- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-24 21:48:10+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/87922e096f3129c61155044a054bf6a8742256fa/hilgemann_noble_1987/model/hilgemann_noble_1987.cellml
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Hilemann-Noble Atrial Cell Model 1987</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model is known to run in OpenCell and COR and reproduce the published results.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: Interactions of electrogenic sodium-calcium exchange, calcium channel and sarcoplasmic reticulum in the mammalian heart have been explored by simulation of extracellular calcium transients measured with tetramethylmurexide in rabbit atrium. The approach has been to use the simplest possible formulations of these mechanisms, which together with a minimum number of additional mechanisms allow reconstruction of action potentials, intracellular calcium transients and extracellular calcium transients. A 3:1 sodium-calcium exchange stoichiometry is assumed. Calcium-channel inactivation is assumed to take place by a voltage-dependent mechanism, which is accelerated by a rise in intracellular calcium; intracellular calcium release becomes a major physiological regulator of calcium influx via calcium channels. A calcium release mechanism is assumed, which is both calcium- and voltage-sensitive, and which undergoes prolonged inactivation. 200 microM cytosolic calcium buffer is assumed. For most simulations only instantaneous potassium conductances are simulated so as to study the other mechanisms independently of time- and calcium-dependent outward current. Thus, the model reconstructs extracellular calcium transients and typical action-potential configuration changes during steady-state and non-steady-state stimulation from the mechanisms directly involved in trans-sarcolemmal calcium movements. The model predicts relatively small trans-sarcolemmal calcium movements during regular stimulation (ca. 2 mumol kg-1 fresh mass per excitation); calcium current is fully activated within 2 ms of excitation, inactivation is substantially complete within 30 ms, and sodium-calcium exchange significantly resists repolarization from approximately -30 mV. Net calcium movements many times larger are possible during non-steady-state stimulation. Long action potentials at premature excitations or after inhibition of calcium release can be supported almost exclusively by calcium current (net calcium influx 5-30 mumol kg-1 fresh mass); action potentials during potentiated post-stimulatory contractions can be supported almost exclusively by sodium-calcium exchange (net calcium efflux 4-20 mumol kg-1 fresh mass). Large calcium movements between the extracellular space and the sarcoplasmic reticulum can take place through the cytosol with virtually no contractile activation. The simulations provide integrated explanations of electrical activity, contractile function and trans-sarcolemmal calcium movements, which were outside the explanatory range of previous models.</para>
<para>The original paper reference is cited below:</para>
<para>
Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of the basic cellular mechanisms, Hilemann, D.W. and Noble, D. 1987,
<emphasis>Proc. R. Soc. Lond.</emphasis>
, B230, 163-205.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2884668&dopt=Abstract">PubMed ID: 2884668</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram of the Hilemann-Noble model showing ionic currents across the sarcolemma</title>
</objectinfo>
<imagedata fileref="hilgemann_noble_1987.png" />
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</mediaobject>
<caption>A schematic diagram describing the current flows across the cell membrane that are captured in the Hilemann-Noble model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<variable cmeta:id="calcium_background_current.RTONF" name="RTONF" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_background_current.Ca_o" name="Ca_o" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_background_current.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E_Ca</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
<ci>RTONF</ci>
<apply>
<ln />
<apply>
<divide />
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_b_Ca</ci>
<apply>
<times />
<ci>g_b_Ca</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_exchanger">
<variable cmeta:id="Na_Ca_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="nanoA" />
<variable cmeta:id="Na_Ca_exchanger.k_NaCa" initial_value="0.01" name="k_NaCa" units="nanoA" />
<variable cmeta:id="Na_Ca_exchanger.n_NaCa" initial_value="3" name="n_NaCa" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger.d_NaCa" initial_value="0.0001" name="d_NaCa" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger.gamma" initial_value="0.5" name="gamma" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="Na_Ca_exchanger.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="Na_Ca_exchanger.RTONF" name="RTONF" public_interface="in" units="millivolt" />
<variable cmeta:id="Na_Ca_exchanger.Ca_o" name="Ca_o" public_interface="in" units="millimolar" />
<variable cmeta:id="Na_Ca_exchanger.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<variable cmeta:id="Na_Ca_exchanger.Na_i" name="Na_i" public_interface="in" units="millimolar" />
<variable cmeta:id="Na_Ca_exchanger.Na_o" name="Na_o" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_NaCa</ci>
<apply>
<divide />
<apply>
<times />
<ci>k_NaCa</ci>
<apply>
<minus />
<apply>
<times />
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>gamma</ci>
<apply>
<minus />
<ci>n_NaCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
<apply>
<power />
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times />
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>gamma</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>n_NaCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
<apply>
<power />
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
<apply>
<times />
<ci>d_NaCa</ci>
<apply>
<plus />
<apply>
<times />
<ci>Ca_i</ci>
<apply>
<power />
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<power />
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0069</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="potassium_background_current">
<variable cmeta:id="potassium_background_current.E_K" name="E_K" public_interface="in" units="millivolt" />
<variable cmeta:id="potassium_background_current.i_b_K" name="i_b_K" public_interface="out" units="nanoA" />
<variable cmeta:id="potassium_background_current.g_b_K" initial_value="0.17" name="g_b_K" units="microS" />
<variable cmeta:id="potassium_background_current.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="potassium_background_current.V" name="V" public_interface="in" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_b_K</ci>
<apply>
<times />
<ci>g_b_K</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="nanoA" />
<variable cmeta:id="time_independent_potassium_current.E_K" name="E_K" public_interface="out" units="millivolt" />
<variable cmeta:id="time_independent_potassium_current.g_K1" initial_value="1.7" name="g_K1" units="microS" />
<variable cmeta:id="time_independent_potassium_current.K_m_K1" initial_value="10" name="K_m_K1" units="millimolar" />
<variable cmeta:id="time_independent_potassium_current.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="time_independent_potassium_current.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="time_independent_potassium_current.RTONF" name="RTONF" public_interface="in" units="millivolt" />
<variable cmeta:id="time_independent_potassium_current.K_c" name="K_c" public_interface="in" units="millimolar" />
<variable cmeta:id="time_independent_potassium_current.K_i" name="K_i" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E_K</ci>
<apply>
<times />
<ci>RTONF</ci>
<apply>
<ln />
<apply>
<divide />
<ci>K_c</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_K1</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>g_K1</ci>
<ci>K_c</ci>
</apply>
<apply>
<plus />
<ci>K_c</ci>
<ci>K_m_K1</ci>
</apply>
</apply>
<apply>
<minus />
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<apply>
<minus />
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="second_inward_calcium_current">
<variable cmeta:id="second_inward_calcium_current.i_si" name="i_si" public_interface="out" units="nanoA" />
<variable cmeta:id="second_inward_calcium_current.i_siCa" name="i_siCa" public_interface="out" units="nanoA" />
<variable cmeta:id="second_inward_calcium_current.i_siK" name="i_siK" public_interface="out" units="nanoA" />
<variable cmeta:id="second_inward_calcium_current.i_siNa" name="i_siNa" public_interface="out" units="nanoA" />
<variable cmeta:id="second_inward_calcium_current.P_si" initial_value="5" name="P_si" units="nanoA_per_millimolar" />
<variable cmeta:id="second_inward_calcium_current.time" name="time" public_interface="in" private_interface="out" units="second" />
<variable cmeta:id="second_inward_calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="second_inward_calcium_current.Ca_i" name="Ca_i" public_interface="in" private_interface="out" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.RTONF" name="RTONF" public_interface="in" units="millivolt" />
<variable cmeta:id="second_inward_calcium_current.Na_i" name="Na_i" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.Na_o" name="Na_o" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.Ca_o" name="Ca_o" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.K_i" name="K_i" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.K_c" name="K_c" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.d" name="d" private_interface="in" units="dimensionless" />
<variable cmeta:id="second_inward_calcium_current.f_Ca" name="f_Ca" private_interface="in" units="dimensionless" />
<variable cmeta:id="second_inward_calcium_current.CaChon" name="CaChon" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_si</ci>
<apply>
<plus />
<ci>i_siCa</ci>
<ci>i_siK</ci>
<ci>i_siNa</ci>
</apply>
</apply>
<apply>
<eq />
<ci>i_siCa</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>P_si</ci>
<ci>d</ci>
<ci>CaChon</ci>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Ca_i</ci>
<apply>
<exp />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_siK</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.002</cn>
