public_interface="in" units="millimolar" />
<variable cmeta:id="capillary_compartment_sodium.Na_e" name="Na_e" public_interface="in" units="millimolar" />
<variable cmeta:id="capillary_compartment_sodium.Qv" name="Qv" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="capillary_compartment_sodium.Qa" name="Qa" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="capillary_compartment_sodium.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="capillary_compartment_sodium.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="capillary_compartment_sodium.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Na_v_calculation">
<eq />
<ci>Na_v</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<times />
<ci>Qa</ci>
<ci>Na_a</ci>
</apply>
<ci>Jv_Na</ci>
</apply>
<ci>Qv</ci>
</apply>
</apply>
<apply id="delta_ev_Na_calculation">
<eq />
<ci>delta_ev_Na</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>Na_v</ci>
<ci>Na_e</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="Jv_Na_calculation">
<eq />
<ci>Jv_Na</ci>
<apply>
<minus />
<apply>
<times />
<ci>Qv</ci>
<ci>Na_v</ci>
</apply>
<apply>
<times />
<ci>Qa</ci>
<ci>Na_a</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="capillary_compartment_potassium">
<variable cmeta:id="capillary_compartment_potassium.K_v" initial_value="5.27" name="K_v" public_interface="out" units="millimolar" />
<variable cmeta:id="capillary_compartment_potassium.delta_ev_K" name="delta_ev_K" public_interface="out" units="millivolt" />
<variable cmeta:id="capillary_compartment_potassium.Jv_K" initial_value="0.0" name="Jv_K" public_interface="out" units="cm3_millimolar_per_minute" />
<variable cmeta:id="capillary_compartment_potassium.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="capillary_compartment_potassium.K_a" name="K_a" public_interface="in" units="millimolar" />
<variable cmeta:id="capillary_compartment_potassium.K_e" name="K_e" public_interface="in" units="millimolar" />
<variable cmeta:id="capillary_compartment_potassium.Qv" name="Qv" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="capillary_compartment_potassium.Qa" name="Qa" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="capillary_compartment_potassium.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="capillary_compartment_potassium.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="capillary_compartment_potassium.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="K_v_calculation">
<eq />
<ci>K_v</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<times />
<ci>Qa</ci>
<ci>K_a</ci>
</apply>
<ci>Jv_K</ci>
</apply>
<ci>Qv</ci>
</apply>
</apply>
<apply id="delta_ev_K_calculation">
<eq />
<ci>delta_ev_K</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>K_v</ci>
<ci>K_e</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="Jv_K_calculation">
<eq />
<ci>Jv_K</ci>
<apply>
<minus />
<apply>
<times />
<ci>Qv</ci>
<ci>K_v</ci>
</apply>
<apply>
<times />
<ci>Qa</ci>
<ci>K_a</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="capillary_compartment_chloride">
<variable cmeta:id="capillary_compartment_chloride.Cl_v" initial_value="112.7" name="Cl_v" public_interface="out" units="millimolar" />
<variable cmeta:id="capillary_compartment_chloride.delta_ev_Cl" name="delta_ev_Cl" public_interface="out" units="millivolt" />
<variable cmeta:id="capillary_compartment_chloride.Jv_Cl" initial_value="0.0" name="Jv_Cl" public_interface="out" units="cm3_millimolar_per_minute" />
<variable cmeta:id="capillary_compartment_chloride.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="capillary_compartment_chloride.Cl_a" name="Cl_a" public_interface="in" units="millimolar" />
<variable cmeta:id="capillary_compartment_chloride.Cl_e" name="Cl_e" public_interface="in" units="millimolar" />
<variable cmeta:id="capillary_compartment_chloride.Qv" name="Qv" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="capillary_compartment_chloride.Qa" name="Qa" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="capillary_compartment_chloride.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="capillary_compartment_chloride.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="capillary_compartment_chloride.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Cl_v_calculation">
<eq />
<ci>Cl_v</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<times />
<ci>Qa</ci>
<ci>Cl_a</ci>
</apply>
<ci>Jv_Cl</ci>
</apply>
<ci>Qv</ci>
</apply>
</apply>
<apply id="delta_ev_Cl_calculation">
<eq />
<ci>delta_ev_Cl</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>Cl_v</ci>
<ci>Cl_e</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="Jv_Cl_calculation">
<eq />
<ci>Jv_Cl</ci>
<apply>
<minus />
<apply>
<times />
<ci>Qv</ci>
<ci>Cl_v</ci>
</apply>
<apply>
<times />
<ci>Qa</ci>
<ci>Cl_a</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="capillary_space">
<variable cmeta:id="capillary_space.pi_v" name="pi_v" public_interface="out" units="Pa" />
<variable cmeta:id="capillary_space.Qv" initial_value="3.6E-8" name="Qv" public_interface="out" units="cm3_per_minute" />
<variable cmeta:id="capillary_space.Pr_v" initial_value="1.45" name="Pr_v" public_interface="out" units="millimolar" />
<variable cmeta:id="capillary_space.Jv_H2O" name="Jv_H2O" public_interface="out" units="cm3_per_minute" />
<variable cmeta:id="capillary_space.z_v" initial_value="24.4" name="z_v" units="dimensionless" />
<variable cmeta:id="capillary_space.Qa" name="Qa" public_interface="in" units="cm3_per_minute" />
<variable cmeta:id="capillary_space.Na_v" name="Na_v" public_interface="in" units="millimolar" />
<variable cmeta:id="capillary_space.K_v" name="K_v" public_interface="in" units="millimolar" />
<variable cmeta:id="capillary_space.Cl_v" name="Cl_v" public_interface="in" units="millimolar" />
<variable cmeta:id="capillary_space.pi_e" name="pi_e" public_interface="in" units="Pa" />
<variable cmeta:id="capillary_space.time" name="time" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Qv_calculation">
<eq />
<ci>Qv</ci>
<apply>
<plus />
<ci>Qa</ci>
<ci>Jv_H2O</ci>
</apply>
</apply>
<apply id="Jv_H2O_calculation">
<eq />
<ci>Jv_H2O</ci>
<apply>
<minus />
<ci>Qv</ci>
<ci>Qa</ci>
</apply>
</apply>
<apply id="pi_v_calculation">
<eq />
<ci>pi_v</ci>
<apply>
<plus />
<ci>Na_v</ci>
<ci>K_v</ci>
<ci>Cl_v</ci>
<ci>Pr_v</ci>
</apply>
</apply>
<apply id="Pr_v_calculation">
<eq />
<ci>Pr_v</ci>
<apply>
<divide />
<apply>
<plus />
<ci>Na_v</ci>
<ci>K_v</ci>
<apply>
<minus />
<ci>Cl_v</ci>
</apply>
</apply>
<ci>z_v</ci>
</apply>
</apply>
</math>
</component>
<component name="arterial_space">
<variable cmeta:id="arterial_space.Qa" initial_value="3.6E-8" name="Qa" public_interface="out" units="cm3_per_minute" />
<variable cmeta:id="arterial_space.Na_a" initial_value="140.0" name="Na_a" public_interface="out" units="millimolar" />
<variable cmeta:id="arterial_space.K_a" initial_value="5.4" name="K_a" public_interface="out" units="millimolar" />
<variable cmeta:id="arterial_space.Cl_a" initial_value="110.0" name="Cl_a" public_interface="out" units="millimolar" />
<variable cmeta:id="arterial_space.Pr_a" initial_value="1.45" name="Pr_a" units="millimolar" />
<variable cmeta:id="arterial_space.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="arterial_space.Pr_v" name="Pr_v" public_interface="in" units="millimolar" />
<variable cmeta:id="arterial_space.Qv" name="Qv" public_interface="in" units="cm3_per_minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Qa_calculation">
<eq />
<ci>Qa</ci>
<apply>
<divide />
<apply>
<times />
<ci>Qv</ci>
<ci>Pr_v</ci>
</apply>
<ci>Pr_a</ci>
</apply>
</apply>
</math>
</component>
<component name="pump_rate">
<variable cmeta:id="pump_rate.P" name="P" public_interface="out" units="micromole_per_minute" />
<variable cmeta:id="pump_rate.P_max" initial_value="4.6E-8" name="P_max" units="micromole_per_minute" />
<variable cmeta:id="pump_rate.Km_Na_i" initial_value="10.0" name="Km_Na_i" units="millimolar" />
