Location: Calcium Dynamics Annotations @ c5079f12eb1d / shorten_wall_2000 / model / shorten_wall_2000.cellml

Author:

neilstephen2001 <npar276@aucklanduni.ac.nz>

Date:

2021-01-25 18:50:11+13:00

Desc:

adding OMEX archives to workspace

Permanent Source URI:

https://models.cellml.org/workspace/7f1/rawfile/c5079f12eb1d8c164a111eea8277d5627c24a0b2/shorten_wall_2000/model/shorten_wall_2000.cellml

<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="shorten_wall_2000" cmeta:id="shorten_2000">
  <documentation xmlns="http://cellml.org/tmp-documentation">
    <article>
      <articleinfo>
        <title>A Hodgkin-Huxley Model Exhibiting Bursting Oscillations</title>
        <author>
          <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
          <affiliation>
            <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
          </affiliation>
        </author>
      </articleinfo>
      <section id="sec_status">
        <title>Model Status</title>
        <para>This model runs in OpenCell and COR and the units are consistent throughout. It it an accurate reproduction of the paper equations but does not reproduce the published results for unknown reasons, possibly because initial conditions for state variables were guessed.</para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        <para>ABSTRACT: We investigate bursting behaviour generated in an electrophysiological model of pituitary corticotrophs. The active and silent phases of this mode of bursting are generated by moving between two stable oscillatory solutions. The bursting is indirectly driven by slow modulation of the endoplasmic reticulum Ca2+ concentration. The model exhibits different modes of bursting, and we investigate mode transitions and similar modes of bursting in other Hodgkin-Huxley models. Bifurcation analysis and the use of null-surfaces facilitate a geometric interpretation of the model bursting modes and action potential generation, respectively.</para>
        <para>The original paper reference is cited below:</para>
        <para>
          A Hodgkin-Huxley Model Exhibiting Bursting Oscillations, Paul R. Shorten and David J.N. Wall, 2000,
          <emphasis>Bulletin of Mathematical Biology</emphasis>
          , 62, 695-715.
          <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10938629&amp;dopt=Abstract">PubMed ID: 10938629</ulink>
        </para>
        <informalfigure float="0" id="fig_cell_diagram">
          <mediaobject>
            <imageobject>
              <objectinfo>
                <title>cell schematic for the model</title>
              </objectinfo>
              <imagedata fileref="shorten_wall_2000.png" />
            </imageobject>
          </mediaobject>
          <caption>
            Schematic diagram of a pituitary corticotroph cell showing the transmembrane ionic currents and the intracellular Ca
            <superscript>2+</superscript>
            dynamics captured by the mathematical model.  Arrows indicate ionic channels and pumps.
            <emphasis>
              I
              <subscript>Ca-L</subscript>
            </emphasis>
            represents an L-type Ca
            <superscript>2+</superscript>
            current responsible for most of the Ca
            <superscript>2+</superscript>
            influx during an action potential.
            <emphasis>
              I
              <subscript>Ca-T</subscript>
            </emphasis>
            is a T-type voltage-sensitive Ca
            <superscript>2+</superscript>
            current.  A voltage-sensitive K
            <superscript>+</superscript>
            current,
            <emphasis>
              I
              <subscript>K-DR</subscript>
            </emphasis>
            , is mainly responsible for action potential repolarisation.  A Ca
            <superscript>2+</superscript>
            -activated K
            <superscript>+</superscript>
            current,
            <emphasis>
              I
              <subscript>K-Ca</subscript>
            </emphasis>
            , is essential for bursting behaviour.  The remaining leak current,
            <emphasis>
              I
              <subscript>leak</subscript>
            </emphasis>
            , represents all other ionic fluxes across the plasma membrane which are not specifically described by the model.
            <emphasis>
              J
              <subscript>eff</subscript>
            </emphasis>
            and
            <emphasis>
              J
              <subscript>up</subscript>
            </emphasis>
            are the ER and plasma membrane Ca
            <superscript>2+</superscript>
            -ATPase pumps, and
            <emphasis>
              J
              <subscript>rel</subscript>
            </emphasis>
            represents the ER Ca
            <superscript>2+</superscript>
            leakage term.  Within the ER and the cytosol, significant portions of Ca
            <superscript>2+</superscript>
            are bound to buffers, denoted by B
            <subscript>er</subscript>
            and B
            <subscript>c</subscript>
            respectively.