<ci>P_si</ci>
<ci>d</ci>
<ci>CaChon</ci>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>K_i</ci>
<apply>
<exp />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>K_c</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_siNa</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01</cn>
<ci>P_si</ci>
<ci>d</ci>
<ci>CaChon</ci>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Na_i</ci>
<apply>
<exp />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>Na_o</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="second_inward_calcium_current_d_gate">
<variable cmeta:id="second_inward_calcium_current_d_gate.d" initial_value="0.0011" name="d" public_interface="out" units="dimensionless" />
<variable cmeta:id="second_inward_calcium_current_d_gate.alpha_d" name="alpha_d" units="per_second" />
<variable cmeta:id="second_inward_calcium_current_d_gate.beta_d" name="beta_d" units="per_second" />
<variable cmeta:id="second_inward_calcium_current_d_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="second_inward_calcium_current_d_gate.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="second_inward_calcium_current_d_gate.delta_d" initial_value="0.0001" name="delta_d" units="millivolt" />
<variable cmeta:id="second_inward_calcium_current_d_gate.E0_d" name="E0_d" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E0_d</ci>
<apply>
<minus />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">24</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
</apply>
</apply>
<apply>
<eq />
<ci>alpha_d</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">120</cn>
<apply>
<lt />
<apply>
<abs />
<ci>E0_d</ci>
</apply>
<ci>delta_d</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">30</cn>
<ci>E0_d</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>E0_d</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<ci>beta_d</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">120</cn>
<apply>
<lt />
<apply>
<abs />
<ci>E0_d</ci>
</apply>
<ci>delta_d</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">12</cn>
<ci>E0_d</ci>
</apply>
<apply>
<minus />
<apply>
<exp />
<apply>
<divide />
<ci>E0_d</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>alpha_d</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>d</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_d</ci>
<ci>d</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="second_inward_calcium_current_f_Ca_gate">
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.f_Ca" initial_value="0.785" name="f_Ca" public_interface="out" units="dimensionless" />
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.alpha_f_Ca" name="alpha_f_Ca" units="per_second" />
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.beta_f_Ca" name="beta_f_Ca" units="per_second" />
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.CaChoff" name="CaChoff" units="dimensionless" />
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.CaChon" name="CaChon" public_interface="out" units="dimensionless" />
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.delta_f" initial_value="0.0001" name="delta_f" units="millivolt" />
<variable cmeta:id="second_inward_calcium_current_f_Ca_gate.E0_f" name="E0_f" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E0_f</ci>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34</cn>
</apply>
</apply>
<apply>
<eq />
<ci>alpha_f_Ca</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">25</cn>
<apply>
<lt />
<apply>
<abs />
<ci>E0_f</ci>
</apply>
<ci>delta_f</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">6.25</cn>
<ci>E0_f</ci>
</apply>
<apply>
<minus />
<apply>
<exp />
<apply>
<divide />
<ci>E0_f</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<ci>beta_f_Ca</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">12</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>E0_f</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>f_Ca</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">120</cn>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>f_Ca</ci>
</apply>
<ci>CaChoff</ci>
</apply>
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>f_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>CaChoff</ci>
</apply>
</apply>
</apply>
<ci>beta_f_Ca</ci>
</apply>
<apply>
<times />
<ci>alpha_f_Ca</ci>
<ci>f_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>CaChoff</ci>
<apply>
<divide />
<ci>Ca_i</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.001</cn>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>CaChon</ci>
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>f_Ca</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>CaChoff</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sarcoplasmic_reticulum_calcium_pump">
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.i_up" name="i_up" public_interface="out" units="millimolar_per_second" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_1" name="K_1" units="dimensionless" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_2" name="K_2" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_cyca" initial_value="0.0003" name="K_cyca" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_xcs" initial_value="0.4" name="K_xcs" units="dimensionless" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_srca" initial_value="0.5" name="K_srca" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.alpha_up" initial_value="3" name="alpha_up" units="millimolar_per_second" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.beta_up" initial_value="0.23" name="beta_up" units="millimolar_per_second" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.Ca_up" name="Ca_up" public_interface="in" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>K_1</ci>
<apply>
<divide />
<apply>
<times />
<ci>K_cyca</ci>
<ci>K_xcs</ci>
</apply>
<ci>K_srca</ci>
</apply>
</apply>
<apply>
<eq />
<ci>K_2</ci>
<apply>
<plus />
<ci>Ca_i</ci>
<apply>
<times />
<ci>Ca_up</ci>
<ci>K_1</ci>
</apply>
<apply>
<times />
<ci>K_cyca</ci>
<ci>K_xcs</ci>
</apply>
<ci>K_cyca</ci>
</apply>
</apply>
<apply>
<eq />
<ci>i_up</ci>
<apply>
<minus />
<apply>
<times />
<apply>
<divide />
<ci>Ca_i</ci>
<ci>K_2</ci>
</apply>
<ci>alpha_up</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>Ca_up</ci>
<ci>K_1</ci>
</apply>
<ci>K_2</ci>
</apply>
<ci>beta_up</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_release">
<variable cmeta:id="calcium_release_i_rel" name="i_rel" public_interface="out" units="millimolar_per_second" />
<variable cmeta:id="calcium_release.VoltDep" name="VoltDep" units="dimensionless" />
<variable cmeta:id="calcium_release.RegBindSite" name="RegBindSite" units="dimensionless" />
<variable cmeta:id="calcium_release.ActRate" name="ActRate" units="per_second" />
<variable cmeta:id="calcium_release.InactRate" name="InactRate" units="per_second" />
<variable cmeta:id="calcium_release.K_leak_rate" initial_value="0" name="K_leak_rate" units="per_second" />
<variable cmeta:id="calcium_release.K_m_rel" initial_value="250" name="K_m_rel" units="per_second" />
<variable cmeta:id="calcium_release.PrecFrac" name="PrecFrac" units="dimensionless" />
<variable cmeta:id="calcium_release.ActFrac" initial_value="0" name="ActFrac" units="dimensionless" />
<variable cmeta:id="calcium_release.ProdFrac" initial_value="0" name="ProdFrac" units="dimensionless" />
<variable cmeta:id="calcium_release.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="calcium_release.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_release.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_release.Ca_rel" name="Ca_rel" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>PrecFrac</ci>
<apply>
<minus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>ActFrac</ci>
</apply>
<ci>ProdFrac</ci>
</apply>
</apply>
<apply>
<eq />
<ci>VoltDep</ci>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08</cn>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>RegBindSite</ci>
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<apply>
<plus />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0005</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<eq />
<ci>ActRate</ci>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">600</cn>
<ci>VoltDep</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">500</cn>
<ci>RegBindSite</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>InactRate</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">60</cn>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">500</cn>
<ci>RegBindSite</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>ActFrac</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>PrecFrac</ci>
<ci>ActRate</ci>
</apply>
<apply>
<times />
<ci>ActFrac</ci>
<ci>InactRate</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>ProdFrac</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>ActFrac</ci>
<ci>InactRate</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">0.6</cn>
<ci>ProdFrac</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_rel</ci>
<apply>
<times />
<apply>
<plus />
<apply>
<times />
<apply>
<power />
<apply>
<divide />
<ci>ActFrac</ci>
<apply>
<plus />
<ci>ActFrac</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>K_m_rel</ci>
</apply>
<ci>K_leak_rate</ci>
</apply>
<ci>Ca_rel</ci>
</apply>
</apply>
</math>
</component>
<component name="calcium_translocation">
<variable cmeta:id="calcium_translocation_i_trans" name="i_trans" public_interface="out" units="millimolar_per_second" />
<variable cmeta:id="calcium_translocation.Ca_rel" name="Ca_rel" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_translocation.Ca_up" name="Ca_up" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_translocation.alpha_tr" initial_value="50" name="alpha_tr" units="per_second" />
<variable cmeta:id="calcium_translocation.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_trans</ci>
<apply>
<times />
<apply>
<minus />
<ci>Ca_up</ci>
<ci>Ca_rel</ci>
</apply>
<ci>alpha_tr</ci>
</apply>
</apply>
</math>
</component>
<component name="extracellular_sodium_concentration">
<variable cmeta:id="extracellular_sodium_concentration.Na_o" initial_value="140" name="Na_o" public_interface="out" units="millimolar" />
</component>
<component name="intracellular_sodium_concentration">
<variable cmeta:id="intracellular_sodium_concentration.Na_i" initial_value="6.5" name="Na_i" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_sodium_concentration.V_i" name="V_i" public_interface="in" units="micrometre3" />