<variable cmeta:id="pump_rate.Km_K_e" initial_value="1.5" name="Km_K_e" units="millimolar" />
<variable cmeta:id="pump_rate.f_NaK" name="f_NaK" units="dimensionless" />
<variable cmeta:id="pump_rate.a_t" name="a_t" units="dimensionless" />
<variable cmeta:id="pump_rate.time" name="time" public_interface="in" units="minute" />
<variable cmeta:id="pump_rate.K_e" name="K_e" public_interface="in" units="millimolar" />
<variable cmeta:id="pump_rate.Na_i" name="Na_i" public_interface="in" units="millimolar" />
<variable cmeta:id="pump_rate.Na_e" name="Na_e" public_interface="in" units="millimolar" />
<variable cmeta:id="pump_rate.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="pump_rate.F" name="F" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="pump_rate.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="pump_rate.delta" name="delta" public_interface="in" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="P_calculation">
<eq />
<ci>P</ci>
<apply>
<times />
<ci>a_t</ci>
<ci>P_max</ci>
<ci>f_NaK</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<power />
<apply>
<divide />
<ci>Km_Na_i</ci>
<ci>Na_i</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<apply>
<divide />
<ci>K_e</ci>
<apply>
<plus />
<ci>Km_K_e</ci>
<ci>K_e</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="f_NaK_calculation">
<eq />
<ci>f_NaK</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">-0.1</cn>
<ci>delta</ci>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">-0.1</cn>
<ci>delta</ci>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<ci>Na_e</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">67.3</cn>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="a_t_calculation">
<eq />
<ci>a_t</ci>
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.35</cn>
<apply>
<divide />
<ci>time</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="minute">15.0</cn>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="intracellular_potassium">
<component_ref component="intracellular_potassium_n_gate" />
</component_ref>
<component_ref component="intracellular_sodium">
<component_ref component="intracellular_sodium_m_gate" />
<component_ref component="intracellular_sodium_h_gate" />
</component_ref>
</group>
<connection>
<map_components component_1="environment" component_2="capillary_compartment_sodium" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="intracellular_sodium" component_2="extracellular_sodium" />
<map_variables variable_1="g_Na" variable_2="g_Na" />
<map_variables variable_1="delta_Na" variable_2="delta_Na" />
</connection>
<connection>
<map_components component_1="intracellular_space" component_2="extracellular_sodium" />
<map_variables variable_1="T" variable_2="T" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="delta" variable_2="delta" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="environment" component_2="capillary_space" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="intracellular_sodium" component_2="intracellular_sodium_m_gate" />
<map_variables variable_1="delta_eq" variable_2="delta_eq" />
<map_variables variable_1="delta" variable_2="delta" />
</connection>
<connection>
<map_components component_1="water_flux" component_2="sodium_flux" />
<map_variables variable_1="Jh_H2O" variable_2="Jh_H2O" />
</connection>
<connection>
<map_components component_1="sodium_flux" component_2="extracellular_sodium" />
<map_variables variable_1="Jh_Na" variable_2="Jh_Na" />
</connection>
<connection>
<map_components component_1="extracellular_potassium" component_2="intracellular_potassium" />
<map_variables variable_1="K_e" variable_2="K_e" />
</connection>
<connection>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.Jh_K">
<dcterms:description>potassium flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_potassium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.g_K_max">
<dcterms:description>maximum voltage-dependent potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#potassium_flux.K_e">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_6">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.Qa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_90">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>arterial blood flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pump_rate.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.Jh_H2O">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_55">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#arterial_space.K_a">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_15">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of potassium in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.g_b_Na">
<dcterms:description>background sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.g_K">
<dcterms:description>potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.Cl_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_9">
<ro:part_of rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:17996" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#potassium_flux.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.V_e">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_3">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>interstitial volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Cl_e">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_8">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#potassium_flux.Jh_K">
<dcterms:description>potassium flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Cl_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_8" />
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#water_flux.V_infinity_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_60">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_3">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:70022" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>extracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_potassium.K_a">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_81">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_15">
<ro:part_of rdf:resource="#entity_13" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.delta_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_50">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>extracellular potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.h_infinity">
<dcterms:description>steady state function of sodium current H-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.C_m">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.K_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_6" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.A_s">
<dcterms:description>cell surface area</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.K_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_6" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_h_gate.h_infinity">
<dcterms:description>steady state function of sodium current H-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#water_flux.Jh_H2O">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_59">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#arterial_space.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#water_flux.V_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_63">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>interstitial volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.delta_ev_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_74">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>capillary sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#yi_fogelson_keener_peskin_2003_version01" semsim:modelName="yi_fogelson_keener_peskin_2003" bqmodel:isDescribedBy="12453453">
<semsim:unknown>Yi et al's 2003 mathematical model of volume shifts and ionic
concentration changes during ischemia and hypoxia.</semsim:unknown>
<semsim:unknown>Neurons</semsim:unknown>
<semsim:unknown>Cardiac Myocyte</semsim:unknown>