          </caption>
        </informalfigure>
      </sect1>
    </article>
  </documentation>
  <units name="millimolar">
    <unit exponent="-1.0" units="litre" />
    <unit prefix="milli" units="mole" />
  </units>
  <units name="per_micrometre">
    <unit exponent="-1.0" units="micrometre" />
  </units>
  <units name="picoL">
    <unit prefix="pico" units="litre" />
  </units>
  <units name="coulomb_per_mole">
    <unit units="coulomb" />
    <unit exponent="-1.0" units="mole" />
  </units>
  <units name="millimolar_per_millisecond">
    <unit units="millimolar" />
    <unit exponent="-1.0" units="millisecond" />
  </units>
  <units name="millimolar_picoL_per_millisecond">
    <unit units="picoL" />
    <unit units="millimolar" />
    <unit exponent="-1.0" units="millisecond" />
  </units>
  <units name="millivolt">
    <unit prefix="milli" units="volt" />
  </units>
  <units name="picoA">
    <unit prefix="pico" units="ampere" />
  </units>
  <units name="micrometre">
    <unit prefix="micro" units="metre" />
  </units>
  <units name="picoL_per_millisecond">
    <unit units="picoL" />
    <unit exponent="-1.0" units="millisecond" />
  </units>
  <units name="millivolt_millimolar">
    <unit units="millimolar" />
    <unit units="millivolt" />
  </units>
  <units name="millimolar_micrometre_per_millisecond">
    <unit exponent="-1.0" units="millisecond" />
    <unit units="millimolar" />
    <unit units="micrometre" />
  </units>
  <units name="picoF">
    <unit prefix="pico" units="farad" />
  </units>
  <units name="nanoS_per_millimolar">
    <unit prefix="nano" units="siemens" />
    <unit exponent="-1.0" units="millimolar" />
  </units>
  <units name="millisecond">
    <unit prefix="milli" units="second" />
  </units>
  <units name="joule_per_kilomole_kelvin">
    <unit exponent="-1.0" units="kelvin" />
    <unit exponent="-1.0" prefix="kilo" units="mole" />
    <unit units="joule" />
  </units>
  <units name="nanoS">
    <unit prefix="nano" units="siemens" />
  </units>
  <units name="millimolar_micrometre_per_millisecond_per_picoA">
    <unit units="millimolar" />
    <unit exponent="-1.0" prefix="pico" units="ampere" />
    <unit units="micrometre" />
    <unit exponent="-1.0" units="millisecond" />
  </units>
  <component name="environment">
    <variable cmeta:id="environment.time" name="time" public_interface="out" units="millisecond" />
    <variable cmeta:id="environment.V_cell" initial_value="1.77" name="V_cell" public_interface="out" units="picoL" />
    <variable cmeta:id="environment.Ca_e" initial_value="20" name="Ca_e" public_interface="out" units="millimolar" />
    <variable cmeta:id="environment.K_e" initial_value="5.6" name="K_e" public_interface="out" units="millimolar" />
    <variable cmeta:id="environment.K_i" initial_value="140" name="K_i" public_interface="out" units="millimolar" />
    <variable cmeta:id="environment.V_tau" initial_value="-60" name="V_tau" public_interface="out" units="millivolt" />
    <variable cmeta:id="environment.k_tau" initial_value="22" name="k_tau" public_interface="out" units="millivolt" />
  </component>
  <component name="membrane">
    <variable cmeta:id="membrane.V" initial_value="-70" name="V" public_interface="out" units="millivolt" />
    <variable cmeta:id="membrane.R" initial_value="8314" name="R" public_interface="out" units="joule_per_kilomole_kelvin" />
    <variable cmeta:id="membrane.T" initial_value="310" name="T" public_interface="out" units="kelvin" />
    <variable cmeta:id="membrane.F" initial_value="96845" name="F" public_interface="out" units="coulomb_per_mole" />
    <variable cmeta:id="membrane.Cm" initial_value="7" name="Cm" units="picoF" />
    <variable cmeta:id="membrane.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="membrane.i_Ca_L" name="i_Ca_L" public_interface="in" units="picoA" />
    <variable cmeta:id="membrane.i_Ca_T" name="i_Ca_T" public_interface="in" units="picoA" />
    <variable cmeta:id="membrane.i_K_DR" name="i_K_DR" public_interface="in" units="picoA" />
    <variable cmeta:id="membrane.i_K_Ca" name="i_K_Ca" public_interface="in" units="picoA" />
    <variable cmeta:id="membrane.i_leak" name="i_leak" public_interface="in" units="picoA" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>V</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <apply>
              <plus />
              <ci>i_Ca_L</ci>
              <ci>i_Ca_T</ci>
              <ci>i_K_DR</ci>
              <ci>i_K_Ca</ci>
              <ci>i_leak</ci>
            </apply>
          </apply>
          <ci>Cm</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="L_type_calcium_current">
    <variable cmeta:id="L_type_calcium_current.i_Ca_L" name="i_Ca_L" public_interface="out" units="picoA" />
    <variable cmeta:id="L_type_calcium_current.phi_Ca" name="phi_Ca" public_interface="out" units="millivolt_millimolar" />
    <variable cmeta:id="L_type_calcium_current.g_Ca_L" initial_value="9" name="g_Ca_L" units="nanoS_per_millimolar" />
    <variable cmeta:id="L_type_calcium_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <variable cmeta:id="L_type_calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="L_type_calcium_current.V_tau" name="V_tau" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="L_type_calcium_current.k_tau" name="k_tau" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="L_type_calcium_current.R" name="R" public_interface="in" units="joule_per_kilomole_kelvin" />
    <variable cmeta:id="L_type_calcium_current.T" name="T" public_interface="in" units="kelvin" />
    <variable cmeta:id="L_type_calcium_current.F" name="F" public_interface="in" units="coulomb_per_mole" />
    <variable cmeta:id="L_type_calcium_current.Ca_e" name="Ca_e" public_interface="in" units="millimolar" />
    <variable cmeta:id="L_type_calcium_current.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
    <variable cmeta:id="L_type_calcium_current.m_L" name="m_L" private_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_Ca_L</ci>
        <apply>
          <times />
          <ci>g_Ca_L</ci>
          <apply>
            <power />
            <ci>m_L</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
          </apply>
          <ci>phi_Ca</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>phi_Ca</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>V</ci>
            <apply>
              <minus />
              <ci>Ca_i</ci>
              <ci>Ca_e</ci>
            </apply>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <times />
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <ci>F</ci>
                  <ci>V</ci>
                </apply>
                <apply>
                  <times />
                  <ci>R</ci>
                  <ci>T</ci>
                </apply>
              </apply>
            </apply>
          </apply>
          <apply>
            <minus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <times />
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <ci>F</ci>
                  <ci>V</ci>
                </apply>
                <apply>
                  <times />
                  <ci>R</ci>
                  <ci>T</ci>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="L_type_calcium_current_m_gate">
    <variable cmeta:id="L_type_calcium_current_m_gate.m_L" initial_value="0" name="m_L" public_interface="out" units="dimensionless" />
    <variable cmeta:id="L_type_calcium_current_m_gate.m_L_infinity" name="m_L_infinity" units="dimensionless" />
    <variable cmeta:id="L_type_calcium_current_m_gate.tau_m_L" name="tau_m_L" units="millisecond" />
    <variable cmeta:id="L_type_calcium_current_m_gate.tau_m_L_max" initial_value="27" name="tau_m_L_max" units="millisecond" />
