Location: Calcium Dynamics Annotations @ 4d6408caaf3e / yi_fogelson_keener_peskin_2003 / model / yi_fogelson_keener_peskin_2003.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-26 14:35:03+13:00
Desc:
modifying rdf files
Permanent Source URI:
https://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/yi_fogelson_keener_peskin_2003/model/yi_fogelson_keener_peskin_2003.rdf
Compare... Download Source 

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#potassium_flux.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Jv_H2O">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>water flux from extracellular space to capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.delta_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.Jv_Cl">
    <dcterms:description>chloride flux from extracellular space to capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Lie_p">
    <dcterms:description>cell membrane water permeability</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.V_e">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_3">
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>interstitial volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.X_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_1">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_0">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:66835"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:36080"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00425"/>
    <dcterms:description>number of protein molecules per cell</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.g_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>sodium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.P">
    <dcterms:description>pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.Na_e">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_4">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Na_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#sodium_flux.Jh_H2O">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#potassium_flux.Jh_K">
    <dcterms:description>potassium flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#chloride_flux.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.Jv_Na">
    <dcterms:description>sodium flux from extracellular space to capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium_n_gate.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.m_infinity">
    <dcterms:description>steady state function of sodium current M-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.delta_ev_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>capillary sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.pi_i">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00509"/>
    <dcterms:description>intracellular fluid pressure</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.Na_v">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_10">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_11">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:63194"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of sodium in capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Jv_Na">
    <dcterms:description>sodium flux from extracellular space to capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Cl_e">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_8">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular chloride</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#potassium_flux.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#water_flux.V_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>interstitial volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.K_e">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_6">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.Jh_Cl">
    <dcterms:description>chloride flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Qv">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>capillary flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Qv">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>capillary flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.P">
    <dcterms:description>pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.K_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#water_flux.tau_2">
    <dcterms:description>total volume elastic time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.g_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.P">
    <dcterms:description>pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#sodium_flux.P_h">
    <dcterms:description>coupling coefficient for ion transport</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#chloride_flux.Cl_infinity_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>steady state concentration of extracellular chloride</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.Cl_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular chloride</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.Jv_H2O">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>water flux from extracellular space to capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#water_flux.tau_1">
    <dcterms:description>extracellular volume elastic time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Na_a">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_12">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_13">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:50720"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of sodium in arterial blood</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.K_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#potassium_flux.Jh_H2O">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.g_Cl">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>chloride current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#sodium_flux.Na_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.K_v">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_14">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_11"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of potassium in capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#potassium_flux.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.Km_Na_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_5">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_0"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.delta_eq">
    <dcterms:description>equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#potassium_flux.K_infinity_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>steady state concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.h_infinity">
    <dcterms:description>steady state function of sodium current H-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#arterial_space.K_a">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_15">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_13"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of potassium in arterial blood</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.A_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium_n_gate.delta_eq">
    <dcterms:description>equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.pi_e">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00509"/>
    <dcterms:description>extracellular fluid pressure</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#chloride_flux.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Na_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.pi_e">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00509"/>
    <dcterms:description>extracellular fluid pressure</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Cl_v">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_16">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_11"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of chloride in capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.delta_i">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>intracellular potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.P_max">
    <dcterms:description>maximum pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#sodium_flux.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Qa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>arterial blood flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.Cl_v">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_16"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of chloride in capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.B_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Cl_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular chloride</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.K_v">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_14"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of potassium in capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.K_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_7">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_0"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#potassium_flux.P_h">
    <dcterms:description>coupling coefficient for ion transport</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.Jv_K">
    <dcterms:description>potassium flux from extracellular space to capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.Qv">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>capillary flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.delta_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#arterial_space.Pr_v">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_18">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_11"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:36080"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of protein in capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium_n_gate.n_infinity">