<semsim:modelName>yi_fogelson_keener_peskin_2003_version01</semsim:modelName>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_m_gate.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_11">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:63194" />
</rdf:Description>
<rdf:Description rdf:about="#water_flux.tau_1">
<dcterms:description>extracellular volume elastic time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.Cl_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_9">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of intracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#water_flux.V_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_3" />
<dcterms:description>interstitial volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#water_flux.tau_2">
<dcterms:description>total volume elastic time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#arterial_space.Cl_a">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_17">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of chloride in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.V_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_3" />
<dcterms:description>interstitial volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.delta_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>extracellular potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#potassium_flux.Jh_H2O">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_69">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.K_v">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_14">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of potassium in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.Lie_p">
<dcterms:description>cell membrane water permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.A_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#pump_rate.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_112">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.g_Na">
<dcterms:description>sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#arterial_space.Cl_a">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_103">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_17">
<ro:part_of rdf:resource="#entity_13" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:17996" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of chloride in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.P_max">
<dcterms:description>maximum pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_flux.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pump_rate.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Na_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_4" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#chloride_flux.Jh_Cl">
<dcterms:description>chloride flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.Cl_v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_85">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_16">
<ro:part_of>
<rdf:Description rdf:about="#entity_11">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:63194" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:17996" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of chloride in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_h_gate.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.Jh_K">
<dcterms:description>potassium flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#sodium_flux.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.m_infinity">
<dcterms:description>steady state function of sodium current M-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_flux.Na_infinity_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_64">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_4">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>steady state concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.Jv_K">
<dcterms:description>potassium flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#chloride_flux.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.Cl_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_56">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_8">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:17996" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.Cl_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_potassium.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_82">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_6">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#arterial_space.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#chloride_flux.P_h">
<dcterms:description>coupling coefficient for ion transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#chloride_flux.Jh_Cl">
<dcterms:description>chloride flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Cl_a">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_17" />
<dcterms:description>concentration of chloride in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Cl_i">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_9" />
<dcterms:description>concentration of intracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.z_e">
<dcterms:description>negative charges per protein molecule in interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.K_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_7">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#arterial_space.Qv">
<dcterms:description>capillary flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_n_gate.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.Jv_H2O">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_54">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.Cl_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_45">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_n_gate.A_n">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#chloride_flux.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#arterial_space.Qa">
<dcterms:description>arterial blood flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_chloride.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_36">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.Qv">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_77">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>capillary flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_space.z_v">
<dcterms:description>negative charges per protein molecule in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.B_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.Cl_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_8" />
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.Jv_Cl">
<dcterms:description>chloride flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.V_i">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_0" />
<dcterms:description>cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#water_flux.V_infinity_T">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_0" />
<dcterms:description>intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#sodium_flux.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.Km_Na_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_5">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.B_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.Na_i">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_5" />
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#sodium_flux.Jh_Na">
<dcterms:description>sodium flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.K_a">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_15" />
<dcterms:description>concentration of potassium in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#arterial_space.Pr_v">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_18">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:36080" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of protein in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_chloride.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_m_gate.m_infinity">
