- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-25 18:50:11+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- https://models.cellml.org/workspace/7f1/rawfile/c5079f12eb1d8c164a111eea8277d5627c24a0b2/chay_1997/model/chay_1997.rdf
<rdf:RDF
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xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
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xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.n_infinity">
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</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#cytosolic_calcium.k_pump">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
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</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>sequestration rate of intracellular calcium</dcterms:description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
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</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
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</rdf:Description>
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</rdf:Description>
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</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
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</rdf:Description>
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</rdf:Description>
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<dcterms:description>activation time constant of delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#Na_leak_current.g_NaL">
<dcterms:description>sodium leak current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#membrane.T">
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<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
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<dcterms:description>activation time constant of calcium current D-gate</dcterms:description>
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<rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.lamda_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.h_infinity">
<dcterms:description>steady state function of fast current H-gate activation variable</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
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</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.Sn">
<dcterms:description>saturation potential of delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.K_NS">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
</rdf:Description>
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<bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.h">
<dcterms:description>fast current H-gate activation variable</dcterms:description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
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</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current_m_gate.Sm">
<dcterms:description>saturation potential of fast current M-gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current_i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current.n">
<dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#Na_leak_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.g_K_Ca">
<dcterms:description>calcium-sensitive potassium current conductance</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
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<dcterms:description>steady state function of fast current M-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#membrane.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#chay_1997"
bqmodel:isDescribedBy="9284334"
semsim:modelName="chay_1997">
<semsim:unknown>Pancreatic Beta-cell</semsim:unknown>
<semsim:unknown>The Chay et al 1997 mathematical model of the effects of extracellular
and intracellular calcium on pancreatic beta cells.</semsim:unknown>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Extracellular And Intracellular Calcium Effects On Pancreatic Beta-Cells</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The university of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model runs in both OpenCell and COR to reproduce the published results. The value for the variable 'Ca_o' in the component 'calcium_current' can be altered to 0, 2.5, 5 or 7.5 mM to reproduce figures 5 a,b,c,d, respectively.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: The extracellular calcium concentration has interesting effects on bursting of pancreatic beta-cells. The mechanism underlying the extracellular Ca2+ effect is not well understood. By incorporating a low-threshold transient inward current to the store-operated bursting model of Chay, this paper elucidates the role of the extracellular Ca2+ concentration in influencing electrical activity, intracellular Ca2+ concentration, and the luminal Ca2+ concentration in the intracellular Ca2+ store. The possibility that this inward current is a carbachol-sensitive and TTX-insensitive Na+ current discovered by others is discussed. In addition, this paper explains how these three variables respond when various pharmacological agents are applied to the store-operated model.</para>
<para>The original paper reference is cited below:</para>
<para>
Effects of extracellular Calcium on Electrical Bursting and Intracellular and Luminal Calcium Oscillations in Insulin Secreting Pancreatic Beta-Cells, Teresa Ree Chay, 1997,
<emphasis>Biophysical Journal</emphasis>
, 73, 1673-1688.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9284334&amp;dopt=Abstract">PubMed ID: 9284334</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>diagram of the mitochondrial Ca2+ handling model</title>
</objectinfo>
<imagedata fileref="chay_1997.png" />
</imageobject>
</mediaobject>
<caption>
A schematic representation of the current and fluxes captured by the Chay 1997 pancreatic beta-cell model. This diagram shows the plasma membrane currents associated with burst and spike oscillations: the fast current, I
<subscript>fast</subscript>
; the calcium current, I
<subscript>
Ca
<superscript>2+</superscript>
</subscript>
; the cationic nonselective inward current, I
<subscript>NS</subscript>
; the delayed-rectifying K
<superscript>+</superscript>
current, I
<subscript>K(dr)</subscript>
, the calcium-sensitive K
<superscript>+</superscript>
current, I
<subscript>K(Ca)</subscript>
; the ATP-sensitive K
<superscript>+</superscript>
current, I
<subscript>K(ATP)</subscript>
; and the Na
<superscript>+</superscript>
leak current, I
<subscript>Na(L)</subscript>
. The ER intracellular Ca
<superscript>2+</superscript>
store is also shown with its associated transmembrane calcium fluxes: calcium release, J
<subscript>rel</subscript>
; and calcium uptake by the Ca
<superscript>2+</superscript>
-ATPase, J
<subscript>pump</subscript>
.
</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>rate of calcium pumping into endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.Sd">
<dcterms:description>saturation potential of calcium current D-gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#Na_leak_current.V_Na">
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
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</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.Vn">
<dcterms:description>half-maximal activation potential of delayed rectifier potassium channel</dcterms:description>
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<rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#Na_leak_current_i_NaL">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium leak current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current.g_K_dr">
<dcterms:description>delayed rectifier potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current.g_fast">
<dcterms:description>fast current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current.h">
<dcterms:description>fast current H-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#membrane.i_NS">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>cationic nonselective inward current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.n">
<dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current.K_Ca">
<bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
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</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#membrane.i_K_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#ATP_sensitive_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.d_infinity">
<dcterms:description>steady state function of calcium current D-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current.Ca_o">
<bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current_f_gate.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current_m_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current.f_infinity">
<dcterms:description>steady state function of calcium current F-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#membrane.i_K_dr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>delayed-rectifying potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current_m_gate.m_infinity">
<dcterms:description>steady state function of fast current M-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.g_NS">
<dcterms:description>cationic non-selective inward current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current_n_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.Vd">
<dcterms:description>half-maximal activation potential of calcium current D-gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#ATP_sensitive_K_current_i_K_ATP">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>ATP-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.VNS">
<dcterms:description>half-maximal activation potential of cationic non-selective inward current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current.T">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#ATP_sensitive_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current_f_gate.K_Ca">
<bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current_f_gate.f_infinity">
<dcterms:description>steady state function of calcium current F-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#delayed_rectifier_K_channel_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#cationic_nonselective_inward_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>pancreatic beta cell membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#environment_time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current.d">
<dcterms:description>calcium current D-gate activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current_h_gate.Vh">
<dcterms:description>half-maximal activation potential of fast current H-gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#membrane.i_NaL">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium leak current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#Ca_sensitive_K_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./chay_1997.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#membrane.i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#fast_current.V_fast">
<dcterms:description>fast current reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./chay_1997.cellml#calcium_current_d_gate.lamda_d">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
</rdf:RDF>