def model individual_TCC as def import using "units_and_constants/units_BG.cellml" for unit mM using unit mM; unit fmol using unit fmol; unit per_fmol using unit per_fmol; unit J_per_mol using unit J_per_mol; unit fmol_per_sec using unit fmol_per_sec; unit C_per_mol using unit C_per_mol; unit J_per_C using unit J_per_C; unit microm3 using unit microm3; unit fF using unit fF; unit fC using unit fC; unit fA using unit fA; unit per_second using unit per_second; unit millivolt using unit millivolt; unit per_sec using unit per_sec; unit J_per_K_per_mol using unit J_per_K_per_mol; unit fmol_per_L using unit fmol_per_L; unit fmol_per_L_per_sec using unit fmol_per_L_per_sec; unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L; unit uM using unit uM; unit mM_per_sec using unit mM_per_sec; unit uM_per_sec using unit uM_per_sec; unit pL using unit pL; unit m_to_u using unit m_to_u; enddef; def import using "units_and_constants/constants_BG.cellml" for comp constants using comp constants; enddef; def comp environment as var time: second {pub: out}; // initial values var q_Ca_i: fmol {init: 1e-888, pub: out}; var q_Ca_o: fmol {init: 1e-888, pub: out}; var q_S00: fmol {init: 1e-888, pub: out}; var q_S10: fmol {init: 1e-888, pub: out}; var q_S20: fmol {init: 1e-888, pub: out}; var q_S01: fmol {init: 1e-888, pub: out}; var q_S11: fmol {init: 1e-888, pub: out}; var q_S21: fmol {init: 1e-888, pub: out}; // From submodule var v_TCC: fmol_per_sec {pub: in}; var v_b00: fmol_per_sec {pub: in}; var v_b01: fmol_per_sec {pub: in}; var v_b10: fmol_per_sec {pub: in}; var v_b11: fmol_per_sec {pub: in}; var v_g00: fmol_per_sec {pub: in}; var v_g10: fmol_per_sec {pub: in}; var v_g20: fmol_per_sec {pub: in}; ode(q_Ca_i, time) = vvv; ode(q_Ca_o, time) = vvv; ode(q_S00, time) = vvv; ode(q_S10, time) = vvv; ode(q_S20, time) = vvv; ode(q_S01, time) = vvv; ode(q_S11, time) = vvv; ode(q_S21, time) = vvv; enddef; def comp TCC_parameters as var kappa_TCC: fmol_per_sec {init: 3667.46, pub: out}; var kappa_b00: fmol_per_sec {init: 54.3421, pub: out}; var kappa_b01: fmol_per_sec {init: 2.00823, pub: out}; var kappa_b10: fmol_per_sec {init: 147.348, pub: out}; var kappa_b11: fmol_per_sec {init: 5.44529, pub: out}; var kappa_g00: fmol_per_sec {init: 0.363554, pub: out}; var kappa_g10: fmol_per_sec {init: 1.97154, pub: out}; var kappa_g20: fmol_per_sec {init: 2.6729, pub: out}; var K_Ca_i: per_fmol {init: 1.76045, pub: out}; var K_Ca_o: per_fmol {init: 11.6865, pub: out}; var K_S00: per_fmol {init: 4.87717, pub: out}; var K_S10: per_fmol {init: 0.899355, pub: out}; var K_S20: per_fmol {init: 0.663368, pub: out}; var K_S01: per_fmol {init: 131.975, pub: out}; var K_S11: per_fmol {init: 24.3362, pub: out}; var K_S21: per_fmol {init: 17.9505, pub: out}; enddef; def