<dcterms:description>steady state function of sodium current M-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#potassium_flux.K_infinity_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_67">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>steady state concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pump_rate.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_109">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium_n_gate.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.delta_Cl">
<dcterms:description>chloride reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Cl_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_8" />
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.Jv_Cl">
<dcterms:description>chloride flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.V_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_49">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>interstitial volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#potassium_flux.K_infinity_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_6" />
<dcterms:description>steady state concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_flux.Jh_H2O">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_66">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.n_infinity">
<dcterms:description>steady state function of potassium current N-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.X_e">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_2">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:36080" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>number of protein molecules in interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_flux.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.Cl_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_8" />
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.z_i">
<dcterms:description>negative charges per protein molecule in cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_58">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.Jv_K">
<dcterms:description>potassium flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.delta_Cl">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_47">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>chloride reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.z_v">
<dcterms:description>negative charges per protein molecule in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.pi_e">
<dcterms:description>extracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Na_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_4" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.Jv_Na">
<dcterms:description>sodium flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_n_gate.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_31">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.delta_e">
<dcterms:description>extracellular potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Qa">
<dcterms:description>arterial blood flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.Qa">
<dcterms:description>arterial blood flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.Na_v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_73">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_10">
<ro:part_of rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium in capillaries</dcterms:description>
</rdf:Description>
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<rdf:Description rdf:about="#sodium_flux.Na_e">
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<rdf:Description rdf:about="#property_65">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
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<rdf:Description rdf:about="#capillary_space.Qv">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_92">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>capillary flow</dcterms:description>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Jv_Cl">
<dcterms:description>chloride flux from extracellular space to capillaries</dcterms:description>
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<rdf:Description rdf:about="#pump_rate.Km_K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_108">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>potassium half-saturation constant for sodium-potassium pump</dcterms:description>
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<rdf:Description rdf:about="#intracellular_potassium_n_gate.B_n">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.Km_K_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_6" />
<dcterms:description>potassium half-saturation constant for sodium-potassium pump</dcterms:description>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.pi_v">
<dcterms:description>capillary fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.h_infinity">
<dcterms:description>steady state function of sodium current H-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.delta_ev_Cl">
<dcterms:description>capillary chloride reversal potential</dcterms:description>
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<rdf:Description rdf:about="#capillary_compartment_potassium.Qa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_84">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
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</semsim:isComputationalComponentFor>
<dcterms:description>arterial blood flow</dcterms:description>
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<rdf:Description rdf:about="#potassium_flux.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.delta_e">
<dcterms:description>extracellular potential</dcterms:description>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#arterial_space.Na_a">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_12">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101" />
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</bqbiol:isPropertyOf>
<dcterms:description>concentration of sodium in arterial blood</dcterms:description>
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<rdf:Description rdf:about="#capillary_compartment_potassium.delta_ev_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_80">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>capillary potassium reversal potential</dcterms:description>
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<rdf:Description rdf:about="#pump_rate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#arterial_space.Na_a">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_101">
<semsim:physicalPropertyOf rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#arterial_space.Pr_v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_105">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_18">
<ro:part_of rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:36080" />
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</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of protein in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.Na_v">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_10">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101" />
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</bqbiol:isPropertyOf>
<dcterms:description>concentration of sodium in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.A_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#chloride_flux.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#chloride_flux.Jh_H2O">
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.Jh_Cl">
<dcterms:description>chloride flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.P_h">
<dcterms:description>coupling coefficient for ion transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_potassium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.Jh_Na">
