- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-06-13 11:44:41+12:00
- Desc:
- Modify the intracelluar K from 4.7 mM to 5.9 mM
- Permanent Source URI:
- https://models.cellml.org/workspace/83f/rawfile/887894c158d460d4505bd3fb26d23a7b939ca442/Components/JKi.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="JKi" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="C_per_mmol" units_ref="C_per_mmol"/>
<units name="J_per_K_mol" units_ref="J_per_K_mol"/>
<units name="mM" units_ref="mM"/>
<units name="mV" units_ref="mV"/>
<units name="per_s" units_ref="per_s"/>
<units name="uM" units_ref="uM"/>
<units name="uM2" units_ref="uM2"/>
<units name="uM_per_s" units_ref="uM_per_s"/>
<units name="uM_per_s_mV" units_ref="uM_per_s_mV"/>
</import>
<import xlink:href="../cellLib/Components/E_Nernst.cellml">
<component component_ref="E_K" name="E_K"/>
</import>
<component name="JKi">
<variable name="R" private_interface="out" public_interface="in" units="J_per_K_mol"/>
<variable name="F" private_interface="out" public_interface="in" units="C_per_mmol"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="G_Ki" public_interface="in" units="uM_per_s_mV"/>
<variable name="v_K" private_interface="in" public_interface="out" units="mV"/>
<variable name="wi_init" public_interface="in" units="dimensionless"/>
<variable initial_value="wi_init" name="w_i" units="dimensionless"/>
<variable name="lambda" public_interface="in" units="per_s"/>
<variable name="K_activationi" units="dimensionless"/>
<variable name="c_w" public_interface="in" units="uM"/>
<variable name="v_Ca3" public_interface="in" units="mV"/>
<variable name="R_K" public_interface="in" units="mV"/>
<variable name="beta" public_interface="in" units="uM2"/>
<variable name="Ki" private_interface="out" public_interface="in" units="mM"/>
<variable name="K_out" private_interface="out" public_interface="in" units="mM"/>
<variable name="t" public_interface="in" units="second"/>
<variable name="c_i" public_interface="in" units="uM"/>
<variable name="v_i" public_interface="in" units="mV"/>
<variable name="J_Ki" public_interface="out" units="uM_per_s"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_Ki</ci>
<apply>
<times/>
<ci>G_Ki</ci>
<ci>w_i</ci>
<apply>
<minus/>
<ci>v_i</ci>
<ci>v_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>w_i</ci>
</apply>
<apply>
<times/>
<ci>lambda</ci>
<apply>
<minus/>
<ci>K_activationi</ci>
<ci>w_i</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_activationi</ci>
<apply>
<divide/>
<apply>
<power/>
<apply>
<plus/>
<ci>c_i</ci>
<ci>c_w</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<ci>c_i</ci>
<ci>c_w</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>beta</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_i</ci>
<ci>v_Ca3</ci>
</apply>
</apply>
<ci>R_K</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="JKi">
<component_ref component="E_K"/>
</component_ref>
</group>
<connection>
<map_components component_1="E_K" component_2="JKi"/>
<map_variables variable_1="E_K" variable_2="v_K"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="K_out"/>
</connection>
</model>
