- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-06-13 11:44:41+12:00
- Desc:
- Modify the intracelluar K from 4.7 mM to 5.9 mM
- Permanent Source URI:
- https://models.cellml.org/workspace/83f/rawfile/887894c158d460d4505bd3fb26d23a7b939ca442/Doc/Components.rst
Components
----------
CellML divides the mathematical model into distinct components, which are able to be re-used.
The main CellML components are:
- The major elements involved in transplasmalemmal ion exchange, including:
- Voltage-operated :math:`Ca^{2+}` channels (VOCC): `JVOCCi <Components/JVOCCi.cellml>`_
- The plasma membrane :math:`Ca^{2+}`-ATPase (PMCA): `JPMCAi <Components/JPMCAi.cellml>`_
- The :math:`Na^{+}/Ca^{2+}` exchanger (NCX): `JNCXi <Components/JNCXi.cellml>`_
- The :math:`Na^{+}/K^{+}` ATPase (NKA): `JNKAi <Components/JNKAi.cellml>`_
- :math:`Ca^{2+}`- and voltage-operated :math:`K^{+}` channels (KC): `JKi <Components/JKi.cellml>`_
- :math:`Cl^{-}` channels (CC): `JCli <Components/JCli.cellml>`_
- Intracellular Ca2+ handling, including:
- The sarcoendoplasmic Ca2+-ATPase (SERCA): `JSERCAi <Components/JSERCAi.cellml>`_
- Calcium Induced Calcium Release (CICR) via the ryanodine receptors: `JCICRi <Components/JCICRi.cellml>`_
- Basal Ca2+ leak: `Jleaki <Components/Jleaki.cellml>`_
- :math:`Ca^{2+}` concentration in the cytosol (c): `Cai <Components/Cai.cellml>`_
- :math:`Ca^{2+}` concentration in sarcoplasmic reticulum (s): `Casr <Components/Casr.cellml>`_
- The dynamics of the cell membrane potential (v): `Vm <Components/Vm.cellml>`_
Each of these blocks is itself a CellML model, which enables us to reuse the various components in future studies and models.
