AE is dependent on pH_i (negatively) and pH_e (positively), J_kinetic is scaled by (1+10^(-ni(pH_i-pKi)))*(1+10^(ne(pH_e-pKe))) This scale is rearranged to scale = (1+Kmi^-ni*[H_i]^ni)*(1+Kme^ne*[H_e]^-ne) Add two reactions to each existing reaction in the 6 state scheme. But only affecting the forward reaction, leaving the reverse alone. Kd = Km^ni(1) and Kd = Km^-ne(2) ni and -ne are the stoichiometries of H_i and H_e In final bond graph, each state Sx is the sum of 3 velocities.