<variable cmeta:id="intracellular_sodium_concentration.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="intracellular_sodium_concentration.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="intracellular_sodium_concentration.i_Na" name="i_Na" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_sodium_concentration.i_b_Na" name="i_b_Na" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_sodium_concentration.i_siNa" name="i_siNa" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_sodium_concentration.i_NaK" name="i_NaK" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_sodium_concentration.i_NaCa" name="i_NaCa" public_interface="in" units="nanoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<plus />
<ci>i_Na</ci>
<ci>i_b_Na</ci>
<apply>
<times />
<ci>i_NaK</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times />
<ci>i_NaCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>i_siNa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="extracellular_calcium_concentration">
<variable cmeta:id="extracellular_calcium_concentration.Ca_o" initial_value="2" name="Ca_o" public_interface="out" units="millimolar" />
<variable cmeta:id="extracellular_calcium_concentration.i_NaCa" name="i_NaCa" public_interface="in" units="nanoA" />
<variable cmeta:id="extracellular_calcium_concentration.Cab" initial_value="2" name="Cab" units="millimolar" />
<variable cmeta:id="extracellular_calcium_concentration.K_diff" initial_value="0.0005" name="K_diff" units="per_second" />
<variable cmeta:id="extracellular_calcium_concentration.Ve" name="Ve" public_interface="in" units="micrometre3" />
<variable cmeta:id="extracellular_calcium_concentration.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="extracellular_calcium_concentration.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="extracellular_calcium_concentration.i_siCa" name="i_siCa" public_interface="in" units="nanoA" />
<variable cmeta:id="extracellular_calcium_concentration.i_b_Ca" name="i_b_Ca" public_interface="in" units="nanoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_o</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<apply>
<minus />
<ci>Cab</ci>
<ci>Ca_o</ci>
</apply>
<ci>K_diff</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
<apply>
<plus />
<ci>i_siCa</ci>
<ci>i_NaCa</ci>
<ci>i_b_Ca</ci>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
<ci>Ve</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="extracellular_potassium_concentration">
<variable cmeta:id="extracellular_potassium_concentration.K_c" initial_value="4" name="K_c" public_interface="out" units="millimolar" />
</component>
<component name="intracellular_potassium_concentration">
<variable cmeta:id="intracellular_potassium_concentration.K_i" initial_value="140" name="K_i" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_potassium_concentration.V_i" name="V_i" public_interface="in" units="micrometre3" />
<variable cmeta:id="intracellular_potassium_concentration.i_K1" name="i_K1" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_potassium_concentration.i_siK" name="i_siK" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_potassium_concentration.i_b_K" name="i_b_K" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_potassium_concentration.i_NaK" name="i_NaK" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_potassium_concentration.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="intracellular_potassium_concentration.F" name="F" public_interface="in" units="coulomb_per_mole" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<plus />
<ci>i_K1</ci>
<ci>i_siK</ci>
<ci>i_b_K</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>i_NaK</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_calcium_concentration">
<variable cmeta:id="intracellular_calcium_concentration_Ca_i" initial_value="1e-5" name="Ca_i" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.Ca_up" initial_value="0.3" name="Ca_up" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.Ca_rel" initial_value="0.3" name="Ca_rel" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.Ca_Calmod" initial_value="0.0005" name="Ca_Calmod" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.Ca_Trop" initial_value="0.0015" name="Ca_Trop" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.Calmod" initial_value="0.02" name="Calmod" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.Trop" initial_value="0.15" name="Trop" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.alpha_Calmod" initial_value="100000" name="alpha_Calmod" units="per_millimolar_second" />
<variable cmeta:id="intracellular_calcium_concentration.beta_Calmod" initial_value="50" name="beta_Calmod" units="per_second" />
<variable cmeta:id="intracellular_calcium_concentration.alpha_Trop" initial_value="100000" name="alpha_Trop" units="per_millimolar_second" />
<variable cmeta:id="intracellular_calcium_concentration.beta_Trop" initial_value="200" name="beta_Trop" units="per_second" />
<variable cmeta:id="intracellular_calcium_concentration.radius" initial_value="0.08" name="radius" units="micrometre" />
<variable cmeta:id="intracellular_calcium_concentration.length" initial_value="0.08" name="length" units="micrometre" />
<variable cmeta:id="intracellular_calcium_concentration.V_i" name="V_i" public_interface="out" units="micrometre3" />
<variable cmeta:id="intracellular_calcium_concentration.Ve" name="Ve" public_interface="out" units="micrometre3" />
<variable cmeta:id="intracellular_calcium_concentration.V_Cell" name="V_Cell" units="micrometre3" />
<variable cmeta:id="intracellular_calcium_concentration.V_i_ratio" name="V_i_ratio" units="dimensionless" />
<variable cmeta:id="intracellular_calcium_concentration.V_rel_ratio" initial_value="0.1" name="V_rel_ratio" units="dimensionless" />
<variable cmeta:id="intracellular_calcium_concentration.V_e_ratio" initial_value="0.4" name="V_e_ratio" units="dimensionless" />
<variable cmeta:id="intracellular_calcium_concentration.V_up_ratio" initial_value="0.01" name="V_up_ratio" units="dimensionless" />
<variable cmeta:id="intracellular_calcium_concentration.i_up" name="i_up" public_interface="in" units="millimolar_per_second" />
<variable cmeta:id="intracellular_calcium_concentration.i_trans" name="i_trans" public_interface="in" units="millimolar_per_second" />
<variable cmeta:id="intracellular_calcium_concentration.i_rel" name="i_rel" public_interface="in" units="millimolar_per_second" />
<variable cmeta:id="intracellular_calcium_concentration.i_NaCa" name="i_NaCa" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_calcium_concentration.i_siCa" name="i_siCa" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_calcium_concentration.i_b_Ca" name="i_b_Ca" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_calcium_concentration.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="intracellular_calcium_concentration.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="intracellular_calcium_concentration.dCaCalmoddt" name="dCaCalmoddt" units="millimolar_per_second" />
<variable cmeta:id="intracellular_calcium_concentration.dCaTropdt" name="dCaTropdt" units="millimolar_per_second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>V_Cell</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.141592654</cn>
<apply>
<power />
<ci>radius</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>length</ci>
</apply>
</apply>
<apply>
<eq />
<ci>V_i_ratio</ci>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>V_e_ratio</ci>
</apply>
<ci>V_up_ratio</ci>
</apply>
<ci>V_rel_ratio</ci>
</apply>
</apply>
<apply>
<eq />
<ci>V_i</ci>
<apply>
<times />
<ci>V_Cell</ci>
<ci>V_i_ratio</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Ve</ci>
<apply>
<times />
<ci>V_Cell</ci>
<ci>V_e_ratio</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<plus />
<ci>i_siCa</ci>
<ci>i_b_Ca</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>i_rel</ci>
<ci>V_rel_ratio</ci>
</apply>
<ci>V_i_ratio</ci>
</apply>
</apply>
<ci>dCaCalmoddt</ci>
</apply>
<ci>dCaTropdt</ci>
</apply>
<ci>i_up</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_up</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<apply>
<divide />
<ci>V_i_ratio</ci>
<ci>V_up_ratio</ci>
</apply>
<ci>i_up</ci>
</apply>
<ci>i_trans</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_rel</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<apply>
<divide />
<ci>V_up_ratio</ci>
<ci>V_rel_ratio</ci>
</apply>
<ci>i_trans</ci>
</apply>
<ci>i_rel</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Calmod</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>alpha_Calmod</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Trop</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>alpha_Trop</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>dCaCalmoddt</ci>
<apply>
<minus />
<apply>
<times />
<ci>alpha_Calmod</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>dCaTropdt</ci>
<apply>
<minus />
<apply>
<times />
<ci>alpha_Trop</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment" />
<component_ref component="membrane">
<component_ref component="intracellular_potassium_concentration" />
<component_ref component="extracellular_calcium_concentration" />
<component_ref component="intracellular_calcium_concentration" />
<component_ref component="second_inward_calcium_current">
<component_ref component="second_inward_calcium_current_d_gate" />
<component_ref component="second_inward_calcium_current_f_Ca_gate" />
</component_ref>
<component_ref component="calcium_translocation" />
<component_ref component="intracellular_sodium_concentration" />
<component_ref component="sodium_potassium_pump" />
<component_ref component="potassium_background_current" />
<component_ref component="sarcoplasmic_reticulum_calcium_pump" />
<component_ref component="time_independent_potassium_current" />
<component_ref component="extracellular_sodium_concentration" />
<component_ref component="calcium_background_current" />
<component_ref component="calcium_release" />
<component_ref component="sodium_background_current" />
<component_ref component="Na_Ca_exchanger" />
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_h_gate" />
<component_ref component="fast_sodium_current_m_gate" />
</component_ref>
<component_ref component="extracellular_potassium_concentration" />
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="second_inward_calcium_current">
