Location: Calcium Dynamics Annotations @ c5079f12eb1d / viswanathan_shaw_rudy_1999_a / model / viswanathan_shaw_rudy_1999_a.rdf

Author:

neilstephen2001 <npar276@aucklanduni.ac.nz>

Date:

2021-01-25 18:50:11+13:00

Desc:

adding OMEX archives to workspace

Permanent Source URI:

https://models.cellml.org/workspace/7f1/rawfile/c5079f12eb1d8c164a111eea8277d5627c24a0b2/viswanathan_shaw_rudy_1999_a/model/viswanathan_shaw_rudy_1999_a.rdf

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel.g">
    <dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_zdv_gate.zdv_ss">
    <dcterms:description>steady state function of transient outward current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.V_myo">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_1">
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226050"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>myoplasmic volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ATP_sensitive_potassium_current.g_K_ATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum ATP-sensitive potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics_i_up">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>calcium flux into sarcoplasmic reticulum through SERCA pumps</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#plateau_potassium_current_i_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.Ki">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_7">
        <bqbiol:isPartOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_1"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_ydv_gate.ydv">
    <dcterms:description>transient outward current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_j_gate.alpha_j">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current.K1_infinity">
    <dcterms:description>steady state function of time-independent potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.g_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum sodium channel conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.Ca_NSR">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_13">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_14">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62390"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of network sarcoplasmic reticulum calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current.g_to">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum transient outward potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.f">
    <dcterms:description>L-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ATP_sensitive_potassium_current.kATP">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_4">
        <bqbiol:isPartOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_1"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel_g_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ATP_sensitive_potassium_current_i_K_ATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>ATP-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#Na_Ca_exchanger.Cai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_f_gate.alpha_f">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#rapid_delayed_rectifier_potassium_current_i_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>rapid delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.K_mTn">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for troponin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_to">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>transient outward potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.G_rel">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.P_Ca">
    <dcterms:description>L-type calcium channel permeability to calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#rapid_delayed_rectifier_potassium_current_xr_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel_i_Ca_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>T-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_zdv_gate.alpha_zdv">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current_K1_gate.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sarcolemmal_calcium_pump_i_p_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_Ca_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_j_gate.j">
    <dcterms:description>fast sodium current slow inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.Ki">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_background_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ATP_sensitive_potassium_current.ATPi">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_8">
        <bqbiol:isPartOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_1"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.K_mup">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for calcium uptake into the sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#plateau_potassium_current.g_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum plateau potassium channel conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current_xs2_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.i_CaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium channel calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.Ko">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_6">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_3">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current.ydv">
    <dcterms:description>transient outward current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.volume">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_18">
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:67196"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>total cell volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_Na_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_background_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.d">
    <dcterms:description>L-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_d_gate.E0_d">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>L-type calcium channel D-gate reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.I_NaK">
    <dcterms:description>maximum sodium-potassium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.Cao">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_5">
        <bqbiol:isPartOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.Nai">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_0">
        <bqbiol:isPartOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_1"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_background_current_i_Ca_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_background_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current_i_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_zdv_gate.tau_zdv">
    <dcterms:description>time constant of transient outward current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.V_JSR">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_11">
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62387"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>junctional sarcoplasmic reticulum volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.i_CaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium channel potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_zdv_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_Ca_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>T-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.I_CaCa">
    <dcterms:description>maximum L-type calcium channel calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#Na_Ca_exchanger.Nai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_f_gate.f_infinity">
    <dcterms:description>steady state function of L-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_f_Ca_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.stim_amplitude">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#Na_Ca_exchanger_i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.Nao">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_2">
        <bqbiol:isPartOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current_K1_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_m_gate.alpha_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#plateau_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current_K1_gate.alpha_K1">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_background_current.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.Nai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_d_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_ns_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#Na_Ca_exchanger.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel_b_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics_i_tr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sodium-potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.V_NSR">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_14"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>junctional sarcoplasmic reticulum volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_CaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium channel potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.K_mNai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.CSQN_max">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_9">