<dcterms:description>sodium flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.X_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_1">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:36080" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>number of protein molecules per cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_m_gate.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#water_flux.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Qv">
<dcterms:description>capillary flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_m_gate.B_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#potassium_flux.P_h">
<dcterms:description>coupling coefficient for ion transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#chloride_flux.Cl_infinity_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_70">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>steady state concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_space.pi_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_99">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00509" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>extracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.pi_i">
<dcterms:description>intracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.pi_i">
<dcterms:description>intracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Na_i">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_5" />
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#potassium_flux.P_h">
<dcterms:description>coupling coefficient for ion transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.Qv">
<dcterms:description>capillary flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.h_infinity">
<dcterms:description>steady state function of sodium current H-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_h_gate.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Qv">
<dcterms:description>capillary flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.K_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_7">
<ro:part_of rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
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</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.g_Cl">
<dcterms:description>chloride current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_chloride.g_Cl">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_33">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
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</semsim:isComputationalComponentFor>
<dcterms:description>chloride current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.z_e">
<dcterms:description>negative charges per protein molecule in interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.delta_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_26">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.g_Cl">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_46">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
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</semsim:isComputationalComponentFor>
<dcterms:description>chloride current conductance</dcterms:description>
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<rdf:Description rdf:about="#intracellular_space.V_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
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</semsim:isComputationalComponentFor>
<dcterms:description>cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#chloride_flux.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#water_flux.Jh_H2O">
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
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<rdf:Description rdf:about="#intracellular_sodium_h_gate.A_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#potassium_flux.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.delta_ev_Cl">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_86">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>capillary chloride reversal potential</dcterms:description>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Jv_Na">
<dcterms:description>sodium flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_48">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#chloride_flux.Cl_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_71">
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular chloride</dcterms:description>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.R">
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.delta_Cl">
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.z_i">
<dcterms:description>negative charges per protein molecule in cell</dcterms:description>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.delta_Na">
<dcterms:description>sodium reversal potential</dcterms:description>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
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<rdf:Description rdf:about="#intracellular_potassium_n_gate.n_infinity">
<dcterms:description>steady state function of potassium current N-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.g_Cl">
<dcterms:description>chloride current conductance</dcterms:description>
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<rdf:Description rdf:about="#capillary_space.Jv_H2O">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_94">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
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</semsim:isComputationalComponentFor>
<dcterms:description>water flux from extracellular space to capillaries</dcterms:description>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.pi_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00509" />
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</semsim:isComputationalComponentFor>
<dcterms:description>intracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#chloride_flux.Cl_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_8" />
<dcterms:description>concentration of extracellular chloride</dcterms:description>
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<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.Na_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_4" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
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<rdf:Description rdf:about="#capillary_compartment_chloride.Cl_a">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of chloride in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.X_e">
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<rdf:Description rdf:about="#property_6">
<semsim:physicalPropertyOf>
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<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:36080" />
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00425" />
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<dcterms:description>number of protein molecules in interstitium</dcterms:description>
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<rdf:Description rdf:about="#property_61">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_space.Pr_v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_93">
<semsim:physicalPropertyOf rdf:resource="#entity_18" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of protein in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.pi_e">
<dcterms:description>extracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Cl_v">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_16">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of chloride in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.C_m">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.A_s">
<dcterms:description>cell surface area</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_40">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Na_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_4" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.K_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_6" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#chloride_flux.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.X_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_51">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>number of protein molecules in interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.Jh_Na">