<component_ref component="second_inward_calcium_current_d_gate" />
<component_ref component="second_inward_calcium_current_f_Ca_gate" />
</component_ref>
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_h_gate" />
<component_ref component="fast_sodium_current_m_gate" />
</component_ref>
</group>
<connection>
<map_components component_1="environment" component_2="calcium_release" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="membrane" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="environment" component_2="Na_Ca_exchanger" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="membrane" component_2="potassium_background_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_siNa" variable_2="i_siNa" />
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="K_c" variable_2="K_c" />
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="potassium_background_current" />
<map_variables variable_1="E_K" variable_2="E_K" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="i_siK" variable_2="i_siK" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current_f_Ca_gate" component_2="second_inward_calcium_current" />
<map_variables variable_1="CaChon" variable_2="CaChon" />
<map_variables variable_1="f_Ca" variable_2="f_Ca" />
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_background_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="fast_sodium_current_h_gate" component_2="fast_sodium_current" />
<map_variables variable_1="h" variable_2="h" />
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="i_K1" variable_2="i_K1" />
</connection>
<connection>
<map_components component_1="extracellular_sodium_concentration" component_2="fast_sodium_current" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current_d_gate" component_2="second_inward_calcium_current" />
<map_variables variable_1="d" variable_2="d" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="calcium_release" />
<map_variables variable_1="Ca_rel" variable_2="Ca_rel" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="i_NaCa" variable_2="i_NaCa" />
</connection>
<connection>
<map_components component_1="membrane" component_2="second_inward_calcium_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="environment" component_2="calcium_translocation" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="Na_Ca_exchanger" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="fast_sodium_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="sodium_potassium_pump" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_Na" variable_2="i_Na" />
</connection>
<connection>
<map_components component_1="sarcoplasmic_reticulum_calcium_pump" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_up" variable_2="i_up" />
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca" />
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="sodium_potassium_pump" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="calcium_background_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="extracellular_calcium_concentration" component_2="Na_Ca_exchanger" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_background_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="membrane" />
<map_variables variable_1="i_si" variable_2="i_si" />
</connection>
<connection>
<map_components component_1="extracellular_calcium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="sarcoplasmic_reticulum_calcium_pump" />
<map_variables variable_1="Ca_up" variable_2="Ca_up" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_b_Na" variable_2="i_b_Na" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="membrane" />
<map_variables variable_1="i_NaCa" variable_2="i_NaCa" />
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_NaK" variable_2="i_NaK" />
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="membrane" />
<map_variables variable_1="i_b_Na" variable_2="i_b_Na" />
</connection>
<connection>
<map_components component_1="extracellular_sodium_concentration" component_2="Na_Ca_exchanger" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="environment" component_2="sodium_background_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="membrane" />
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca" />
</connection>
<connection>
<map_components component_1="potassium_background_current" component_2="membrane" />
<map_variables variable_1="i_b_K" variable_2="i_b_K" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="i_siCa" variable_2="i_siCa" />
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="membrane" />
<map_variables variable_1="i_Na" variable_2="i_Na" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="second_inward_calcium_current_d_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="fast_sodium_current" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="extracellular_calcium_concentration" component_2="calcium_background_current" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_NaCa" variable_2="i_NaCa" />
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_release" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_exchanger" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="calcium_release" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_rel" variable_2="i_rel" />
</connection>
<connection>
<map_components component_1="environment" component_2="membrane" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="sodium_potassium_pump" />
<map_variables variable_1="K_c" variable_2="K_c" />
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="fast_sodium_current" />
<map_variables variable_1="K_c" variable_2="K_c" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="V_i" variable_2="V_i" />
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="membrane" />
<map_variables variable_1="i_K1" variable_2="i_K1" />
</connection>
<connection>
<map_components component_1="environment" component_2="potassium_background_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="fast_sodium_current_m_gate" component_2="fast_sodium_current" />
<map_variables variable_1="m" variable_2="m" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="second_inward_calcium_current_f_Ca_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="sodium_background_current" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="membrane" />
<map_variables variable_1="i_NaK" variable_2="i_NaK" />
</connection>
<connection>
<map_components component_1="intracellular_potassium_concentration" component_2="fast_sodium_current" />
<map_variables variable_1="K_i" variable_2="K_i" />
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="i_NaK" variable_2="i_NaK" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_siCa" variable_2="i_siCa" />
</connection>
<connection>
<map_components component_1="potassium_background_current" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="i_b_K" variable_2="i_b_K" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="Na_Ca_exchanger" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_NaCa" variable_2="i_NaCa" />
</connection>
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<dcterms:description>concentration of extracellular calcium</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current.K_i">
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<rdf:Description rdf:about="#property_64">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current_h_gate.alpha_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.Ca_i">
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<dcterms:description>concentration of intracellular calcium</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.alpha_Calmod">
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<rdf:Description rdf:about="#fast_sodium_current_m_gate.E0_m">
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<rdf:Description rdf:about="#property_18">
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<dcterms:description>fast sodium current M-gate reversal potential</dcterms:description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#Na_Ca_exchanger.RTONF">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Ve">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.T">
<dcterms:description>absolute temperature</dcterms:description>
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<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.i_up">
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<rdf:Description rdf:about="#property_71">
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</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux into sarcoplasmic reticulum through SERCA pumps</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_potassium_concentration.i_K1">
<dcterms:description>time-independent potassium current</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#intracellular_calcium_concentration.beta_Calmod">
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</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#potassium_background_current.i_b_K">
<dcterms:description>background potassium current</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current.Ca_i">
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<rdf:Description rdf:about="#property_60">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
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<rdf:Description rdf:about="#calcium_release_i_rel">
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<rdf:Description rdf:about="#property_77">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
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</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux out of sarcoplasmic reticulum through ryanodine receptors</dcterms:description>
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<rdf:Description rdf:about="#intracellular_potassium_concentration.i_K1">
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<rdf:Description rdf:about="#property_101">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_release.time">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#entity_5">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022" />
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Ca_rel">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#entity_9">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226050" />
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</bqbiol:isPropertyOf>