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62353"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>maximum concentration of calsequestrin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.K_mCMDN">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_15">
        <bqbiol:isPartOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_1"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62343"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for calmodulin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.K_m_ns_Ca">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant of non-specific calcium-activated current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current.Nao">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.Tn_max">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_16">
        <bqbiol:isPartOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_1"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62338"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>maximum concentration of troponin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel.E_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.i_CaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium channel calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#rapid_delayed_rectifier_potassium_current.g_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum rapid potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel.b">
    <dcterms:description>T-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current.Ki">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.stim_period">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.Nao">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.I_ns_K">
    <dcterms:description>maximum calcium-activated calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_background_current.Cao">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#rapid_delayed_rectifier_potassium_current.xr">
    <dcterms:description>rapid delayed rectifier potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_m_gate.E0_m">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>fast sodium current M-gate reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.m">
    <dcterms:description>fast sodium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ATP_sensitive_potassium_current.Ko">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.Cai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current_xs1_gate.tau_xs1">
    <dcterms:description>time constant of slow delayed rectifier potassium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ATP_sensitive_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current_xs1_gate.xs1">
    <dcterms:description>slow delayed rectifier potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.Nai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_zdv_gate.zdv">
    <dcterms:description>transient outward current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.Ko">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>total L-type calcium channel current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>rapid delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.Nao">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#Na_Ca_exchanger.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_background_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.i_p_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#viswanathan_1999_M"
     bqmodel:isDescribedBy="10318671"
     semsim:modelName="viswanathan_shaw_rudy_1999_a">
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;Updated Luo-Rudy Mammalian Ventricular Model II&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Bioengineering Institute, University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This version was created by Penny Noble of Oxford University and is known to run in PCEnv and COR. &#xD;
This is the M-CELL VARIANT of the model.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;ABSTRACT: BACKGROUND: A growing body of evidence suggests that heterogeneity of ion channel expression and electrophysiological characteristics is an important property of the ventricular myocardium. The 2 components of the delayed rectifier potassium current, IKr (rapid) and IKs (slow), play a dominant role in the repolarization of the action potential and are important determinants of its duration. METHODS AND RESULTS: In this report, the effects of heterogeneities of IKr and IKs on action potential duration (APD) and its rate dependence (adaptation) are studied with the use of the LRd model of a mammalian ventricular cell. Results demonstrate the importance of IKs density variations in heterogeneity of repolarization. Cells with reduced IKs (eg, mid-myocardial M cells) display long APD and steep dependence of APD on rate. Mechanistically, accumulation of IKs activation and increased sodium calcium exchange current, INaCa, secondary to Na+ accumulation at a fast rate underlie the steep APD-rate relation of these cells. When cells are electrotonically coupled in a multicellular fiber through resistive gap junction, APD differences are reduced. The results demonstrate strong dependence of APD heterogeneity on the degree of intercellular coupling even in the normal physiological range. Highly reduced coupling maximizes APD heterogeneity. CONCLUSIONS: Heterogeneity of IKs:IKr density strongly influences APD and its rate dependence. However, in the intact myocardium, the degree of gap-junction coupling may be an important factor that determines the manifestation of APD heterogeneity and dispersion of repolarization. The clinical significance of this study is in the context of repolarization abnormalities and associated arrhythmias (eg, long QT syndrome and torsade de pointes).&lt;/para&gt;&#xD;
      &lt;para&gt;The complete paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study, Prakash C. Viswanathan, BE; Robin M. Shaw, PhD; and Yoram Rudy, PhD, 1999,&#xD;
        &lt;emphasis&gt;Circulation&lt;/emphasis&gt;&#xD;
        , 99, 2466-2474.&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;list_uids=10318671&amp;amp;dopt=Abstract"&gt;PubMed ID: 10318671&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_cell_diagram_shaw"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;cell diagram of the shaw and viswanathan models showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="viswanathan_1999.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;A schematic diagram of the 1999 Viswanathan et al. model.&lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
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    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_m_gate.m">
    <dcterms:description>fast sodium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.h">
    <dcterms:description>fast sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.Nai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current_K1_gate.beta_K1">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_ns_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.K_mKo">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>potassium half-saturation constant for sodium-potassium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_f_Ca_gate.Km_Ca">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant of L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#Na_Ca_exchanger.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#Na_Ca_exchanger.n_NaCa">
    <dcterms:description>cooperativity parameter of sodium-calcium exchanger</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.E_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.I_up">
    <dcterms:description>calcium uptake flux into sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.i_CaNa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium channel sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.P_K">