<dcterms:description>sodium flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_h_gate.B_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.Cl_v">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_16" />
<dcterms:description>concentration of chloride in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pump_rate.P_max">
<dcterms:description>maximum pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.Na_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_4" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#sodium_flux.P_h">
<dcterms:description>coupling coefficient for ion transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.K_i">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_7" />
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#arterial_space.Pr_a">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_19">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:36080" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of protein in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.g_Na">
<dcterms:description>sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.Na_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_4" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.P_h">
<dcterms:description>coupling coefficient for ion transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#sodium_flux.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.Qv">
<dcterms:description>capillary flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_44">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#chloride_flux.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.K_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_6" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#yi_fogelson_keener_peskin_2003_version01" bqmodel:isDescribedBy="12453453" />
<rdf:Description rdf:about="#intracellular_space.Lie_p">
<dcterms:description>cell membrane water permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#arterial_space.Pr_a">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_104">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_19">
<ro:part_of rdf:resource="#entity_13" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:36080" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of protein in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#chloride_flux.P_h">
<dcterms:description>coupling coefficient for ion transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.K_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_24">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.Na_i">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_5" />
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_chloride.Cl_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_35">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#arterial_space.Qv">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_106">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>capillary flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.Cl_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_88">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_chloride.delta_Cl">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_34">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>chloride reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Jh_H2O">
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.X_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_1">
<ro:part_of rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:36080" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>number of protein molecules per cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_flux.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_space.Cl_v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_98">
<semsim:physicalPropertyOf rdf:resource="#entity_16" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of chloride in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#potassium_flux.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_potassium.K_v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_79">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_14">
<ro:part_of rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.delta_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Na_v">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_10" />
<dcterms:description>concentration of sodium in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.Jv_Cl">
<dcterms:description>chloride flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#water_flux.V_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_62">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#water_flux.V_infinity_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_3" />
<dcterms:description>extracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_potassium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_space.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#potassium_flux.Jh_H2O">
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_41">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_potassium.Qv">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_83">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>capillary flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.K_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_6" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.K_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_6" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium_n_gate.B_n">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#potassium_flux.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#chloride_flux.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_flux.Jh_Na">
<dcterms:description>sodium flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_29">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.m_infinity">
<dcterms:description>steady state function of sodium current M-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#water_flux.tau_1">
<dcterms:description>extracellular volume elastic time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#sodium_flux.Jh_H2O">
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.Jv_Na">
<dcterms:description>sodium flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Na_a">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_12" />
<dcterms:description>concentration of sodium in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#sodium_flux.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_chloride.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#entity_13">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:50720" />
</rdf:Description>
<rdf:Description rdf:about="#arterial_space.Qa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_100">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>arterial blood flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.pi_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_52">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00509" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>intracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#water_flux.tau_2">
<dcterms:description>total volume elastic time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_chloride.Cl_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_32">
<semsim:physicalPropertyOf rdf:resource="#entity_9" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.g_Na_max">
<dcterms:description>maximum voltage-dependent sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_potassium.Jv_K">