<dcterms:description>concentration of calcium in release site</dcterms:description>
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<rdf:Description rdf:about="#calcium_background_current.V">
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<rdf:Description rdf:about="#property_35">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.dCaTropdt">
<dcterms:description>rate of change of calcium-bound troponin</dcterms:description>
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<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.alpha_up">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="#sodium_potassium_pump_i_NaK">
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<rdf:Description rdf:about="#property_20">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_release.InactRate">
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</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_background_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#second_inward_calcium_current.Na_o">
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<rdf:Description rdf:about="#property_62">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.E0_f">
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<rdf:Description rdf:about="#property_70">
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.i_trans">
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<rdf:Description rdf:about="#property_116">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
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</semsim:isComputationalComponentFor>
<dcterms:description>calcium transfer flux from the network sarcoplasmic reticulum to the junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#potassium_background_current.E_K">
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<rdf:Description rdf:about="#property_44">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>potassium reversal potential</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.alpha_Trop">
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<rdf:Description rdf:about="#second_inward_calcium_current.i_siNa">
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<rdf:Description rdf:about="#property_58">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>second inward sodium current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_potassium_concentration.i_b_K">
<dcterms:description>background potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release.InactRate">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current.Na_i">
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<rdf:Description rdf:about="#property_14">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_2">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29101" />
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</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#extracellular_calcium_concentration.Ca_o">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_7" />
<dcterms:description>concentration of extracellular calcium</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.delta_f">
<dcterms:description>saturation potential of second inward calcium current inactivation gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.stim_duration">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release.K_m_rel">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_rel_ratio">
<dcterms:description>volume ratio of release site</dcterms:description>
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<rdf:Description rdf:about="#intracellular_sodium_concentration.i_NaCa">
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<rdf:Description rdf:about="#property_91">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current.K_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_potassium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release.RegBindSite">
<dcterms:description>regulatory calcium binding site</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current_h_gate.V">
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<rdf:Description rdf:about="#property_19">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_release.RegBindSite">
<dcterms:description>regulatory calcium binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current.E_mh">
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<rdf:Description rdf:about="#property_11">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>fast sodium current H-gate reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current.g_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
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</semsim:isComputationalComponentFor>
<dcterms:description>fast sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Trop">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#entity_12">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62338" />
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</bqbiol:isPropertyOf>
<dcterms:description>concentration of troponin</dcterms:description>
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<rdf:Description rdf:about="#intracellular_sodium_concentration.i_siNa">
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<rdf:Description rdf:about="#property_89">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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<dcterms:description>second inward sodium current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.P_si">
<dcterms:description>maximum second inward calcium current conductance</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current.h">
<dcterms:description>fast sodium current inactivation variable</dcterms:description>
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<rdf:Description rdf:about="#calcium_release.Ca_i">
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<rdf:Description rdf:about="#property_79">
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.CaChon">
<dcterms:description>fraction of channels inactivated by voltage-dependent process</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#extracellular_calcium_concentration.F">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_trans">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sodium_potassium_pump.K_c">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#entity_4">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
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</bqbiol:isPropertyOf>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current.time">
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<rdf:Description rdf:about="#time_independent_potassium_current.V">
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<dcterms:description>membrane potential</dcterms:description>
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<dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.i_siCa">
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<rdf:Description rdf:about="#calcium_background_current.Ca_o">
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<rdf:Description rdf:about="#property_36">
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<dcterms:description>concentration of extracellular calcium</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.K_xcs">
<dcterms:description>rate of calcium transfer between cytosol and sarcoplasmic reticulum</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#Na_Ca_exchanger.V">
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_background_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
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<rdf:Description rdf:about="#property_108">
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<ro:part_of rdf:resource="#entity_3" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium-bound calmodulin</dcterms:description>
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<dcterms:description>concentration of calcium-bound calmodulin</dcterms:description>
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<dcterms:description>concentration of calcium in release site</dcterms:description>
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<rdf:Description rdf:about="#time_independent_potassium_current.RTONF">
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<rdf:Description rdf:about="#sodium_potassium_pump.K_mNa">
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<rdf:Description rdf:about="#property_22">
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<dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#time_independent_potassium_current.V">
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current_m_gate.delta_m">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.stim_end">
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<rdf:Description rdf:about="#potassium_background_current.i_b_K">
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<rdf:Description rdf:about="#property_45">
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<dcterms:description>background potassium current</dcterms:description>
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<rdf:Description rdf:about="#extracellular_calcium_concentration.Ve">
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<rdf:Description rdf:about="#property_95">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_8">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:67196" />
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
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</semsim:isComputationalComponentFor>
<dcterms:description>volume of endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.K_xcs">
<dcterms:description>rate of calcium transfer between cytosol and sarcoplasmic reticulum</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current_h_gate.time">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.beta_up">
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<rdf:Description rdf:about="#calcium_release.ActFrac">
<dcterms:description>activator fraction</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_sodium_concentration.time">
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<rdf:Description rdf:about="#extracellular_calcium_concentration.Cab">
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<rdf:Description rdf:about="#property_94">
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_m_gate.V">
