Location: Calcium Dynamics Annotations @ b24005e7fdb5 / winograd_destexhe_sanchezvives_2008 / model / winograd_destexhe_sanchezvives_2008.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-24 22:25:06+13:00
Desc:
adding OMEX archives to workspace
Permanent Source URI:
https://models.cellml.org/workspace/7f1/rawfile/b24005e7fdb523ed7a40bb482604b2d30e7b4020/winograd_destexhe_sanchezvives_2008/model/winograd_destexhe_sanchezvives_2008.rdf
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<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#kinetic.p_1">
    <dcterms:description>fraction of hyperpolarisation-activated cationic channels in second messenger-bound P1 state</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#membrane.I_app">
    <dcterms:description>externally applied stimulus current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#rate_constants.k_4">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KM_p_gate.p_inf">
    <dcterms:description>steady state function of slow potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_m_gate.beta">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_h.I_h">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>hyperpolarisation-activated cationic current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_m_gate.V_T">
    <dcterms:description>threshold voltage</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#G_nonlin.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_CaL.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_Na.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KD_n_gate.n">
    <dcterms:description>delayed rectifier potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#stimulus_protocol.i_stimStart">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#rate_constants.alpha">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_KM.p">
    <dcterms:description>slow potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KD_n_gate.alpha_n">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#kinetic.p_0">
    <dcterms:description>fraction of hyperpolarisation-activated cationic channels in second messenger-bound P0 state</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#rate_constants.k_1Ca">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#CaL_q_gate.tau_q">
    <dcterms:description>time constant of L-type calcium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KD_n_gate.V_T">
    <dcterms:description>threshold voltage</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KD_n_gate.tau_n">
    <dcterms:description>activation time constant of delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_m_gate.m_inf">
    <dcterms:description>steady state function of sodium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#rate_constants.h_inf">
    <dcterms:description>steady state function of sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_KM.g_KM">
    <dcterms:description>slow potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#dCa_i_dt.tau_r">
    <dcterms:description>calcium removal time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#stimulus_protocol.period">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#kinetic.k_3p">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_CaL.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#stimulus_protocol.I_app">
    <dcterms:description>externally applied stimulus current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_CaL.P_Ca">
    <dcterms:description>L-type calcium channel permeability to calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_KM.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#CaL_q_gate.q">
    <dcterms:description>L-type calcium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#CaL_q_gate.q_inf">
    <dcterms:description>steady state function of L-type calcium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_Na.V_S">
    <dcterms:description>spike voltage</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#stimulus_protocol.i_stimAmplitude">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_CaL.G">
    <dcterms:description>function of voltage and ionic concentrations</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#G_nonlin.Z">
    <dcterms:description>valence of calcium ion</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#rate_constants.k_2">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_h_gate.V_T">
    <dcterms:description>threshold voltage</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#kinetic.k_2">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#membrane.I_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#G_nonlin.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#kinetic.c_1">
    <dcterms:description>fraction of hyperpolarisation-activated cationic channels in closed state</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#dCa_i_dt.Ca_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#entity_2">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#entity_3">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226054"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracelullar calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#kinetic.beta">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#membrane.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_CaL.q">
    <dcterms:description>L-type calcium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#dCa_i_dt.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_leak.I_leak">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>leakage current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_h.g_hbar">
    <dcterms:description>hyperpolarisation-activated cationic current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#stimulus_protocol.i_stimEnd">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#CaL_q_gate.beta_q">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_KM.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#membrane.C_m">
    <dcterms:description>membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_Na.V_T">
    <dcterms:description>threshold voltage</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#membrane.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_h_gate.h_inf">
    <dcterms:description>steady state function of sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#CaL_q_gate.alpha_q">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_Na.m">
    <dcterms:description>sodium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KD_n_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_KD.I_KD">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#kinetic.k_1Ca">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#rate_constants.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./winograd_destexhe_sanchezvives_2008.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracelullar calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KM_p_gate.tau_p">
    <dcterms:description>activation time constant of slow potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#environment.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#rate_constants.V_S">
    <dcterms:description>spike voltage</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_KD.V_T">
    <dcterms:description>threshold voltage</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#membrane.V_S">
    <dcterms:description>spike voltage</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#rate_constants.p_1">
    <dcterms:description>fraction of hyperpolarisation-activated cationic channels in second messenger-bound P1 state</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#dCa_i_dt.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_h.o_2">
    <dcterms:description>fraction of hyperpolarisation-activated cationic channels in open O2 state</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#kinetic.k_4">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_h.cac">
    <bqbiol:isPropertyOf rdf:resource="./winograd_destexhe_sanchezvives_2008.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-activation constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#membrane.I_KD">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_h_gate.alpha_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KM_p_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KM_p_gate.p">
    <dcterms:description>slow potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#G_nonlin.I_CaL">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_m_gate.tau_m">
    <dcterms:description>time constant of sodium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_h.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./winograd_destexhe_sanchezvives_2008.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracelullar calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#Na_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_Na.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#KM_p_gate.tau_max">
    <dcterms:description>maximum activation time constant of slow potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#membrane.I_KM">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>slow potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#I_KD.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./winograd_destexhe_sanchezvives_2008.cellml#winograd_destexhe_sanchez_vives_2008"
     bqmodel:isDescribedBy="18474856"
     semsim:modelName="winograd_destexhe_sanchez_vives_2008">
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;Hyperpolarization-Activated Graded Persistent Activity in the Prefrontal Cortex&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Geoffrey&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Nunns&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Bioengineering Institute, The University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This model runs in PCEnv and is based off the NEURON code for this paper. The units are continuous throughout but the model does not recreate the published results. It utilizes DAE solving techniques and advances in these could result in better output.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;Abstract: We describe a phenomenon of hyperpolarization-activated graded persistent activity (HAGPA) in prefrontal cortex neurons. Successive hyperpolarizing pulses induced increasingly higher rates of tonic firing that remained stable for tens of seconds, allowing the neuron to retain a memory of the previous history of stimulation. This phenomenon occurred at the cellular level and in the absence of neuromodulators. Neurons with HAGPA had a sag during hyperpolarization, and blocking h-current eliminated the sag and prevented HAGPA, suggesting that the activation of this hyperpolarization-activated cationic current was necessary for the occurrence of the phenomenon. A single-neuron biophysical model including h-current modulation by intracellular calcium was able to display HAGPA. This form of neuronal memory not only allows the transformation of inhibition into an increase of firing rate, but also endows neurons with a mechanism to compute the properties of successive inputs into persistent activity, thus solving a difficult computational problem.&lt;/para&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Hyperpolarization-Activated Graded Persistent Activity in the Prefrontal Cortex, Milena Winograd, Alain Destexhe, Maria V. Sanchez-Vives, 2008,&#xD;
        &lt;emphasis&gt;Proceedings of the National Academy of the Sciences of the United States of America&lt;/emphasis&gt;&#xD;
        , 105, 7298-7303.&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;list_uids=18474856&amp;amp;dopt=Abstract"&gt;PubMed ID: 18474856&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_reaction_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;model diagram&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="winograd_2008.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;Schematic diagram of the neuron model.&lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
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