    <variable cmeta:id="L_type_calcium_current_m_gate.V_m_L" initial_value="-18" name="V_m_L" units="millivolt" />
    <variable cmeta:id="L_type_calcium_current_m_gate.k_m_L" initial_value="12" name="k_m_L" units="millivolt" />
    <variable cmeta:id="L_type_calcium_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="L_type_calcium_current_m_gate.V_tau" name="V_tau" public_interface="in" units="millivolt" />
    <variable cmeta:id="L_type_calcium_current_m_gate.k_tau" name="k_tau" public_interface="in" units="millivolt" />
    <variable cmeta:id="L_type_calcium_current_m_gate.time" name="time" public_interface="in" units="millisecond" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>m_L</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>m_L_infinity</ci>
            <ci>m_L</ci>
          </apply>
          <ci>tau_m_L</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>m_L_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <ci>V_m_L</ci>
                  <ci>V</ci>
                </apply>
                <ci>k_m_L</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>tau_m_L</ci>
        <apply>
          <divide />
          <ci>tau_m_L_max</ci>
          <apply>
            <plus />
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <ci>V</ci>
                  <ci>V_tau</ci>
                </apply>
                <ci>k_tau</ci>
              </apply>
            </apply>
            <apply>
              <times />
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                    <apply>
                      <minus />
                      <ci>V_tau</ci>
                      <ci>V</ci>
                    </apply>
                  </apply>
                  <ci>k_tau</ci>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="T_type_calcium_current">
    <variable cmeta:id="T_type_calcium_current.i_Ca_T" name="i_Ca_T" public_interface="out" units="picoA" />
    <variable cmeta:id="T_type_calcium_current.g_Ca_T" initial_value="10" name="g_Ca_T" units="nanoS_per_millimolar" />
    <variable cmeta:id="T_type_calcium_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <variable cmeta:id="T_type_calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current.V_tau" name="V_tau" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current.k_tau" name="k_tau" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current.phi_Ca" name="phi_Ca" public_interface="in" units="millivolt_millimolar" />
    <variable cmeta:id="T_type_calcium_current.m_T" name="m_T" private_interface="in" units="dimensionless" />
    <variable cmeta:id="T_type_calcium_current.h_T" name="h_T" private_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_Ca_T</ci>
        <apply>
          <times />
          <ci>g_Ca_T</ci>
          <apply>
            <power />
            <ci>m_T</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
          </apply>
          <ci>h_T</ci>
          <ci>phi_Ca</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="T_type_calcium_current_m_gate">
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    <variable cmeta:id="T_type_calcium_current_m_gate.m_T_infinity" name="m_T_infinity" units="dimensionless" />
    <variable cmeta:id="T_type_calcium_current_m_gate.tau_m_T" name="tau_m_T" units="millisecond" />
    <variable cmeta:id="T_type_calcium_current_m_gate.tau_m_T_max" initial_value="10" name="tau_m_T_max" units="millisecond" />
    <variable cmeta:id="T_type_calcium_current_m_gate.V_m_T" initial_value="-30" name="V_m_T" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current_m_gate.k_m_T" initial_value="10.5" name="k_m_T" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current_m_gate.V_tau" name="V_tau" public_interface="in" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current_m_gate.k_tau" name="k_tau" public_interface="in" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current_m_gate.time" name="time" public_interface="in" units="millisecond" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>m_T</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>m_T_infinity</ci>
            <ci>m_T</ci>
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          <ci>tau_m_T</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>m_T_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
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            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <ci>V_m_T</ci>
                  <ci>V</ci>
                </apply>
                <ci>k_m_T</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>tau_m_T</ci>
        <apply>
          <divide />
          <ci>tau_m_T_max</ci>
          <apply>
            <plus />
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <ci>V</ci>
                  <ci>V_tau</ci>
                </apply>
                <ci>k_tau</ci>
              </apply>
            </apply>
            <apply>
              <times />
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              <apply>
                <exp />
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                    <apply>
                      <minus />
                      <ci>V_tau</ci>
                      <ci>V</ci>
                    </apply>
                  </apply>
                  <ci>k_tau</ci>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="T_type_calcium_current_h_gate">
    <variable cmeta:id="T_type_calcium_current_h_gate.h_T" initial_value="0" name="h_T" public_interface="out" units="dimensionless" />
    <variable cmeta:id="T_type_calcium_current_h_gate.h_T_infinity" name="h_T_infinity" units="dimensionless" />
    <variable cmeta:id="T_type_calcium_current_h_gate.tau_h_T" initial_value="15" name="tau_h_T" units="millisecond" />
    <variable cmeta:id="T_type_calcium_current_h_gate.V_h_T" initial_value="-57" name="V_h_T" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current_h_gate.k_h_T" initial_value="5" name="k_h_T" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current_h_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="T_type_calcium_current_h_gate.time" name="time" public_interface="in" units="millisecond" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>h_T</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>h_T_infinity</ci>
            <ci>h_T</ci>
          </apply>
          <ci>tau_h_T</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>h_T_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <ci>V</ci>
                  <ci>V_h_T</ci>
                </apply>
                <ci>k_h_T</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="voltage_sensitive_K_current">
    <variable cmeta:id="voltage_sensitive_K_current.i_K_DR" name="i_K_DR" public_interface="out" units="picoA" />
    <variable cmeta:id="voltage_sensitive_K_current.phi_K" name="phi_K" public_interface="out" units="millivolt_millimolar" />
    <variable cmeta:id="voltage_sensitive_K_current.g_K_DR" initial_value="0.1" name="g_K_DR" units="nanoS_per_millimolar" />
    <variable cmeta:id="voltage_sensitive_K_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
    <variable cmeta:id="voltage_sensitive_K_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
    <variable cmeta:id="voltage_sensitive_K_current.R" name="R" public_interface="in" units="joule_per_kilomole_kelvin" />
    <variable cmeta:id="voltage_sensitive_K_current.T" name="T" public_interface="in" units="kelvin" />
    <variable cmeta:id="voltage_sensitive_K_current.F" name="F" public_interface="in" units="coulomb_per_mole" />
    <variable cmeta:id="voltage_sensitive_K_current.K_e" name="K_e" public_interface="in" units="millimolar" />
    <variable cmeta:id="voltage_sensitive_K_current.K_i" name="K_i" public_interface="in" units="millimolar" />
