- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-25 20:32:57+13:00
- Desc:
- modifying composite annotations
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/8f4c90b98ea0253dc01be6f1950c133cec18ca5e/albrecht_colegrove_hongpaisan_pivovarova_andrews_friel_2001/model/albrecht_colegrove_hongpaisan_pivovarova_andrews_friel_2001.rdf
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<article>
<articleinfo>
<title>Multiple Modes of Calcium-induced Calcium Release in Sympathetic Neurons</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model is consistently represented within the CellML but contains sets of algebraic equations that prevent the model from being solved in currently available software - 03/08.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Calcium is an important signalling ion, and changes in Ca
<superscript>2+</superscript>
concentration ([Ca
<superscript>2+</superscript>
]) regulate diverse processes in many cellular compartments. In excitable cells, depolarisation-induced Ca
<superscript>2+</superscript>
entry increases [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
, leading to secondary changes in [Ca
<superscript>2+</superscript>
] within organelles such as mitochondria and ER that regulate specific Ca
<superscript>2+</superscript>
-sensitive targets within these organelles. Although mitochondria accumulate Ca
<superscript>2+</superscript>
in response to depolarisation-evoked [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
elevations (see
<ulink url="${HTML_EXMPL_COLEGROVE_MODEL}">
The Colegrove
<emphasis>et al</emphasis>
Model Of Mitochondrial Ca
<superscript>2+</superscript>
Uptake And Release, 2000
</ulink>
), the ER has been described as either a Ca
<superscript>2+</superscript>
source or sink. Different modes of net ER Ca
<superscript>2+</superscript>
transport are expected to have very different effects on cytoplasmic and intraluminal Ca
<superscript>2+</superscript>
signals and on the processes they regulate.
</para>
<para>
In their 2001 model, Meredith A. Albrecht, Stephen L. Colegrove, Jarin Hongpaisan, Natalia B. Pivovarova, S. Brian Andrews and David D. Friel have examined the relationship between changes in [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
and [Ca
<superscript>2+</superscript>
]
<subscript>ER</subscript>
during weak depolarisation in sympathetic neurons. The total Ca
<superscript>2+</superscript>
flux during the recovery phase following membrane depolarisation was divided into four components (see
<xref linkend="fig_cell_diagram" />
below). One representing net Ca
<superscript>2+</superscript>
extrusion across the plasma membrane (J
<subscript>extru</subscript>
), one representing Ca
<superscript>2+</superscript>
entry through voltage-gated Ca
<superscript>2+</superscript>
channels (J
<subscript>ICa</subscript>
), one representing ER Ca
<superscript>2+</superscript>
uptake via a Ca
<superscript>2+</superscript>
ATPase (J
<subscript>SERCA</subscript>
) and one representing passive ER Ca
<superscript>2+</superscript>
release. This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in
<xref linkend="sec_download_this_model" />
.
</para>
<para>The complete original paper reference is cited below:</para>
<para>
<ulink url="http://www.jgp.org/cgi/content/abstract/118/1/83">
Multiple Modes of Calcium-induced Calcium Release in Sympathetic Neurons I: Attenuation of Endoplasmic Reticulum Ca
<superscript>2+</superscript>
Accumulation at Low [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
during Weak Depolarisation
</ulink>
, Meredith A. Albrecht, Stephen L. Colegrove, Jarin Hongpaisan, Natalia B. Pivovarova, S. Brian Andrews and David D. Friel, 2001,
<ulink url="http://www.jgp.org/">
<emphasis>The Journal Of General Physiology</emphasis>
</ulink>
, 118, 83-100. (
<ulink url="http://www.jgp.org/cgi/content/full/118/1/83">Full text</ulink>
and
<ulink url="http://www.jgp.org/cgi/reprint/118/1/83.pdf">PDF</ulink>
versions of the article are available for Journal Members on the JGP website.)
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=11429446&amp;dopt=Abstract">PubMed ID: 11429446</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell schematic for the model</title>
</objectinfo>
<imagedata fileref="albrecht_2001.png" />
</imageobject>
</mediaobject>
<caption>
Schematic of the model indicating Ca
<superscript>2+</superscript>
compartmentation in the extracellular matrix, cytosol and the ER and pathways for Ca
<superscript>2+</superscript>
ion movement between the compartments.
</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
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