    <dcterms:description>L-type calcium channel permeability to potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.Nao">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current.Nai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump_i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sodium-potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.K_mrel">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for calcium release from the sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current_xs2_gate.tau_xs2">
    <dcterms:description>time constant of slow delayed rectifier potassium current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_background_current_i_Na_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>total L-type calcium channel current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_ydv_gate.ydv_ss">
    <dcterms:description>steady state function of transient outward current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.Cao">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_ydv_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics_i_leak">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>leakage current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_background_current.E_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#rapid_delayed_rectifier_potassium_current.Rect">
    <dcterms:description>steady state function of rapid delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.stim_end">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.Cainfluxtrack">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_f_gate.tau_f">
    <dcterms:description>time constant of L-type calcium channel inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_ydv_gate.tau_ydv">
    <dcterms:description>time constant of transient outward current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.stim_duration">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_d_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#rapid_delayed_rectifier_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel_b_gate.b_inf">
    <dcterms:description>steady state function of T-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_f_gate.beta_f">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sarcolemmal_calcium_pump.I_pCa">
    <dcterms:description>maximum sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current_K1_gate.K1_infinity">
    <dcterms:description>steady state function of time-independent potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.Ca_JSR">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_12"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of junctional sarcoplasmic reticulum calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel_f_Ca_gate.Cai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_ns_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ATP_sensitive_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.K_mCSQN">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#entity_10">
        <bqbiol:isPartOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_11"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62353"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for calsequestrin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.Ko">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current.g_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum time-independent potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_to">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>transient outward potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current_xs2_gate.xs2_infinity">
    <dcterms:description>steady state function of slow delayed rectifier potassium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_j_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.Cai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current.zdv">
    <dcterms:description>transient outward current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.A_cap">
    <dcterms:description>capacitive membrane area</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#plateau_potassium_current.Kp">
    <dcterms:description>steady state function of plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.G_rel_overload">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_h_gate.h">
    <dcterms:description>fast sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.i_ns_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel_b_gate.tau_b">
    <dcterms:description>time constant of T-type calcium channel activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#rapid_delayed_rectifier_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.stim_start">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.I_CaNa">
    <dcterms:description>maximum L-type calcium channel sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.preplength">
    <dcterms:description>cell length</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel_g_gate.g">
    <dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current.Ko">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_m_gate.delta_m">
    <dcterms:description>saturation potential of fast sodium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#environment_time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel_b_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.dVdt">
    <dcterms:description>change in membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current_i_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>slow delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_j_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#plateau_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.I_CaK">
    <dcterms:description>maximum L-type calcium channel potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_h_gate.beta_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#Na_Ca_exchanger.K_NaCa">
    <dcterms:description>maximum sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_background_current.g_Cab">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum background calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#slow_delayed_rectifier_potassium_current.E_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>slow delayed rectifier potassium current reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current_m_gate.beta_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.Nao">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current.Ki">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.A_cap">
    <dcterms:description>capacitive membrane area</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_zdv_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_zdv_gate.beta_zdv">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#rapid_delayed_rectifier_potassium_current_xr_gate.xr">
    <dcterms:description>rapid delayed rectifier potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current_i_ns_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#fast_sodium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#time_independent_potassium_current.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.K_leak">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel_g_gate.tau_g">
    <dcterms:description>time constant of T-type calcium channel inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#rapid_delayed_rectifier_potassium_current.Ko">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_potassium_pump.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#non_specific_calcium_activated_current.Nai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current_ydv_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#Na_Ca_exchanger.Cao">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.Cao">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.i_Na_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#sodium_background_current.g_Nab">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum background sodium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_background_current.E_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#T_type_Ca_channel.g_CaT">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum T-type calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_background_current.Cai">
    <bqbiol:isPropertyOf rdf:resource="./viswanathan_shaw_rudy_1999_a.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#calcium_dynamics.G_rel_max">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#membrane.i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sodium-potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#L_type_Ca_channel.P_Na">
    <dcterms:description>L-type calcium channel permeability to sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#ionic_concentrations.radius">
    <dcterms:description>cell radius</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./viswanathan_shaw_rudy_1999_a.cellml#transient_outward_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
</rdf:RDF>