    <variable cmeta:id="voltage_sensitive_K_current.n" name="n" private_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_K_DR</ci>
        <apply>
          <times />
          <ci>g_K_DR</ci>
          <ci>n</ci>
          <ci>phi_K</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>phi_K</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>V</ci>
            <apply>
              <minus />
              <ci>K_i</ci>
              <ci>K_e</ci>
            </apply>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <times />
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
                  <ci>F</ci>
                  <ci>V</ci>
                </apply>
                <apply>
                  <times />
                  <ci>R</ci>
                  <ci>T</ci>
                </apply>
              </apply>
            </apply>
          </apply>
          <apply>
            <minus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <times />
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
                  <ci>F</ci>
                  <ci>V</ci>
                </apply>
                <apply>
                  <times />
                  <ci>R</ci>
                  <ci>T</ci>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="voltage_sensitive_K_current_n_gate">
    <variable cmeta:id="voltage_sensitive_K_current_n_gate.n" initial_value="0" name="n" public_interface="out" units="dimensionless" />
    <variable cmeta:id="voltage_sensitive_K_current_n_gate.n_infinity" name="n_infinity" units="dimensionless" />
    <variable cmeta:id="voltage_sensitive_K_current_n_gate.tau_n" initial_value="20" name="tau_n" units="millisecond" />
    <variable cmeta:id="voltage_sensitive_K_current_n_gate.V_n" initial_value="-20" name="V_n" units="millivolt" />
    <variable cmeta:id="voltage_sensitive_K_current_n_gate.k_n" initial_value="4.5" name="k_n" units="millivolt" />
    <variable cmeta:id="voltage_sensitive_K_current_n_gate.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="voltage_sensitive_K_current_n_gate.time" name="time" public_interface="in" units="millisecond" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>n</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <ci>n_infinity</ci>
            <ci>n</ci>
          </apply>
          <ci>tau_n</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>n_infinity</ci>
        <apply>
          <divide />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <exp />
              <apply>
                <divide />
                <apply>
                  <minus />
                  <ci>V_n</ci>
                  <ci>V</ci>
                </apply>
                <ci>k_n</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="Ca_activated_K_current">
    <variable cmeta:id="Ca_activated_K_current.i_K_Ca" name="i_K_Ca" public_interface="out" units="picoA" />
    <variable cmeta:id="Ca_activated_K_current.g_K_Ca" initial_value="0.09" name="g_K_Ca" units="nanoS_per_millimolar" />
    <variable cmeta:id="Ca_activated_K_current.Kc" initial_value="0.0004" name="Kc" units="millimolar" />
    <variable cmeta:id="Ca_activated_K_current.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="Ca_activated_K_current.V" name="V" public_interface="in" units="millivolt" />
    <variable cmeta:id="Ca_activated_K_current.phi_K" name="phi_K" public_interface="in" units="millivolt_millimolar" />
    <variable cmeta:id="Ca_activated_K_current.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_K_Ca</ci>
        <apply>
          <times />
          <apply>
            <divide />
            <apply>
              <times />
              <ci>g_K_Ca</ci>
              <apply>
                <power />
                <ci>Ca_i</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
              </apply>
            </apply>
            <apply>
              <plus />
              <apply>
                <power />
                <ci>Ca_i</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
              </apply>
              <apply>
                <power />
                <ci>Kc</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
              </apply>
            </apply>
          </apply>
          <ci>phi_K</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="leak_current">
    <variable cmeta:id="leak_current.i_leak" name="i_leak" public_interface="out" units="picoA" />
    <variable cmeta:id="leak_current.g_L" initial_value="0.3" name="g_L" units="nanoS" />
    <variable cmeta:id="leak_current.V_L" initial_value="-67" name="V_L" units="millivolt" />
    <variable cmeta:id="leak_current.time" name="time" public_interface="in" units="millisecond" />
    <variable cmeta:id="leak_current.V" name="V" public_interface="in" units="millivolt" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>i_leak</ci>
        <apply>
          <times />
          <ci>g_L</ci>
          <apply>
            <minus />
            <ci>V</ci>
            <ci>V_L</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="ER_calcium">
    <variable cmeta:id="ER_calcium.Ca_er" initial_value="0.0172" name="Ca_er" public_interface="out" units="millimolar" />
    <variable cmeta:id="ER_calcium.J_rel" name="J_rel" public_interface="out" units="millimolar_picoL_per_millisecond" />
    <variable cmeta:id="ER_calcium.J_up" name="J_up" public_interface="out" units="millimolar_picoL_per_millisecond" />
    <variable cmeta:id="ER_calcium.V_er" name="V_er" units="picoL" />
    <variable cmeta:id="ER_calcium.K_er" initial_value="0.0002" name="K_er" units="millimolar" />
    <variable cmeta:id="ER_calcium.f_er" initial_value="0.0025" name="f_er" units="dimensionless" />
    <variable cmeta:id="ER_calcium.P" initial_value="0.0012" name="P" units="picoL_per_millisecond" />
    <variable cmeta:id="ER_calcium.v_er" initial_value="0.00005" name="v_er" units="millimolar_picoL_per_millisecond" />
    <variable cmeta:id="ER_calcium.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
    <variable cmeta:id="ER_calcium.V_cell" name="V_cell" public_interface="in" units="picoL" />
    <variable cmeta:id="ER_calcium.time" name="time" public_interface="in" units="millisecond" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>Ca_er</ci>
        </apply>
        <apply>
          <times />
          <apply>
            <divide />
            <apply>
              <minus />
              <ci>f_er</ci>
            </apply>
            <ci>V_er</ci>
          </apply>
          <apply>
            <minus />
            <ci>J_rel</ci>
            <ci>J_up</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>J_rel</ci>
        <apply>
          <times />
          <ci>P</ci>
          <apply>
            <minus />
            <ci>Ca_er</ci>
            <ci>Ca_i</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>J_up</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>v_er</ci>
            <apply>
              <power />
              <ci>Ca_i</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
          <apply>
            <plus />
            <apply>
              <power />
              <ci>Ca_i</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
            <apply>
              <power />
              <ci>K_er</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>V_er</ci>
        <apply>
          <times />
          <ci>V_cell</ci>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.15</cn>
        </apply>
      </apply>
    </math>
  </component>
  <component name="cytosolic_calcium">
    <variable cmeta:id="cytosolic_calcium.Ca_i" initial_value="0.00026" name="Ca_i" public_interface="out" units="millimolar" />
    <variable cmeta:id="cytosolic_calcium.V_c" name="V_c" units="picoL" />