<dcterms:description>potassium flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_chloride.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pump_rate.Na_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_111">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#chloride_flux.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_flux.P_h">
<dcterms:description>coupling coefficient for ion transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#chloride_flux.Jh_H2O">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_72">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Qa">
<dcterms:description>arterial blood flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.delta_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_43">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium_n_gate.A_n">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.Jh_Cl">
<dcterms:description>chloride flux from damaged to healthy interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Jv_H2O">
<dcterms:description>water flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.Na_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_57">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#water_flux.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Lie_p">
<dcterms:description>cell membrane water permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.K_v">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_14" />
<dcterms:description>concentration of potassium in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.g_b_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>background sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.delta_eq">
<dcterms:description>equilibrium potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.Jv_K">
<dcterms:description>potassium flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Lie_p">
<dcterms:description>cell membrane water permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pump_rate.Km_Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_107">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.P">
<dcterms:description>pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.g_b_K">
<dcterms:description>background potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.Na_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_37">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.Na_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_76">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.Na_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.delta_ev_Na">
<dcterms:description>capillary sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.g_K_max">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_28">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>maximum voltage-dependent potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.n_infinity">
<dcterms:description>steady state function of potassium current N-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pump_rate.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.V_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>interstitial volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.delta_Na">
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium_n_gate.n_infinity">
<dcterms:description>steady state function of potassium current N-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_chloride.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.X_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_2" />
<dcterms:description>number of protein molecules in interstitium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.delta_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_30">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.Pr_v">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_18" />
<dcterms:description>concentration of protein in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_space.pi_e">
<dcterms:description>extracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#sodium_flux.Na_infinity_e">
<bqbiol:isPropertyOf rdf:resource="yi_fogelson_keener_peskin_2003.cellml#entity_4" />
<dcterms:description>steady state concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#arterial_space.K_a">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_102">
<semsim:physicalPropertyOf rdf:resource="#entity_15" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in arterial blood</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.delta_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.g_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_space.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_sodium.Qa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_78">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>arterial blood flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.g_Na_max">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>maximum voltage-dependent sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_space.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#extracellular_chloride.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#capillary_compartment_chloride.Qv">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_89">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00299" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>capillary flow</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.g_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_39">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_space.pi_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_53">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00509" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>extracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.g_b_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_27">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>background potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#pump_rate.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.pi_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00509" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>extracellular fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#potassium_flux.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_68">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.Na_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#potassium_flux.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium.m_infinity">
<dcterms:description>steady state function of sodium current M-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium.g_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_42">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pump_rate.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_110">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_space.pi_v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_91">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00509" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>capillary fluid pressure</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.Jv_Na">
<dcterms:description>sodium flux from extracellular space to capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#potassium_flux.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#potassium_flux.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_space.delta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_space.K_v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_97">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#capillary_space.Na_v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_96">
<semsim:physicalPropertyOf rdf:resource="#entity_10" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium in capillaries</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_sodium.delta_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.delta">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293" />
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium.g_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>potassium current conductance</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
