def model individual_Ks as def import using "units_and_constants/units_BG.cellml" for unit mM using unit mM; unit fmol using unit fmol; unit per_fmol using unit per_fmol; unit J_per_mol using unit J_per_mol; unit fmol_per_sec using unit fmol_per_sec; unit C_per_mol using unit C_per_mol; unit J_per_C using unit J_per_C; unit microm3 using unit microm3; unit fF using unit fF; unit fC using unit fC; unit fA using unit fA; unit per_second using unit per_second; unit millivolt using unit millivolt; unit per_sec using unit per_sec; unit J_per_K_per_mol using unit J_per_K_per_mol; unit fmol_per_L using unit fmol_per_L; unit fmol_per_L_per_sec using unit fmol_per_L_per_sec; unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L; unit uM using unit uM; unit mM_per_sec using unit mM_per_sec; unit uM_per_sec using unit uM_per_sec; unit pL using unit pL; unit m_to_u using unit m_to_u; enddef; def import using "units_and_constants/constants_BG.cellml" for comp constants using comp constants; enddef; def comp environment as var time: second {pub: out}; // initial values var q_K_i: fmol {init: 1e-888, pub: out}; var q_K_o: fmol {init: 1e-888, pub: out}; var q_S_Ks00: fmol {init: 1e-888, pub: out}; var q_S_Ks01: fmol {init: 1e-888, pub: out}; var q_S_Ks10: fmol {init: 1e-888, pub: out}; var q_S_Ks11: fmol {init: 1e-888, pub: out}; // From submodule var v_Ks: fmol_per_sec {pub: in}; var v_xs1: fmol_per_sec {pub: in}; var v_xs2: fmol_per_sec {pub: in}; var v_xs3: fmol_per_sec {pub: in}; var v_xs4: fmol_per_sec {pub: in}; ode(q_K_i, time) = vvv; ode(q_K_o, time) = vvv; ode(q_S_Ks00, time) = vvv; ode(q_S_Ks01, time) = vvv; ode(q_S_Ks10, time) = vvv; ode(q_S_Ks11, time) = vvv; enddef; def comp Ks_parameters as var kappa_Ks: fmol_per_sec {init: 27.8683, pub: out}; var kappa_xs1: fmol_per_sec {init: 0.0131575, pub: out}; var kappa_xs2: fmol_per_sec {init: 0.0469146, pub: out}; var kappa_xs3: fmol_per_sec {init: 0.0131575, pub: out}; var kappa_xs4: fmol_per_sec {init: 0.0469146, pub: out}; var K_K_i: per_fmol {init: 1.42292, pub: out}; var K_K_o: per_fmol {init: 1.61696, pub: out}; var K_S_Ks00: per_fmol {init: 0.0885882, pub: out}; var K_S_Ks01: per_fmol {init: 0.0248451, pub: out}; var K_S_Ks10: per_fmol {init: 0.0248451, pub: out}; var K_S_Ks11: per_fmol {init: 0.00696797, pub: out}; enddef; def comp Ks as var time: second {pub: in}; var R: J_per_K_per_mol {pub: in}; var T: kelvin {pub: in}; // parameters var kappa_Ks: fmol_per_sec {pub: in}; var kappa_xs1: fmol_per_sec {pub: in}; var kappa_xs2: fmol_per_sec {pub: in}; var kappa_xs3: fmol_per_sec {pub: in}; var kappa_xs4: fmol_per_sec {pub: in}; var K_K_i: per_fmol {pub: in}; var K_K_o: per_fmol {pub: in}; var K_S_Ks00: per_fmol {pub: in}; var K_S_Ks01: per_fmol {pub: in}; var K_S_Ks10: per_fmol {pub: in}; var K_S_Ks11: per_fmol {pub: in}; // Input from global environment var q_K_i: fmol {pub: in}; var q_K_o: fmol {pub: in}; var q_S_Ks00: fmol {pub: in}; var q_S_Ks01: fmol {pub: in}; var q_S_Ks10: fmol {pub: in}; var q_S_Ks11: fmol {pub: in}; // Constitutive parameters var mu_K_i: J_per_mol; var mu_K_o: J_per_mol; var mu_S_Ks00: J_per_mol; var mu_S_Ks01: J_per_mol; var mu_S_Ks10: J_per_mol; var mu_S_Ks11: J_per_mol; var v_Ks: fmol_per_sec {pub: out}; var v_xs1: fmol_per_sec {pub: out}; var v_xs2: fmol_per_sec {pub: out}; var v_xs3: fmol_per_sec {pub: out}; var v_xs4: fmol_per_sec {pub: out}; mu_K_i = R*T*ln(K_K_i*q_K_i); mu_K_o = R*T*ln(K_K_o*q_K_o); mu_S_Ks00 = R*T*ln(K_S_Ks00*q_S_Ks00); mu_S_Ks01 = R*T*ln(K_S_Ks01*q_S_Ks01); mu_S_Ks10 = R*T*ln(K_S_Ks10*q_S_Ks10); mu_S_Ks11 = R*T*ln(K_S_Ks11*q_S_Ks11); v_Ks = ppp; v_xs1 = ppp; v_xs2 = ppp; v_xs3 = ppp; v_xs4 = ppp; enddef; def map between environment and Ks for vars time and time; vars q_K_i and q_K_i; vars q_K_o and q_K_o; vars q_S_Ks00 and q_S_Ks00; vars q_S_Ks01 and q_S_Ks01; vars q_S_Ks10 and q_S_Ks10; vars q_S_Ks11 and q_S_Ks11; vars v_Ks and v_Ks; vars v_xs1 and v_xs1; vars v_xs2 and v_xs2; vars v_xs3 and v_xs3; vars v_xs4 and v_xs4; enddef; def map between Ks and Ks_parameters for vars kappa_Ks and kappa_Ks; vars kappa_xs1 and kappa_xs1; vars kappa_xs2 and kappa_xs2; vars kappa_xs3 and kappa_xs3; vars kappa_xs4 and kappa_xs4; vars K_K_i and K_K_i; vars K_K_o and K_K_o; vars K_S_Ks00 and K_S_Ks00; vars K_S_Ks01 and K_S_Ks01; vars K_S_Ks10 and K_S_Ks10; vars K_S_Ks11 and K_S_Ks11; enddef; def map between constants and Ks for vars R and R; vars T and T; enddef; enddef;