    <variable cmeta:id="cytosolic_calcium.K_p" initial_value="0.00008" name="K_p" units="millimolar" />
    <variable cmeta:id="cytosolic_calcium.f_cyt" initial_value="0.01" name="f_cyt" units="dimensionless" />
    <variable cmeta:id="cytosolic_calcium.v_p" initial_value="0.000045" name="v_p" units="millimolar_micrometre_per_millisecond" />
    <variable cmeta:id="cytosolic_calcium.J_in" name="J_in" units="millimolar_micrometre_per_millisecond" />
    <variable cmeta:id="cytosolic_calcium.J_eff" name="J_eff" units="millimolar_micrometre_per_millisecond" />
    <variable cmeta:id="cytosolic_calcium.alpha" initial_value="0.0000074" name="alpha" units="millimolar_micrometre_per_millisecond_per_picoA" />
    <variable cmeta:id="cytosolic_calcium.beta" initial_value="0.47" name="beta" units="per_micrometre" />
    <variable cmeta:id="cytosolic_calcium.i_Ca_L" name="i_Ca_L" public_interface="in" units="picoA" />
    <variable cmeta:id="cytosolic_calcium.i_Ca_T" name="i_Ca_T" public_interface="in" units="picoA" />
    <variable cmeta:id="cytosolic_calcium.J_rel" name="J_rel" public_interface="in" units="millimolar_picoL_per_millisecond" />
    <variable cmeta:id="cytosolic_calcium.J_up" name="J_up" public_interface="in" units="millimolar_picoL_per_millisecond" />
    <variable cmeta:id="cytosolic_calcium.V_cell" name="V_cell" public_interface="in" units="picoL" />
    <variable cmeta:id="cytosolic_calcium.time" name="time" public_interface="in" units="millisecond" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>Ca_i</ci>
        </apply>
        <apply>
          <plus />
          <apply>
            <times />
            <apply>
              <divide />
              <ci>f_cyt</ci>
              <ci>V_c</ci>
            </apply>
            <apply>
              <minus />
              <ci>J_rel</ci>
              <ci>J_up</ci>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>f_cyt</ci>
            <ci>beta</ci>
            <apply>
              <minus />
              <ci>J_in</ci>
              <ci>J_eff</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>J_in</ci>
        <apply>
          <times />
          <apply>
            <minus />
            <ci>alpha</ci>
          </apply>
          <apply>
            <plus />
            <ci>i_Ca_L</ci>
            <ci>i_Ca_T</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>J_eff</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>v_p</ci>
            <apply>
              <power />
              <ci>Ca_i</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
          <apply>
            <plus />
            <apply>
              <power />
              <ci>Ca_i</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
            <apply>
              <power />
              <ci>K_p</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>V_c</ci>
        <apply>
          <times />
          <ci>V_cell</ci>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.85</cn>
        </apply>
      </apply>
    </math>
  </component>
  <group>
    <relationship_ref relationship="containment" />
    <component_ref component="membrane">
      <component_ref component="ER_calcium" />
      <component_ref component="voltage_sensitive_K_current">
        <component_ref component="voltage_sensitive_K_current_n_gate" />
      </component_ref>
      <component_ref component="Ca_activated_K_current" />
      <component_ref component="T_type_calcium_current">
        <component_ref component="T_type_calcium_current_h_gate" />
        <component_ref component="T_type_calcium_current_m_gate" />
      </component_ref>
      <component_ref component="cytosolic_calcium" />
      <component_ref component="leak_current" />
      <component_ref component="L_type_calcium_current">
        <component_ref component="L_type_calcium_current_m_gate" />
      </component_ref>
    </component_ref>
  </group>
  <group>
    <relationship_ref relationship="encapsulation" />
    <component_ref component="voltage_sensitive_K_current">
      <component_ref component="voltage_sensitive_K_current_n_gate" />
    </component_ref>
    <component_ref component="T_type_calcium_current">
      <component_ref component="T_type_calcium_current_h_gate" />
      <component_ref component="T_type_calcium_current_m_gate" />
    </component_ref>
    <component_ref component="L_type_calcium_current">
      <component_ref component="L_type_calcium_current_m_gate" />
    </component_ref>
  </group>
  <connection>
    <map_components component_1="cytosolic_calcium" component_2="Ca_activated_K_current" />
    <map_variables variable_1="Ca_i" variable_2="Ca_i" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="leak_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="cytosolic_calcium" />
    <map_variables variable_1="V_cell" variable_2="V_cell" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="voltage_sensitive_K_current_n_gate" component_2="voltage_sensitive_K_current" />
    <map_variables variable_1="n" variable_2="n" />
  </connection>
  <connection>
    <map_components component_1="cytosolic_calcium" component_2="ER_calcium" />
    <map_variables variable_1="Ca_i" variable_2="Ca_i" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="voltage_sensitive_K_current" />
    <map_variables variable_1="F" variable_2="F" />
    <map_variables variable_1="R" variable_2="R" />
    <map_variables variable_1="V" variable_2="V" />
    <map_variables variable_1="T" variable_2="T" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="T_type_calcium_current" />
    <map_variables variable_1="k_tau" variable_2="k_tau" />
    <map_variables variable_1="V_tau" variable_2="V_tau" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="membrane" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="L_type_calcium_current" />
    <map_variables variable_1="F" variable_2="F" />
    <map_variables variable_1="R" variable_2="R" />
    <map_variables variable_1="V" variable_2="V" />
    <map_variables variable_1="T" variable_2="T" />
  </connection>
  <connection>
    <map_components component_1="T_type_calcium_current" component_2="T_type_calcium_current_m_gate" />
    <map_variables variable_1="V" variable_2="V" />
    <map_variables variable_1="time" variable_2="time" />
    <map_variables variable_1="V_tau" variable_2="V_tau" />
    <map_variables variable_1="k_tau" variable_2="k_tau" />
  </connection>
  <connection>
    <map_components component_1="environment" component_2="Ca_activated_K_current" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="T_type_calcium_current_h_gate" component_2="T_type_calcium_current" />
    <map_variables variable_1="h_T" variable_2="h_T" />
  </connection>
  <connection>
    <map_components component_1="cytosolic_calcium" component_2="L_type_calcium_current" />
    <map_variables variable_1="Ca_i" variable_2="Ca_i" />
  </connection>
  <connection>
    <map_components component_1="membrane" component_2="T_type_calcium_current" />
    <map_variables variable_1="V" variable_2="V" />
  </connection>
  <connection>
    <map_components component_1="L_type_calcium_current" component_2="T_type_calcium_current" />
    <map_variables variable_1="phi_Ca" variable_2="phi_Ca" />
  </connection>
  <connection>
    <map_components component_1="T_type_calcium_current" component_2="T_type_calcium_current_h_gate" />
    <map_variables variable_1="V" variable_2="V" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="ER_calcium" component_2="cytosolic_calcium" />
    <map_variables variable_1="J_up" variable_2="J_up" />
    <map_variables variable_1="J_rel" variable_2="J_rel" />
  </connection>
  <connection>
    <map_components component_1="L_type_calcium_current" component_2="membrane" />
    <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L" />