comp TCC as var time: second {pub: in}; var R: J_per_K_per_mol {pub: in}; var T: kelvin {pub: in}; // parameters var kappa_TCC: fmol_per_sec {pub: in}; var kappa_b00: fmol_per_sec {pub: in}; var kappa_b01: fmol_per_sec {pub: in}; var kappa_b10: fmol_per_sec {pub: in}; var kappa_b11: fmol_per_sec {pub: in}; var kappa_g00: fmol_per_sec {pub: in}; var kappa_g10: fmol_per_sec {pub: in}; var kappa_g20: fmol_per_sec {pub: in}; var K_Ca_i: per_fmol {pub: in}; var K_Ca_o: per_fmol {pub: in}; var K_S00: per_fmol {pub: in}; var K_S10: per_fmol {pub: in}; var K_S20: per_fmol {pub: in}; var K_S01: per_fmol {pub: in}; var K_S11: per_fmol {pub: in}; var K_S21: per_fmol {pub: in}; // Input from global environment var q_Ca_i: fmol {pub: in}; var q_Ca_o: fmol {pub: in}; var q_S00: fmol {pub: in}; var q_S10: fmol {pub: in}; var q_S20: fmol {pub: in}; var q_S01: fmol {pub: in}; var q_S11: fmol {pub: in}; var q_S21: fmol {pub: in}; // Constitutive parameters var mu_Ca_i: J_per_mol; var mu_Ca_o: J_per_mol; var mu_S00: J_per_mol; var mu_S10: J_per_mol; var mu_S20: J_per_mol; var mu_S01: J_per_mol; var mu_S11: J_per_mol; var mu_S21: J_per_mol; var v_TCC: fmol_per_sec {pub: out}; var v_b00: fmol_per_sec {pub: out}; var v_b01: fmol_per_sec {pub: out}; var v_b10: fmol_per_sec {pub: out}; var v_b11: fmol_per_sec {pub: out}; var v_g00: fmol_per_sec {pub: out}; var v_g10: fmol_per_sec {pub: out}; var v_g20: fmol_per_sec {pub: out}; mu_Ca_i = R*T*ln(K_Ca_i*q_Ca_i); mu_Ca_o = R*T*ln(K_Ca_o*q_Ca_o); mu_S00 = R*T*ln(K_S00*q_S00); mu_S10 = R*T*ln(K_S10*q_S10); mu_S20 = R*T*ln(K_S20*q_S20); mu_S01 = R*T*ln(K_S01*q_S01); mu_S11 = R*T*ln(K_S11*q_S11); mu_S21 = R*T*ln(K_S21*q_S21); v_TCC = ppp; v_b00 = ppp; v_b01 = ppp; v_b10 = ppp; v_b11 = ppp; v_g00 = ppp; v_g10 = ppp; v_g20 = ppp; enddef; def map between environment and TCC for vars time and time; vars q_Ca_i and q_Ca_i; vars q_Ca_o and q_Ca_o; vars q_S00 and q_S00; vars q_S10 and q_S10; vars q_S20 and q_S20; vars q_S01 and q_S01; vars q_S11 and q_S11; vars q_S21 and q_S21; vars v_TCC and v_TCC; vars v_b00 and v_b00; vars v_b01 and v_b01; vars v_b10 and v_b10; vars v_b11 and v_b11; vars v_g00 and v_g00; vars v_g10 and v_g10; vars v_g20 and v_g20; enddef; def map between TCC and TCC_parameters for vars kappa_TCC and kappa_TCC; vars kappa_b00 and kappa_b00; vars kappa_b01 and kappa_b01; vars kappa_b10 and kappa_b10; vars kappa_b11 and kappa_b11; vars kappa_g00 and kappa_g00; vars kappa_g10 and kappa_g10; vars kappa_g20 and kappa_g20; vars K_Ca_i and K_Ca_i; vars K_Ca_o and K_Ca_o; vars K_S00 and K_S00; vars K_S10 and K_S10; vars K_S20 and K_S20; vars K_S01 and K_S01; vars K_S11 and K_S11; vars K_S21 and K_S21; enddef; def map between constants and TCC for vars R and R; vars T and T; enddef; enddef;