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<rdf:Description rdf:about="#property_17">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#sodium_potassium_pump.V">
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<rdf:Description rdf:about="#property_23">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#calcium_release.V">
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<rdf:Description rdf:about="#property_78">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#potassium_background_current.g_b_K">
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<rdf:Description rdf:about="#property_46">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
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</semsim:isComputationalComponentFor>
<dcterms:description>potassium background current conductance</dcterms:description>
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<rdf:Description rdf:about="#sodium_potassium_pump.Na_i">
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<rdf:Description rdf:about="#property_24">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
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<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.K_cyca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_73">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>half-saturation constant of calcium binding to cytosolic enzymes</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_concentration.K_i">
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<rdf:Description rdf:about="#property_99">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.K_cyca">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
<dcterms:description>half-saturation constant of calcium binding to cytosolic enzymes</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current.d">
<dcterms:description>second inward calcium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.i_siK">
<dcterms:description>second inward potassium current</dcterms:description>
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<rdf:Description rdf:about="#intracellular_sodium_concentration.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_85">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
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<rdf:Description rdf:about="#intracellular_sodium_concentration.i_b_Na">
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<rdf:Description rdf:about="#property_88">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.dCaCalmoddt">
<dcterms:description>rate of change of calcium-bound calmodulin</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current.m">
<dcterms:description>fast sodium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#Na_Ca_exchanger.Na_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_2" />
<dcterms:description>concentration of intracellular sodium</dcterms:description>
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<rdf:Description rdf:about="#sodium_background_current_i_b_Na">
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<rdf:Description rdf:about="#property_27">
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</semsim:isComputationalComponentFor>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_background_current.E_Ca">
<dcterms:description>calcium reversal potential</dcterms:description>
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<rdf:Description rdf:about="#intracellular_calcium_concentration.dCaCalmoddt">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_121">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>rate of change of calcium-bound calmodulin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.dCaTropdt">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_122">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>rate of change of calcium-bound troponin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_h_gate.beta_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="#intracellular_calcium_concentration.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#extracellular_calcium_concentration.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sodium_background_current.V">
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#intracellular_potassium_concentration.V_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_100">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>cytosolic volume</dcterms:description>
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<rdf:Description rdf:about="#Na_Ca_exchanger_i_NaCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#extracellular_calcium_concentration.K_diff">
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<rdf:Description rdf:about="#second_inward_calcium_current_d_gate.delta_d">
<dcterms:description>saturation potential of second inward calcium current activation gate</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sodium_background_current.E_Na">
<dcterms:description>sodium reversal potential</dcterms:description>
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<dcterms:description>second inward calcium current activation variable</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_sodium_concentration.V_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_9" />
<dcterms:description>cytosolic volume</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sodium_potassium_pump.i_NaK_max">
<dcterms:description>maximum sodium-potassium pump current</dcterms:description>
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<rdf:Description rdf:about="#time_independent_potassium_current.g_K1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_50">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
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</semsim:isComputationalComponentFor>
<dcterms:description>time-independent potassium current conductance</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#time_independent_potassium_current.K_m_K1">
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<dcterms:description>calcium half-saturation constant for time-independent potassium current</dcterms:description>
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<rdf:Description rdf:about="#intracellular_calcium_concentration.radius">
<dcterms:description>cell radius</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.alpha_up">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="#time_independent_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.f_Ca">
<dcterms:description>second inward calcium current inactivation variable</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.Na_o">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#time_independent_potassium_current.E_K">
<dcterms:description>potassium reversal potential</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.stim_start">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sodium_background_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#second_inward_calcium_current.Ca_o">
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<rdf:Description rdf:about="#property_63">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#environment_time">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_translocation.Ca_rel">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_9" />
<dcterms:description>concentration of calcium in release site</dcterms:description>
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<rdf:Description rdf:about="#Na_Ca_exchanger.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_42">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.i_siNa">
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<dcterms:description>saturation potential of second inward calcium current inactivation gate</dcterms:description>
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<rdf:Description rdf:about="#potassium_background_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#membrane.i_NaCa">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_concentration.V_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_86">
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</semsim:isComputationalComponentFor>
<dcterms:description>cytosolic volume</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.CaChon">
<dcterms:description>fraction of channels inactivated by voltage-dependent process</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.time">
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<rdf:Description rdf:about="#membrane.stim_end">
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<rdf:Description rdf:about="#calcium_background_current.g_b_Ca">
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<dcterms:description>product fraction</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.alpha_f_Ca">
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<rdf:Description rdf:about="#second_inward_calcium_current.i_si">
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<rdf:Description rdf:about="#property_55">
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<dcterms:description>total second inward current</dcterms:description>
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<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#membrane.F">
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<semsim:isComputationalComponentFor>
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<dcterms:description>concentration of intracellular calcium</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current.V">
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<rdf:Description rdf:about="#property_12">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current_h_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release.ActFrac">
<dcterms:description>activator fraction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_pump.K_mK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>potassium half-saturation constant for sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_translocation.Ca_rel">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_82">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in release site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_background_current.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_pump.K_c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.i_Stim">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_K1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_background_current.E_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_26">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#membrane.stim_duration">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_concentration.i_siK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_102">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>second inward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release.VoltDep">