    <dcterms:description>steady state function of potassium current N-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.Jh_Na">
    <dcterms:description>sodium flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#arterial_space.Na_a">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_12"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of sodium in arterial blood</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.delta_ev_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>capillary potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.delta_Cl">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>chloride reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.Km_K_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>potassium half-saturation constant for sodium-potassium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#chloride_flux.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.Cl_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_9">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_0"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular chloride</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.K_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.delta_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#sodium_flux.Na_infinity_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>steady state concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#yi_fogelson_keener_peskin_2003_version01"
     semsim:modelName="yi_fogelson_keener_peskin_2003"
     bqmodel:isDescribedBy="12453453">
    <semsim:unknown>Yi et al's 2003 mathematical model of volume shifts and ionic 
        concentration changes during ischemia and hypoxia.</semsim:unknown>
    <semsim:unknown>Neurons</semsim:unknown>
    <semsim:unknown>Cardiac Myocyte</semsim:unknown>
    <semsim:modelName>yi_fogelson_keener_peskin_2003_version01</semsim:modelName>
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;Modelling Volume Shifts and Ionic Concentration Changes during Ischemia and Hypoxia&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Bioengineering Institute, University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This is the original unchecked version of the model imported from the previous&#xD;
            CellML model repository, 24-Jan-2006.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;Ischemia arises when both blood flow and oxygen transport to a tissue stop, while hypoxia describes a condition where normal blood flow continues but there is a reduction in the supply of oxygen to the tissue.  For both hypoxia and ischemia, depriving the tissue of oxygen causes cells to switch from aerobic to anaerobic respiration.  This results in reduced ATP synthesis, which in turn decreases the effectiveness of the cell membrane ion pumps, especially the Na-K-ATPase pump.  Additionally, in the case of ischemia, reduced blood flow has the effect of reducing the tissue's supply of metabolic substrates, and it also reduces the efficiency of waste product removal.&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Ischemia and hypoxia have been experimentally studied in a wide variety of species and different tissue types.  Tissue responses to ischemia include swelling of the intracellular space, shrinkage of the extracellular space, and an increase in the extracellular potassium concentration ([K&#xD;
        &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
        ]&#xD;
        &lt;subscript&gt;e&lt;/subscript&gt;&#xD;
        ).  In neural tissue, this increase in extracellular potassium concentration occurs in two stages; an initial rapid increase from about 5 mM to 55 mM, followed by a slower increase up to 80 mM.  In cardiac myocytes, there are generally three phases observed: a rapid increase, a relative plateau, and a second, slower increase.  These increases in extracellular potassium concentration may have important pathological consequences.  For example, in cardiac ischemia, the increased [K&#xD;
        &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
        ]&#xD;
        &lt;subscript&gt;e&lt;/subscript&gt;&#xD;
        may cause arrhythmias.&#xD;
      &lt;/para&gt;&#xD;
      &lt;para&gt;In 2003, Chung-Seon Yi, Aaron L. Fogelson, James P. Keener, and Charles S. Peskin studied the possible mechanisms underlying extracellular potassium accumulation during ischemia.  They developed a simple Hodgkin-Huxley type ionic model, which unlike other previously published models of cardiac myocytes, includes extracellular volume, capillary flow and the influence of nearby healthy tissue as variables (see figure 1 and figure 2 below).  The model describes events in a tissue consisting of a collection of homogeneous cells subject to ischemia or hypoxia, a homogeneous extracellular space surrounding three cells, a capillary compartment representing the vasculature for this piece of tissue, and another compartment corresponding to the healthy tissue surrounding the ischemic or hypoxic tissue.  The first three compartments combine to form the damaged tissue.&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Model simulations produce a response to ischemia similar to that seen in neural tissue, and the mechanisms underlying this process in the model is elucidated.  However, Yi&#xD;
        &lt;emphasis&gt;et al.&lt;/emphasis&gt;&#xD;
        found that the same underlying mechanism is not present in the cardiac ion model, and they suggest that this difference may explain the qualitative difference in response observed in cardiac tissue.&#xD;
      &lt;/para&gt;&#xD;
      &lt;para&gt;The complete original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        &lt;ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;amp;_udi=B6WMD-4789XHH-8&amp;amp;_user=140507&amp;amp;_coverDate=01%2F07%2F2003&amp;amp;_rdoc=8&amp;amp;_fmt=summary&amp;amp;_orig=browse&amp;amp;_srch=%23toc%236932%232003%23997799998%23365817!&amp;amp;_cdi=6932&amp;amp;_sort=d&amp;amp;_docanchor=&amp;amp;wchp=dGLbVzz-lSztz&amp;amp;_acct=C000011498&amp;amp;_version=1&amp;amp;_urlVersion=0&amp;amp;_userid=140507&amp;amp;md5=d49670d50ea95b76f07fd616d782751a"&gt;A Mathematical Study of Volume Shifts and Ionic Concentration Changes during Ischemia and Hypoxia&lt;/ulink&gt;&#xD;
        , Chung-Seon Yi, Aaron L. Fogelson, James P. Keener, and Charles S. Peskin, 2003,&#xD;
        &lt;ulink url="http://www.sciencedirect.com/science?_ob=JournalURL&amp;amp;_cdi=6932&amp;amp;_auth=y&amp;amp;_acct=C000011498&amp;amp;_version=1&amp;amp;_urlVersion=0&amp;amp;_userid=140507&amp;amp;md5=c8e64d20ff203cda2255f4b6b7affe4f"&gt;&#xD;
          &lt;emphasis&gt;Theoretical Journal of Biology&lt;/emphasis&gt;&#xD;
        &lt;/ulink&gt;&#xD;
        , 220, 83-106. (A PDF version of the article is available to subscribers of the Theoretical Journal of Biology.)&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;list_uids=12453453&amp;amp;dopt=Abstract"&gt;PubMed ID: 12453453&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_schematic_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;schematic diagram&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="yi_2003a.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;&#xD;
          A schematic diagram of the Yi&#xD;
          &lt;emphasis&gt;et al.&lt;/emphasis&gt;&#xD;
          2003 mathematical model.  In the tissue damaged by ischemia or hypoxia there are three compartments: an intracellular space within a collection of homogeneous cells; the extracellular space surrounding these cells; and the capillary space serving the cells.  In addition there is a fourth compartment which represents the extracellular space of the undamaged tissue.  The cell membrane separates the intracellular and extracellular compartments, and the capillary wall separates the extracellular space from the capillary space.&#xD;
        &lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
      &lt;informalfigure float="0" id="fig_cell_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;cell diagram&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="yi_2003b.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;&#xD;
          A schematic diagram describing the ionic components of the Yi&#xD;
          &lt;emphasis&gt;et al.&lt;/emphasis&gt;&#xD;
          2003 mathematical model.  Sodium, chloride and potassium ions are exchanged between the intracellular and extracellular environments through channels and via the sodium-potassium pump.  Water is also passed between the various components.&#xD;
        &lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#sodium_flux.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.g_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>sodium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.delta_ev_Cl">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>capillary chloride reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.g_b_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>background sodium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#potassium_flux.K_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#chloride_flux.Cl_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular chloride</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.g_K_max">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>maximum voltage-dependent potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.z_v">