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    <map_variables variable_1="phi_K" variable_2="phi_K" />
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    <rdf:Description rdf:about="#T_type_calcium_current_m_gate.m_T_infinity">
      <dcterms:description>steady state function of T-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current.phi_K">
      <dcterms:description>potassium equilibrium potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.i_K_Ca">
      <dcterms:description>calcium-activated potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#environment.k_tau">
      <dcterms:description>slope factor for time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_h_gate.k_h_T">
      <dcterms:description>slope factor for T-type calcium channel inactivation</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#cytosolic_calcium.i_Ca_T">
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_m_gate.tau_m_T">
      <dcterms:description>T-type calcium channel activation time constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current.g_Ca_L">
      <dcterms:description>L-type calcium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_h_gate.h_T">
      <dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.i_K_DR">
      <dcterms:description>voltage-sensitive potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.P">
      <dcterms:description>endoplasmic reticulum permeability</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#Ca_activated_K_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#environment.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current.m_L">
      <dcterms:description>L-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_m_gate.m_T">
      <dcterms:description>T-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.f_er">
      <dcterms:description>endoplasmic reticulum calcium buffering factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current_m_gate.V_tau">
      <dcterms:description>midpoint potential of time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#cytosolic_calcium.J_in">
      <dcterms:description>calcium flux into the cell</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current_m_gate.k_tau">
      <dcterms:description>slope factor for time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current.R">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#Ca_activated_K_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_26">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_m_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#leak_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current.V_tau">
      <dcterms:description>midpoint potential of time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.alpha">
      <dcterms:description>calcium current to flux proportionality constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current.i_Ca_L">
      <dcterms:description>L-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_h_gate.V_h_T">
      <dcterms:description>T-type calcium channel half-inactivation potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_m_gate.k_m_T">
      <dcterms:description>slope factor for T-type calcium channel activation</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#ER_calcium.Ca_i">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_3" />
      <dcterms:description>concentration of intracellular calcium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_h_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_K_DR">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_7">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>voltage-sensitive potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current.phi_Ca">
      <dcterms:description>calcium equilibrium potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current_n_gate.n_infinity">
      <dcterms:description>steady state function of voltage-sensitive potassium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_m_gate.tau_m_T">
      <dcterms:description>T-type calcium channel activation time constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_m_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_17">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current_m_gate.tau_m_L_max">
      <dcterms:description>maximum L-type calcium channel activation time constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.V_cell">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_36">
          <semsim:physicalPropertyOf rdf:resource="#entity_0" />
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>volume of cell</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current_m_gate.k_m_L">
      <dcterms:description>slope factor for L-type calcium channel activation</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_m_gate.V_tau">
      <dcterms:description>midpoint potential of time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current_n_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_23">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.tau_n">
      <dcterms:description>voltage-sensitive potassium channel activation time constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current.n">
      <dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#Ca_activated_K_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#Ca_activated_K_current.i_K_Ca">
      <dcterms:description>calcium-activated potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#leak_current.V_L">
      <dcterms:description>leakage reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current.i_Ca_L">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_10">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>L-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#ER_calcium.P">
      <dcterms:description>endoplasmic reticulum permeability</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current.T">
      <dcterms:description>absolute temperature</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#ER_calcium.J_rel">
      <dcterms:description>calcium release flux from the endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current.h_T">
      <dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current.V_tau">
      <dcterms:description>midpoint potential of time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current.K_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_22">
          <semsim:physicalPropertyOf rdf:resource="#entity_5" />
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of intracellular potassium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current.phi_Ca">
      <dcterms:description>calcium equilibrium potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_K_Ca">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_8">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium-activated potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.V_er">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_33">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_10">
              <ro:part_of rdf:resource="#entity_1" />
              <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:63842" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>volume of endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.K_er">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_34">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_11">
              <ro:part_of>
                <rdf:Description rdf:about="#entity_9">
                  <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:63842" />
                </rdf:Description>
              </ro:part_of>
              <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of potassium in endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.R">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current.g_K_DR">