<dcterms:description>voltage dependence of calcium release</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_concentration.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.V_up_ratio">
<dcterms:description>volume ratio of uptake site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_e_ratio">
<dcterms:description>volume ratio of endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_Stim">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_i_ratio">
<dcterms:description>volume ratio of cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.beta_Calmod">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#extracellular_potassium_concentration.K_c">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_4" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#potassium_background_current.g_b_K">
<dcterms:description>potassium background current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.Ca_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.i_b_Ca">
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#hilgemann_noble_1987" bqmodel:isDescribedBy="2884668" />
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.f_Ca">
<dcterms:description>second inward calcium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_concentration.i_b_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_103">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>background potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#time_independent_potassium_current_i_K1">
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.delta_m">
<dcterms:description>saturation potential of fast sodium current activation gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#potassium_background_current.E_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#potassium_background_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_47">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_background_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_29">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.Ca_up">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_75">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in uptake site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.delta_d">
<dcterms:description>saturation potential of second inward calcium current activation gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#Na_Ca_exchanger.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.i_up">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_115">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux into sarcoplasmic reticulum through SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#potassium_background_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current.K_c">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_4" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_sodium_concentration.i_NaCa">
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.Ca_up">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_106">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in uptake site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.CaChoff">
<dcterms:description>fraction of channels with calcium-bound regulatory site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.beta_f_Ca">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration_Ca_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_105">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#potassium_background_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_39">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current_h_gate.h">
<dcterms:description>fast sodium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.V_i_ratio">
<dcterms:description>volume ratio of cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.k_NaCa">
<dcterms:description>maximum sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.Na_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_2" />
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#Na_Ca_exchanger.Ca_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_translocation.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.alpha_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release.Ca_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_sodium_concentration.i_siNa">
<dcterms:description>second inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.i_b_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_120">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_b_Ca">
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Ca_Trop">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_12" />
<dcterms:description>concentration of calcium-bound troponin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#Na_Ca_exchanger.Na_o">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_0" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration_Ca_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_sodium_concentration.i_b_Na">
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_potassium_concentration.V_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_9" />
<dcterms:description>cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current.Na_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_2" />
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_release.PrecFrac">
<dcterms:description>precursor fraction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_b_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release_i_rel">
<dcterms:description>calcium flux out of sarcoplasmic reticulum through ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.f_Ca">
<dcterms:description>second inward calcium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_potassium_concentration.K_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_6" />
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.beta_Trop">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#time_independent_potassium_current.K_m_K1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_51">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium half-saturation constant for time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_Cell">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_10" />
<dcterms:description>cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.beta_d">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.K_c">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_4" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_NaCa">
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_m_gate.beta_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.V_Cell">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_114">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_up">
<dcterms:description>calcium flux into sarcoplasmic reticulum through SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.i_NaCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_118">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sodium_potassium_pump.Na_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_2" />
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.i_rel">
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<rdf:Description rdf:about="#property_117">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
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<dcterms:description>calcium flux out of sarcoplasmic reticulum through ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_release.VoltDep">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_4" />
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<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_4" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Ca_up">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
<dcterms:description>concentration of calcium in uptake site</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current.Na_o">
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<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current_h_gate.h">
<dcterms:description>fast sodium current inactivation variable</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.i_si">
<dcterms:description>total second inward current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#Na_Ca_exchanger.k_NaCa">
<dcterms:description>maximum sodium-calcium exchanger current</dcterms:description>
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<rdf:Description rdf:about="#intracellular_calcium_concentration.V_rel_ratio">
<dcterms:description>volume ratio of release site</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current.Na_o">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_0" />
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_potassium_concentration.i_siK">
<dcterms:description>second inward potassium current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.length">
<dcterms:description>cell length</dcterms:description>
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<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.K_srca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_74">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>half-saturation constant of calcium binding to sarcoplasmic reticulum enzymes</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_translocation_i_trans">
<dcterms:description>calcium transfer flux from the network sarcoplasmic reticulum to the junctional sarcoplasmic reticulum</dcterms:description>
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<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
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<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_107">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in release site</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sodium_background_current.Na_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_2" />
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<rdf:Description rdf:about="#second_inward_calcium_current.V">