    <dcterms:description>negative charges per protein molecule in capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#sodium_flux.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.delta_eq">
    <dcterms:description>equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.Na_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.delta_e">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>extracellular potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.pi_i">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00509"/>
    <dcterms:description>intracellular fluid pressure</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.delta_e">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>extracellular potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.P_h">
    <dcterms:description>coupling coefficient for ion transport</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Jh_H2O">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.K_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Cl_a">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_17">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_13"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of chloride in arterial blood</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.Pr_v">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_18"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of protein in capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.C_m">
    <dcterms:description>membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#potassium_flux.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#sodium_flux.Jh_Na">
    <dcterms:description>sodium flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.V_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>interstitial volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.X_e">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_2">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:36080"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00425"/>
    <dcterms:description>number of protein molecules in interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.Qa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>arterial blood flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#chloride_flux.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.Jv_K">
    <dcterms:description>potassium flux from extracellular space to capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#water_flux.V_infinity_T">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>intracellular volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.Qv">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>capillary flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.Na_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#arterial_space.Pr_a">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#entity_19">
        <bqbiol:isPartOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_13"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:36080"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of protein in arterial blood</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.delta_eq">
    <dcterms:description>equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Lie_p">
    <dcterms:description>cell membrane water permeability</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.h_infinity">
    <dcterms:description>steady state function of sodium current H-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#arterial_space.Qa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>arterial blood flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.z_i">
    <dcterms:description>negative charges per protein molecule in cell</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#water_flux.V_infinity_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>extracellular volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium_n_gate.B_n">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.P">
    <dcterms:description>pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#sodium_flux.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_chloride.g_Cl">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>chloride current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.A_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.K_a">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_15"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of potassium in arterial blood</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.A_s">
    <dcterms:description>cell surface area</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.Cl_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular chloride</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.g_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.P">
    <dcterms:description>pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#water_flux.Jh_H2O">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#arterial_space.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.K_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.X_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00425"/>
    <dcterms:description>number of protein molecules in interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.m_infinity">
    <dcterms:description>steady state function of sodium current M-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_h_gate.delta_eq">
    <dcterms:description>equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#water_flux.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.Cl_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular chloride</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_chloride.delta_Cl">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>chloride reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#chloride_flux.P_h">
    <dcterms:description>coupling coefficient for ion transport</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.g_b_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>background potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#chloride_flux.Jh_H2O">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>water flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium.n_infinity">
    <dcterms:description>steady state function of potassium current N-gate activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.pi_v">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00509"/>
    <dcterms:description>capillary fluid pressure</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#chloride_flux.Jh_Cl">
    <dcterms:description>chloride flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.delta">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.delta_eq">
    <dcterms:description>equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#environment.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_space.pi_e">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00509"/>
    <dcterms:description>extracellular fluid pressure</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.K_i">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_sodium.delta_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_space.z_e">
    <dcterms:description>negative charges per protein molecule in interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_potassium.Qa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>arterial blood flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#water_flux.V_i">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>cell volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.g_Na_max">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>maximum voltage-dependent sodium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.Cl_i">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular chloride</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_potassium_n_gate.A_n">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_sodium_m_gate.B_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Qa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>arterial blood flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.V_i">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>cell volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#arterial_space.Qv">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
    <dcterms:description>capillary flow</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Na_v">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of sodium in capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_chloride.Jv_Cl">
    <dcterms:description>chloride flux from extracellular space to capillaries</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#extracellular_potassium.Jh_K">
    <dcterms:description>potassium flux from damaged to healthy interstitium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#intracellular_space.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#pump_rate.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#arterial_space.Cl_a">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_17"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of chloride in arterial blood</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./yi_fogelson_keener_peskin_2003.cellml#capillary_compartment_sodium.Na_e">
    <bqbiol:isPropertyOf rdf:resource="./yi_fogelson_keener_peskin_2003.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
</rdf:RDF>