      <dcterms:description>voltage-sensitive potassium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#environment.Ca_e">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_1">
          <semsim:physicalPropertyOf rdf:resource="#entity_2" />
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of extracellular calcium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_16">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current.g_K_DR">
      <dcterms:description>voltage-sensitive potassium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_h_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_18">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_m_gate.tau_m_T_max">
      <dcterms:description>maximum T-type calcium channel activation time constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_m_gate.k_m_T">
      <dcterms:description>slope factor for T-type calcium channel activation</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#entity_1">
      <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:83098" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current_m_gate.m_L_infinity">
      <dcterms:description>steady state function of L-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#ER_calcium.J_up">
      <dcterms:description>calcium uptake flux from the endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.J_rel">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_31">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium release flux from the endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current.m_T">
      <dcterms:description>T-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_20">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_37">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of intracellular calcium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#ER_calcium.V_er">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_4" />
      <dcterms:description>volume of endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#Ca_activated_K_current.g_K_Ca">
      <dcterms:description>calcium-activated potassium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.i_Ca_T">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_41">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current.g_Ca_T">
      <dcterms:description>T-type calcium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.i_Ca_T">
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current.m_T">
      <dcterms:description>T-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.V_n">
      <dcterms:description>voltage-sensitive potassium channel half-activation potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current_m_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current_n_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_35">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of intracellular calcium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current.F">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#ER_calcium.V_cell">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_0" />
      <dcterms:description>volume of cell</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_h_gate.tau_h_T">
      <dcterms:description>T-type calcium channel inactivation time constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_leak">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_9">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>leakage current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#ER_calcium.K_er">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_4" />
      <dcterms:description>concentration of potassium in endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.n">
      <dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current.i_Ca_T">
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#environment.Ca_e">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_2" />
      <dcterms:description>concentration of extracellular calcium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current.k_tau">
      <dcterms:description>slope factor for time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current.V_tau">
      <dcterms:description>midpoint potential of time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#environment.V_tau">
      <dcterms:description>midpoint potential of time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#ER_calcium.v_er">
      <dcterms:description>maximum SERCA pump current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current_m_gate.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_14">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#cytosolic_calcium.alpha">
      <dcterms:description>calcium current to flux proportionality constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#Ca_activated_K_current.Ca_i">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_3" />
      <dcterms:description>concentration of intracellular calcium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current.phi_Ca">
      <dcterms:description>calcium equilibrium potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_m_gate.m_T">
      <dcterms:description>T-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#leak_current.g_L">
      <dcterms:description>leakage current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.f_cyt">
      <dcterms:description>cytosolic calcium buffering factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.T">
      <dcterms:description>absolute temperature</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_h_gate.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current.i_Ca_T">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_15">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>T-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#leak_current.g_L">
      <dcterms:description>leakage current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.Ca_er">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_30">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_8">
              <ro:part_of rdf:resource="#entity_9" />
              <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.i_leak">
      <dcterms:description>leakage current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current.h_T">
      <dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#cytosolic_calcium.J_up">
      <dcterms:description>calcium uptake flux from the endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#leak_current.i_leak">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_28">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>leakage current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current_n_gate.n">
      <dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#environment.K_e">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_2">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_4">
              <ro:part_of rdf:resource="#entity_3" />
              <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29103" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of extracellular potassium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#voltage_sensitive_K_current.K_e">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_21">
          <semsim:physicalPropertyOf rdf:resource="#entity_4" />
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of extracellular potassium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_h_gate.tau_h_T">
      <dcterms:description>T-type calcium channel inactivation time constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current_m_gate.k_tau">