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<rdf:Description rdf:about="#property_59">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release.ActRate">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#extracellular_calcium_concentration.i_siCa">
<dcterms:description>second inward calcium current</dcterms:description>
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<rdf:Description rdf:about="#intracellular_sodium_concentration.i_Na">
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<rdf:Description rdf:about="#property_87">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>fast sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_rel">
<dcterms:description>calcium flux out of sarcoplasmic reticulum through ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.i_up">
<dcterms:description>calcium flux into sarcoplasmic reticulum through SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.stim_start">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>fast sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.Ca_o">
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<rdf:Description rdf:about="#property_40">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
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<rdf:Description rdf:about="#membrane.i_NaK">
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<rdf:Description rdf:about="#property_5">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_up_ratio">
<dcterms:description>volume ratio of uptake site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.beta_f_Ca">
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<rdf:Description rdf:about="#extracellular_calcium_concentration.i_siCa">
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<rdf:Description rdf:about="#property_96">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>second inward calcium current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.i_NaCa">
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
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<rdf:Description rdf:about="#time_independent_potassium_current.E_K">
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<rdf:Description rdf:about="#property_49">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</semsim:isComputationalComponentFor>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#time_independent_potassium_current.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
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<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022" />
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.K_2">
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<rdf:Description rdf:about="#property_72">
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.stim_period">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.Ca_i">
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<rdf:Description rdf:about="#property_69">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
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<rdf:Description rdf:about="#membrane.i_si">
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<rdf:Description rdf:about="#property_8">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>total second inward current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_calcium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
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<rdf:Description rdf:about="#calcium_translocation.alpha_tr">
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<rdf:Description rdf:about="#calcium_background_current_i_b_Ca">
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<rdf:Description rdf:about="#property_33">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>calcium background current</dcterms:description>
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<rdf:Description rdf:about="#second_inward_calcium_current.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_61">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current_i_Na">
<dcterms:description>fast sodium current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current_h_gate.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#extracellular_sodium_concentration.Na_o">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_0" />
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="#sodium_background_current.g_b_Na">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
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</semsim:isComputationalComponentFor>
<dcterms:description>sodium background current conductance</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sodium_background_current.g_b_Na">
<dcterms:description>sodium background current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.Trop">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_111">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of troponin</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current_i_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>fast sodium current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.stim_amplitude">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318" />
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.beta_m">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.K_srca">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_8" />
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<rdf:Description rdf:about="#membrane.i_b_Na">
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<rdf:Description rdf:about="#property_2">
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</semsim:isComputationalComponentFor>
<dcterms:description>sodium background current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.i_Na">
<dcterms:description>fast sodium current</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.C_m">
<dcterms:description>membrane capacitance</dcterms:description>
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<rdf:Description rdf:about="#fast_sodium_current.m">
<dcterms:description>fast sodium current activation variable</dcterms:description>
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.alpha_d">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_release.Ca_rel">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_9" />
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</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#intracellular_calcium_concentration.alpha_Trop">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="#extracellular_potassium_concentration.K_c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_98">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="#membrane.i_b_K">
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<dcterms:description>background potassium current</dcterms:description>
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<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_2" />
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<rdf:Description rdf:about="#intracellular_calcium_concentration.V_e_ratio">
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<rdf:Description rdf:about="hilgemann_noble_1987.cellml#calcium_background_current.g_b_Ca">
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<dcterms:description>calcium background current</dcterms:description>
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<dcterms:description>membrane potential</dcterms:description>
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<dcterms:description>cytosolic volume</dcterms:description>
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calmodulin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#Na_Ca_exchanger_i_NaCa">
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#sodium_potassium_pump_i_NaK">
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Calmod">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_11" />
<dcterms:description>concentration of calmodulin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#time_independent_potassium_current.K_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_6" />
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#intracellular_sodium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_43">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.Ve">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_113">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>volume of endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.C_m">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#fast_sodium_current.K_i">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_6" />
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#time_independent_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.i_b_Na">
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.beta_up">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.alpha_Calmod">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.K_c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_65">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#time_independent_potassium_current.g_K1">
<dcterms:description>time-independent potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#membrane.i_si">
<dcterms:description>total second inward current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#second_inward_calcium_current.CaChon">
<dcterms:description>fraction of channels inactivated by voltage-dependent process</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_background_current.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_30">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_translocation.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.Ca_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_41">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.stim_period">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#Na_Ca_exchanger.Ca_o">
<bqbiol:isPropertyOf rdf:resource="hilgemann_noble_1987.cellml#entity_7" />
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="hilgemann_noble_1987.cellml#extracellular_calcium_concentration.i_b_Ca">
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.CaChon">
<dcterms:description>fraction of channels inactivated by voltage-dependent process</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.length">
<dcterms:description>cell length</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_m_gate.alpha_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
</rdf:RDF>
</model>