      <dcterms:description>slope factor for time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current.F">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current.K_i">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_3" />
      <dcterms:description>concentration of intracellular potassium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current.i_K_DR">
      <dcterms:description>voltage-sensitive potassium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.Cm">
      <dcterms:description>membrane capacitance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_h_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.R">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current.F">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
    </rdf:Description>
    <rdf:Description rdf:about="#Ca_activated_K_current.g_K_Ca">
      <dcterms:description>calcium-activated potassium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#environment.K_i">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_3" />
      <dcterms:description>concentration of intracellular potassium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#cytosolic_calcium.i_Ca_L">
      <dcterms:description>L-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_11">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.F">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
    </rdf:Description>
    <rdf:Description rdf:about="#Ca_activated_K_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#ER_calcium.v_er">
      <dcterms:description>maximum SERCA pump current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_m_gate.tau_m_T_max">
      <dcterms:description>maximum T-type calcium channel activation time constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current.g_Ca_L">
      <dcterms:description>L-type calcium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#leak_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current.F">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.V">
      <dcterms:description>membrane potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#leak_current.V_L">
      <dcterms:description>leakage reversal potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_m_gate.V_tau">
      <dcterms:description>midpoint potential of time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current.k_tau">
      <dcterms:description>slope factor for time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.K_p">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_39">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>half-maximal activity constant of SERCA pump</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_m_gate.k_tau">
      <dcterms:description>slope factor for time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current_m_gate.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#cytosolic_calcium.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current_m_gate.k_m_L">
      <dcterms:description>slope factor for L-type calcium channel activation</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#cytosolic_calcium.V_c">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_3" />
      <dcterms:description>volume of cytosol</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current.g_Ca_T">
      <dcterms:description>T-type calcium current conductance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#shorten_2000" bqmodel:isDescribedBy="10938629" semsim:modelName="shorten_wall_2000">
      <semsim:unknown>Pituitary Corticotrophs</semsim:unknown>
      <semsim:unknown>Shorten and Wall's 2000 Hodgkin-Huxley type mathematical model of 
         bursting oscillations in pituitary corticotrophs.</semsim:unknown>
      <semsim:modelName>shorten_2000</semsim:modelName>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current_m_gate.V_m_L">
      <dcterms:description>L-type calcium channel half-activation potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#voltage_sensitive_K_current.T">
      <dcterms:description>absolute temperature</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#environment.V_cell">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_0" />
      <dcterms:description>volume of cell</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#environment.K_e">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_2" />
      <dcterms:description>concentration of extracellular potassium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.v_p">
      <dcterms:description>maximum plasma membrane pump rate</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current.m_L">
      <dcterms:description>L-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.J_rel">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_42">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium release flux from the endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#ER_calcium.Ca_er">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_4" />
      <dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current_m_gate.m_L_infinity">
      <dcterms:description>steady state function of L-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#membrane.Cm">
      <dcterms:description>membrane capacitance</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#cytosolic_calcium.f_cyt">
      <dcterms:description>cytosolic calcium buffering factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_m_gate.m_T_infinity">
      <dcterms:description>steady state function of T-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.J_up">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_43">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium uptake flux from the endoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_h_gate.V_h_T">
      <dcterms:description>T-type calcium channel half-inactivation potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.i_Ca_L">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_5">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>L-type calcium current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_m_gate.V_m_T">
      <dcterms:description>T-type calcium channel half-activation potential</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current.T">
      <dcterms:description>absolute temperature</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.J_eff">
      <dcterms:description>calcium flux out of the cell</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current_h_gate.k_h_T">
      <dcterms:description>slope factor for T-type calcium channel inactivation</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current.Ca_e">
      <bqbiol:isPropertyOf rdf:resource="shorten_wall_2000.cellml#entity_2" />
      <dcterms:description>concentration of extracellular calcium</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#T_type_calcium_current.k_tau">
      <dcterms:description>slope factor for time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#L_type_calcium_current_m_gate.m_L">
      <dcterms:description>L-type calcium channel activation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#T_type_calcium_current_h_gate.h_T_infinity">
      <dcterms:description>steady state function of T-type calcium channel inactivation variable</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#L_type_calcium_current_m_gate.V_tau">
      <dcterms:description>midpoint potential of time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="shorten_wall_2000.cellml#environment.V_tau">
      <dcterms:description>midpoint potential of time factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cytosolic_calcium.beta">
      <dcterms:description>ratio of cell surface area to cytosolic volume</dcterms:description>
    </rdf:Description>
  </rdf:RDF>
</model>